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Topic Review
Regulators of Fibrinolysis in Oral Cavity
The oral cavity is a unique environment that consists of teeth surrounded by periodontal tissues, oral mucosae with minor salivary glands, and terminal parts of major salivary glands that open into the oral cavity. It is a first-line defense against most viral and bacterial pathogens. Fibrinolytic factors of the plasminogen (Plg)/plasmin (Pm) system, their soluble and membrane receptors, and fragments, such as suPAR (soluble urokinase plasminogen activator receptor) modulate physiological and pathological conditions, especially inflammation.  Fibrinolysis, the removal of fibrin, is the primary function of fibrinolytic factors. Under physiological conditions, fibrinolytic factors are present in the oral cavity and secreted mostly with saliva. Under the inflammation plasminogen/plasmin system performs fibrinolytic and non-fibrinolytic functions: cytokines or proteases (MMPs) are activated, receptors such as suPAR are shed from the surface promoting cell migration, and modulation of the inflammatory response. Viruses, like SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), exploit the fibrinolytic system to promote host cell infection.
  • 661
  • 10 Feb 2023
Topic Review
Osteoimmunology in Periodontitis
Periodontitis is one of the most common oral diseases resulting in gingival inflammation and tooth loss. Growing evidence indicates that it results from dysbiosis of the oral microbiome, which interferes with the host immune system, leading to bone destruction. Immune cells activate periodontal ligament cells to express the receptor activator of nuclear factor kappa-B (NF-κB) ligand (RANKL) and promote osteoclast activity. Osteocytes have active roles in periodontitis progression in the bone matrix. Local proteins are involved in bone regeneration through functional immunological plasticity.
  • 656
  • 02 Jun 2022
Topic Review
Disinfectants to Clean Thermoplastic Polymeric Appliances in Orthodontics
Chemical disinfectants can use corrosion of the thermoplastic appliances and change in color, resulting in shorter service life. It is difficult to determine the optimum disinfection time interval of chemical disinfectants, and most often, the treatments are not aligned with the consumer use patterns, making it difficult in regard to cleaning patterns.
  • 653
  • 24 Jun 2022
Topic Review
Silver-Containing Solutions for Deep Caries Management
Silver is a broad-spectrum antimicrobial agent that can be used for caries management. Dentists used silver-containing solutions for deep cavity disinfection before restoration. Silver fluoride, silver nitrate, silver diamine nitrate, silver diamine fluoride, and nano-silver fluoride were used in deep cavities for antimicrobial purposes. Indirect silver fluoride application induced pulp inflammation and reparative dentine in most cases, and pulp necrosis in some cases. Direct silver nitrate application caused blood clots and a wide inflammatory band in the pulp, whilst indirect silver nitrate application caused hypoplasia in shallow cavities and partial pulp necrosis in deep cavities. Direct silver diamine fluoride application induced pulp necrosis, while indirect silver diamine fluoride application induced a mild inflammatory response and reparative dentine formation.
  • 652
  • 12 May 2023
Topic Review
COVID and Dentistry
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of the current Coronavirus Disease 2019 (COVID-19) pandemic, whose first case was reported in December 2019 in Wuhan, Hubei province, China. In January 2021, the pandemic is still ongoing and is getting worse [1]. Dental surgery is considered to be a profession at high risk for being infected, and therefore transmitting SARS-CoV-2. Our professional practice was disrupted by lockdowns, resulting in reduced activity, new dental protocols and additional costs for staff protective equipment. This has caused unexpected financial difficulties for many dental practitioners. Even with treatments or vaccines, our professional practice will probably never revert back to the previous situation, as the new constraints may become permanent.
  • 649
  • 23 Jun 2021
Topic Review
Cleft Lip Palate Patient
Cleft lip and palate (CLP) are craniofacial dysmorphisms that fall within the anomalies of the developmental jaws as they are congenital malformations characterized by the arrested development of the homonymous regions of the maxillofacial district. Orofacial clefts occur due to failure of migration or fusion in the embryonic period of intrauterine life; craniofacial skeletal structures, hard and soft tissues of the oral cavity are particularly involved. The cause of cleft lip and/or palate (CLP) is thought to be multifactorial, namely through genetic or environmental factors.
  • 636
  • 23 Sep 2021
Topic Review
Plant-Derived Exosome-like Nanoparticle as Biomolecules
Plant-derived exosome-like nanoparticles (PDENs) comprise various bioactive biomolecules. As an alternative cell-free therapeutic approach, they have the potential to deliver nano-bioactive compounds to the human body, and thus lead to various anti-inflammatory, antioxidant, and anti-tumor benefits.
  • 627
  • 04 May 2023
Topic Review
PEEK in Fixed Dental Prostheses
The success of a fixed dental restoration depends on three key factors: biomechanical behavior (wear resistance and fracture resistance), marginal fit, and aesthetics, generating extremely strict demands for the restoration material. Zirconia has become a popular alternative to metal in fixed dental prostheses, known for its excellent aesthetics. More importantly, zirconia exhibits better wear resistance than metal and alloys. PEEK is proposed as a promising alternative material to zirconia because of its superior mechanical properties. PEEK is also significantly less abrasive than zirconia. 
  • 623
  • 24 Jun 2022
Topic Review
Pediatric Dentistry
Pediatric dentistry is the branch of dentistry dealing with children's oral health through the education, promotion, prevention and care of oral pathologies. Oral health is an essential part of the overall health and wellbeing. Good oral health needs not only sound teeth and periodontium, but also the wellbeing of all structures of the mouth, jaw, oral, and peri-oral tissues. Most oral health conditions are largely preventable in children and can be treated in their early stages. Caries represent one of the most common non-communicable diseases and the most prevalent among oral diseases in childhood, despite being easily prevented. Factors contributing to oral diseases are an unhealthy diet (rich in fermentable sugars), inadequate oral hygiene, and low fluoride exposure.
  • 616
  • 03 Sep 2021
Topic Review
Endodontic–Periodontal Lesions
Endodontic–periodontal lesions (EPLs) are chronic inflammatory lesions in the mouth caused by multiple factors. Both periapical and marginal periodontitis are characterized by infection and inflammation around the affected teeth, suggesting that the theory of complex systems might describe the progression of EPL.
  • 615
  • 27 Oct 2022
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