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Topic Review
PGT-M for Premature Ovarian Failure
Primary ovarian failure (POF) is caused by follicle exhaustion and is associated with menstrual irregularities and elevated gonadotropin levels, which lead to infertility before the age of 40 years. The etiology of POI is mostly unknown, but a heterogeneous genetic and familial background can be identified in a subset of cases. Abnormalities in the fragile X mental retardation 1 gene (FMR1) are among the most prevalent monogenic causes of POI. These abnormalities are caused by the expansion of an unstable CGG repeat in the 5′ untranslated region of FMR1. Expansions over 200 repeats cause fragile X syndrome (FXS), whereas expansions between 55 and 200 CGG repeats, which are defined as a fragile X premutation, have been associated with premature ovarian failure type 1 (POF1) in heterozygous females. Preimplantation genetic testing for monogenic diseases (PGT-M) can be proposed when the female carries a premutation or a full mutation. 
  • 116
  • 19 Jan 2024
Topic Review
Problems in Paddy Procurement System in Bangladesh
Bangladesh derives one-half of its agricultural GDP and one-sixth of its national income from paddy. It is crucial to the farmers’ ability to survive. The majority of farmers in Bangladesh are classified as middle- or low-income. They must frequently take out loans to cultivate paddy. Moreover, they are compelled to sell their paddy at a lower price immediately after harvesting for primarily two reasons: the lack of storage facilities; and the immediate need for money to pay back loans taken out to buy labour, seeds, fertiliser, insecticides, and other necessities, and to fund daily costs.
  • 401
  • 19 Jan 2024
Topic Review
Gel-Based Membranes
Gel-based membranes, a fusion of polymer networks and liquid components, have emerged as versatile tools in a variety of technological domains thanks to their unique structural and functional attributes. Historically rooted in basic filtration tasks, advancements in synthetic strategies have increased the mechanical strength, selectivity, and longevity of these membranes.
  • 284
  • 19 Jan 2024
Topic Review
Transport of Nanoparticles into Plants
The transport of matter into plants, also known as plant uptake, is a crucial process for the growth and development of plants. Plants require various essential nutrients, water, and gases for their survival and growth. The transport in plants extends beyond water, nutrients, and gases, encompassing the movement of various particles or nanoparticles, as well as other exogenous materials. This includes genetic material such as double-stranded RNA (dsRNA). Nanoparticles can be transported into plants for several reasons, often as a result of environmental exposure or as a part of research and development efforts. The transport of nanoparticles into plants can have various implications, both beneficial and potentially concerning, depending on the type of nanoparticles and the intended purpose. 
  • 250
  • 19 Jan 2024
Topic Review
Nutritional Importance of Lentils
The legume family includes approximately 19,300 species across three large subfamilies, of which Papilionoideae stands out with 13,800 species. Lentils were one of the first crops to be domesticated by humans. They are diploid legumes that belong to the Papilionoidea subfamily and are of agricultural importance because of their resistance to drought and the fact that they grow in soil with a pH range of 5.5–9; therefore, they are cultivated in various types of soil, and so they have an important role in sustainable food and feed systems in many countries. In addition to their agricultural importance, lentils are a rich source of protein, carbohydrates, fiber, vitamins, and minerals. They are key to human nutrition since they are an alternative to animal proteins, decreasing meat consumption. 
  • 174
  • 18 Jan 2024
Topic Review
Applications of Bacillus subtilis Spores
Bacillus subtilis spores offer several advantages that make them attractive for protein display. They can be used in a wide array of biotechnological and industrial applications such as vaccines, bioabsorbants to remove toxic chemicals, whole-cell catalysts, bioremediation, and biosensors. Lastly, spores are easily produced in large quantities, have a good safety record, and can be used as additives in foods and drugs.
  • 97
  • 18 Jan 2024
Topic Review
Seaweed Diversity and Bioactive Compounds
Seaweed, a miscellaneous group of marine algae, has long been recognized for its rich nutritional composition and bioactive compounds, being considered nutraceutical ingredient. Seaweeds are abundant sources of essential vitamins, minerals, polysaccharides, polyphenols, and unique secondary metabolites, which reveal a wide range of biological activities. These bioactive compounds possess potential therapeutic properties, making them intriguing candidates for drug leads in various medical applications and pharmaceutical drug development.
  • 301
  • 18 Jan 2024
Topic Review
Role of Complement System in Alzheimer’s Disease Pathogenesis
As an essential component of the innate immune system, the complement system is responsible for the defense against pathogens. The complement cascade has complex roles in the central nervous system (CNS), numerous reports have implicated the classical complement cascade in both brain development and decline. More specifically, complement dysfunction has been implicated in neurodegenerative disorders, such as Alzheimer’s disease (AD), which is the most common form of dementia. Synapse loss is one of the main pathological hallmarks of AD and correlates with memory impairment. 
  • 127
  • 18 Jan 2024
Topic Review
EVs’ Mechanisms of HSP Transmission among TME Cells
From an evolutive perspective, tumor cells endure successive turnover upon stress conditions and pressure to adapt to new environments. These cells use exceptional communication skills to share biological information to “survive upon every metabolic cost”. The tumor microenvironment (TME) is a miscellaneous collection of cells, factors, and extracellular vesicles (EVs). EVs are small lipid bilayer-delimited particles derived from cells with sizes ranging from 100 to 1000 nm. Exosomes (<160 nm) are the minor subtype of EVs, originating from the endosomal pathways. The TME also contains “giant” vesicles, microvesicles (100–1000 nm, MV), originated from membrane blebbing. EVs can act as intercellular communication mediators, contributing to many biological processes, by carrying different biomolecules, such as proteins, lipids, nucleic acids, and metabolites. EV secretion can promote either tumor cell survival or manage their stress to death. Tumor-derived EVs transfer adaptative stress signaling to recipient cells, reprograming these cells. Heat shock proteins (HSP) are prominent stress response regulators, specifically carried by exosomes. HSP-loaded EVs reprogram tumor and TME cells to acquire mechanisms contributing to tumor progression and therapy resistance. The intercellular communication mediated by HSP-loaded EVs favors the escape of tumor cells from the endoplasmic reticulum stress, hypoxia, apoptosis, and anticancer therapies. Extracellular HSPs activate and deactivate the immune response, induce cell differentiation, change vascular homeostasis, and help to augment the pre-metastatic niche formation.
  • 103
  • 18 Jan 2024
Topic Review
Chloroquine and Chemotherapeutic Compounds in Experimental Cancer Treatment
Chloroquine (CQ) and its derivate hydroxychloroquine (HCQ), the compounds with recognized ability to suppress autophagy, have been tested in experimental works and in clinical trials as adjuvant therapy for the treatment of tumors of different origin to increase the efficacy of cytotoxic agents. Such a strategy can be effective in overcoming the resistance of cancer cells to standard chemotherapy or anti-angiogenic therapy. The majority of experimental studies has shown that CQ/HCQ can effectively sensitize cancer cells to cytotoxic agents and increase the potential of chemotherapy, however, the results of clinical trials are often inconsistent. Although pharmacological suppression of autophagy remains a promising tool for increasing the efficacy of standard chemotherapy, the development of more specific inhibitors is required.
  • 87
  • 18 Jan 2024
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