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Topic Review
Cough Medicine
Cough medicines are medications used in those with coughing and related conditions. There is, however, no good evidence that over-the-counter cough medications reduce coughing. While they are used by 10% of American children in any given week, they are not recommended in Canada and the United States in children 6 years or younger because of lack of evidence showing effect and concerns of harm.
  • 1.4K
  • 21 Nov 2022
Topic Review
Transit of Venus, 1639
The first known observations and recording of a transit of Venus were made in 1639 by the English astronomers Jeremiah Horrocks and his friend and correspondent William Crabtree. The pair made their observations independently on 4 December that year (24 November under the Julian calendar then used in England); Horrocks from Carr House, then in the village of Much Hoole, Lancashire, and Crabtree from his home in Broughton, near Manchester. The friends, followers of the new astronomy of Johannes Kepler, were self-taught mathematical astronomers who had worked methodically to correct and improve Kepler's Rudolphine tables by observation and measurement. In 1639, Horrocks was the only astronomer to realise that a transit of Venus was imminent; others became aware of it only after the event when Horrocks's report of it was circulated. Although the friends both died within five years of making their observations, their ground-breaking work was influential in establishing the size of the Solar System; for this and their other achievements Horrocks and Crabtree, along with their correspondent William Gascoigne, are considered to be the founding fathers of British research astronomy.
  • 1.4K
  • 06 Dec 2022
Topic Review
Neuropeptide Y in Energy Balance Regulation
Energy balance is regulated by several hormones and peptides, and neuropeptide Y is one of the most crucial in feeding and energy expenditure control. The neuropeptide Y (NPY), is a potent orexigenic peptide pointed out as an obesogenic factor. NPY is regulated by a series of peripheral nervous and humoral signals that are responsive to nutrient sensing, but its role in the energy balance is also intricately related to the energetic status, namely mitochondrial function.
  • 1.4K
  • 25 Apr 2023
Topic Review
Fully Implanted Hearing Systems
The ear and brain work together in the hearing process. Sound energy in the audible frequency range (20 Hz–20 kHz) propagates through air medium as an acoustical mechanical wave which enters from the outer ear towards the middle ear to vibrate the eardrum. 
  • 1.4K
  • 02 Aug 2021
Topic Review Peer Reviewed
Doctoral Supervision: A Best Practice Review
A “doctoral student” is the term for a student undertaking the highest level of university degree (a doctorate). “Supervisor” is the term for the academic, or academics, who act as their guide. Unlike taught classroom-based degree courses, doctoral degrees in the UK are normally only, or mainly, focused upon a single intensive research study into a specific topic. Such degree courses facilitate the development of students into highly specialist autonomous researchers capable of independent thought. Typically, a blend of support is provided to each doctoral student which consists of an elective development program of research methods learning opportunities alongside dedicated supervisor support from one or more academic members of staff called “supervisors”. It is the expectation that each supervisor will act as a guide and mentor for the doctoral student, thereby enabling them to successfully complete their program of research. This entry relates primarily to the UK model of supervising a doctoral student. Doctoral programs in other countries may differ.
  • 1.4K
  • 05 Jan 2023
Topic Review
Human Polyomaviruses NCCR Genetic diversity
The genomes of polyomaviruses are characterized by their tripartite organization with an early region, a late region and a noncoding control region (NCCR). The early region encodes proteins involved in replication and transcription of the viral genome, while expression of the late region generates the capsid proteins. Transcription regulatory sequences for expression of the early and late genes, as well as the origin of replication are encompassed in the NCCR. Cell tropism of polyomaviruses not only depends on the appropriate receptors on the host cell, but cell-specific expression of the viral genes is also governed by the NCCR.
  • 1.4K
  • 24 Dec 2020
Topic Review
Mitochondrial Metal Ion Transport
The homeostasis of mitochondrial metal ions plays an important role in maintaining mitochondria and cell functions and regulating multiple diseases. In particular, channels and transporters for transporting mitochondrial metal ions are very critical, which can be used as potential targets to treat neurodegeneration, cardiovascular diseases, cancer, diabetes and other metabolic diseases. This review summarizes the current research on several types of mitochondrial metal ion channels/transporters and their functions in cell metabolism and diseases, providing strong evidence and therapeutic strategies for further insights into related diseases.
