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Topic Review
Forest Volatile Organic Compounds
This article provides a biochemical description of forest Biogenic Volatile Organic Compounds (BVOCs), namely any organic substance, except carbon dioxide and monoxide, mostly emitted by plants and having vapor pressure high enough to be vaporized in relevant amounts into the forest air. An estimation of the average contribution of forests to the atmospheric composition is mentioned. Additionally, a brief analysis of functional roles that BVOCs play for plant physiology and forest ecology is reported, including the importance of non-tree-derived BVOCs. Finally, biochemical pathways leading to the natural production of most forest BVOCs are described.
  • 1.5K
  • 02 Feb 2021
Topic Review
Anti-Cancer Quinone
Natural quinones are secondary metabolites of plant and are categorized as benzoquinone, naphthoquinone, phenanthrenequinone, and anthraquinone according to their aromatic carbon skeleton [3]. Quinones are highly electrophilic molecules that accept one- or two-electrons from flavoenzymes and iron-sulfur proteins to form semiquinone or hydroquinone. They exert cytotoxic effects through alkylating proteins or DNA and affect the redox cycle with their semiquinone radicals to generate reactive oxygen species.
  • 1.5K
  • 27 Oct 2020
Topic Review
Functions of Circular RNAs
Circular RNAs (circRNAs) are a distinctive class of regulatory non-coding RNAs characterised by the presence of covalently closed ends. They are evolutionary conserved molecules, and although detected in different tissues, circRNAs resulted specifically enriched in the nervous system, where they might play an important role in neuronal specification and activity.  Notably, deregulation of circRNAs expression has been linked with various neurological disorders. Little is known about circRNA mode of action, the few species characterized have been shown to act as molecular decoy for microRNAs (miRNAs) or RNA binding proteins (RBPs), to control transcription of their host genes and, although classify as ncRNAs, some of them hold the capacity to direct synthesis of short peptides/proteins.    
  • 1.5K
  • 30 Jul 2020
Topic Review
16p12.2 Microdeletion
16p12.2 microdeletion is a chromosomal change in which a small amount of genetic material on chromosome 16 is deleted. The deletion occurs on the short (p) arm of the chromosome at a location designated p12.2. Common characteristics that have been described in people with a 16p12.2 microdeletion include developmental delay, delayed speech, intellectual disability that ranges from mild to profound, weak muscle tone (hypotonia), slow growth resulting in short stature, an usually small head (microcephaly), malformations of the heart, recurrent seizures (epilepsy), and psychiatric and behavioral problems.
  • 1.5K
  • 23 Dec 2020
Topic Review
Post-Traumatic Stress Disorder and Thalamus
Post-traumatic stress disorder is a common mental disorder, with high lifetime prevalence approximately 6–10% . The prevalence of PTSD in trauma-exposed people has been approximately 20%. PTSD is induced by traumatic stress including life threatening, actual or threatened severe injury, and sexual violence. In DSM-V criteria, PTSD has the following symptoms: intrusion of unwanted memory updates related to traumatic stress, avoidance for reminders, negative alterations in mood, and hyper-arousal. Conservatively, fear-conditioned learning involving the amygdala has been considered one of the causative factors.
  • 1.5K
  • 03 Mar 2021
Topic Review
CD44 Receptor
CD44 is a receptor described as a single span transmembrane glycoprotein without kinase activity whose ubiquitous and constitutive expression has been observed on many different cells.
  • 1.5K
  • 18 Mar 2021
Topic Review
Entompathogen Wasps
Parasitoid wasps inject eggs into the host insect along with several factors that modulate the immune response, in addition these molecular structures and compounds, present at the surface of the gamete, contribute to the evasive and depressive strategies of the parasitoid by facilitating the development of eggs and larvae within the host body.
  • 1.5K
  • 09 Nov 2020
Topic Review
Coronaviruses
There are various coronaviruses high and low pathogenicity. The first being associated with a high morbidity and mortality. The SARS-CoV-2 leading to COVID-19 has spread globally and is associated with a high mortality especially in elderly patients and with certain comorbidities (hypertension, obesity, diabetes, etc). Currently there are only limited evidence-based treatment options such as dexamethason, remdesivir, and ICU care. Multiple treatment strategies are being evaluated since the pandemic is still evolving in most countries. 
  • 1.5K
  • 10 Mar 2021
Topic Review
Zinc and autophagy in AMD
Zinc supplementation is reported to slow down the progression of age-related macular degeneration (AMD), but there is no general consensus on the beneficiary effect on zinc in AMD. As zinc can stimulate autophagy that is declined in AMD, it is rational to assume that it can slow down its progression. As melanosomes are the main reservoir of zinc in the retina, zinc may decrease the number of lipofuscin granules that are substrates for autophagy. The triad zinc–autophagy–AMD could explain some controversies associated with population studies on zinc supplementation in AMD as the effect of zinc on AMD may be modulated by genetic background. This aspect was not determined in many studies regarding zinc in AMD. Zinc deficiency induces several events associated with AMD pathogenesis, including increased oxidative stress, lipid peroxidation and the resulting lipofuscinogenesis. The latter requires autophagy, which is impaired. This is a vicious cycle-like reaction that may contribute to AMD progression. Promising results with zinc deficiency and supplementation in AMD patients and animal models, as well as emerging evidence of the importance of autophagy in AMD, are the rationale for future research on the role of autophagy in the role of zinc supplementation in AMD.
  • 1.5K
  • 30 Jul 2020
Topic Review
Antioxidant Activity of Natural Products
Natural products identified with potential antioxidant activity need to be further evaluated in the cellular model. Antioxidant activity of a large number of natural products will not extrapolate its performance in the biological system, either in vitro as cellular assays or in vivo as animal model studies. Thus, it is necessary to examine the bioavailability, metabolism and mechanism of action in a living system to prove potential antioxidant activities of new natural products.
  • 1.5K
  • 09 Dec 2021
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