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Biography
Susanne Hoeber Rudolph
Susanne Hoeber Rudolph (April 3, 1930 – December 23, 2015) was an American author, political thinker and educationist. She was a William Benton Distinguished Service Professor Emerita at the University of Chicago and was actively interested in Politics, Political Economy and Political Sociology of South Asia, State Formation, Max Weber and the Politics of Category and Culture.[1] The Governme
  • 515
  • 29 Dec 2022
Biography
Susana Martinez-Conde
Susana Martinez-Conde (born October 1, 1969) is a neuroscientist and science writer. She is a professor of ophthalmology, neurology, and physiology & pharmacology at the State University of New York, Downstate Medical Center, where she directs the Laboratory of Integrative Neuroscience. She directed laboratories previously at the Barrow Neurological Institute and University College London.[1] He
  • 521
  • 28 Nov 2022
Topic Review
Survivin Small Molecules Inhibitors
Survivin, as a member of the inhibitor of apoptosis proteins (IAPs) family, acts as a suppressor of apoptosis and plays a central role in cell division. Survivin has been considered as an important cancer drug target because it is highly expressed in many types of human cancers, while it is effectively absent from terminally differentiated normal tissues. Moreover, survivin is involved in tumor cell resistance to chemotherapy and radiation.
  • 486
  • 23 Feb 2023
Topic Review
Surveillance of Avian Influenza Viruses
The measures employed for curbing AI outbreaks and morbidities have played major roles in the journey towards global AI control. Although commendable progress has been made, more effective surveillance programmes, treatment regimens and prophylactic vaccines, which are capable of tackling the rapidly evolving AIV need to be developed. Effective control measures are the best option at preventing an AI panzootic which at present seems inevitable. To achieve this, AIV surveillance serves as an important tool for the understanding of the evolutionary patterns and epidemiology of AIVs.
  • 596
  • 23 Aug 2021
Topic Review
Surgical Management of Rectal Cancer
Successful oncologic resection in rectal cancer relies on the surgical tenants of wide local excision of the disease to establish clear margin status and resection of adequate lymph nodes for staging. The introduction of, and adherence to, complete total mesorectal excision, which is the resection of the total mesorectal envelope containing the local lymphatic drainage of the rectum, has contributed a large part to the improved operative outcomes and long-term survival for rectal cancer patients. Notably, total mesorectal excision has produced a notable reduction in rectal cancer recurrence by 30 to 40%.
  • 611
  • 06 Apr 2022
Topic Review
Surgical Management of Pancreatic Neuroendocrine Tumours (pNETs)
Pancreatic neuroendocrine tumours (pNETs) are a group of rare neoplasms with an incidence of 1–2/100,000 inhabitants/year. They represent 2% of all pancreatic neoplasms and are characterized by a great heterogeneity according to their genetic or sporadic origin, their functional or non-functional character, their degree of locoregional or systemic invasion and their single or multiple localization. The reference curative treatment is surgical resection of the pancreatic tumor in specialized high-volume centres, after a multidisciplinary discussion involving surgeons, oncologists, radiologists and pathologists.
  • 615
  • 14 Jan 2022
Topic Review
Surfactant Dysfunction
Surfactant dysfunction is a lung disorder that causes breathing problems.
  • 505
  • 23 Dec 2020
Topic Review
Surfactant and the Glycocalyx
Gas exchange in the lung takes place via the air-blood barrier in the septal walls of alveoli. The tissue elements that oxygen molecules have to cross are the alveolar epithelium, the interstitium and the capillary endothelium. The epithelium that lines the alveolar surface is covered by a thin and continuous liquid lining layer. Pulmonary surfactant acts at this air-liquid interface. By virtue of its biophysical and immunomodulatory functions, surfactant keeps alveoli open, dry and clean. What needs to be added to this picture is the glycocalyx of the alveolar epithelium. Here, we briefly review what is known about this glycocalyx and how it can be visualized using electron microscopy. The application of colloidal thorium dioxide as a staining agent reveals differences in the staining pattern between type I and type II alveolar epithelial cells and shows close associations of the glycocalyx with intraalveolar surfactant subtypes such as tubular myelin. These morphological findings indicate that specific spatial interactions between components of the surfactant system and those of the alveolar epithelial glycocalyx exist which may contribute to the maintenance of alveolar homeostasis, in particular to alveolar micromechanics, to the functional integrity of the air-blood barrier, to the regulation of the thickness and viscosity of the alveolar lining layer, and to the defence against inhaled pathogens. Exploring the alveolar epithelial glycocalyx in conjunction with the surfactant system opens novel physiological perspectives of potential clinical relevance for future research.
  • 927
  • 03 May 2021
Topic Review
Surface-Functionalized Nanoparticles for Bio-Application
Surface functionalization of nanoparticles applies to the use of covalent and non-covalent bonds—such as hydrogen bonds, electrostatic force, and the van der Waals interactions—to integrate diverse organic and inorganic molecules at the nanoscale. Typically, multiple linker molecules are used to form covalent bonds between ligands and the surfaces of nanoparticles (NPs).
  • 2.0K
  • 20 Apr 2022
Topic Review
Surface Proteins of Parasite Eimeria Species Infecting Chickens
Poultry is the first source of animal protein for human consumption. Chicken coccidiosis is a highly widespread enteric disease caused by Eimeria spp. which causes significant economic losses to the poultry industry worldwide; however, the impact on family poultry holders or backyard production—which plays a key role in food security and involves mainly rural women—has been little explored. Coccidiosis disease is controlled by good husbandry measures, chemoprophylaxis, and/or live vaccination. Current limitations on the use of live vaccines have led to research in next-generation vaccines based on recombinant or live-vectored vaccines. Next-generation vaccines are required to control this complex parasitic disease, and for this purpose, protective antigens need to be identified.
  • 456
  • 20 Jun 2023
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