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Topic Review
Pyrimidine Biosynthetic Enzyme CAD
CAD (Carbamoyl-phosphate synthetase 2, Aspartate transcarbamoylase, and Dihydroorotase) is a multifunctional protein that participates in the initial three speed-limiting steps of pyrimidine nucleotide synthesis. Over the past two decades, extensive investigations have been conducted to unmask CAD as a central player for the synthesis of nucleic acids, active intermediates, and cell membranes. Meanwhile, the important role of CAD in various physiopathological processes has also been emphasized.
  • 1.3K
  • 27 Oct 2021
Topic Review
The Similarity between Personality Traits and Basic Emotions
A great deal of evidence suggests that personality and emotions are linked via coping behaviors and that emotional features can be viewed as an emergent attribute for personality. Personality traits are the building blocks of personality, and psychologists have made many efforts to define and organize personality traits. They are often bundled together based on broad personality factors, such as the dimensions or the Big Five trait taxonomy. These personality traits are closely related to emotional characteristics and reflect emotional types and intensity in certain situations, as well as how individuals learn to cope with these emotions. Personality traits can in turn influence how people feel emotionally when things come up.
  • 977
  • 09 Sep 2022
Topic Review
Domestic Violence and Abuse
Domestic violence is considered to be all acts of physical, sexual, psychological or economic violence that occur within the family or domestic unit or between former or current spouses or partners, whether or not the perpetrator shares or has shared the same residence with the victim.
  • 929
  • 21 Jun 2021
Topic Review
The Role of the Cerebellum in Spatial Navigation
Although the function of the cerebellum has typically been associated with motor functions, several recent studies point to the cerebellum being involved in various cognitive functions, including spatial navigation. More specifically, clinical and neuroimaging evidence  suggests a functional and anatomical distinction between sensorimotor and cognitive cerebellum. The latter includes lobule VI, Crus I and II and lobule VIIB of the posterior lobe, which have been linked to different aspects of executive functions.
  • 898
  • 18 May 2022
Topic Review
Growth Hormone and IGF1 Actions in Kidney
Growth hormone (GH) exerts multiple effects on different organs including the kidneys, either directly or via its main mediator, insulin-like-growth factor-1 (IGF-1).
  • 880
  • 17 Dec 2021
Topic Review
Vascular Smooth Muscle Cells Biomechanics
Cardiovascular diseases are one of the leading causes of global death in developing countries. More than 80% of cardiovascular disease-associated mortality is attributable to atherosclerosis, a chronic inflammatory disease of the vessel wall. During the development of atherosclerosis and other cardiovascular diseases, vascular smooth muscle cells (SMCs) continuously shift from a contractile state towards other phenotypes that differ substantially from differentiated SMCs.
  • 779
  • 22 Sep 2021
Topic Review
Caregiver Burden
Caregiver burden is the stress which is perceived by caregivers due to the home care situation. The subjective burden is considered to be one of the most important predictors of negative outcomes from the home care situation.
  • 594
  • 10 Oct 2022
Topic Review
Social Isolation and Loneliness during the COVID-19
The COVID-19 pandemic has resulted in a predominantly global quarantine response that has been associated with social isolation, loneliness, and anxiety. Notwithstanding the efficacy of quarantine as a tool to limit the spread of disease, it also creates social isolation. Social isolation is an objective state in which an individual is alone, and is a sufficient, but not necessary, condition to produce the subjective feeling of loneliness. More specifically, some individuals may be socially isolated but experience this as a natural and healthy state in normal conditions; however, the prolongation of social isolation, particularly in unnatural conditions (e.g., in response to a global pandemic) can become a hazardous state to individual health. Loneliness is a similar yet distinct case: it is a subjective state in which a person feels that their social connections are inadequate (even though they may have a substantial social network). Both of these concepts relate to social connections and the maintenance of a healthy support network. The health implications of social isolation and loneliness during quarantine have a heterogenous and comorbid nature and, as a result, form a link to anxiety.
  • 589
  • 28 Jan 2022
Topic Review
Target-Based Small Molecule Drug for Colorectal Cancer
Cancer does not develop from a single gene defect in a similar way to how it occurs in other diseases such as cystic fibrosis or muscular dystrophy. Instead, cancer becomes invasive in the event that there are multiple cancer gene mutations where the safeguarding mechanisms could not protect the normal and healthy mammalian cells from their lethal effects. As a result, it is better to think of cancer genes that have been altered as contributing to, rather than causing, cancer. The development of colorectal cancer involves a multiple step process incited by a distinctive genomic instability which encourages the cancerous cells to multiply, as well as increases the chances of cell survival.
  • 558
  • 05 Jul 2022
Topic Review
Circulating Cell-Free DNA Levels in Psychiatric Diseases
The cell-free DNA (cfDNA) levels are known to increase in biological fluids in various pathological conditions. However, the data on circulating cfDNA in severe psychiatric disorders, including schizophrenia, bipolar disorder (BD), and depressive disorders (DDs), is contradictory. The meta-analysis showed that the levels of total cfDNA and genomic cfDNA in patients with schizophrenia are significantly higher than in healthy donors (SMD values of 0.61 and 0.6, respectively; p < 0.00001). Data on mitochondrial cfDNA in schizophrenia were scarce. Meta-analysis in BD and DDs found no significant differences in the level of mitochondrial cfDNA. However, further research on mitochondrial and genomic cfDNA levels in psychiatric disorders is needed due to the data heterogeneity.
