Topic Review
Chromatin Remodeler CHD8
Chromodomain Helicase DNA-binding 8 (CHD8) is a high confidence risk factor for autism spectrum disorders (ASDs) and the genetic cause of a distinct neurodevelopmental syndrome with the core symptoms of autism, macrocephaly, and facial dysmorphism. The role of CHD8 is well-characterized at the structural, biochemical, and transcriptional level. By contrast, much less is understood regarding how mutations in CHD8 underpin altered brain function and mental disease. Studies on various model organisms have been proven critical to tackle this challenge.
  • 515
  • 12 Feb 2021
Topic Review
Cicisbeo
In 18th- and 19th-century Italy, the cicisbeo (Italian pronunciation: [tʃitʃizˈbɛːo]; plural: cicisbei), or cavalier servente (chevalier servant in French), was the professed gallant and perhaps lover in a sexual sense of a married woman, who attended her at public entertainments, to church and other occasions and had privileged access to his mistress. The arrangement is comparable to the Spain cortejo or estrecho and, to a lesser degree, to the France petit-maître. The exact etymology of the word is unknown; some evidence suggests it originally meant "in a whisper" (perhaps an onomatopeic word). Other accounts suggest it is an inversion of bel cece, which means "beautiful chick (pea)". According to OED, the first recorded usage of the term in English was found in a letter by Lady Mary Wortley Montagu dated 1718. The term appears in Italian in Giovanni Maria Muti's "Quaresimale Del Padre Maestro Fra Giovanni Maria Muti De Predicatori" of 1708 (p. 734).
  • 858
  • 22 Nov 2022
Topic Review
Circassian Beauties
Circassian beauty or Adyghe beauty (Adyghe: Адыгэ пшъашъэ, romanized: Adıgə pş̂aş̂ə) is a stereotype and a belief used to refer to an idealized image of the women of the Circassian people of the Northwestern Caucasus. A fairly extensive literary history suggests that Circassian women were thought to be unusually beautiful, spirited, and elegant, and as such were desirable as concubines. This reputation dates back to the Late Middle Ages, when the Circassian coast was frequented by traders from Genoa, and the founder of the Medici dynasty, Cosimo de' Medici, had an illegitimate son from a Circassian slave. During the Ottoman Empire and Persian Safavid and Qajar dynasties, Circassian women living as slaves in the Sultan's Imperial Harem and Shah's harems started to build their reputation as extremely beautiful and genteel, which then became a common trope in Western Orientalism. As a result of this reputation, in Europe and America Circassians were often characterised as ideals of feminine beauty in poetry and art. Cosmetic products were advertised, from the 18th century on, using the word "Circassian" in the title, or claiming that the product was based on substances used by the women of Circassia. In consequence, most wives of several Ottoman Sultans were ethnic Circassians converted to Islam, e.g. Valide Sultans (Empress mothers), including Perestü Valide Sultan, Şevkefza Valide Sultan, Tirimüjgan Valide Sultan, Nükhetseza Başhanımefendi, other important Hatuns (Ladies) and Sultans like Şemsiruhsar Hatun and Saçbağlı Sultan, Haseki sultans (chief consorts) such as Hümaşah Haseki Sultan, Hatice Muazzez Haseki Sultan, and Ayşe Haseki Sultan besides numerous Başkadınefendis (most senior consorts), including Bedrifelek I, Bidar II, Kamures I, and Servetseza I as well as Kadınefendis (senior consorts) such as Bezmara VI, Düzdidil III, Hayranıdil II, Meyliservet IV, Mihrengiz II, Neşerek III, Nurefsun II, Reftaridil II, Şayan III, amongst many others, or İkbals (honoured lady consorts), most notable of them being Cevherriz II, Ceylanyar II, Dilfirib I, Nalanıdil III, and Nergis IV in addition to Gözdes (favourite lady consorts), including Dürdane I, Hüsnicenan III, Safderun IV, amongst others. The "golden age" of the Circassian beauty may be considered to be between the 1770s, when the Russian Empire seized the Crimean Khanate and cut off their slave trade, which increased the demand for Circassian women in Near Eastern harems; and the 1860s, when the Russians massacred thousands of Circassians and conquered Circassia. In the 1860s the showman P. T. Barnum exhibited women who he claimed were Circassian beauties. They wore a distinctive curly, big hair style, which had no precedent in earlier portrayals of Circassians, but which was soon copied by other female performers in the United States, who became known as "moss-haired girls". This hair style was a sort of exhibit's trademark and was achieved by washing the hair of women in beer, drying it and then teasing it. It is not clear why Barnum chose this hairstyle. It may have been a reference to the Circassian fur hat, rather than the hair. There were also several classical Turkish music pieces and poems that praise the beauty of the Circassian ethnic group like "Lepiska Saçlı Çerkes" (Straight, flaxen-haired Circassian; "lepiska" refers to long blonde hair which is straight, as if flatironed). As a foreign group, they were always praised in Turkey for what they labeled as distinct and pure European features.
