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Topic Review
MCPIP1
MCPIP1 (also known as regnase-1) is encoded by the ZC3H12A gene and is composed of 599 amino acids that encode a 66-kDa protein. MCPIP1 is a potent anti-inflammatory protein, and plays many roles within the regulation of the immune response.
  • 1.0K
  • 22 Oct 2020
Topic Review
The Chromosome Organization in the Cell Nuclei
The spatial organization of the genome into the cell nucleus plays a central role in controlling several genome functions, such as gene expression and DNA replication timing during the S-phase of the cell cycle. Here we show how chromosomes are organized in the cell nucleus according to the gene density and to the GC-level of the various chromosomal bands, allowing a corrected and coordinated gene expression during cell life. The human genome, such as the genome of the other mammals, is composed by two very different parts: one very gene-dense, replicated at the onset of the S-phase, very GC-rich and the other endowed with opposite features. These two genomic compartments are localized far apart within a chromosome, with regions having intermediate properties located between them. This determines a zig-zag organization of the larger chromosomes, to position the gene-poorest genome compartment at the nuclear periphery and the gene-richest one at the nuclear interior.
  • 1.0K
  • 05 Jan 2022
Topic Review
Exposome
The “exposome” is the cumulative exposures (diet, exercise, environmental exposure, vaccination, genetics, etc.) an individual has experienced and provides a mechanism for the establishment of immune training or immunotolerance. It is becoming increasingly clear that trained immunity constitutes a delicate balance between the dose, duration, and order of exposures. Upon innate stimuli, trained immunity or tolerance is shaped by epigenetic and metabolic changes that alter hematopoietic stem cell lineage commitment and responses to infection. Due to the immunomodulatory role of the exposome, understanding innate immune training is critical for understanding why some individuals exhibit protective phenotypes while closely related individuals may experience immunotolerant effects (e.g., the order of exposure can result in completely divergent immune responses). Research on the exposome and trained immunity may be leveraged to identify key factors for improving vaccination development, altering inflammatory disease development, and introducing potential new prophylactic treatments, especially for diseases such as COVID-19, which is currently a major health issue for the world. Furthermore, continued exposome research may prevent many deleterious effects caused by immunotolerance that frequently result in host morbidity or mortality. 
  • 1.0K
  • 09 Dec 2020
Topic Review
CIPA
Congenital insensitivity to pain with anhidrosis (CIPA) has two characteristic features: the inability to feel pain and temperature, and decreased or absent sweating (anhidrosis). This condition is also known as hereditary sensory and autonomic neuropathy type IV. The signs and symptoms of CIPA appear early, usually at birth or during infancy, but with careful medical attention, affected individuals can live into adulthood.
  • 1.0K
  • 04 Jan 2021
Topic Review
Carnitine Acyl-carnitine Carrier
The SLC25A20 transporter, also known as carnitine acyl-carnitine carrier (CAC), catalyzes the transport of short, medium and long carbon chain acyl-carnitines across the mitochondrial inner membrane in exchange for carnitine. The 30-year story of the protein responsible for this function started with its purification from rat liver mitochondria. 
  • 1.0K
  • 07 Apr 2021
Topic Review
GOLPH3, a PI(4)P Binding Protein
Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for several intracellular functions, including Golgi ribbon structure maintenance, Golgi glycosylation and vesicle trafficking. It is amplified in several solid tumor types and its overexpression correlates with poor prognosis. GOLPH3 influences tumorigenesis through (i) regulation of Golgi-to-plasma membrane trafficking; (ii) turnover and glycosylation of cancer-relevant glycoproteins; (iii) influence on DNA damage response and maintenance of genomic stability.
  • 1.0K
  • 27 Oct 2020
Topic Review
FAAH and Major Depressive Disorder
Altered activity of fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system, has been implicated in several neuropsychiatric disorders, including major depressive disorder (MDD). It is speculated that increased brain FAAH expression is correlated with increased depressive symptoms.
  • 1.0K
  • 02 Jun 2021
Topic Review
α-Synuclein Aggregation in Treatment of Parkinson’s Disease
Parkinson’s disease, the second most common neurodegenerative disorder worldwide, is characterized by the accumulation of protein deposits in the dopaminergic neurons. These deposits are primarily composed of aggregated forms of α-Synuclein (α-Syn). PD is a complex pathology initially associated with motor deficiencies, as a result of an acute neuronal loss in substantia nigra pars compacta (SNc), with a significant dopaminergic (DA) impairment.
  • 1.0K
  • 31 Mar 2023
Topic Review
Thousand-Year Rose
The Thousand-year Rose (German: Tausendjähriger Rosenstock, literally: Thousand-year-old Rosebush) is also known as the Rose of Hildesheim. It grows on the apse of the Hildesheim Cathedral, a Catholic cathedral in Hildesheim, Germany, that is dedicated to the Assumption of Mary. The cathedral and the adjacent St. Michael's Church have been on the UNESCO list of World Heritage Sites since 1985. The rose that climbs on the wall of the cathedral's apse is believed to be the oldest living rose in the world. A Rosa canina, commonly known as a wild dog rose, grows against the eastern apse of the cathedral, which is around 21 metres (69 ft) high and 9 metres (30 ft) wide. The rose bush reaches a height of around 10 metres (33 ft) and documentation verifies its age at approximately 700 years. Slight variations arise in the tale of the establishment of the diocese by King Louis the Pious at Hildesheim in 815 but the rose bush is a common theme in all versions. The cathedral was destroyed by Allied bombers in 1945 during the Second World War, but the roots of the rose bush survived and it blossomed again among the ruins. According to legend, while the rose bush flourishes, Hildesheim will prosper. A poem about the rose was published in 1896. In the early twentieth century, after visiting the cathedral and seeing the rose, author Mabel Wagnalls was inspired to write a book, which went on to form the basis of a silent film.
  • 1.0K
  • 08 Nov 2022
Topic Review
The Complement System in Human Viral Diseases
The complement system (CS) is part of the human immune system, consisting of more than 30 proteins that play a vital role in the protection against various pathogens and diseases, including viral diseases. Activated via three pathways, the classical pathway (CP), the lectin pathway (LP), and the alternative pathway (AP), the complement system leads to the formation of a membrane attack complex (MAC) that disrupts the membrane of target cells, leading to cell lysis and death. Due to the increasing number of reports on its role in viral diseases, which may have implications for research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
  • 1.0K
  • 28 Feb 2022
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