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Topic Review
List of Canis Species and Subspecies
Canis, the genus of mammals commonly known as wolves, dingos, dogs, coyotes, and jackals, contains several living species, many divided into numerous subspecies, as well as numerous recently extinct and extinct prehistoric species. Domestic dogs are not usually granted taxonomic variety names below the level of either their species name, or subspecies name so they do not appear here with their popular breed names as individual entries. The New Guinea singing dog and any other varieties of subspecies appear as individual entries here when their taxonomic considerations now suggest that they are varieties of subspecies other than domestic dogs, such as of dingoes. References for taxonomic classification, issues, and current considerations, especially in light of DNA revelations year to year, are found in the articles on individual canids; as this article is only a list, the extensive literature and specifics of these issues for each canid are beyond the scope of reference notes here. Furthermore, articles on the species in this list's section headings, and details of their evolutionary, divergent, interbreeding, geolocational and human-culture mediated shifts contain references on which this list relies when including and positioning its entries. References to this article are thus of two sorts, those pertaining to wholesale sourcing of entries, especially those that do not yet have their own Wikipedia articles, and the far more extensive references in existing Wikipedia articles for each entry, header species, and other relevant taxon.
  • 1.1K
  • 22 Nov 2022
Topic Review
MBD5-Associated Neurodevelopmental Disorder
MBD5-associated neurodevelopmental disorder (MAND) is a condition that affects neurological and physical development.
  • 1.1K
  • 24 Dec 2020
Topic Review
Machine Learning and Vegetable Science
Along with essential nutrients and trace elements, vegetables provide raw materials for the food processing industry. Despite this, plant diseases and unfavorable weather patterns continue to threaten the delicate balance between vegetable production and consumption. It is critical to utilize machine learning (ML) in this setting because it provides context for decision-making related to breeding goals. 
  • 1.1K
  • 29 Jan 2022
Topic Review
G-Quadruplexes: Emerging Anticancer Roles
G-quadruplexes, a family of (thermodynamically and kinetically stable) tetraplex helices, are non-canonical secondary structures derived from guanine (G)-rich sequences of nucleic acids. G-quadruplexes were found to occur in functionally-important regions of the human genome, including the telomere tandem sequences, several proto-oncogene promoters and other regulatory regions, ribosomal DNA (rDNA), as well as mRNA sequences encoding for proteins with roles in tumorigenesis, thus establishing a clear connection between G-quadruplexes and known hallmarks of cancer. Stabilization of G-quadruplexes belonging to the above categories, by means of small-molecule intervention, has been correlated with a range of anticancer effects, which has led to classifying G-quadruplexes as novel potential targets in anticancer research. The most common ways in which G-quadruplexes are now understood to serve in an anticancer capacity are presented herein.
  • 1.1K
  • 03 Mar 2021
Topic Review
Volatile Fatty Acid recovery
Volatile fatty acids (VFAs) are low-molecular-weight carboxylic acids containing two to six carbon atoms that are produced as the final product of acidogenic fermentation in anaerobic digestion process.
  • 1.1K
  • 28 Sep 2021
Topic Review
Endoplasmic Reticulum-Related Protein Targeting and Protein Transport
Cells use an impressive array of components to enable the safe transport of protein cargo from the cytosolic ribosomes to the endoplasmic reticulum. Safety during the transit is warranted by the interplay of cytosolic chaperones, membrane receptors, and protein translocases that together form functional networks and serve as protein targeting and translocation routes. While two targeting routes to the endoplasmic reticulum, SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins), prefer targeting determinants at the N- and C-terminus of the cargo polypeptide, respectively, the discovered SND (SRP-independent) route seems to preferentially cater for cargos with non-generic targeting signals that are less hydrophobic or more distant from the termini. 
  • 1.1K
  • 19 Mar 2022
Topic Review
De Novo Synthesized Estradiol
The estrogen estradiol is a potent neuroactive steroid that may regulate brain structure and function. Although the eff ects of estradiol have been historically associated with gonadal secretion, the discovery that this steroid may be synthesized within the brain has expanded this traditional concept. Indeed, it is accepted that de novo synthesized estradiol in the nervous system (nE2) may modulate several aspects of neuronal physiology, including synaptic transmission and plasticity, thereby influencing a variety of behaviors. These modulations may be on a time scale of minutes via non-classical and often membrane-initiated mechanisms or hours and days by classical actions on gene transcription. Besides the high level, recent investigations in the cerebellum indicate that even a low aromatase expression can be related to the fast nE2 eff ect on brain functioning. These pieces of evidence point to the importance of an on-demand and localized nE2 synthesis to rapidly contribute to regulating synaptic transmission. This review is geared at exploring a new scenario for the impact of estradiol on brain processes as it emerges from the nE2 action on cerebellar neurotransmission and cerebellum-dependent learning.
  • 1.1K
  • 30 Oct 2020
Topic Review
Prenatal Hypoxia
Prenatal hypoxia is a common complication in pregnancy, developing from various causes. Prenatal hypoxia during the prenatal period can interfere with the developmental trajectory and lead to developing hypertension in adulthood. Prenatal hypoxia is often associated with intrauterine growth restriction that interferes with metabolism and can lead to multilevel changes. 
  • 1.1K
  • 23 Mar 2022
Topic Review
Hepatitis C Virus
HCV leads to chronic infection in many patients that may progress to liver cirrhosis and hepatocellular carcinoma (HCC). The interferon (IFN) response is a critical component of the antiviral innate immune response against HCV infection. IFN signaling promotes the expression of many factors that can block the viral replication cycle. These IFN-induced antiviral factors can act at every level of HCV infection by decreasing viral entry, replication, transcription, translation, packaging and release. However, the antiviral state can generate significant collateral damage to the cell, requiring very tight control over the magnitude and duration of the IFN response. This is partially achieved through IFN-mediated negative self-regulation that helps in the termination of the IFN response and the return to homeostasis. However, these negative regulatory mechanisms can be hijacked by HCV to increase viral replication and promote productive infections.
  • 1.1K
  • 28 Oct 2020
Topic Review
Description and Phytoconstituents of Sapindus mukorossi Gaertn.
Sapindus mukorossi Gaertn., also called the washnut, is a tropical tree of the Sapindaceae family. The plant owes its name to its cleaning and washing properties used by the local population as a natural detergent. The most important ingredients of the plant are triterpenoid saponins contained in many parts of the plant, inducing fruits, galls, or roots. The tree also contains other valuable, biologically active compounds that are obtained by extraction methods. Raw or purified extract and isolated saponins are valuable plant products that can be used in the food, pharmaceutical, cosmetic, and chemical industries.
  • 1.1K
  • 20 Sep 2022
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