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Topic Review
Zebrafish Research
Zebrafish (Danio rerio) are a versatile and invaluable model organism in scientific research. These small, freshwater fish have gained prominence due to their transparency, rapid development, and genetic tractability. Zebrafish embryos are transparent, allowing researchers to observe developmental processes in real time, making them ideal for studies in developmental biology. Their genetic makeup can be easily manipulated, enabling forward and reverse genetics studies, including the use of advanced techniques like CRISPR-Cas9. Zebrafish have made significant contributions to various research areas, such as neurobiology, where their neural development and behaviors are studied. They are also crucial in disease modeling, including cancer, cardiovascular diseases, and neurodegenerative disorders, providing insights into disease mechanisms and potential therapies. Furthermore, zebrafish play a pivotal role in drug discovery, toxicology, regenerative medicine, and environmental studies. Despite certain limitations, their unique attributes continue to drive breakthroughs in scientific understanding and medical advancements.
  • 292
  • 09 Oct 2023
Topic Review
Zebrafish Nephron Segment Development
Nephrons are the functional units which comprise the kidney. Each nephron contains a number of physiologically unique populations of specialized epithelial cells that are organized into discrete domains known as segments.
  • 404
  • 24 Mar 2023
Topic Review
Zebrafish Motile Cilia
Zebrafish is a vertebrate teleost widely used in many areas of research. As embryos, they develop quickly and provide unique opportunities for research studies owing to their transparency for at least 48 h post fertilization. Zebrafish have many ciliated organs that include primary cilia as well as motile cilia. Using zebrafish as an animal model helps to better understand human diseases such as Primary Ciliary Dyskinesia (PCD), an autosomal recessive disorder that affects cilia motility, currently associated with more than 50 genes. 
  • 750
  • 22 Sep 2021
Topic Review
Zebrafish Models of Neuroblastoma
For nearly a decade, researchers in the field of pediatric oncology have been using zebrafish as a model for understanding the contributions of genetic alternations to the pathogenesis of neuroblastoma (NB), and exploring the molecular and cellular mechanisms that underlie neuroblastoma initiation and metastasis.
  • 893
  • 18 Mar 2021
Topic Review
Zebrafish Models for Skeletal Muscle Senescence
Aging and sarcopenic changes in skeletal muscles not only reduce locomotor activities in elderly people but also increase the chance of trauma, such as bone fractures, and the incidence of other diseases, such as metabolic syndrome, due to reduced physical activity.
  • 543
  • 22 Dec 2022
Topic Review
Zebrafish Model of Psychiatric Disorders
Psychiatric disorders are highly prevalent brain pathologies that represent an urgent, unmet biomedical problem. Since reliable clinical diagnoses are essential for the treatment of psychiatric disorders, their animal models with robust, relevant behavioral and physiological endpoints become necessary. Zebrafish (Danio rerio) display well-defined, complex behaviors in major neurobehavioral domains which are evolutionarily conserved and strikingly parallel to those seen in rodents and humans.
  • 428
  • 19 May 2023
Topic Review
Zebrafish Larvae Behavior Models for Pre-Clinical Assays
Phenotype-based screenings can transpose the organism’s compensatory pathways by adopting multi-target strategies for treating complex diseases, and zebrafish emerged as an important model for biomedical research and drug screenings. Zebrafish’s clear correlation between neuro-anatomical and physiological features and behavior is very similar to that verified in mammals, enabling the construction of reliable and relevant experimental models for neurological disorders research. Zebrafish presents highly conserved physiological pathways that are found in higher vertebrates, including mammals, along with a robust behavioral repertoire. Moreover, it is very sensitive to pharmacological/environmental manipulations, and these behavioral phenotypes are detected in both larvae and adults. These advantages align with the 3Rs concept and qualify the zebrafish as a powerful tool for drug screenings and pre-clinical trials.
  • 368
  • 01 Jul 2022
Topic Review
Zebrafish Kidney's Response to Fasting
Animals obtain nutrition and energy by eating and to achieve a balance between growth and body health. When the nutrient intake is abnormal, the growth status changes, presumably resulting in changes in the intrinsic immune system. The zebrafish (Danio rerio), a well-known fish model organism, can serve as a suitable model to explore the changes happened to the innate immune system. In this study, the zebrafish underwent 3 weeks of fasting and refeeding for 3 to 7day periods. During this period, zebrafish displayed a specific growth phenomenon so called compensatory growth (CG), accompanied by increased susceptibility to pathogens after starvation. The kidneys suffering starvation displayed an increase of the amount of melano-macrophage centers and appeared oxidative stress, and the antioxidant enzymes activity like CAT, GSH-Px and SOD increased after fasting. In addition, the activity of ALP and lysozyme as well as il-1β mRNA expression enhanced after starvation. Taken together, oxidative stress caused by starvation and the danger-associated molecular patterns produced by injured renal tubules may have contributed to inflammation. This study showed that the function of the innate immune system in zebrafish could be influenced by nutrition status. Further study is needed to explore how starvation increases susceptibility and how the metabolic state influences different kinds of immune cells.
  • 554
  • 21 Jun 2021
Topic Review
Zebrafish Heart Development
Proper development and function of the vertebrate heart is vital for embryonic and postnatal life. Many congenital heart defects in humans are associated with disruption of genes that direct the formation or maintenance of atrial and pacemaker cardiomyocytes at the venous pole of the heart. Zebrafish are an outstanding model for studying vertebrate cardiogenesis, due to the conservation of molecular mechanisms underlying early heart development, external development, and ease of genetic manipulation.
  • 1.3K
  • 23 Feb 2021
Topic Review
Zebrafish and High-Throughput Cardiac Research
Heart disease is the leading cause of death in the United States and worldwide. Understanding the molecular mechanisms of cardiac development and regeneration will improve diagnostic and therapeutic interventions against heart disease. In this direction, zebrafish is an excellent model because several processes of zebrafish heart development are largely conserved in humans, and zebrafish has several advantages as a model organism. Zebrafish transcriptomic profiles undergo alterations during different stages of cardiac development and regeneration which are revealed by RNA-sequencing. ChIP-sequencing has detected genome-wide occupancy of histone post-translational modifications that epigenetically regulate gene expression and identified a locus with enhancer-like characteristics. ATAC-sequencing has identified active enhancers in cardiac progenitor cells during early developmental stages which overlap with occupancy of histone modifications of active transcription as determined by ChIP-sequencing. 
  • 385
  • 31 Dec 2021
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