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Topic Review
Antisense Oligonucleotide-Based Therapy of Viral Infections
Antisense oligonucleotide (ASO) technology exploits a single-strand short oligonucleotide to either cause target RNA degradation or sterically block the binding of cellular factors or machineries to the target RNA. Chemical modification or bioconjugation of ASOs can enhance both its pharmacokinetic and pharmacodynamic performance, and it enables customization for a specific clinical purpose. ASO-based therapies have been used for treatment of genetic disorders, cancer and viral infections. In particular, ASOs can be rapidly developed for newly emerging virus and their reemerging variants. 
  • 1.2K
  • 29 Mar 2022
Topic Review
Incretin Hormones
The term incretin was introduced in 1932 to describe compounds produced by intestinal mucosa in response to nutrient ingestion, which were capable of reducing blood glucose. There are two known incretins: glucose-dependent insulinotropic polypeptide (GIP) produced by the K cells of an upper gut and glucagon-like peptide-1 (GLP-1) produced by the L cells of a lower gut. Incretins play a crucial role in stimulating insulin and glucagon secretion by the pancreas.
  • 1.2K
  • 18 Mar 2021
Biography
Harold G. White
Harold G. "Sonny" White is a mechanical engineer, aerospace engineer and applied physicist who is the Advanced Propulsion Team Lead for the NASA Engineering Directorate and is known for proposing new Alcubierre drive concepts and promoting advanced propulsion projects, under development at the NASA Johnson Space Center, including the first practical experiment to test the existence of Alcubierre
  • 1.2K
  • 17 Nov 2022
Topic Review
Physaliidae
The Portuguese man o' war (Physalia physalis), also known as the man-of-war, bluebottle, blue bottle jellyfish, or floating terror is a marine hydrozoan found in the Atlantic Ocean and the Indian Ocean. It is considered to be the same species as the Pacific man o' war, which is found mainly in the Pacific Ocean. The Portuguese man o' war is the only species in the genus Physalia, which in turn is the only genus in the family Physaliidae. It has numerous venomous microscopic nematocysts which deliver a painful sting powerful enough to kill fish, and has been known to occasionally kill humans. Although it superficially resembles a jellyfish, the Portuguese man o' war is in fact a siphonophore. Like all siphonophores, it is a colonial organism, made up of many smaller units called zooids. All zooids in a colony are genetically identical, but fulfill specialized functions such as feeding and reproduction, and together allow the colony to operate as a single individual.
  • 1.2K
  • 27 Oct 2022
Topic Review
Mechanobiology of Chondrocytes
This entry is associated with a review article, published in MDPI Applied Sciences on 23 April 2020, about the current knowledge on the mechanical stimulation of mesenchymal stem cells for cartilage regeneration. Loading stresses, physiologically experienced by chondrocytes, regulate the production of glycosaminoglycan and collagen, as well as promote and preserve cell viability. Therefore, there is a rising interest in the development of devices that impose mechanical stimuli, such as compression and shear stress, on mesenchymal stem cells. The mentioned review will analyze the dynamics within the joint, the physiological stimuli experienced by the chondrocytes, and how the biomechanical stimulation can be applied to a stem cell culture in order to induce chondrogenesis. In addition to that, paper lists some of the current applications in the field.
  • 1.2K
  • 29 Oct 2020
Topic Review
Pomphorhynchus Laevis
Pomphorhynchus laevis is an endo-parasitic acanthocephalan worm, with a complex life cycle, that can modify the behaviour of its intermediate host, the freshwater amphipod Gammarus pulex. P. laevis does not contain a digestive tract and relies on the nutrients provided by its host species. In the fish host this can lead to the accumulation of lead in P. laevis by feeding on the bile of the host species.
  • 1.2K
  • 21 Oct 2022
Topic Review
Patagonian Berries
In this review, we focus on five fruit species growing in Patagonia with high potential as a functional food (i.e., maqui, murta, calafate, arrayán, and Chilean strawberry); giving a little background on the fruit quality; and discussing the recent research data available—regarding the particular compound profile, their processing, and clinical assays— of these Patagonian berries.
  • 1.2K
  • 01 Jul 2021
Topic Review
Synthetic Cathinones
New psychoactive substances represent a public health threat since they are not controlled by international conventions, are easily accessible online and are sold as a legal alternative to illicit drugs. Among them, synthetic cathinones are widely abused due to their stimulant and hallucinogenic effects. To circumvent the law, new derivatives are clandestinely synthesized and, therefore, synthetic cathinones keep emerging on the drug market, with their chemical and toxicological properties still unknown.
  • 1.2K
  • 08 Jul 2022
Biography
Neil Peart
Neil Ellwood Peart OC (/pɪərt/; September 12, 1952 – January 7, 2020) was a Canadian musician, songwriter, and author, best known as the drummer and primary lyricist of the rock band Rush. Peart earned numerous awards for his musical performances, including an induction into the Modern Drummer Readers Poll Hall of Fame in 1983, making him the youngest person ever so honoured.[1] His drumming
  • 1.2K
  • 16 Nov 2022
Topic Review
Von Willebrand Factor
The von Willebrand factor (vWF) is a plasma protein that mediates platelet adhesion and leukocyte recruitment to vascular injury sites and carries coagulation factor VIII, a building block of the intrinsic pathway of coagulation. A steep rise in shear rates, which may occur at sites of arterial stenosis and injury, is crucial for unfolding and activation of vWF. The hemostatic activity of vWF is counterbalanced by ADAMTS-13, a vWF-cleaving protease. The presence of ultra-large multimers of vWF in the bloodstream is associated with spontaneous thrombosis, whereas its deficiency leads to bleeding.
  • 1.2K
  • 12 Nov 2020
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