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Biography
Sergey Vyacheslavovich Savelyev
Sergey Vyacheslavovich Savelyev (Russian: Серге́й Вячесла́вович Саве́льев; born March 7, 1959)[1] is a Russian doctor of biological Sciences, Professor,[2] author of the idea of cerebral sorting. Born in Moscow, he graduated from the Biology and Chemistry Faculty of MGZPI (now the Sholokhov Moscow State University for Humanities), worked at the Brain Institute of
  • 1.1K
  • 06 Dec 2022
Topic Review
Description and Phytoconstituents of Sapindus mukorossi Gaertn.
Sapindus mukorossi Gaertn., also called the washnut, is a tropical tree of the Sapindaceae family. The plant owes its name to its cleaning and washing properties used by the local population as a natural detergent. The most important ingredients of the plant are triterpenoid saponins contained in many parts of the plant, inducing fruits, galls, or roots. The tree also contains other valuable, biologically active compounds that are obtained by extraction methods. Raw or purified extract and isolated saponins are valuable plant products that can be used in the food, pharmaceutical, cosmetic, and chemical industries.
  • 1.1K
  • 20 Sep 2022
Topic Review
Hepatitis E Genome Organization
Hepatitis E virus (HEV), a pathogen that causes acute viral hepatitis, is a small icosahedral, quasi-enveloped, positive ssRNA virus. Its genome has three open reading frames (ORFs), with ORF1 and ORF3 encoding for nonstructural and regulatory proteins, respectively, while ORF2 is translated into the structural, capsid protein. ORF2 is most widely used for vaccine development in viral hepatitis. Hepatitis E virus-like particles (VLPs) are potential vaccine candidates against HEV infection. VLPs are composed of capsid subunits mimicking the natural configuration of the native virus but lack the genetic material needed for replication. As a result, VLPs are unable to replicate and cause disease, constituting safe vaccine platforms. Currently, the recombinant VLP-based vaccine Hecolin® against HEV is only licensed in China.
  • 1.1K
  • 07 Aug 2020
Topic Review
Promising Lead Compounds for Resistant-Tuberculosis
According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities. Incomplete therapeutic regimen, meager dosing, and the capability of the latent and/or active state tubercular bacilli to abide and do survive against contemporary first-line and second-line antitubercular drugs escalate the prevalence of drug-resistant tuberculosis. To explore and identify the most potential antitubercular drug candidate among various reported compounds, here we focused to highlight the promising lead derivatives of isoniazid, coumarin, griselimycin, and antimicrobial peptides. The aim of the present review is to fascinate significant lead compounds in the development of potential clinical drug candidates that might be more precise and effective against drug-resistant tuberculosis, the world research looking for a long time.
  • 1.1K
  • 10 Dec 2020
Topic Review
Melatonin Regulate ROS and NO
Abiotic stress in plants is an increasingly common problem in agriculture, and thus, studies on plant treatments with specific compounds that may help to mitigate these effects have increased in recent years. Melatonin (MET) application and its role in mitigating the negative effects of abiotic stress in plants have become important in the last few years. MET, a derivative of tryptophan, is an important plant-related response molecule involved in the growth, development, and reproduction of plants, and the induction of different stress factors. In addition, MET plays a protective role against different abiotic stresses such as salinity, high/low temperature, high light, waterlogging, nutrient deficiency and stress combination by regulating both the enzymatic and non-enzymatic antioxidant defense systems. Moreover, MET interacts with many signaling molecules, such as reactive oxygen species (ROS) and nitric oxide (NO), and participates in a wide variety of physiological reactions. It is well known that NO produces S-nitrosylation and NO2-Tyr of important antioxidant-related proteins, with this being an important mechanism for maintaining the antioxidant capacity of the AsA/GSH cycle under nitro-oxidative conditions, as extensively reviewed here under different abiotic stress conditions.
  • 1.1K
  • 18 Nov 2020
Topic Review
Coronavirus Disease 19 Pathogenesis
The coronavirus disease 19 (COVID-19) is caused by the highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has affected the global population despite socioeconomic status and amazed surveillance agencies for its incidence, mortality, and recovery rates.
  • 1.1K
  • 09 Nov 2020
Topic Review
The Gene Elongation Mechanism
Gene elongation is a molecular mechanism consisting of an in-tandem duplication of a gene and divergence and fusion of the two copies, resulting in a gene constituted by two divergent paralogous modules. Several examples of genes with internal sequence repetitions are reported in literature; thus, gene elongation might have shaped the structures of many genes during the first steps of molecular and cellular evolution.  
  • 1.1K
  • 28 Oct 2020
Topic Review
Biomass-Based Chemical Looping Gasification
Chemical Looping Gasification is a process allowing for the conversion of solid feedstock (e.g. biomass) into N2-free, high-calorific syngas or producer gas. The process utilizes the ability of so-called oxygen carriers (e.g. ilmenite, iron ore) to take up and release oxygen in oxidizing and reducing atmospheres, respectively. Employing this characteristic, the oxygen carrier is cycled between two or more reactors to transport oxygen into the so-called fuel reactor, where the inlet feedstock is firstly gasified using steam or CO2, before intermediate gaseous products (e.g. H2, CH4) are further oxidized by the oxygen carrier, providing additional process heat to drive the endothermic gasification reactions. The loop is then closed as the reduced oxygen carrier is re-oxidized in a so-called air reactor, using the oxygen contained in ambient air, resulting in a stream of pure nitrogen at the air reactor outlet.
  • 1.1K
  • 03 Nov 2021
Topic Review
Seaweeds of Poultry Feeds
Poultry are birds which render economic services to humans as a primary supplier of meat, egg and raw materials for different industries (feather, waste products, etc.), source of income and employment to people when compared to other domestic animals. Currently, there is an interest in the application of seaweeds in poultry nutrition. Seaweeds (called also macroalgae), which include green (Chlorophyceae), brown (Phaeophyceae) and red algae (Rhodophyceae), are a naturally occurring source of the biomass that develops in variable environments (results also from eutrophication) and is easily cultivated. Seaweeds as a rich source of bioactive compounds when included into feed can improve poultry health and performance as well as increase the quality of poultry products (eggs, meat).
  • 1.1K
  • 28 Aug 2020
Topic Review
Phytochemical and Potential Properties of Seaweeds
Seaweeds have been employed as source of highly bioactive secondary metabolites that could act as key medicinal components. Seaweeds have many uses: they are consumed as fodder, and have been used in medicines, cosmetics, energy, fertilizers, and industrial agar and alginate biosynthesis. The beneficial effects of seaweed are mostly due to the presence of minerals, vitamins, phenols, polysaccharides, and sterols, as well as several other bioactive compounds. These compounds seem to have antioxidant, anti-inflammatory, anti-cancer, antimicrobial, and anti-diabetic activities.
  • 1.1K
  • 01 Aug 2022
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