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Topic Review
Ovarian Aging
Ovarian aging has a genetic basis that conditions the ovarian activity via a plethora of cell-signaling pathways that control the functions of different types of cells in the ovary. There are various factors that can influence these pathways so as to reduce their efficiency. Oxidative stress, often related to mitochondrial dysfunction, leading to the apoptosis of ovarian cells, can be at the origin of vicious circles in which the primary cause feeds back other abnormalities, resulting in an overall decline in the ovarian activity and in the quantity and quality of oocytes.
  • 866
  • 27 Feb 2021
Topic Review
Nanoparticles in the Food Industry
Nanoparticles (NPs) are clusters of atoms in the nano-scale. The use of inorganic NPs has expanded into various industries including food manufacturing, agriculture, cosmetics, and construction. This has allowed NPs access to the human gastrointestinal tract, yet little is known about their impact on human health. As the gut microbiome continues to be increasingly implicated in various gut diseases of unknown etiology, researchers have begun studying the potentially toxic effects of NPs on the gut microbiome and gut barrier. This research has been invaluable in determining the impact of NPs on the intestinal tract ultimately showing that NPs have the potential to contribute to diseases including inflammatory bowel disease and colorectal cancer. With a focus on inorganic nanoparticles, this review presents a discussion of these studies while highlighting NP characteristics, study design, and techniques. Additionally, NP-induced changes to microbial composition are compared with disease-associated alterations in order to elucidate a potential link.
  • 866
  • 11 Mar 2021
Topic Review
Enoxacin as a Small-Molecule Enhancer of microRNA
Enoxacin is a second-generation quinolone with promising anticancer activity. In contrast to other members of the quinolone group, it exhibits an extraordinary cytotoxic mechanism of action. Enoxacin enhances RNA interference and promotes microRNA processing, as well as the production of free radicals. Interestingly, apart from its proapoptotic, cell cycle arresting and cytostatic effects, enoxacin manifests a limitation of cancer invasiveness. The underlying mechanisms are the competitive inhibition of vacuolar H+-ATPase subunits and c-Jun N-terminal kinase signaling pathway suppression. The mentioned mechanisms seem to contribute to a safer, more selective and more effective anticancer therapy.
  • 866
  • 08 Jul 2022
Topic Review
DDX20
DEAD-box decapping enzyme 20 (DDX20) is a putative RNA-decapping enzyme that can be identified by the conserved motif Asp–Glu–Ala–Asp (DEAD). Cellular processes involve numerous RNA secondary structure alterations, including translation initiation, nuclear and mitochondrial splicing, and assembly of ribosomes and spliceosomes. DDX20 reportedly plays an important role in cellular transcription and post-transcriptional modifications. On the one hand, DDX20 can interact with various transcription factors and repress the transcriptional process. On the other hand, DDX20 forms the survival motor neuron complex and participates in the assembly of snRNP, ultimately affecting the RNA splicing process. Finally, DDX20 can potentially rely on its RNA-unwinding enzyme function to participate in microRNA (miRNA) maturation and act as a component of the RNA-induced silencing complex. 
  • 866
  • 26 Oct 2023
Topic Review
Immunosuppressive Roles of Galectin-1
Genetic alterations are heritable, and as a result the cells harboring these aberrations are subject to Darwinian selection. Immunologically, tumor cells can be regarded as modified self-cells that have eluded typical growth-regulating machinery. The evasion of immune surveillance is an accepted hallmark of tumor progression, and treatment strategies for targeting immune-suppressive pathways have led to enhanced patient survival in multiple cancers.
  • 865
  • 29 Sep 2021
Topic Review
ncRNA Subtypes, Biogenesis, and Turnover
Epigenetics investigates modifications in the expression of genes that do not depend on the underlying DNA sequence. Some studies have confirmed that environmental factors, such as toxicants, may promote a phenotype or a disease in an individual or even in the subsequent progeny through epigenetic alterations. Several epigenetic mechanisms, including modifications in DNA (e.g., methylation), histones, and non-protein coding RNAs (ncRNAs) can change genome expression under the exogenous influenc. The latent interest in epigenetics has resulted in breakthroughs in seminal concepts in diseases ranging from autoimmune conditions to cancer, congenital diseases, mental retardation, endocrine diseases, pediatric diseases, neuropsychiatric disorders, and many others.
