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Topic Review
Technologies for Crop Nitrogen Diagnosis
       Nitrogen (N) plays a key role in the growth of agricultural crops, efficient and precise tools for diagnosis of N status is key to improving crop productivity and reducing environmental pollution. Recent development of non-destructive optical techniques, such as spectroscopy and machine vision technologies, have laid a good foundation for real-time monitoring and precise management of crop N status. We mainly focused on the contribution of spectral and machine vision technology to the accurate diagnosis of crop N status from three aspects: system selection, data processing, and estimation methods. In order to provide useful information for readers.
  • 1.1K
  • 09 Feb 2021
Topic Review
Aquaporin
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enabling the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrogen peroxide) and ions. AQPs are expressed throughout the human body.
  • 1.1K
  • 18 Feb 2022
Topic Review
Iron Deficiency
Iron deficiency (ID) is the most frequent nutritional deficiency in the whole population worldwide, and the second most common cause of anemia in the elderly. Anemia in aged subjects impacts health and quality of life, and it is associated with several negative outcomes, such as longer time of hospitalization and a higher risk of disability. Furthermore, it is an independent risk factor of increased morbidity and mortality. Even though iron deficiency anemia is a common disorder in older adults, it should be not considered as a normal ageing consequence, but a sign of underlying dysfunction. Relating to the pathophysiology in Iron Deficiency Anemia (IDA), hepcidin has a key role in iron homeostasis. It downregulates the iron exporter ferroportin, inhibiting both iron absorption and release. Furthermore, IDA at old age is frequently dependent on blood loss, especially caused by gastrointestinal lesions. Thus, a diagnostic algorithm for IDA should include invasive investigation such as endoscopic procedures. The treatment choice is influenced by the severity of anemia, underlying conditions, comorbidities, and the clinical state of the patient. Correction of anemia and iron supplementation should be associated with the treatment of the causal disease.
  • 1.1K
  • 27 Oct 2020
Topic Review
EV-Based Vaccines
Extracellular vesicles (EVs) are secreted from almost all human cells and mediate intercellular communication by transferring heterogeneous molecules (i.e., DNA, RNAs, proteins, and lipids). In this way, EVs participate in various biological processes, including immune responses. Viruses can hijack EV biogenesis systems for their dissemination, while EVs from infected cells can transfer viral proteins to uninfected cells and to immune cells in order to mask the infection or to trigger a response. Several studies have highlighted the role of native or engineered EVs in the induction of B cell and CD8(+) T cell reactions against viral proteins, strongly suggesting these antigen-presenting EVs as a novel strategy for vaccine design, including the emerging COVID-19. EV-based vaccines overcome some limitations of conventional vaccines and introduce novel unique characteristics useful in vaccine design, including higher bio-safety and efficiency as antigen-presenting systems and as adjuvants.
  • 1.1K
  • 02 Feb 2021
Topic Review
Virtual Fencing Technology for Cattle Management
Maximizing annual pasture consumption without negatively impacting individual cow performance is of great importance in grass-based dairy and beef systems due to pasture being the most cost-effective nutrient source. However, the disadvantages of conventional and electric fencing include material and labor costs and increased manual labor. Virtual fencing has been developed and evaluated for almost two decades. The evolution of precision livestock farming, specifically virtual fencing, presents new opportunities for maximizing the utilization of available pasture land. Virtual fencing technology decreases the labor involved in physical fencing, provides greater adaptability to changes in pasture conditions, increases precision and efficiency, and offers additional flexibility in grazing management practices. However, that innovative technology should be further developed, and improvements should include decreasing the total costs of the system and increasing its application to other technological groups of ruminants, e.g., suckler cows with calves, increasing the efficiency of the system operation in large areas and a larger number of animals. 
  • 1.1K
  • 27 Feb 2023
Topic Review
Akkermansia muciniphila
Akkermansia muciniphila is one of the early occupants (in first year of life) of the intestinal tract with 108 cell/gm or more than 1% of total faecal microbes.
  • 1.1K
  • 05 Aug 2021
Topic Review
Upcycling of Brewers' Spent Grains
Brewers' spent grains (BSGs) are the most important by-product of the brewing industry and are rich in protein and fiber. However, abundant amounts of BSGs are discarded annually worldwide. This project aimed to employ and compare innovative drying techniques to introduce snacks with protein sources derived from leftover BSGs. This study explored the dehydration kinetics of BSGs and the effect of three different drying methods—oven drying (OD), freeze drying (FD), and vacuum microwave drying (VMD)—on their protein content and functionality. Then, an energy and exergy analysis for the drying methods was given. Accordingly, a snack product (baked chips) using the dehydrated BSGs was developed by a sensory panel study to assess consumer acceptability of the final products. It was found that the VMD process took less drying time (48 min) compared to OD (50 min), with higher effectiveness as a drying process. VMD-treated BSG also showed moderate protein functionality and the highest overall acceptability when used in baked chips. Thus, VMD might be used as a sustainable drying technology for thermal treatment and valorization of BSG. In addition to having implications for dietary health, findings can help improve the economy of the breweries and other industries that deal with the processing of grains by valorizing their process waste and contributing to sustainability.
  • 1.1K
  • 28 Oct 2020
Biography
Jakob von Uexküll
Jakob Johann Baron von Uexküll (German: [ˈʏkskʏl]; 8 September 1864 – 25 July 1944) was a Baltic German biologist who worked in the fields of muscular physiology, animal behaviour studies, and the cybernetics of life. However, his most notable contribution is the notion of Umwelt, used by semiotician Thomas Sebeok and philosopher Martin Heidegger. His works established biosemiotics [1] as
  • 1.1K
  • 08 Dec 2022
Topic Review
Zika Virus
Zika virus (ZIKV) is an emergent arthropod-borne virus whose outbreak in Brazil has brought major public health problems. Infected individuals have different symptoms, including rash and pruritus, which can be relieved by the administration of antiallergics. In the case of pregnant women, ZIKV can cross the placenta and infect the fetus leading to congenital defects. We have identified that mast cells in the placentae of patients who had Zika during pregnancy can be infected. This led to our investigation on the possible role of mast cells during a ZIKV infection, using the HMC-1 cell line. We analyzed their permissiveness to infection, release of mediators and ultrastructural changes. Flow cytometry detection of ZIKV-NS1 expression 24h post infection in 45.3% of cells showed that HMC-1 cells are permissive to ZIKV infection. Following infection, β-hexosaminidase was measured in the supernatant of the cells with a notable release at 30 min. In addition, an increase in TNF-α, IL-6, IL-10 and VEGF levels were measured at 6h and 24h post infection. Lastly, different intracellular changes were observed in an ultrastructural analysis of infected cells. Our findings suggest that mast cells may represent an important source of mediators that can activate other immune cell types during a ZIKV infection, which has the potential to being a major contributor in the spread of the virus in cases of vertical transmission.
  • 1.1K
  • 30 Oct 2020
Topic Review
ARP2/3 Complex-Driven Actin Polymerization in RSV Infection
Respiratory syncytial virus (RSV) is the leading viral agent causing bronchiolitis and pneumonia in children under five years old worldwide. The RSV infection cycle starts with macropinocytosis-based entry into the host airway epithelial cell membrane, followed by virus transcription, replication, assembly, budding, and spread. It is not surprising that the host actin cytoskeleton contributes to different stages of the RSV replication cycle. RSV modulates actin-related protein 2/3 (ARP2/3) complex-driven actin polymerization for a robust filopodia induction on the infected lung epithelial A549 cells, which contributes to the virus’s budding, and cell-to-cell spread. 
  • 1.1K
  • 05 Jan 2022
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