Topic Review
Diabetic Cardiac Fibroblast Phenotype
Diabetic cardiomyopathy involves remodeling of the heart in response to diabetes that includes microvascular damage, cardiomyocyte hypertrophy, and cardiac fibrosis. Cardiac fibrosis is a major contributor to diastolic dysfunction that can ultimately result in heart failure with preserved ejection fraction. Under high glucose conditions cardiac fibroblasts, the final effector cell in the process of cardiac fibrosis, respond by making increased amounts of extracellular matrix. This process involves multiple molecular pathways.
  • 991
  • 27 Oct 2020
Biography
Sergey Vyacheslavovich Savelyev
Sergey Vyacheslavovich Savelyev (Russian: Серге́й Вячесла́вович Саве́льев; born March 7, 1959)[1] is a Russian doctor of biological Sciences, Professor,[2] author of the idea of cerebral sorting. Born in Moscow, he graduated from the Biology and Chemistry Faculty of MGZPI (now the Sholokhov Moscow State University for Humanities), worked at the Brain Institute of
  • 991
  • 06 Dec 2022
Topic Review
Biopesticide Encapsulation Using Supercritical CO2
As an alternative to synthetic pesticides, natural chemistries from living organisms, are not harmful to nontarget organisms and the environment, can be used as biopesticides, nontarget. However, to reduce the reactivity of active ingredients, avoid undesired reactions, protect from physical stress, and control or lower the release rate, encapsulation processes can be applied to biopesticides. The use of supercritical fluid technology (SFT), mainly carbon dioxide (CO2), to encapsulate biopesticides is highlighted, as they reduce the use of organic solvents, have simpler separation processes, and achieve high-purity particles. 
  • 990
  • 27 Jul 2021
Topic Review
Structuralism
Biological or process structuralism is a school of biological thought that objects to an exclusively Darwinian or adaptationist explanation of natural selection such as is described in the 20th century's modern synthesis. It proposes instead that evolution is guided differently, basically by more or less physical forces which shape the development of an animal's body, and sometimes implies that these forces supersede selection altogether. Structuralists have proposed different mechanisms that might have guided the formation of body plans. Before Darwin, Étienne Geoffroy Saint-Hilaire argued that animals shared homologous parts, and that if one was enlarged, the others would be reduced in compensation. After Darwin, D'Arcy Thompson hinted at vitalism and offered geometric explanations in his classic 1917 book On Growth and Form. Adolf Seilacher suggested mechanical inflation for "pneu" structures in Ediacaran biota fossils such as Dickinsonia. Günter P. Wagner argued for developmental bias, structural constraints on embryonic development. Stuart Kauffman favoured self-organisation, the idea that complex structure emerges holistically and spontaneously from the dynamic interaction of all parts of an organism. Michael Denton argued for laws of form by which Platonic universals or "Types" are self-organised. Stephen J. Gould and Richard Lewontin proposed biological "spandrels", features created as a byproduct of the adaptation of nearby structures. Gerd B. Müller and Stuart A. Newman argued that the appearance in the fossil record of most of the current phyla in the Cambrian explosion was "pre-Mendelian"[lower-alpha 1] evolution caused by physical factors. Brian Goodwin, described by Wagner as part of "a fringe movement in evolutionary biology", denies that biological complexity can be reduced to natural selection, and argues that pattern formation is driven by morphogenetic fields. Darwinian biologists have criticised structuralism, emphasising that there is plentiful evidence both that natural selection is effective and, from deep homology, that genes have been involved in shaping organisms throughout evolutionary history. They accept that some structures such as the cell membrane self-assemble, but deny the ability of self-organisation to drive large-scale evolution.
  • 990
  • 30 Nov 2022
Topic Review
Fyn
Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years after the original description of Fyn, this protein continues to attract extreme interest because of its multiplicity of actions in the molecular signaling pathways underlying neurodevelopmental as well as neuropathologic events. Fyn is a common factor in healthy and diseased brains that targets different proteins and shapes different transduction signals according to the neurological conditions. In particular, Fyn mediates signaling pathways involved in neuronal differentiation and plasticity that have been subjected to considerable attention lately, opening the fascinating scenario to target Fyn TK for the development of potential therapeutic interventions for the treatment of CNS injuries and certain neurodegenerative disorders like Alzheimer's disease.
  • 991
  • 05 Nov 2020
Biography
Philipp
Philipp, Prince of Eulenburg and Hertefeld, Count of Sandels (German: Philipp Friedrich Karl Alexander Botho Fürst zu Eulenburg und Hertefeld Graf von Sandels; 12 February 1847 – 17 September 1921) was a diplomat and composer of Imperial Germany who achieved considerable influence as the closest friend of Wilhelm II. He was the central member of the so-called Liebenberg Circle, a group of art
  • 986
  • 24 Nov 2022
Topic Review
Periphylla
The helmet jellyfish (Periphylla periphylla) is a luminescent, red-colored jellyfish of the deep sea, belonging to the order Coronatae of the phylum Cnidaria. It is the only species in the monotypic genus Periphylla. They are the only known scyphozoan to undergo sexual propagation that lacks a planula stage. Not only is their reproductive cycle unique, so are their living conditions. They are found in deeper parts of the ocean due to them being photophobic.
  • 990
  • 27 Oct 2022
Topic Review
Iron Deficiency in Celiac Disease
Iron deficiency anemia (IDA) is the most recognized type of anemia in patients with celiac disease (CD) and may be present in over half of patients at the time of diagnosis. Folate and vitamin B12 malabsorption, nutritional deficiencies, inflammation, blood loss, development of refractory CD, and concomitant Heliobacter pylori infection are other causes of anemia in such patients. The decision to replenish iron stores and the route of administration (oral or intravenous) are controversial due, in part, to questions surrounding the optimal formulation and route of administration.
  • 989
  • 09 Oct 2021
Topic Review
Mango Peel Pectin: Recovery, Functionality and Sustainable Uses
Mango peel is the byproduct of agro-processing and has been used for high value-added components such as polysaccharide biopolymers. Pectin derived from the peel is yet to be exploited to its greatest extent, particularly in terms of its separation and physiochemical properties, which limit its applicability to dietary fiber in culinary applications. The functionality of the mango peel pectin (MPP) strongly depends on the molecular size and degree of esterification which highlight the importance of isolation and characterisation of pectin from this novel resource.
  • 989
  • 29 Mar 2022
Topic Review
Xia-Gibbs Syndrome
Xia-Gibbs syndrome is a neurological disorder characterized by weak muscle tone (hypotonia), mild to severe intellectual disability and delayed development.
  • 990
  • 24 Dec 2020
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