Topic Review
Pseudoplatystoma Catfishes in the Neotropics
Species of the genus Pseudoplatystoma, the long-whiskered catfishes, are important in commercial and recreational fisheries in South America, and some species have become key to regional aquaculture. Some species of the genus are under pressure due to overfishing and the negative impacts of dams. 
  • 538
  • 14 Jun 2023
Topic Review
Tumor-Derived Exosomes in Preparing the Pre-metastatic Niche
Tumor-derived exosomes play a multifaceted role in preparing the pre-metastatic niche, promoting cancer dissemination, and regulating cancer cell dormancy. Tumor-derived exosomes are small vesicles that are released by tumor cells and contain a variety of molecules, including proteins, lipids and nucleic acids. They play a key role in cancer progression and metastasis by modulating the tumor microenvironment, promoting cancer cell survival and growth, and communicating with nearby cells. As such, these exosomes can act as vehicles for delivering pro-tumorigenic information and signals, helping to propagate cancer in the body.
  • 407
  • 14 Jun 2023
Topic Review
Sex Differences in Oxidative Stress and Neoplastic Diseases
Genetic, developmental, biochemical, and environmental variables interact intricately to produce sex differences. The significance of sex differences in cancer susceptibility is being clarified by numerous studies. Epidemiological research and cancer registries have revealed over the past few years that there are definite sex variations in cancer incidence, progression, and survival. However, oxidative stress and mitochondrial dysfunction also have a significant impact on the response to treatment of neoplastic diseases. Young women may be more protected from cancer than men because most of the proteins implicated in the regulation of redox state and mitochondrial function are under the control of sexual hormones. 
  • 274
  • 14 Jun 2023
Topic Review
The Gene Family of Voltage-Gated ChLoride Channels
Endosomes and lysosomes are intracellular vesicular organelles with important roles in cell functions such as protein homeostasis, clearance of extracellular material, and autophagy. Endolysosomes are characterized by an acidic luminal pH that is critical for proper function. Five members of the gene family of voltage-gated ChLoride Channels (CLC proteins) are localized to endolysosomal membranes, carrying out anion/proton exchange activity and thereby regulating pH and chloride concentration. Mutations in these vesicular CLCs cause global developmental delay, intellectual disability, various psychiatric conditions, lysosomal storage diseases, and neurodegeneration, resulting in severe pathologies or even death. 
  • 295
  • 14 Jun 2023
Topic Review
Nanotechnology for Precision Agriculture
By adopting nanotechnology-based precision agricultural practices, the farming community can reduce agrochemicals while maintaining high crop productivity, protecting soil and water health, and contributing to a cleaner environment.
  • 682
  • 14 Jun 2023
Topic Review
Exosomes as Biomarkers for Cancer Progression
In the endosome compartment, exosome synthesis occurs when multivesicular bodies mature into intraluminal vesicles. Upon fusion with the plasma membrane, intraluminal vesicles release exosomes into the extracellular space. Exosomes can be retrieved by endocytosis or receptor-mediated uptake, suggesting a selective intercellular communication between the donor and recipient cells. They are contain nucleic acids or proteins, which appear to be strategically used to modify the recipient cell’s function in a way that benefits the donor cell. This process is vital for cell-to-cell communication and for the transfer of genetic information. Uniquely positioning exosomes to serve as messengers of information which can be used to gain insight into a multitude of diseases. By isolating exosomes, researching their components and understanding their intended destination, these small vesicles of information become invaluable for diagnosing and treating conditions, making them a powerful tool in biomedical research.
  • 353
  • 14 Jun 2023
Topic Review
Factors Accompanying Spaceflights: Effects on the Retina
Spaceflight (SF) increases the risk of developmental, regenerative, and physiological disorders in animals and humans. Astronauts, besides bone loss, muscle atrophy, and cardiovascular and immune system alterations, undergo ocular disorders affecting posterior eye tissues, including the retina. Under microgravity conditions, mammals show disturbances in the retinal vascular system and increased risk of oxidative stress that can lead to cell death in the retina.
  • 259
  • 14 Jun 2023
Topic Review
Interactions between Entomopathogenic Fungi and Nematodes
Entomopathogenic nematodes (EPNs) belonging to the genera Steinernema Travassos (Rhabditida: Steinernematidae) and Heterorhabditis Poinar (Rhabditida: Heterorhabditidae) are obligate and lethal parasites of insects. Their infective juveniles (IJs), non-feeding and usually soil dwelling, hold in their foregut symbiotic bacteria that play an important and essential role in killing susceptible insects. Entomopathogenic fungi, mainly Ascomycetes, are regularly found infecting insects in the environment, especially in the soil. The species of the genera Metarhizium Sorokin, and Beauveria Vuill. are the best known entomopathogenic fungi. These organisms usually attach to the external body of insects by conidia adhering to the host’s cuticle. Under the right temperature and humidity conditions, these spores germinate, grow as hyphae, and colonize the insect’s body. After a few days (4–7), the insect is usually killed, especially by fungal toxins, and new spores are formed in or on the insect (sporulation), ready to be spread in the environment.
  • 638
  • 14 Jun 2023
Topic Review
Warburg Effect
Otto Warburg discovered that cancer cells use a fermentative rather than oxidative metabolism even though the former is more inefficient in terms of energy production per molecule of glucose. Cancer cells increase the use of this fermentative metabolism even in the presence of oxygen, and this process is called aerobic glycolysis or the Warburg effect.
  • 546
  • 14 Jun 2023
Topic Review
Applications of Omics Technologies in Forest Plants
The ecological and economic values of forest plants have been gradually recognized worldwide. However, the growing global demand for new forest plant varieties with higher wood production capacity and better stress tolerance cannot be satisfied by conventional phenotype-based breeding, marker-assisted selection, and genomic selection.
  • 210
  • 14 Jun 2023
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