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Tang, P. ADCADN. Encyclopedia. Available online: https://encyclopedia.pub/entry/6018 (accessed on 18 September 2026).
Tang P. ADCADN. Encyclopedia. Available at: https://encyclopedia.pub/entry/6018. Accessed September 18, 2026.
Tang, Peter. "ADCADN" Encyclopedia, https://encyclopedia.pub/entry/6018 (accessed September 18, 2026).
Tang, P. (2021, January 04). ADCADN. In Encyclopedia. https://encyclopedia.pub/entry/6018
Tang, Peter. "ADCADN." Encyclopedia. Web. 04 January, 2021.
ADCADN
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/autosomal-dominant-cerebellar-ataxia-deafness-and-narcolepsy

Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCADN) is a nervous system disorder with signs and symptoms that usually begin in mid-adulthood and gradually get worse.

genetic conditions

References

  1. Baets J, Duan X, Wu Y, Smith G, Seeley WW, Mademan I, McGrath NM, Beadell NC, Khoury J, Botuyan MV, Mer G, Worrell GA, Hojo K, DeLeon J, Laura M, Liu YT,Senderek J, Weis J, Van den Bergh P, Merrill SL, Reilly MM, Houlden H, GrossmanM, Scherer SS, De Jonghe P, Dyck PJ, Klein CJ. Defects of mutant DNMT1 are linkedto a spectrum of neurological disorders. Brain. 2015 Apr;138(Pt 4):845-61. doi:10.1093/brain/awv010.
  2. Kernohan KD, Cigana Schenkel L, Huang L, Smith A, Pare G, Ainsworth P;Care4Rare Canada Consortium, Boycott KM, Warman-Chardon J, Sadikovic B.Identification of a methylation profile for DNMT1-associated autosomal dominantcerebellar ataxia, deafness, and narcolepsy. Clin Epigenetics. 2016 Sep 5;8:91.doi: 10.1186/s13148-016-0254-x.
  3. Moghadam KK, Pizza F, La Morgia C, Franceschini C, Tonon C, Lodi R, Barboni P,Seri M, Ferrari S, Liguori R, Donadio V, Parchi P, Cornelio F, Inzitari D,Mignarri A, Capocchi G, Dotti MT, Winkelmann J, Lin L, Mignot E, Carelli V,Plazzi G. Narcolepsy is a common phenotype in HSAN IE and ADCA-DN. Brain. 2014Jun;137(Pt 6):1643-55. doi: 10.1093/brain/awu069.
  4. Walker LA, Bourque P, Smith AM, Warman Chardon J. Autosomal dominantcerebellar ataxia, deafness, and narcolepsy (ADCA-DN) associated with progressivecognitive and behavioral deterioration. Neuropsychology. 2017 Mar;31(3):292-303. doi: 10.1037/neu0000322.
  5. Winkelmann J, Lin L, Schormair B, Kornum BR, Faraco J, Plazzi G, Melberg A,Cornelio F, Urban AE, Pizza F, Poli F, Grubert F, Wieland T, Graf E, Hallmayer J,Strom TM, Mignot E. Mutations in DNMT1 cause autosomal dominant cerebellarataxia, deafness and narcolepsy. Hum Mol Genet. 2012 May 15;21(10):2205-10. doi: 10.1093/hmg/dds035.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
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Entry Collection: MedlinePlus
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Update Date: 04 Jan 2021
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