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Tang, P. Vitiligo. Encyclopedia. Available online: https://encyclopedia.pub/entry/5990 (accessed on 20 September 2026).
Tang P. Vitiligo. Encyclopedia. Available at: https://encyclopedia.pub/entry/5990. Accessed September 20, 2026.
Tang, Peter. "Vitiligo" Encyclopedia, https://encyclopedia.pub/entry/5990 (accessed September 20, 2026).
Tang, P. (2021, January 04). Vitiligo. In Encyclopedia. https://encyclopedia.pub/entry/5990
Tang, Peter. "Vitiligo." Encyclopedia. Web. 04 January, 2021.
Vitiligo
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/vitiligo

Vitiligo is a condition that causes patchy loss of skin coloring (pigmentation). The average age of onset of vitiligo is in the mid-twenties, but it can appear at any age. It tends to progress over time, with larger areas of the skin losing pigment. Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body.

genetic conditions

References

  1. Boissy RE, Spritz RA. Frontiers and controversies in the pathobiology ofvitiligo: separating the wheat from the chaff. Exp Dermatol. 2009Jul;18(7):583-5. doi: 10.1111/j.1600-0625.2008.00826.x. Epub 2009 Mar 6. Citation on PubMed or Free article on PubMed Central
  2. Halder RM, Chappell JL. Vitiligo update. Semin Cutan Med Surg. 2009Jun;28(2):86-92. doi: 10.1016/j.sder.2009.04.008. Review. Citation on PubMed
  3. Jin Y, Birlea SA, Fain PR, Ferrara TM, Ben S, Riccardi SL, Cole JB, Gowan K,Holland PJ, Bennett DC, Luiten RM, Wolkerstorfer A, van der Veen JP, Hartmann A, Eichner S, Schuler G, van Geel N, Lambert J, Kemp EH, Gawkrodger DJ, Weetman AP, Taïeb A, Jouary T, Ezzedine K, Wallace MR, McCormack WT, Picardo M, Leone G,Overbeck A, Silverberg NB, Spritz RA. Genome-wide association analyses identify13 new susceptibility loci for generalized vitiligo. Nat Genet. 2012 May6;44(6):676-80. doi: 10.1038/ng.2272. Citation on PubMed or Free article on PubMed Central
  4. Jin Y, Birlea SA, Fain PR, Gowan K, Riccardi SL, Holland PJ, Mailloux CM,Sufit AJ, Hutton SM, Amadi-Myers A, Bennett DC, Wallace MR, McCormack WT, KempEH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K,van Geel N, Lambert J, Overbeck A, Spritz RA. Variant of TYR and autoimmunitysusceptibility loci in generalized vitiligo. N Engl J Med. 2010 May6;362(18):1686-97. doi: 10.1056/NEJMoa0908547. Epub 2010 Apr 21. Citation on PubMed or Free article on PubMed Central
  5. Jin Y, Birlea SA, Fain PR, Mailloux CM, Riccardi SL, Gowan K, Holland PJ,Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, PicardoM, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A,Spritz RA. Common variants in FOXP1 are associated with generalized vitiligo. NatGenet. 2010 Jul;42(7):576-8. doi: 10.1038/ng.602. Epub 2010 Jun 6. Citation on PubMed or Free article on PubMed Central
  6. Jin Y, Riccardi SL, Gowan K, Fain PR, Spritz RA. Fine-mapping of vitiligosusceptibility loci on chromosomes 7 and 9 and interactions with NLRP1 (NALP1). JInvest Dermatol. 2010 Mar;130(3):774-83. doi: 10.1038/jid.2009.273. Epub 2009 Sep3. Citation on PubMed or Free article on PubMed Central
  7. LaBerge GS, Bennett DC, Fain PR, Spritz RA. PTPN22 is genetically associatedwith risk of generalized vitiligo, but CTLA4 is not. J Invest Dermatol. 2008Jul;128(7):1757-62. doi: 10.1038/sj.jid.5701233. Epub 2008 Jan 17. Citation on PubMed
  8. Laberge GS, Birlea SA, Fain PR, Spritz RA. The PTPN22-1858C>T (R620W)functional polymorphism is associated with generalized vitiligo in the Romanianpopulation. Pigment Cell Melanoma Res. 2008 Apr;21(2):206-8. doi:10.1111/j.1755-148X.2008.00443.x. Citation on PubMed
  9. Richmond JM, Frisoli ML, Harris JE. Innate immune mechanisms in vitiligo:danger from within. Curr Opin Immunol. 2013 Dec;25(6):676-82. doi:10.1016/j.coi.2013.10.010. Epub 2013 Nov 12. Review. Citation on PubMed or Free article on PubMed Central
  10. Smith AG, Sturm RA. Multiple genes and locus interactions in susceptibility tovitiligo. J Invest Dermatol. 2010 Mar;130(3):643-5. doi: 10.1038/jid.2009.403. Citation on PubMed
  11. Spritz RA. Recent progress in the genetics of generalized vitiligo. J GenetGenomics. 2011 Jul 20;38(7):271-8. doi: 10.1016/j.jgg.2011.05.005. Epub 2011 Jun 12. Review. Citation on PubMed or Free article on PubMed Central
  12. Spritz RA. The genetics of generalized vitiligo. Curr Dir Autoimmun.2008;10:244-57. doi: 10.1159/000131501. Review. Citation on PubMed
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
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Update Date: 04 Jan 2021
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