  • 1.4K
  • 23 Jul 2021
Topic Review
Hypofractionation for Localized Prostate Cancer
Prostate cancer is the most commonly diagnosed cancer among men around the world. Radiotherapy is a standard of care treatment option for men with localized prostate cancer. Over the years, radiation delivery modalities have contributed to increased precision of treatment, employing radiobiological insights to shorten the overall treatment time, improving the control of the disease without increasing toxicities.
  • 1.4K
  • 16 Aug 2021
Topic Review
Zero-Waste City Construction in Xuzhou
The rapidly growing output of solid waste has brought tremendous pressure to urban development. China launched an action plan known as “Zero-waste city” (ZWC), that refers to an urban development model aimed at reducing the generation of and enhancing the recycling of solid waste, in order to alleviate environmental impacts. Xuzhou, as one of the 11 pilot cities selected by the Ministry of Ecology and Environment, is the chosen object of this study. Based on the analysis of material flow and the national policy objectives, five main approaches are put forward in line with the characteristics of Xuzhou, and good results have been achieved in solid waste management through practical experience.
  • 1.4K
  • 15 Dec 2021
Topic Review
Utilization of Additive Manufacturing
Additive manufacturing (AM) is a key technology for advancing many fields, including electrical machines. It offers unparalleled design freedom together with low material waste and fast prototyping, which is why it has become to focus of many researchers. AM, known in the consumer space as 3D printing, is a technology with the ability to manufacture practically any object for which a 3D model can be created, without the complexity and specific geometry of the part significantly impacting the manufacturing costs. 
  • 1.4K
  • 21 Apr 2022
Topic Review
Oxidative Stress in Cancer Cell Metabolism
Reactive oxygen species (ROS) are important in regulating normal cellular processes whereas deregulated ROS leads to the development of a diseased state in humans including cancers. Several studies have been found to be marked with increased ROS production which activates pro-tumorigenic signaling, enhances cell survival and proliferation and drives DNA damage and genetic instability. However, higher ROS levels have been found to promote anti-tumorigenic signaling by initiating oxidative stress-induced tumor cell death. Tumor cells develop a mechanism where they adjust to the high ROS by expressing elevated levels of antioxidant proteins to detoxify them while maintaining pro-tumorigenic signaling and resistance to apoptosis. Therefore, ROS manipulation can be a potential target for cancer therapies as cancer cells present an altered redox balance in comparison to their normal counterparts.
  • 1.4K
  • 11 May 2022
Topic Review
Infinity
In philosophy and theology, infinity is explored in articles under headings such as the Absolute, God, and Zeno's paradoxes. In Greek philosophy, for example in Anaximander, 'the Boundless' is the origin of all that is. He took the beginning or first principle to be an endless, unlimited primordial mass (ἄπειρον, apeiron). The Jain metaphysics and mathematics were the first to define and delineate different "types" of infinities. The work of the mathematician Georg Cantor first placed infinity into a coherent mathematical framework. Keenly aware of his departure from traditional wisdom, Cantor also presented a comprehensive historical and philosophical discussion of infinity. In Christian theology, for example in the work of Duns Scotus, the infinite nature of God invokes a sense of being without constraint, rather than a sense of being unlimited in quantity.
  • 1.4K
  • 16 Nov 2022
Topic Review
NS320xx
The NS32000, sometimes known as the 32k, is a series of microprocessors produced by National Semiconductor. The first member of the family, the 32016, came to market in 1982, making it the first 32-bit general-purpose microprocessor on the market. However, the 32016 contained a large number of bugs and often could not be run at its rated speed. These problems, and the presence of the similar Motorola 68000, led to almost no use in the market. Several improved versions followed, including 1985's 32032 which was essentially a bug-fixed 32016 with an external 32-bit data bus possible due to improvements in chip carriers that were becoming common in the market. However, it offered only about 50% better speed than the 32016, and was outperformed by the 32-bit Motorola 68020, released a year prior. The 32532, released in 1987, outperformed the competing Motorola 68030 by almost two times, but by this time most interest in microprocessors had turned to RISC platforms and this otherwise excellent design saw almost no use as well. National was working on further improvements in the 32732, but eventually gave up attempting to compete in the central processing unit (CPU) space. Instead, the basic 32000 architecture was combined with several support systems and relaunched as the Swordfish microcontroller. This had some success in the market before it was replaced by the CompactRISC architecture in mid-1990s.
