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Topic Review
Neurodegeneration with Brain Iron Accumulation
The syndromes of neurodegeneration with brain iron accumulation (NBIA) encompass a group of invalidating and progressive rare diseases that share the abnormal accumulation of iron in the basal ganglia. The onset of NBIA disorders ranges from infancy to adulthood. Main clinical signs are related to extrapyramidal features (dystonia, parkinsonism and choreoathetosis), and neuropsychiatric abnormalities. Ten NBIA forms are widely accepted to be caused by mutations in the genes PANK2, PLA2G6, WDR45, C19ORF12, FA2H, ATP13A2, COASY, FTL1, CP, and DCAF17. However, many patients remain without a genetic diagnosis, and therefore, there must be additional yet undiscovered NBIA genes. The genetic heterogeneity and the corresponding encoded proteins emphasize that several pathways are involved in NBIA syndromes: iron and lipid metabolism, mitochondrial dynamics, and autophagy. Moreover, for these forms as well as for many neurodegenerative conditions, mitochondrial dysfunction and oxidative stress are common mechanisms of disease.
  • 934
  • 22 Sep 2021
Topic Review
Food Plants in Rural Home Gardens (Bulgaria)
The home garden is a unique human-nature interspace that accommodates a diverse spectrum of plant species and provides multiple services to households. One of the most important roles of home gardens is to shelter the agricultural plant diversity that provides for diverse and healthy nutrition, especially in rural communities. 
  • 935
  • 26 Nov 2021
Topic Review
Cucumber Green Mottle Mosaic Virus
Cucumber green mottle mosaic virus (CGMMV), as a typical seed-borne virus, causes costly and devastating diseases in the vegetable trade worldwide.
  • 935
  • 29 Nov 2021
Topic Review
‘Chen Xi’ Rose
Flower color is one of the most prominent traits of rose flowers and determines their ornamental value. The ‘Chen Xi’ variety of rose has a very beautiful flower showing color changes during the blooming, which contributes a lot to its ornamental value. 
  • 934
  • 22 Oct 2021
Topic Review
Pharmacological Aspects of Moringa oleifera
Moringa oleifera is an ancient remedy plant, known as the miraculous plant due to its many prominent uses and significant health benefits. It is a nutrient-rich plant, with exceptional bioactive compounds, such as polyphenols that possess several medicinal properties. Many significant studies have been carried out to evaluate the ethnomedicinal and pharmacological properties of M. oleifera in various applications.
  • 935
  • 27 Sep 2022
Topic Review
Encapsulation Systems for Antimicrobial Food Packaging Components
Encapsulation is defined as the process to entrap one substance (active agent) within another substance, yielding small particles that release their contents at controlled rates over prolonged periods of time and under specific conditions. Antimicrobial active packaging has emerged as an effective technology to reduce microbial growth in food products increasing both their shelf-life and microbial safety for the consumer while maintaining their quality and sensorial properties. 
  • 933
  • 12 Jan 2022
Biography
B. A. Chopade
Professor B. A. Chopade is a distinguish scientist, innovator and academician of international repute. His research area includes microbiology, biotechnology and nanotechnology. He is research mentor, institution builder, great visionary and innovative administrator. Currently he is working as Vice-Chancellor as well as advisor to the Pro- Chancellor at AKS University, Satna, Madhya Pradesh, Ind
  • 934
  • 22 Feb 2023
Topic Review
Microbiota–Gut–Brain Axis in Mood Disorders
The microbiota–gut–brain axis is a bidirectional communication pathway that enables the gut microbiota to communicate with the brain through direct and indirect signaling pathways to influence brain physiology, function, and even behavior. Several taxonomic changes in the gut microbiota have been reported in neurodevelopmental disorders, mood disorders such as anxiety and depression, and neurodegenerative disorders such as Alzheimer’s disease. 
  • 933
  • 17 Feb 2022
Topic Review
Biosynthesis of Lasso Peptides
Lasso peptides are a subclass of ribosomally synthesized and post-translationally modified peptides (RiPPs) and feature the threaded, lariat knot-like topology. The basic post-translational modifications (PTMs) of lasso peptide contain two steps, including the leader peptide removal of the ribosome-derived linear precursor peptide by an ATP-dependent cysteine protease, and the macrolactam cyclization by an ATP-dependent macrolactam synthetase.
  • 933
  • 26 Jul 2022
Topic Review
Interferon Lambda
Interferons (IFN) are crucial for the innate immune response. Slightly more than two decades ago, a new type of IFN was discovered: the lambda IFN (type III IFN). Like other IFN, the type III IFN display antiviral activity against a wide variety of infections, they induce expression of antiviral, interferon-stimulated genes (MX1, OAS, IFITM1), and they have immuno-modulatory activities that shape adaptive immune responses. Unlike other IFN, the type III IFN signal through distinct receptors is limited to a few cell types, primarily mucosal epithelial cells. Type III IFN elicit fewer inflammatory responses than the Type I IFN and are gaining interest as antiviral treatments.
  • 933
  • 08 Feb 2021
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