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Topic Review
Reactive Species on Amino Acids
Reactive oxygen species ROS can be triggered by exogenous sources (tobacco, pollution, xenobiotics, drugs, ionizing radiation and so on), but they can also be generated inside the cell by two different mechanisms: enzymatic and non-enzymatic; in both cases, they can have irreversible effects on animal and plant cells and tissues. The superoxide anion •O2− is unstable and cannot pass through membranes, but is rapidly converted to hydrogen peroxide H2O2 and it is membrane-permeable. In the Fenton reaction, H2O2 produces the hydroxyl radical •OH + −OH, which is highly reactive in the mitochondrial matrix. Elevated levels of ROS lead to increased mtDNA damage.
  • 1.0K
  • 23 Nov 2022
Topic Review
Fire-Fighting Adapter
The presented article presents an innovative solution of a fire-fighting adapter based on the basic hypothesis: to provide sufficient technical support in difficult terrain conditions for water transport logistics in order to quickly prevent the spread and destruction of forest fire. At present, when forest fires begin, it is often quite complicated to provide sufficient technical support for the quick prevention and elimination of fires. This fact is largely eliminated by the designed fire-fighting adapter. The mentioned fire-fighting adapter can be used as a fire-fighting mobile device with a base machine of a forest wheeled skidder (LKT), part of the long-distance transport of water in difficult terrain (lake system), a water tank in difficult terrain with the possibility of filling the Bambi bag with a helicopter, part of the long-distance transport of water in the case of a difficult water source without a forest access road network, and a mobile device for emergency transportation of materials in difficult terrain. In addition to the use for fighting forest fires, the fire adapter can also be used to provide for transport of water for forest nurseries (irrigation), freshly planted areas in the event of prolonged drought, the filling of watering-places for forest animals and filling puddles in the dry season. When designing the supporting frame, we used and imitated the evolutionary approach of nature in the form of generative design. The presented paper deals with the use of modern composite materials in the design of superstructures for base machines, which gradually acquire meaning. The main reason for the increasing use of fiberglass is to achieve higher strength and safer weight reduction. This adapter is designed for forest wheel tractors that reach 40% slope availability, areable to work on the stand area, overcome obstacles and are available in sufficient quantities in all Slovak forest areas.
  • 1.0K
  • 18 Aug 2020
Topic Review
Plasmid DNA for Therapeutic Applications in Cancer
Plasmid DNA can be developed to treat different diseases, such as infections and cancer. In most cancers, the immune system is limited or suppressed, allowing cancer cells to grow. DNA vaccination has demonstrated its capacity to stimulate the immune system to fight against cancer cells.
  • 1.0K
  • 15 Sep 2022
Topic Review
Obesity-Related Changes in HDL Metabolism
In obese individuals, atherogenic dyslipidemia is a very common and important factor in the increased risk of cardiovascular disease. Adiposity-associated dyslipidemia is characterized by low high-density lipoprotein cholesterol (HDL-C) levels and an increase in triglyceride-rich lipoproteins. Several factors and mechanisms are involved in lowering HDL-C levels in the obese state and HDL quantity and quality is closely related to levels of adiponectin. Recent studies have shown that obesity profoundly alters HDL metabolism, resulting in altered HDL subclass distribution, composition, and function. 
  • 1.0K
  • 11 Dec 2020
Topic Review
Clinical nutrition management of sarcopenia/T2DM utilizing amino acids
Sarcopenia develops over time as a result of aging, and typically leads to muscle loss, a concurrent increase in fat mass, and a variety of health issues leading to an overall poor quality of life. There is some evidence that sarcopenia may be a contributing to the development of type 2 diabetes mellitus (T2DM) in the elderly, and therefore nutritional management is key in the prevention of both sarcopenia and T2DM. The primary focus of nutritional management lays in the amount and quality of protein intake, which has led to the development of clinical nutritional therapies involving amino acids to improve muscle protein synthesis and decrease sarcopenia symptoms. In the work herein, we present and evaluate data derived from human trials regarding the utilization of hydroxyl-methyl butyrate (HMB), L-leucine (Leu), L-glutamine (Gln) and L-arginine (Arg) supplementation for optimal management of sarcopenia in geriatric patients, a topic of significant clinical nutrition interest which may have important implications in T2DM management.
  • 1.0K
  • 29 Oct 2020
Topic Review
Mitophagy
Mitophagy is a selective autophagic process that eliminates unnecessary and/or damaged mitochondria. Therefore, it is a central hormetic mechanism of mitochondrial quality and quantity control, essential for cellular homeostasis. Its dysregulation has been shown to be a key event in metabolic related diseases and it is the target of emerging therapeutical approaches in this field.
  • 1.0K
  • 28 May 2021
Topic Review
Cannabis sativa
Cannabis sativa is one of the oldest medicinal plants in the world. It was introduced into Western medicine during the early 19th century. It contains a complex mixture of secondary metabolites, including cannabinoids and non-cannabinoid-type constituents. 
  • 1.0K
  • 18 May 2021
Topic Review
LAMM Syndrome
Congenital deafness with labyrinthine aplasia, microtia, and microdontia (also called LAMM syndrome) is a condition that affects development of the ears and teeth.
  • 1.0K
  • 04 Jan 2021
Topic Review
Immunological Responses of Trichuris sp.
Trichuris sp. infection has appeared as a pathological burden in the population, but the immunomodulation features could result in an opportunity to discover novel treatments for diseases with prominent inflammatory responses. Regarding the immunological aspects, the innate immune responses against Trichuris sp. are also responsible for determining subsequent immune responses, including the activation of innate lymphoid cell type 2 (ILC2s), and encouraging the immune cell polarization of the resistant host phenotype. Nevertheless, this parasite can establish a supportive niche for worm survival and finally avoid host immune interference. Trichuris sp. could skew antigen recognition and immune cell activation and proliferation through the generation of specific substances, called excretory/secretory (ESPs) and soluble products (SPs), which mainly mediate its immunomodulation properties. 
  • 1.0K
  • 02 Jul 2021
Biography
Joseph Polchinski
Joseph Gerard Polchinski Jr.[1] (May 16, 1954 – February 2, 2018) was an American theoretical physicist and string theorist.[2][3] Polchinski was born in White Plains, New York, the elder of two children to Joseph Gerard Polchinski Sr. (1929–2002),[4] a financial consultant and manager, and Joan (née Thornton), an office worker and homemaker.[5] Polchinski is primarily of Irish descent w
  • 1.0K
  • 28 Nov 2022
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