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Biography
Paul Winchell
Paul Winchell (né Wilchinsky; December 21, 1922 – June 24, 2005) was an American ventriloquist, comedian, actor, voice artist, humanitarian, and inventor whose career flourished in the 1950s and 1960s. From 1950 to 1954, he hosted The Paul Winchell Show, which also used two other titles during its prime time run on NBC: The Speidel Show, and What's My Name?. From 1965–1968, Winchell hosted
  • 1.7K
  • 23 Nov 2022
Topic Review
Nanoparticles
Iron oxide nanoparticles are frequently used in various biomedical applications, in particular as magnetic resonance imaging contrast agents in liver imaging. Indeed, number of iron oxide nanoparticles have been withdrawn due to their poor clinical performance and/or toxicity issues. In the literature it has been criticized that failure of clinical applications is to a large extent due to poor understanding of the sub-cellular molecular targets of nanoparticles. Nanoparticles were found to change the activity of autophagic flux via lysosome-dependent signalling. However, precise underlying mechanisms of such modulation remain poorly understood.
  • 1.7K
  • 03 Feb 2021
Topic Review
List of Fictional Crocodiles and Alligators
This is a list of fictional crocodiles and alligators from literature, folklore and myth, mascots and emblems of teams and organizations, comics, films, animations and video games. This list is subsidiary to the list of fictional animals. It is restricted to notable crocodilian characters from notable works of fiction. Characters that appear in multiple media may have separate listings for each appearance, while in instances where a character has appeared in several separate works in a single medium, only the earliest will be recorded here.
  • 1.7K
  • 21 Oct 2022
Topic Review
QuEChERS Application to the Determination of Pyrrolizidine Alkaloids
The identification of concerning high levels of pyrrolizidine alkaloids (PAs) in a wide variety of food products has raised the occurrence of these natural toxins as one of the main current issues of the food safety field. Consequently, a regulation with maximum concentration levels of these alkaloids has been published to monitor their occurrence in several foodstuffs. According to legislation, the analytical methodologies developed for their determination must include multiresidue extractions with high selectivity and sensitivity, as a set of 21 + 14 PAs should be simultaneously monitored. However, the multiresidue extraction of these alkaloids is a difficult task due to the high complexity of food and feed samples. Accordingly, although solid-phase extraction is still the technique most widely used for sample preparation, the QuEChERS method can be a suitable alternative for the simultaneous determination of multiple analytes, providing green extraction and clean-up of samples in a quick and cost-effective way.
  • 1.7K
  • 12 May 2022
Topic Review
3D Genome
The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled us to understand the 3D spatial organization of the genome. Chromosome capture methods using a ligation approach and the visualization tool of a 3D genome browser have facilitated detailed exploration of the genome. 
  • 1.7K
  • 04 Nov 2021
Topic Review
Diversity and Role of Latex in Plant Physiology
Latex, a sticky emulsion produced by specialized cells called laticifers, is a crucial part of a plant’s defense system against herbivory and pathogens. It consists of a broad spectrum of active compounds, which are beneficial not only for plants, but for human health as well, enough to mention the use of morphine or codeine from poppy latex.
  • 1.7K
  • 30 Nov 2021
Topic Review
Breast Cancer Pathology and Biomarkers
This contribution describes breast pathology and breast cancer incidence and mortality statistics. The contribution also discusses the clinical performance of already approved breast cancer biomarkers and their performance is compared to novel discovered breast cancer biomarkers.
  • 1.7K
  • 28 Jul 2020
Topic Review
HEK293 Cell Line
The HEK293 cell line has earned its place as a producer of biotherapeutics. In addition to its ease of growth in serum-free suspension culture and its amenability to transfection, this cell line’s most important attribute is its human origin, which makes it suitable to produce biologics intended for human use. At the present time, the growth and production properties of the HEK293 cell line are inferior to those of non-human cell lines, such as the Chinese hamster ovary (CHO) and the murine myeloma NSO cell lines. However, the modification of genes involved in cellular processes, such as cell proliferation, apoptosis, metabolism, glycosylation, secretion, and protein folding, in addition to bioprocess, media, and vector optimization, have greatly improved the performance of this cell line.
  • 1.7K
  • 07 Jul 2021
Topic Review
Biogenic amines in Fish
The occurrence of biogenic amines in fish is directly associated with microorganisms with decarboxylase activity. These compounds are generally detoxified by oxidases in the intestinal tract of humans, but some conditions, such as alcohol consumption, enzyme deficiency, or monoamino-oxidase antidepressant use, can make their intake by food dangerous. Due to its toxicity, histamine is a unique biogenic amine with regulatory limits for fishery products. This review focuses on biogenic amines in fish, with a detailed picture of the number of alert notifications or intoxication events reported in the last years. The favoring conditions for their formation, as well as the main preventive and control measures to ensure public health, are also reviewed.
  • 1.7K
  • 18 Dec 2020
Topic Review
LABs and Silage Production
Lactic acid bacteria (LAB) are considered potent natural additives for animal feed production due to the efficient production of biological metabolites—notably, higher lactic acid content with marginal level acetic acid and other organic acids. Furthermore, LAB can utilize water-soluble carbohydrates and convert them into valuable organic acids, which increase the acidification of the surrounding environment. Rapid acidification (lower pH) could help to prevent undesirable microbial growth and toxic secondary metabolite secretion.
  • 1.7K
  • 07 Jan 2022
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