  • 865
  • 20 Apr 2022
Topic Review
miR-23b-3p, miR-124-3p, and miR-218-5p Regulate Cervical Cancer Progression
In cervical cancer (CC), miR-23b-3p, miR-124-3p, and miR-218-5p have been found to act as tumor suppressors by regulating cellular processes related to progression and metastasis.
  • 865
  • 28 Nov 2022
Topic Review
Extracellular Vesicles Application as Drug Delivery Carriers
Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by cells of various origins. They contain different biological cargoes, protecting them from degradation by environmental factors. There is an opinion that EVs have a number of advantages over synthetic carriers, creating new opportunities for drug delivery. There are minimal requirements for carriers used for therapeutic nucleic acids (tNAs) delivery in the clinic. Briefly, they should provide for long circulation, low immunogenicity, and high intracellular accumulation of tNAs, simultaneously. In addition, the tNA delivery system must be biodegradable and act in a specific manner. A number of reviews have already discussed the use of EVs as a delivery system in various aspects: the EV surface molecules potentially involved in their interaction with recipient cells, the doses of EVs used for preclinical studies, strategies for engineering EVs with specific targeting ligands, approaches used for increasing the EV stability in the bloodstream. 
  • 865
  • 05 May 2023
Topic Review
Seaweed-Based Molecules
Seaweeds are a novel source of potentially active compounds (proteins–lectins, phycobiliproteins, peptides, amino acids, polyphenols, and polysaccharides) to be exploited in human health benefits, such as antiviral, anticancer, anticoagulant, anti-obesity, and diabetes modulator. Shannon and Abu-Ghannam, suggested seaweed as nutraceuticals or functional foods with dietary benefits beyond their fundamental macronutrients, highlighting their significant effect on obesity and dietary related disease. This study also suggested recent developments of seaweed applications for human health from epidemiological and functional food perspectives.
  • 864
  • 15 Sep 2021
Topic Review
Glycolysis under Circadian Control
Glycolysis is considered a main metabolic pathway in highly proliferative cells, including endothelial, epithelial, immune, and cancer cells. Although oxidative phosphorylation (OXPHOS) is more efficient in ATP production per mole of glucose, proliferative cells rely predominantly on aerobic glycolysis, which generates ATP faster compared to OXPHOS and provides anabolic substrates to support cell proliferation and migration. Cellular metabolism, including glucose metabolism, is under strong circadian control. Circadian clocks control a wide array of metabolic processes, including glycolysis, which exhibits a distinct circadian pattern.
  • 864
  • 12 Jan 2022
Topic Review
Role of miRs in Polyphenol-Mediated Anticancer
The anticancer effects of daily consumption of polyphenols. These dietary polyphenols include chlorogenic acid, curcumin, epigallocatechin-3-O-gallate, genistein, quercetin, and resveratrol. These polyphenols have similar chemical and biological properties in that they can act as antioxidants and exert the anticancer effects via cell signaling pathways involving their reactive oxygen species (ROS)-scavenging activity. These polyphenols may also act as pro-oxidants under certain conditions, especially at high concentrations. Epigenetic modifications, including dysregulation of noncoding RNAs (ncRNAs) such as microRNAs, long noncoding RNAs, and circular RNAs are now known to be involved in the anticancer effects of polyphenols. These polyphenols can modulate the expression/activity of the component molecules in ROS-scavenger-triggered anticancer pathways (RSTAPs) by increasing the expression of tumor-suppressive ncRNAs and decreasing the expression of oncogenic ncRNAs in general. Multiple ncRNAs are similarly modulated by multiple polyphenols. Many of the targets of ncRNAs affected by these polyphenols are components of RSTAPs. Therefore, ncRNA modulation may enhance the anticancer effects of polyphenols via RSTAPs in an additive or synergistic manner, although other mechanisms may be operating as well.
  • 864
  • 19 Dec 2022
Topic Review
Ribonuclease Inhibitor
Protein synthesis is a highly complex process executed by well-organized translation machinery. Ribosomes, tRNAs and mRNAs are the principal components of this machinery whereas RNA binding proteins and ribosome interacting partners act as accessory factors. Angiogenin (ANG) – Ribonuclease inhibitor (RNH1) system is one such accessory part of the translation machinery that came into focus afresh due to its unconventional role in the translation.