  • 1.4K
  • 21 Nov 2022
Biography
Uschi Steigenberger
Ursula "Uschi" Steigenberger (25 April 1951 — 12 December 2018) OBE FInstP was a German condensed matter physicist and director of the ISIS neutron source. She was one of the founders of the Institute of Physics Juno Award. Steigenberger was born in Augsburg. She studied physics at the University of Würzburg, where she remained for her graduate studies. She earned a PhD in condensed matter
  • 1.4K
  • 01 Dec 2022
Topic Review
Application of Polyphenols in Cancer Therapy
The characteristics of polyphenols in modulating redox homeostasis have been widely applied in cancer prevention and treatment, which lays the basis for the discovery and development of natural anticancer drugs. Indeed, many polyphenols have been explored in preclinical or clinical trials, but the drawbacks of polyphenols generally disturb their versatile properties in clinical settings
  • 1.4K
  • 17 Jan 2023
Topic Review
Fluorescent Organic Small Molecule Probes
Fluorescence imaging technology provides a visual tool for medicine, showing great potential in the fields of molecular biology, cellular immunology and oncology. In recent years, organic fluorescent probes have attracted much attention in the bioanalytical field. Among various organic fluorescent probes, fluorescent organic small molecule probes (FOSMPs) have become a research hotspot due to their excellent physicochemical properties, such as good photostability, high spatial and temporal resolution, as well as excellent biocompatibility. FOSMPs have proved to be suitable for in vivo bioimaging and detection. 
  • 1.4K
  • 17 Jan 2023
Topic Review
Cell Culture
The cultivation of cells in a favorable artificial environment has become a versatile tool in cellular and molecular biology. Cultured primary cells and continuous cell lines are indispensable in investigations of basic, biomedical, and translational research.
  • 1.4K
  • 10 Mar 2023
Topic Review
Digital Escape Rooms in STEM Education
The traditional lecture-based model of teaching and learning has led to the exploration of innovative approaches including digital escape rooms. Digital escape rooms offer an immersive and engaging experience that promotes critical thinking, problem-solving, and teamwork, making them a unique opportunity to address the challenges of science, technology, engineering, and math (STEM) education, which is often perceived as difficult, boring, and intimidating.
  • 1.4K
  • 26 May 2023
Topic Review
Effect of Licorice on Oral Health
Licorice (Radix glycyrrhizae) is a plant root extract widely used in various applications, including cosmetics, food supplements, and traditional medicine. It has a long history of medicinal use in different cultures due to its diverse pharmacological properties. Licorice has traditionally been used for treating gastrointestinal problems, respiratory infections, cough, bronchitis, arthritis, and skin conditions. The potential therapeutic benefits of licorice for oral health have gained significant interest.
  • 1.4K
  • 20 Nov 2023
Topic Review
Reversible Solid Oxide Cell
A reversible solid oxide cell (rSOC) is a solid-state electrochemical device that is operated alternatively as a solid oxide fuel cell (SOFC) and a solid oxide electrolysis cell (SOEC). Similarly to SOFCs, rSOCs are made of a dense electrolyte sandwiched between two porous electrodes. Their operating temperature ranges from 600°C to 900°C, hence they benefit from enhanced kinetics of the reactions and increased efficiency with respect to low-temperature electrochemical technologies. When utilized as a fuel cell, the reversible solid oxide cell is capable of oxidizing one or more gaseous fuels to produce electricity and heat. When used as an electrolysis cell, the same device can consume electricity and heat to convert back the products of the oxidation reaction into valuable fuels. These gaseous fuels can be pressurized and stored for a later use. For this reason, rSOCs are recently receiving increased attention due to their potential as an energy storage solution on the seasonal scale.
  • 1.4K
  • 19 Oct 2022
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