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Topic Review
Structural and Regulation Aspects of IGF2
Insulin-like growth factor two (IGF-II) is a key protein regulating growth, particularly during normal fetal development, but it is also often dysregulated during tumorigenesis. IGF-II belongs to a larger system including several different regulatory factors and generally referred to as the “IGF system”. IGF-I and IGF-II are the main ligands of the type 1 IGF receptor (IGF-1R).
  • 523
  • 28 Jun 2022
Topic Review
Structural and Functional Features of Pyridoxal Phosphate-Binding Protein
The pyridoxal phosphate-binding protein (PLPBP) family (also termed ProsC/PROSC or COG0325 family) members are found in all kingdoms of life, exemplified by the proteins YBL036C (yeast), YggS (Gram-negative bacteria), YlmE (Gram-positive bacteria), PipY (cyanobacteria), PLPHP (humans) and HTH5 (rice). 
  • 482
  • 02 Nov 2022
Topic Review
Structural and Functional Diversity among FGF Signals
Fibroblast growth factors (FGFs) encode a large family of growth factor proteins that activate several intracellular signaling pathways to control diverse physiological functions. The human genome encodes 22 FGFs that share a high sequence and structural homology with those of other vertebrates. FGFs orchestrate diverse biological functions by regulating cellular differentiation, proliferation, and migration. Dysregulated FGF signaling may contribute to several pathological conditions, including cancer. Notably, FGFs exhibit wide functional diversity among different vertebrates spatiotemporally. A comparative study of FGF receptor ligands and their diverse roles in vertebrates ranging from embryonic development to pathological conditions may expand our understanding of FGF.
  • 234
  • 06 May 2023
Topic Review
Strontium Functionalization of Biomaterials for Bone Tissue Engineering
Strontium (Sr) is a trace element taken with nutrition and found in bone in close connection to native hydroxyapatite. Sr is involved in a dual mechanism of coupling the stimulation of bone formation with the inhibition of bone resorption, as reported in the literature. Interest in studying Sr has increased in the last decades due to the development of strontium ranelate (SrRan), an orally active agent acting as an anti-osteoporosis drug. However, the use of SrRan was subjected to some limitations starting from 2014 due to its negative side effects on the cardiac safety of patients. In this scenario, an interesting perspective for the administration of Sr is the introduction of Sr ions in biomaterials for bone tissue engineering (BTE) applications. This strategy has attracted attention thanks to its positive effects on bone formation, alongside the reduction of osteoclast activity, proven by in vitro and in vivo studies.
  • 637
  • 07 Mar 2022
Topic Review
Strongyloides stercoralis
Strongyloidiasis belongs to the group of neglected tropical diseases, due to diagnostic difficulties and the lack of systematic screening. 
  • 407
  • 08 Oct 2021
Topic Review
Stroke
Stroke is the second leading cause of death and a major contributor to disability worldwide. The prevalence of stroke is highest in developing countries, with ischemic stroke being the most common type. Considerable progress has been made in our understanding of the pathophysiology of stroke and the underlying mechanisms leading to ischemic insult. Stroke therapy primarily focuses on restoring blood flow to the brain and treating stroke-induced neurological damage. Lack of success in recent clinical trials has led to significant refinement of animal models, focus-driven study design and use of new technologies in stroke research. Simultaneously, despite progress in stroke management, post-stroke care exerts a substantial impact on families, the healthcare system and the economy. Improvements in pre-clinical and clinical care are likely to underpin successful stroke treatment, recovery, rehabilitation and prevention. In this review, we focus on the pathophysiology of stroke, major advances in the identification of therapeutic targets and recent trends in stroke research.
  • 1.4K
  • 07 Apr 2021
Topic Review
Strobilanthes Callosus
Strobilanthes callosa Nees (Synonym: Carvia callosa (Nees) Bremek) is a shrub found mainly in the low hills of the western ghats all along the west coast of India . Its standardized Hindi language name is Maruadona (मरुआदोना) by which it is called in the state of Madhya Pradesh where it is also found. In the state of Maharashtra in the Marathi language and other local dialects and in the neighboring state of Karnataka the shrub is locally known as Karvi, sometimes spelled in English as Karvy. This shrub belongs to the genus Strobilanthes which was first scientifically described by Nees in the 19th century. The genus has around 350 species, of which at least 46 are found in India. Most of these species show an unusual flowering behaviour, varying from annual to 16-year blooming cycles, on the national scale there is often confusion about which plant is flowering.
  • 623
  • 21 Nov 2022
Topic Review
Strigolactone-Mediated Bud Outgrowth
Strigolactones (SLs), being a novel class of phytohormone, are known to play a key role in branching decisions, where they act as a negative regulator of bud outgrowth. They can achieve this by modulating polar auxin transport to interrupt auxin canalisation, and independently of auxin by acting directly within buds by promoting the key branching inhibitor TEOSINTE BRANCHED1.
  • 467
  • 17 Jan 2023
Topic Review
Strigolactone Biosynthesis, and Signaling Pathways
Strigolactones (SLs) are carotenoid derivatives that occur naturally in plants and are defined as novel phytohormones that regulate plant metabolism, growth, and development. Strigolactone assists plants in the acquisition of defensive characteristics against drought stress by initiating physiological responses and mediating the interaction with soil microorganisms. 
  • 690
  • 27 Dec 2022
Topic Review
Stress-Related Hormones in Drosophila melanogaster
The response of living beings to adverse conditions, known as the stress reaction, is a complex mechanism including various signaling pathways and hormones. Some are evolutionarily conserved, such as the insulin signaling pathway, others, such as 20-hydroxyecdysone, adipokinetic or juvenile hormones, are taxon-specific in insects. Key components of the neuroendocrine stress reaction in insects are biogenic amines (dopamine and octopamine), juvenile hormone, 20-hydroxyecdysone, adipokinetic hormone and insulin-like peptides. 
  • 392
  • 06 Jun 2023
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