  • 556
  • 08 Mar 2023
Topic Review
Circulatory microRNAs in Major Depressive Disorder
Major depressive disorder (MDD) is the most prevalent, chronic, and complicated neuropsychiatric disorder of the current era, causing 800,000 people to commit suicides annually (WHO, 2020). In MDD, several miRNAs have been identified in disease progression by targeting various pathogenic proteins or associated pathways, and they are dysregulated by pathogenic protein expression.
  • 554
  • 24 Feb 2022
Topic Review
Biomarkers of Post-COVID Depression
Post-COVID depression affects people who have had SARS-CoV-2 infection. A very important issue for the mental health of the general population is to look for the causes of this complication and its biomarkers. This will help in faster diagnosis and effective treatment of the affected patients. 
  • 527
  • 28 Jan 2022
Topic Review
Application of Antipsychotic Drugs in Mood Disorders
Since their first application in psychiatry seventy years ago, antipsychotic drugs, besides schizophrenia, have been widely used in the treatment of mood disorders. First-generation antipsychotics (FGAs), such as phenothiazines and haloperidol, were mainly applied for the treatment of acute mania, as well as psychotic depression when combined with antidepressants. The second-generation, so-called atypical antipsychotics (SGAs), such as clozapine, risperidone, olanzapine, and quetiapine, have antimanic activity and are also effective for the maintenance treatment of bipolar disorder. Additionally, quetiapine exerts therapeutic action in bipolar depression. Among third-generation antipsychotics (TGAs) aripiprazole and cariprazine have antimanic activity, lurasidone, cariprazine, lumateperone exert a significant antidepressant effect in bipolar depression; while there is evidence for the efficacy of aripiprazole and lurasidone in the prevention of recurrence in bipolar disorder.
  • 481
  • 08 Mar 2023
Topic Review
Genetic Factors Related to N-Methyl-D-Aspartate Receptors Dysfunction
Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, although the aetiology of ADHD is not yet understood. One proposed theory for developing ADHD is N-methyl-D-aspartate receptors (NMDARs) dysfunction. NMDARs are involved in regulating synaptic plasticity and memory function in the brain. Abnormal expression or polymorphism of some genes associated with ADHD results in NMDAR dysfunction.
  • 457
  • 23 Aug 2023
Topic Review
Biological Alterations Underlying Suicidal Behaviour
Suicidal behaviour is a complex, multi-factorial, polygenic and independent mental health problem caused by a combination of alterations and dysfunctions of several biological pathways and disruption of normal mechanisms in brain regions that remain poorly understood and need further investigation to be deciphered. Suicide complexity and unpredictability gained international interest as a field of research. Several studies have been conducted at the neuropathological, inflammatory, genetic, and molecular levels to uncover the triggers behind suicidal behaviour and develop convenient and effective therapeutic or at least preventive procedures.
  • 450
  • 03 Apr 2023
Topic Review
Overgeneral Autobiographical Memory
Overgeneral autobiographical memory (OGM) is an inability to retrieve specific memories from one's autobiographical memory. Instead, general memories are recalled, such as repeated events or events occurring over broad periods. For example, when asked to recall a happy event, a person who exhibits OGM may say, "when I was on vacation last month" instead of remembering a single incident, such as, "my high school graduation." Research shows a correlation between OGM and certain mental illnesses, such as major depressive disorder (MDD) and posttraumatic stress disorder (PTSD).
  • 449
  • 08 Nov 2022
Topic Review
Status of Oxidative Stress in Alcohol Dependence
Alcohol-induced oxidative stress (OS) plays a pivotal role in the pathophysiology of alcohol dependence (AD). The opposite trends in the level of SOD and GPx activities in serum/plasma and erythrocytes of male patients could be used as the biomarker of alcohol-induced OS injury, and the synergistic changes of MDA, vitamin B12, albumin, bilirubin, and homocysteine levels should also be considered.
  • 449
  • 25 Oct 2022
Topic Review
Structural Diversity of Secondary Metabolites from Marine-Derived Bacillus
The marine is a highly complex ecosystem including various microorganisms. Bacillus species is a predominant microbialflora widely distributed in marine ecosystems. Bacillus species can grow rapidly and tolerate extremely adverse environmental conditions such as extreme ambient temperature, salinity and pH, high pressure and nutrient deficiency. B. subtilis can adopt several responses when faced with the depletion of essential nutrients, including motility, secretion of extracellular enzymes, genetic transformation, antibiotic production, and finally sporulation. The genus Bacillus is a prolific producer of bioactive metabolites, including more than 350 kinds of rod-shaped and Gram-positive bacteria. 
  • 444
  • 08 Oct 2022
Topic Review
Considerations about PD Treatment
The treatment of PD starts when motor signs are developed. Current treatments include pharmacologic therapy, physical therapy, rehabilitating therapy and surgery. Physical therapy and exercise are beneficial in PD patients for both motor and non-motor symptoms. The activities include speech therapy, nutrition, physiotherapy, and support groups.
  • 434
  • 20 Apr 2021
Topic Review
Cultured Cells Exposed to Oxidative Stress
In 1972, Brunk and Ericsson found that significant amounts of lysosomal acid phosphatases leak through the ultrastructurally intact lysosomal membrane in cultured glioma cells. Subsequently, Brunk and his colleagues established the concept of lysosomal membrane permeabilization (LMP) in a series of works using cultured cells which were exposed to artificial oxidative stress. 
  • 416
  • 06 Feb 2023
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