  • 3.0K
  • 24 Nov 2022
Topic Review
Circular Economy Management of WEEE in Italy
Waste Electrical and Electronic Equipment (WEEE) management is one of the key waste value chains in the EU Circular Action Plan. Electrical and electronic devices are mainly used within urban systems as a consequence of increasing purchasing power, quality of life, and access to grid electricity. The consequent generation of WEEE requires appropriate management, based on urban collection centres and collection and recovery networks, an increase in awareness of the recoverable valuable materials, the need to prevent environmental impacts, and the potential for new jobs in the urban mining sector.
  • 261
  • 27 Jun 2023
Topic Review
Circular Food Supply Chains Barriers
The concept of the circular economy (CE) has gained importance worldwide recently since it offers a wider perspective in terms of promoting sustainable production and consumption with limited resources. However, few studies have investigated the barriers to CE in circular food supply chains. 
  • 798
  • 30 Jun 2021
Topic Review
Circular Operations Management in Higher Education
The circular economy relates to sustainability challenges involving waste and pollution elimination, the circulation of physical products and materials (minimizing economic loss), and the regeneration of nature. Operations management is crucial for leading and conducting the necessary business processes and operations to facilitate these efforts. In light of these sustainability demands, there is a need for Higher Education (HE) students to gain the essential knowledge and skills beyond disciplinary expertise in isolation, to promote sustainable development now and in their future careers. Additionally, considering sustainability issues in HE provides stimulating and pertinent learning challenges that can enhance student learning outcomes, motivation, and engagement.
  • 736
  • 05 Feb 2024
Topic Review
Circum-Saharan Prehistory through the Lens of mtDNA Diversity
African history has been significantly influenced by the Sahara, which has represented a barrier for migrations of all living beings, including humans. Major exceptions were the gene flow events that took place between North African and sub-Saharan populations during the so-called African Humid Periods, especially in the Early Holocene (11.5 to 5.5 thousand years ago), and more recently in connection with trans-Saharan commercial routes. The research indicates that maternal gene flow must have been important in this circum-Saharan space, not only within North Africa and the Sahel/Savannah belt but also between these two regions.
  • 607
  • 25 Mar 2022
Topic Review
Citizen Participation and Climate Change
Citizen-led mitigation and adaptation are key to climate policy advancement and acceleration, particularly within an urban development context. The top-down approach requires the development of clear action plans for the involvement and engagement of citizens to accelerate bottom-up climate mitigation and adaptation efforts within the urban context.
  • 564
  • 31 Mar 2022
Topic Review
Citizen Participation in City Management and Governance
Citizen participation in the management and governance of their cities is not a simple process, even when city authorities value citizen opinions. To optimize this process and face diminishing public trust due to scandals, corruption, worsening of the economic situation and inequalities, city authorities are changing and updating government mechanisms to increase citizen participation.
  • 937
  • 07 Nov 2022
Topic Review
Citizen-Centric Smart Cities
The citizen-centric smart city is conceptualised from the citizenship perspective which stressed on the citizen's responsibilities and participatory governance practices in a smart city (Malek, Lim and Yigitcanlar, 2021). This conception argues that instead of the traditional view on fulfilling the citizen's needs, the citizens should co-produce, participate and contribute to building the smart city together with the government and corporates.
  • 1.8K
  • 14 Sep 2021
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