  • 863
  • 07 Feb 2021
Topic Review
Post-Acute Sequela of SARS-CoV-2
The COVID-19 pandemic has paralleled the great Spanish flu pandemic of 1918–1919 in the United States. Previous historical accounts have strongly suggested a post-viral syndrome and, currently, a post-COVID-19 viral syndrome is unquestionable, which shares many of the characteristics of myalgic encephalomyelitis/chronic fatigue syndrome that is present globally. The original term for this post-acute sequela of SARS-CoV-2 (PASC) was termed long haulers by those who were affected with this syndrome and it is now termed long COVID (LC) or PASC. International researchers and clinicians are desperately trying to better understand the pathobiological mechanisms possibly involved in this syndrome. This review aims to summarize many of the cumulated findings associated with LC/PASC and provides supportive and representative illustrations and transmission electron micrographic remodeling changes within brain tissues associated with a stress type of injury as occurs in the classic db/db and novel BTBR ob/ob obesity and diabetes mellitus mice models. These models are utilized to merely provide a response to metabolic stress injury wound healing mechanisms that are also present in humans. This review posits that neuroglial activation and chronic neuroinflammation may be a common denominator for the development of the complex LC/PASC syndrome following acute COVID-19 due to SARS-CoV-2.  This review was written with the intent of describing the mounting problem of Long COVID or PASC referred to by patients as Long-Haulers and the authors' personal experience with treating patients with the post-viral syndrome of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) due to HSV-1 encephalitis and a cluster of patients with human cytomegalic virus (hCMV) infections who were suffering from what is now termed Long COVID- Post-Acute Sequela of Coronavirus-2 or PASC.  
  • 863
  • 24 Sep 2021
Topic Review
Myelin Basic Protein Interaction Landscape
Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in autoimmune neurodegeneration and multiple sclerosis particularly. MBP is highly positively charged and lacks a distinct structure in solution, and therefore its intracellular partners are still mostly enigmatic. Here authors used combination of formaldehyde-induced cross-linking followed by immunoprecipitation and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to elucidate the interaction network of MBP in mammalian cells and provide the list of potential MBP interacting proteins.
  • 863
  • 15 Nov 2021
Topic Review
Cyclic Nucleotide (cNMP) Analogues
Cyclic nucleotides are important signaling molecules involved in cellular events in pro- and eukaryotes, and analogues of this type of molecules are promising drug candidates.
  • 863
  • 07 Dec 2021
Topic Review
SH003 as a Therapeutic Anticancer Agent
SH003, a novel herbal medicine containing Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii, showed the potential to act as an anticancer agent in previous research studies.
  • 863
  • 29 Mar 2022
Topic Review
CCCTC-Binding Factor for Chromatin Regulation
Chromatin, a macromolecular complex of DNA, RNA, and proteins, provides a framework for the packaging of genetic material within the cell nucleus. Its organization plays a crucial role in gene expression and is regulated by a diverse array of protein complexes in response to a dynamic code of histone posttranslational modifications and DNA modifications. Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D structure of chromatin. Because of its multivalent properties and plasticity to bind various sequences, CTCF is similar to a Swiss knife for genome organization.
  • 863
  • 25 May 2023
Topic Review
Therapy for Sickle Cell Disease
Sickle cell disease (SCD) is a severe hereditary form of anemia that results from a single mutation in the sixth codon of the gene encoding the β-globin chain (from glutamic acid to valine) of the adult Hb tetramer (α2β2), which is prone to polymerization at low oxygen levels.
  • 862
  • 22 Jun 2021
Topic Review
Hybrid Polylactide Blends
Conformation of polylactide macromolecules can be adjusted by interactions with some specific additives (arylamides, hydrazides, 1,3:2,4-dibenzylidene-d-sorbitol, orotic acid, humic acids, fulvic acids, nanocellulose, and cyclodextrins) due to the formation of hydrogen bonds or host-guest complexes. This “soft templating” may enhance nucleation of polymer crystals and influence the properties of polylactide blends.
  • 861
  • 11 Aug 2020
Topic Review
Molybdoenzymes-Dependent Nitric Oxide Formation
Nitric oxide radical (NO) is a signalling molecule involved in several physiological and pathological processes and a new nitrate-nitrite-NO pathway has emerged as a physiological salvage pathway that operates under challenging conditions, when the "classic" L-arginine-dependent NO synthases are hindered. To catalyse the reduction of nitrite to NO, mammalian cells can use different metalloproteins that are present in cells to perform other functions (moonlighting). Among the so far identified ''non-dedicated nitrite reductases'', the molybdenum-containing enzymes stand out as very efficient NO synthases due to their well know ability to catalyse oxygen atom transfer reactions.
  • 861
  • 10 Aug 2023
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