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Topic Review
ADCADN
Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCADN) is a nervous system disorder with signs and symptoms that usually begin in mid-adulthood and gradually get worse.
  • 865
  • 04 Jan 2021
Topic Review
adCSNB
Autosomal dominant congenital stationary night blindness is a disorder of the retina, which is the specialized tissue at the back of the eye that detects light and color.
  • 568
  • 04 Jan 2021
Topic Review
ADCY5-related Dyskinesia
ADCY5-related dyskinesia is a movement disorder; the term "dyskinesia" refers to abnormal involuntary movements. The abnormal movements that occur in ADCY5-related dyskinesia typically appear as sudden (paroxysmal) jerks, twitches, tremors, muscle tensing (dystonia), or writhing (choreiform) movements, and can affect the limbs, neck, and face.
  • 529
  • 23 Dec 2020
Topic Review
Addax
The addax (Addax nasomaculatus), also known as the white antelope and the screwhorn antelope, is an antelope native to the Sahara Desert. The only member of the genus Addax, it was first described scientifically by Henri de Blainville in 1816. As suggested by its alternative name, the pale antelope has long, twisted horns - typically 55 to 80 cm (22 to 31 in) in females and 70 to 85 cm (28 to 33 in) in males. Males stand from 105 to 115 cm (41 to 45 in) at the shoulder, with females at 95 to 110 cm (37 to 43 in). They are sexually dimorphic, as the females are smaller than the males. The colour of the coat depends on the season - in the winter, it is greyish-brown with white hindquarters and legs, and long, brown hair on the head, neck, and shoulders; in the summer, the coat turns almost completely white or sandy blonde. The addax mainly eats grasses and leaves of any available shrubs, leguminous herbs and bushes. They are well-adapted to exist in their desert habitat, as they can live without water for long periods of time. Addax form herds of five to 20 members, consisting of both males and females. They are led by the oldest female. Due to its slow movements, the addax is an easy target for its predators: humans, lions, leopards, cheetahs and African wild dogs. Breeding season is at its peak during winter and early spring. The natural habitat of the addax are arid regions, semideserts and sandy and stony deserts. The addax is a critically endangered species of antelope, as classified by the IUCN. Although extremely rare in its native habitat due to unregulated hunting, it is quite common in captivity. The addax was once abundant in North Africa; however it is currently only native to Chad, Mauritania, and Niger. It is extirpated from Algeria, Egypt, Libya, Sudan, and Western Sahara, but has been reintroduced into Morocco and Tunisia.
  • 570
  • 14 Oct 2022
Topic Review
Addax (Genus)
The addax (Addax nasomaculatus), also known as the white antelope and the screwhorn antelope, is an antelope native to the Sahara Desert. The only member of the genus Addax, it was first described scientifically by Henri de Blainville in 1816. As suggested by its alternative name, the pale antelope has long, twisted horns - typically 55 to 80 cm (22 to 31 in) in females and 70 to 85 cm (28 to 33 in) in males. Males stand from 105 to 115 cm (41 to 45 in) at the shoulder, with females at 95 to 110 cm (37 to 43 in). They are sexually dimorphic, as the females are smaller than the males. The colour of the coat depends on the season - in the winter, it is greyish-brown with white hindquarters and legs, and long, brown hair on the head, neck, and shoulders; in the summer, the coat turns almost completely white or sandy blonde. The addax mainly eats grasses and leaves of any available shrubs, leguminous herbs and bushes. They are well-adapted to exist in their desert habitat, as they can live without water for long periods of time. Addax form herds of five to 20 members, consisting of both males and females. They are led by the oldest female. Due to its slow movements, the addax is an easy target for its predators: humans, lions, leopards, cheetahs and African wild dogs. Breeding season is at its peak during winter and early spring. The natural habitat of the addax are arid regions, semideserts and sandy and stony deserts. The addax is a critically endangered species of antelope, as classified by the IUCN. Although extremely rare in its native habitat due to unregulated hunting, it is quite common in captivity. The addax was once abundant in North Africa; however it is currently only native to Chad, Mauritania, and Niger. It is extirpated from Algeria, Egypt, Libya, Sudan, and Western Sahara, but has been reintroduced into Morocco and Tunisia.
  • 633
  • 04 Nov 2022
Topic Review
Added-Value Compounds for Food Industry
In an increasingly resource-constrained era, using waste and by-products from grain processing has a wide appeal. This is due to the nutritive value and economic aspects of this process and due to its compatibility with the trend towards more sustainable food systems.
  • 182
  • 17 Oct 2023
Topic Review
Adenine Phosphoribosyltransferase Deficiency
Adenine phosphoribosyltransferase (APRT) deficiency is an inherited condition that affects the kidneys and urinary tract. The most common feature of this condition is recurrent kidney stones; urinary tract stones are also a frequent symptom. Kidney and urinary tract stones can create blockages in the urinary tract, causing pain during urination and difficulty releasing urine.
  • 373
  • 24 Dec 2020
Topic Review
Adeno-Associated Viruses
Adeno-associated viruses (AAVs) are a convenient tool for gene therapy delivery. According to the current classification, they are divided into the species AAV A and AAV B within the genus Dependoparvovirus. Historically AAVs were also subdivided on the intraspecies level into 13 serotypes, which differ in tissue tropism and targeted gene delivery capacity. Serotype, however, is not a universal taxonomic category, and their assignment is not always robust. Cross-reactivity has been shown, indicating that classification could not rely on the results of serological tests alone. Moreover, since the isolation of AAV4, all subsequent AAVs were subdivided into serotypes based primarily on genetic differences and phylogenetic reconstructions.
  • 420
  • 23 May 2022
Topic Review
Adenosine A1 Receptor and Epilepsy
Adenosine acts as an endogenous anticonvulsant and seizure terminator in the brain. Many of its anticonvulsive effects are mediated through activation of the adenosine A1 receptor, a G protein-coupled receptor with a wide array of targets. Various signaling pathways are involved in the neuronal inhibition caused by adenosine A1 receptor activation. These include direct interactions of G protein subunits, the adenyl cyclase pathway and the phospholipase C pathway, which all mediate neuronal hyperpolarization and suppression of synaptic transmission.
  • 1.7K
  • 19 Jan 2021
Topic Review
Adenosine Deaminase 2 Deficiency
Adenosine deaminase 2 (ADA2) deficiency is a disorder characterized by abnormal inflammation of various tissues. Signs and symptoms can begin anytime from early childhood to adulthood. The severity of the disorder also varies, even among affected individuals in the same family.
  • 346
  • 24 Dec 2020
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