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Topic Review
VNPs for Anti-Cancer Therapy
Naturally occurring viral nanomaterials have gained popularity owing to their biocompatible and biodegradable nature. Plant virus nanoparticles (VNPs) can be used as nanocarriers for a number of biomedical applications. Plant VNPs are inexpensive to produce, safe to administer and efficacious as treatments. Features which distinguish plant viruses from synthetic nanocarriers include stability, flexibility, diversity in shape and size for use in drug delivery and the nontoxic nature of plant viruses in humans. Cancer is one of the most common death causing disease worldwide and it is characterized by uncontrolled rapid cell division and differentiation. VNPs are an ideal choice to apply for cancer treatment owing to the enhanced permeation and retention (EPR) potential of cancer cells for these nanoparticles, whereas VNPs cannot penetrate through healthy tissues due to tightly packed endothelial cells.
  • 670
  • 16 Sep 2021
Topic Review
VLSI Structures for DNA Sequencing
DNA sequencing is a critical functionality in biomedical research, and technical advances that improve it have important implications for human health. The overall structure of DNA is negatively charged and has a negative electrostatic potential due to a negatively charged phosphate backbone. Nucleotides are electroactive compounds that produce reduction and oxidation signals after hybridization. These high electrostatic potentials can be exploited with VLSI charge-sensitive electronic structures. The sequence of DNA is encoded within each nitrogenous base: adenine (A), guanine (G), cytosine (C), or thymine (T), and this 4-bit system allows for large amounts of information to be stored in a single DNA molecule, which may contain upward of 3 billion bases. 
  • 602
  • 28 Mar 2022
Biography
Vladimir Karapetoff
Vladimir Karapetoff (January 8, 1876 in Saint Petersburg, Russian Empire – January 11, 1948) was a Russian-American electrical engineer, inventor, professor, and author. He was the son of Nikita Ivanovich Karapetov and Anna Joakimovna Karapetova. Karapetoff first studied at Petersburg State University of Means of Communication taking his first certification in 1897 and a second in 1902. Dur
  • 346
  • 08 Dec 2022
Topic Review
VKORC1 Gene
Vitamin K epoxide reductase complex subunit 1.
  • 332
  • 23 Dec 2020
Topic Review
Vitro Tissue Culture-Induced Variation
Somaclonal variation includes genetic or epigenetic changes exhibited between clonal regenerants and their corresponding donor plants derived via in vitro tissue cultures (A. Leva, L.M.R. Rinaldi, in Encyclopedia of Applied Plant Sciences (Second Edition), 2017). It usually assumes that the changes are being transmitted during a generative cycle. However, in some cases, to stress the fact that not all changes are either not analyzed in the progeny or may not be sexually transmitted, the tissue culture-induced variation seems to reflect better the issue (Quantification of the tissue-culture induced variation in barley (Hordeum vulgare L.) Bednarek, PT., Orłowska, R., Koebner, RMD., Zimny, J. 2007 BMC Plant Biology 7 (1), 1-9).
  • 642
  • 06 Aug 2021
Topic Review
Vitro Plant Regeneration
Plants generally have the highest regenerative ability because they show a high degree of developmental plasticity. Although the basic principles of plant regeneration date back many years, understanding the cellular, molecular, and physiological mechanisms based on these principles is currently in progress. In addition to the significant effects of some factors such as medium components, phytohormones, explant type, and light on the regeneration ability of an explant, recent reports evidence the involvement of molecular signals in organogenesis and embryogenesis responses to explant wounding, induced plant cell death, and phytohormones interaction. However, some cellular behaviors such as the occurrence of somaclonal variations and abnormalities during the in vitro plant regeneration process may be associated with adverse effects on the efficacy of plant regeneration. A review of past studies suggests that, in some cases, regeneration in plants involves the reprogramming of distinct somatic cells, while in others, it is induced by the activation of relatively undifferentiated cells in somatic tissues. However, this review covers the most important factors involved in the process of plant regeneration and discusses the mechanisms by which plants monitor this process.
  • 1.0K
  • 02 Nov 2020
Topic Review
Vitiligo
Vitiligo is a condition that causes patchy loss of skin coloring (pigmentation). The average age of onset of vitiligo is in the mid-twenties, but it can appear at any age. It tends to progress over time, with larger areas of the skin losing pigment. Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body.
  • 676
  • 04 Jan 2021
Topic Review
Vitelliform Macular Dystrophy
Vitelliform macular dystrophy is a genetic eye disorder that can cause progressive vision loss. This disorder affects the retina, the specialized light-sensitive tissue that lines the back of the eye. Specifically, vitelliform macular dystrophy disrupts cells in a small area near the center of the retina called the macula. The macula is responsible for sharp central vision, which is needed for detailed tasks such as reading, driving, and recognizing faces. Vitelliform macular dystrophy causes a fatty yellow pigment (lipofuscin) to build up in cells underlying the macula. Over time, the abnormal accumulation of this substance can damage cells that are critical for clear central vision. As a result, people with this disorder often lose their central vision, and their eyesight may become blurry or distorted. Vitelliform macular dystrophy typically does not affect side (peripheral) vision or the ability to see at night. Researchers have described two forms of vitelliform macular dystrophy with similar features. The early-onset form (known as Best disease) usually appears in childhood; the onset of symptoms and the severity of vision loss vary widely. The adult-onset form begins later, usually in mid-adulthood, and tends to cause vision loss that worsens slowly over time. The two forms of vitelliform macular dystrophy each have characteristic changes in the macula that can be detected during an eye examination.
  • 451
  • 23 Dec 2020
Topic Review
Vitamins in Treatment of Parkinson’s Disease
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder after Alzheimer’s disease. Pathophysiologically, it is characterized by intracytoplasmic aggregates of α-synuclein protein in the Lewy body and loss of dopaminergic neurons from substantia nigra pars compacta and striatum regions of the brain. Although the exact mechanism of neurodegeneration is not fully elucidated, it has been reported that environmental toxins such as MPTP, rotenone, paraquat, and MPP+ induce oxidative stress, which is one of the causative factors for it. There is no complete cure. However, the indispensable role of oxidative stress in mediating PD indicates that antioxidant therapy could be a possible therapeutic strategy against the disease. The deficiency of vitamins has been extensively co-related to PD. Dietary supplementation of vitamins with antioxidant, anti-inflammatory, anti-apoptotic, and free radical scavenging properties could be the potential neuroprotective therapeutic strategy. 
  • 597
  • 24 Feb 2023
Topic Review
Vitamins B1, B3 and B6 in Charcot–Marie–Tooth Disease
The molecular mechanisms of Charcot–Marie–Tooth (CMT) disease, involving impaired vitamin metabolism and/or actions, are considered in light of the potential therapeutic actions of vitamins B1, B3 and B6 in the disease.
  • 665
  • 27 Jun 2023
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