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Topic Review
Benign Migratory Glossitis
Geographic tongue, also known by several other terms, is a condition of the mucous membrane of the tongue, usually on the dorsal surface. It is a common condition, affecting approximately 2–3% of the general population. It is characterized by areas of smooth, red depapillation (loss of lingual papillae) which migrate over time. The name comes from the map-like appearance of the tongue, with the patches resembling the islands of an archipelago. The cause is unknown, but the condition is entirely benign (importantly, it does not represent oral cancer), and there is no curative treatment. Uncommonly, geographic tongue may cause a burning sensation on the tongue, for which various treatments have been described with little formal evidence of efficacy.
  • 1.2K
  • 27 Sep 2022
Topic Review
Taxa of the Genus Iris
Some wild, morphologically diverse taxa of the genus Iris L. in the broad Alpine-Dinaric area have never been explored molecularly, and/or have ambiguous systematic status. The main aims of our research were to perform a molecular study of critical Iris taxa from that area (especially a narrow endemic species I. adriatica, for which we also analysed genome size) and to explore the contribution of eight microsatellites and highly variable chloroplast DNA (ndhJ, rpoC1) markers to the understanding of the Iris taxa taxonomy and phylogeny. 
  • 1.2K
  • 21 Oct 2020
Topic Review
Genetic Engineering of Eggplant
Eggplant (Solanum melongena) is the third most important vegetable in Asia and of considerable importance in the Mediterranean belt. Although global eggplant production has been increasing in recent years, productivity is limited due to insects, diseases, and abiotic stresses. Genetic engineering offers new traits to eggplant, such as seedless parthenocarpic fruits, varieties adapted to extreme climatic events (i.e., sub- or supra-optimal temperatures), transcription factor regulation, overexpressing osmolytes, antimicrobial peptides, Bacillusthuringiensis (Bt) endotoxins, etc. 
  • 1.2K
  • 04 Aug 2021
Topic Review
Chemistry, Occurrence, Properties of Carotenoids
Carotenoids are natural lipophilic pigments and antioxidants that are present in many fruits and vegetables. The consumption of carotenoids is correlated with positive health effects and a decreased risk of several chronic diseases. Provitamin A carotenoids (β-carotene, α-carotene, γ-carotene, and β-cryptoxanthin) are essential for the development and maintenance of sight. β-carotene, α-carotene, zeaxanthin, β-cryptoxanthin, lutein, and lycopene have high antioxidant activity and promote free radical scavenging, which helps protect against chronic diseases.
  • 1.2K
  • 06 Feb 2023
Topic Review
BBSOAS Neurodevelopmental Disorder: Clinical Manifestations and Mouse Models
Bosch–Boonstra–Schaaf Optic Atrophy Syndrome (BBSOAS; OMIM 615722; ORPHA 401777) is a genetic neurodevelopmental syndrome caused by the haploinsufficiency of the NR2F1 gene, a key transcriptional regulator of brain and eye development. Although intellectual disability, developmental delay and visual impairment are arguably the most common symptoms affecting BBSOAS patients, multiple additional features are often reported, including epilepsy, autistic traits and hypotonia. These features can be present alone or as comorbidities, with a severity degree that presumably varies depending on the type of NR2F1 genetic perturbation, following a still not well characterized genotype–phenotype correlation. Pathogenic BBSOAS point mutations are principally located in the two most conserved functional domains of the NR2F1 protein: the DNA-binding domain (DBD), responsible for the interaction with target gene regulatory sequences, and the ligand-binding domain (LBD), necessary for dimerization and co-factor binding. 
  • 1.2K
  • 27 Apr 2022
Topic Review
Toxicology of Deoxynivalenol
Deoxynivalenol is a toxic compound produced by filamentous fungi and represents a threat to public health. It is not possible to totally extinguish fungal contamination in crops such as wheat and corn and thereby avoid the production of this toxin.
  • 1.2K
  • 03 Mar 2022
Topic Review
Passive Electrolocation in Fish
Passive electrolocation is a process where certain species of fish or aquatic amphibians can detect electric fields using specialized electroreceptors to detect and to locate the source of an external electric field in its environment creating the electric field. These external electric fields can be produced by any bioelectrical process in an organism, especially by actions of the nerves or muscles of fish, or indeed by the specially developed electric organs of fish. Other fields are induced by movement of a conducting organism through the earth's magnetic field, or from atmospheric electricity. Electrolocating fish use this ability to detect prey, locate other fish, avoid predators, and perhaps to navigate by the Earth's magnetic field. Electroreceptors probably evolved once or twice early in vertebrate evolution, but the sense was apparently lost in amniotes, and in a large number of the Actinopterygii (ray finned fishes) only to reappear independently in two teleost clades. In fish, the ampullary receptor is a specialized receptor that it uses to sense these electric fields and allows the fish to follow electric field lines to their source. Sharks primarily use specialized receptors, called Ampullae of Lorenzini, to detect their prey's low frequency DC fields and may also use their receptors in navigation by the Earth's magnetic field. Weakly electric fish use their ampullary receptors and tuberous receptors to detect the weakly electric fields produced by other fish, as well as for possible predator avoidance. Passive electrolocation contrasts with active electrolocation, in which the animal emits its own weak self generated electric field and detects nearby objects by detecting the distortion of its produced electric field. In active electrolocation the animal senses its own electromotor discharge or reafference instead of some externally generated electric field or discharge.
  • 1.2K
  • 17 Oct 2022
Topic Review
Novel Delivery Systems of Polyphenols
Polyphenols encapsulated in liposomes are known to produce more substantial effects on targeted cells than unencapsulated polyphenols, while having minimal cytotoxicity in healthy cells. 
  • 1.2K
  • 29 Sep 2021
Topic Review
Microsatellite Instability
Microsatellite Instability (MSI) is the hallmark of Lynch syndrome and it was first described in colorectal cancer patients in 1913. Later the definition was broadened and extracolonic tumors have been included.
  • 1.2K
  • 19 Jan 2021
Topic Review
Health Benefits of Noni Juice
Noni juice is a globally popular health beverage originating in the tropics. Traditional healers believe the noni plant to be useful in treating a wide range of maladies. Consumers throughout the world have similar perceptions. To better understand the potential health benefits of noni juice, human intervention studies are reviewed and discussed.
  • 1.2K
  • 22 Jul 2021
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