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Topic Review
GeneCards
GeneCards is a database of human genes that provides genomic, proteomic, transcriptomic, genetic and functional information on all known and predicted human genes. It is being developed and maintained by the Crown Human Genome Center at the Weizmann Institute of Science. The database aims at providing a quick overview of the current available biomedical information about the searched gene, including the human genes, the encoded proteins, and the relevant diseases. The GeneCards database provides access to free Web resources about more than 7000 all known human genes that integrated from >90 data resources, such as HGNC, Ensembl, and NCBI. The core gene list is based on approved gene symbols published by the HUGO Gene Nomenclature Committee (HGNC). The information is carefully gathered and selected from these databases by its engine. If the search does not return any results, this database will give several suggestions to help users accomplish their search depending on the type of query and offer direct links to other databases’ search engine. Over time, the GeneCards database has developed a suite of tools (GeneDecks, GeneLoc, GeneALaCart) that has more specialised capability. Since 1998, the GeneCards database has been widely used by bioinformatics, genomics and medical communities for more than 15 years.
  • 1.1K
  • 17 Oct 2022
Topic Review
PP2A during Mitosis in Yeasts
Cell cycle regulation is largely based on protein phospho-dephosphorylation events, catalyzed by cyclin dependent kinases (Cdks) and phosphatases (PPases), respectively. During many years the Cdks were considered the main component of the cell cycle control system. Recently, the importance of the counteracting PPases has emerged. Research on yeast has provided many insights into such contribution. Here we present an overview of the protein phosphatase 2A family's roles during mitosis.
  • 1.1K
  • 23 Oct 2020
Topic Review
The Sumoylation Pathway
Post-translational modifications (PTMs) are key regulators of most biological processes. Besides phosphorylation, methylation, acetylation and others, covalent modification of proteins by small polypeptides of the ubiquitin-like modifiers (UBLs) family have gained importance. Among UBLs, the small ubiquitin-like modifier (SUMO), of ~90 amino acids and discovered in the nineties, has proven to regulate most cellular processes. The sumoylation pathway is quite similar to the ubiquitination pathway, but there is its own set of enzymes for modification by SUMO.
  • 1.1K
  • 25 Jul 2022
Topic Review
The Luminous Fungi of Japan
Luminous fungi have long attracted public attention in Japan, from old folklore and fiction to current tourism, children’s toys, games, and picture books. 25 species of luminous fungi have been discovered in Japan, which correspond to approximately one-fourth of the globally recognized species. This species richness is arguably due to the abundant presence of mycophiles looking to find new mushroom species and a tradition of night-time activities, such as firefly watching, in Japan.
  • 1.1K
  • 31 May 2023
Topic Review
Obesity
Obesity, a complex and multifactorial disease associated with excessive adiposity or body fat, currently affects over a third of the world’s population. Obesity is closely related to a significant increase in the morbidity risk of chronic diseases, such as disability, depression, type 2 diabetes, hypertension, cardiovascular diseases, cancers, and mortality, thus representing a serious public health problem. According to the World Health Organization (WHO), the body mass index (BMI) is used as a tool to assess overweight or obesity; a BMI ≥ 40 kg/m2 is characteristic of severe obesity. Rare genetic obesity disorders are characterized by mutations of genes strongly involved in the central or peripheral regulation of energy balance. These mutations are effective in causing the early onset of severe obesity and insatiable hunger (hyperphagia), suggesting that the genetic component can contribute to 40–70% of obesity.”
  • 1.1K
  • 13 Jan 2022
Topic Review
Ferroptosis
Ferroptosis is a type of cell death, caused by iron-mediated peroxidation of cellular lipids, that leads to tissue dysfunction in several human diseases including Friedreich's ataxia.
  • 1.1K
  • 25 Nov 2020
Topic Review
H2O Soft Seltzer & Water-Based Beverages Hydration
H2O Sonoma Soft Seltzer is a non-alcoholic water-based beverage, that is infused with the juice of varietal wine grapes, dealcoholized wine, and flavor extracts.  The Beverage Guidance System has established dietary recommendations for daily intake of commonly consumed beverages including water, tea, coffee, milk, non-calorically sweetened beverages, and calorically sweetened beverages. As obesity in America continues to be a growing problem, this guidance becomes of increasing importance due to many beverages’ potential links to Type 2 Diabetes Mellitus (T2DM), Cardiovascular disease (CVD), and numerous other harmful health effects. However, the growing popularity of “better for you” beverages is causing a shift in the market, with consumers requesting healthier beverage options. Beverages simultaneously present advantages while posing concerns that need to be evaluated and considered. Current trends of the beverage market such as the novel Soft Seltzer category as an alternative to Hard Seltzer and various mashups emerge.
  • 1.1K
  • 29 Mar 2022
Topic Review
GNSS Time-Based Clustering Of Mobile Laser Scanning Data From Forest
Mobile laser scanning (MLS) is a progressive technology that has already demonstrated its ability to provide highly accurate measurements of road networks. Mobile innovation of the laser scanning has also found its use in forest mapping over the last decade. In most cases, existing methods for forest data acquisition using MLS result in misaligned scenes of the forest, scanned from different views appearing in one point cloud. These difficulties are caused mainly by forest canopy blocking the global navigation satellite system (GNSS) signal and limited access to the forest. We propose an approach to the processing of MLS data of forest scanned from different views with two mobile laser scanners under heavy canopy. Misaligned scenes of the forest acquired from different views were successfully extracted from the raw MLS point cloud using GNSS time-based point clustering. In order to align extracted MLS data acquired from different views under heavy forest canopy, the iterative closest point (ICP) algorithm was used. An average misalignment of 7.2 mm was achieved for the point clouds aligned using ICP algorithm. DBH was estimated from the aligned MLS data using a simple circle-fitting method with a root-mean-square error of 3.06 cm.
  • 1.1K
  • 30 Oct 2020
Topic Review
Veterinary Medicine
Veterinary medicine is the branch of medicine that deals with the prevention, management, diagnosis, and treatment of disease, disorder, and injury in animals. Along with this, it deals with animal rearing, husbandry, breeding, research on nutrition, and product development. The scope of veterinary medicine is wide, covering all animal species, both domesticated and wild, with a wide range of conditions that can affect different species. Veterinary medicine is widely practiced, both with and without professional supervision. Professional care is most often led by a veterinary physician (also known as a veterinarian, veterinary surgeon, or "vet"), but also by paraveterinary workers, such as veterinary nurses or technicians. This can be augmented by other paraprofessionals with specific specialties, such as animal physiotherapy or dentistry, and species-relevant roles such as farriers. Veterinary science helps human health through the monitoring and control of zoonotic disease (infectious disease transmitted from nonhuman animals to humans), food safety, and through human applications via medical research. They also help to maintain food supply through livestock health monitoring and treatment, and mental health by keeping pets healthy and long-living. Veterinary scientists often collaborate with epidemiologists and other health or natural scientists, depending on type of work. Ethically, veterinarians are usually obliged to look after animal welfare. Veterinarians diagnose, treat, and help keep animals safe and healthy.
  • 1.1K
  • 30 Nov 2022
Topic Review
Electrical Source Imaging
Electrical Source Imaging (ESI) is an imaging technique utilized to localize the activated brain regions by incorporating temporal and spatial components from electroencephalogram (EEG) signals. 
  • 1.1K
  • 13 Jul 2021
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