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Topic Review
Testicular Glycogen Metabolism
Glycogen metabolism is a potential source of glucose to both testicular somatic (namely Sertoli and Leydig cells) and germ cells. Many of the enzymes involved in the pathways of the synthesis and degradation of glycogen were identified in these cells, emphasising the relevance of this complex carbohydrate. Glycogen, however, has other non-canonical functions in testicular cells; besides its role as a source of energy, it is also associated with events such as cellular differentiation and apoptosis.
  • 503
  • 16 Sep 2022
Topic Review
Testicular Germ-Cell Tumours (TGCT)
Testicular Germ Cell Tumors (TGCTs) are the second most common form of Germ Cell Tumour after benign ovarian teratomas. They are considered a “curable cancer” due to their exceptionally high survival rate of their patients: young caucasian men mostly. A better stratification of those patients would mean an improvement in their quality of life, which is currently diminished by the aggressiveness of prognostic treatments. The knowledge about the relation between TGCTs and the immune system could give keys to improve prognosis, diagnosis and treatment of this cancer.
  • 371
  • 24 May 2022
Topic Review
TERT Promoter Mutations in Gliomas
Telomere length maintenance systems perform an essential function in preserving genome stability. Abnormalities in the functioning of these systems, such as telomerase reactivation, usually play a key role in the course of oncogenesis.TERTp mutations are not found in ordinary human cells, but are often associated with malignant tumor progression and increased cell proliferation in CNS tumor diseases, especially in gliomas. The availability of molecular evaluation of the TERTp mutational status of CNS tumor lesions contributes to more accurate and reliable diagnosis and timely decisions regarding patient follow-up with selection of the most appropriate and applicable treatment protocols.
  • 796
  • 12 Apr 2022
Topic Review
TERT Gene in Polyploid Plants
The gene coding for the telomerase reverse transcriptase (TERT) is essential for the maintenance of telomeres. Previously we described the presence of three TERT paralogs in the allotetraploid plant Nicotiana tabacum, while a single TERT copy was identified in the paleopolyploid model plant Arabidopsis thaliana. Here we examine the presence, origin and functional status of TERT variants in allotetraploid Nicotiana species of diverse evolutionary ages and their parental genome donors, as well as in other diploid and polyploid plant species. A combination of experimental and in silico bottom-up analyses of TERT gene copies in Nicotiana polyploids revealed various patterns of retention or loss of parental TERT variants and divergence in their functions. RT–qPCR results confirmed the expression of all the identified TERT variants. In representative plant and green algal genomes, our synteny analyses show that their TERT genes were located in a conserved locus that became advantageous after the divergence of eudicots, and the gene was later translocated in several plant groups. In various diploid and polyploid species, translocation of TERT became fixed in target loci that show ancient synapomorphy.
  • 544
  • 03 Jun 2021
Topic Review
TERT Gene
Telomerase reverse transcriptase: The TERT gene provides instructions for making one component of an enzyme called telomerase.
  • 398
  • 24 Dec 2020
Topic Review
TERT Expression Regulation by Epigenetics
Maintenance of telomeres is a fundamental step in human carcinogenesis and is primarily regulated by telomerase and the human telomerase reverse transcriptase gene (TERT). Improved understanding of the transcriptional control of this gene may provide potential therapeutic targets. Epigenetic modifications are a prominent mechanism to control telomerase activity and regulation of the TERT gene. 
  • 514
  • 29 Apr 2021
Biography
Terry Speed
Terence Paul "Terry" Speed (born 14 March 1943),[1] FAA FRS[2] is an Australia n statistician. A senior principal research scientist at the Walter and Eliza Hall Institute of Medical Research,[3][4][5] he is known for his contributions to the analysis of variance and bioinformatics, and in particular to the analysis of microarray data. Speed obtained a Ph.D. from Monash University in 1968 wit
  • 534
  • 21 Nov 2022
Biography
Terri Attwood
Teresa K. Attwood is a Professor of Bioinformatics in the Department of Computer Science and School of Biological Sciences at the University of Manchester and a visiting fellow at the European Bioinformatics Institute (EMBL-EBI).[1] She held a Royal Society University Research Fellowship at University College London (UCL) from 1993 to 1999 and at the University of Manchester from 1999 to 2002.[2
  • 813
  • 16 Nov 2022
Topic Review
Terretonin
Endophytic fungi are proving to be an excellent source of chemical entities with unique structures and varied bioactivities. Terretonin (TE) and its structurally related derivatives are a class of meroterpenoids, possessing the same unique tetracyclic core skeleton, which have been reported from the Aspergillus genus.
  • 353
  • 11 Jan 2022
Topic Review
Terpenoid Transport in Plants
Contrary to the biosynthetic pathways of many terpenoids, which are well characterized and elucidated, their transport inside subcellular compartments and the secretion of reaction intermediates and final products at the short- (cell-to-cell), medium- (tissue-to-tissue), and long-distance (organ-to-organ) levels are still poorly understood, with some limited exceptions.
  • 519
  • 15 Feb 2023
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