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Topic Review
Germplasm Resources and Distribution of Oaks in China
Oaks (Quercus spp.) are a major component of subtropical and temperate forests in the Northern Hemisphere. There are approximately 464 species, and they are dominant tree species in ecosystems. Oaks have a long history of cultivation in Europe, North America, and other continents. They are also cultivated and distributed in most provinces of China.
  • 1.2K
  • 16 Jan 2023
Topic Review
Synthetic Cathinones
New psychoactive substances represent a public health threat since they are not controlled by international conventions, are easily accessible online and are sold as a legal alternative to illicit drugs. Among them, synthetic cathinones are widely abused due to their stimulant and hallucinogenic effects. To circumvent the law, new derivatives are clandestinely synthesized and, therefore, synthetic cathinones keep emerging on the drug market, with their chemical and toxicological properties still unknown.
  • 1.2K
  • 08 Jul 2022
Topic Review
Discriminative Measurement for Radon Isotopes
Radon and thoron measurement studies have been widely conducted and reported all over the world. Generally, the techniques used relate to the passive nuclear track detectors. Though some surveys shown that passive monitors for radon are sensitive to thoron, and hence the measured results might be probably overestimated the radon concentration. This study investigated the radon and thoron measurement in domestic and international using passive radon-thoron discriminative measuring device, commercially named RADUET. This paper attempts to provide an understanding and evident roadmap for discriminative measurements of radon isotopes.
  • 1.2K
  • 05 Nov 2020
Topic Review
Downy Mildew Detection and Diagnostics
Downy mildews affect important crops and cause severe losses in production worldwide. Accurate identification and monitoring of these plant pathogens, especially at early stages of the disease, is fundamental in achieving effective disease control. The rapid development of molecular methods for diagnosis has provided more specific, fast, reliable, sensitive, and portable alternatives for plant pathogen detection and quantification than traditional approaches. 
  • 1.2K
  • 11 Jun 2021
Topic Review
GRKs
G protein-coupled receptor (GPCR) kinases (GRKs) play an important role in the regulation of signaling of GPCRs that bind neurotransmitters. The canonical model of GPCR desensitization posits that GRKs phosphorylate ligand-activated GPCRs, and this phosphorylation prepares receptors for the high-affinity binding of arrestin proteins. Arrestin binding prevents further G protein coupling, promotes receptor internalization, and initiates and/or facilitates specific branches of signaling. Existing data suggest that the role of GPCR phosphorylation by GRKs is distinct in different receptors. The relationship between G protein- and arrestin-mediated signaling on the one hand, and therapeutic and side effects of drugs on the other, is more complex than is widely believed. Also, the relationship between rapid (minutes to hours) GRK/arrestin-mediated regulation and long-term (days to weeks) neural plasticity remains to be elucidated. 
  • 1.2K
  • 19 Jan 2021
Topic Review
Annin Rich Extracts Traditional Applications
Tannins are polyphenolic compounds historically utilized in textile and adhesive industries, but also in traditional human and animal medicines or foodstuffs.
  • 1.2K
  • 04 Feb 2021
Topic Review
Endocytosis in Health and Disease
Endocytosis is a mechanistic process, associated with internalization of the extracellular materials such as microbes, cellular components, nutrients, or macromolecules. Conventionally, eukaryotic cells use the endocytosis process for the absorption of molecules and secretion of signaling transmitters (hormones and cytokines) to maintain cellular homeostasis. Endocytosis machinery is a well-conserved physiological process in lower to higher organisms, which has been frequently acquired for cellular defense, immune responses, uptake, and energy metabolism. 
  • 1.2K
  • 13 Feb 2023
Biography
Arlie Petters
Arlie Oswald Petters, MBE (born February 8, 1964) is a Belizean-American mathematical physicist, who is the Benjamin Powell Professor of Mathematics and a Professor Physics and Economics at Duke University.[1] Petters is a founder of mathematical astronomy, focusing on problems connected to the interplay of gravity and light and employing tools from astrophysics, cosmology, general relativity, h
  • 1.2K
  • 24 Nov 2022
Topic Review
T Helper Cells in IBD
Inflammatory bowel disease (IBD) is a chronic disorder manifested as Crohn’s disease (CD) and ulcerative colitis (UC) characterized by intestinal inflammation and involves a dysregulated immune response against commensal microbiota through the activation of CD4 T helper cells. T helper cell differentiation to effector or regulatory phenotypes is controlled by cytokine networks and transcriptional regulators. Distinct polarized T helper cells are able to alter their phenotypes to adapt to diverse and fluctuating physiological environments. T helper cells exhibit intrinsic instability and flexibility to express cytokines of other lineages or transdifferentiate from one T helper cell type to another in response to various perturbations from physiological cytokine milieu as a means of promoting local immunity in response to injury or ensure tissue homeostasis. Furthermore, functional plasticity and diversity of T helper cells are associated with pathogenicity and are critical for immune homeostasis and prevention of autoimmunity. In this review, we provide deeper insights into the combinatorial extrinsic and intrinsic signals that control plasticity and transdifferentiation of T helper cells and also highlight the potential of exploiting the genetic reprogramming plasticity of T helper cells in the treatment of IBD.
  • 1.2K
  • 28 Oct 2020
Topic Review
Development of CDK4/6 Inhibitors
CDKs, a family of serine/threonine kinases, regulate cell cycle progression into the four distinct phases G1, S (DNA synthesis), G2 and M, and are crucially involved in the regulation of cell division and proliferation.
  • 1.2K
  • 23 Apr 2021
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