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Topic Review
Three-Dimensional Printing Technologies for Oral Films
The interest in buccal drug delivery is under consideration due to some distinct properties compared to the traditional pharmaceutical formulations for oral administration: significantly higher bioavailability, a faster absorption rate of the drug, and substantial compliance for special needs patients. Oral films are obtained through various technologies, from conventional tools to 3D and 4D printing approaches. Three-dimensional printing can solve the formulation problems of producing oral films (OFs).
  • 1.4K
  • 06 Sep 2023
Topic Review
Fungi Remediate Soils Contaminated by War-like Activities
Fungi comprise the largest kingdom of higher organisms on the planet: eukaryotes with complex cell structures and abilities to make tissues and organs. Hyphae filaments have a rigid, complex cell wall and moving protoplasm (cytosol) divided into compartments by cross walls termed septa, allowing cellular components to move through these. The plasma membrane comprises a phospholipid bilayer associated with transmembrane proteins and ergosterol and some enzymes such as integral membrane proteins chitin synthase and glucan synthase. The release of enzymes into the extracellular environment, which many fungal species carry out, and the high contact area between filamentous fungi and the soil make these organisms promising for the degradation or immobilization of pollutants (explosives, metals, metalloids, radionuclides, and herbicides) in soil impacted by War-like activities.
  • 1.4K
  • 17 Feb 2024
Topic Review
The Impact of Sustainability Reporting on Financial Performance
Solving sustainability challenges has become an integral feature of leading companies playing a decisive and pivotal role in reaching the Sustainable Development Goals. The 17 Sustainable Development Goals (SDGs) defined by this Agenda form a conceptually new field of conditions and tasks for enterprises, for the implementation or achievement of which it is necessary to adapt or transform production and management business processes to ensure the implementation of green and socially responsible business models.
  • 1.4K
  • 30 Oct 2023
Topic Review
PI3K/AKT/mTOR and MAPK Pathways in Gastric Cancer
Gastric cancer (GC) is the fourth leading cause of death worldwide, with more than 1 million cases diagnosed every year. Helicobacter pylori represents the main risk factor, being responsible for 78% of the cases. Increased amounts of salt, pickled food, red meat, alcohol, smoked food, and refined sugars negatively affect the stomach wall, contributing to GC development.
  • 1.4K
  • 08 Feb 2024
Topic Review
Aerial Bombardment and International Law
Air warfare must comply with laws and customs of war, including international humanitarian law by protecting the victims of the conflict and refraining from attacks on protected persons. These restraints on aerial warfare are covered by the general laws of war, because unlike war on land and at sea—which are specifically covered by rules such as the 1907 Hague Convention and Protocol I additional to the Geneva Conventions, which contain pertinent restrictions, prohibitions and guidelines—there are no treaties specific to aerial warfare. To be legal, aerial operations must comply with the principles of humanitarian law: military necessity, distinction, and proportionality: An attack or action must be intended to help in the military defeat of the enemy; it must be an attack on a military objective, and the harm caused to civilians or civilian property must be proportional and not excessive in relation to the concrete and direct military advantage anticipated.
  • 1.4K
  • 28 Oct 2022
Topic Review
Nondestructive Monitoring in RC Elements
The structural and damage assessment of a reinforced concrete (RC) beam subjected to a four-point bending laboratory test is presented. Different nondestructive testing (NDT) techniques have been used with distributed fiber optic sensors (FOS) and acoustic emission (AE) sensors. The recorded AE activity results in good agreement with FOS strain measurements. At different loading steps, digital image correlation (DIC) analysis was also conducted.
  • 1.4K
  • 30 Oct 2020
Topic Review
Teleorthodontics
Teleorthodontics generally refers to any orthodontic care delivered through information technology. A common and relevant example could be that of colleagues being able to discuss the digital records of clinical cases over the Internet and to exchange advice and share experience. However, the primary aim set of dental teleassistance in orthodontics is to reduce patients’ office visits whilst maintaining regular monitoring, without compromising the results. Teleorthodontics can manage most orthodontic emergencies, reassuring and following patients remotely. It can also become a cutting-edge screening system able to reduce patients’ waiting time for specialist advice.Although teleorthodontics is just at its beginnings, it appears to be worthy of further investigations to objectively evaluate the efficacy, cost-effectiveness, and long-term results. It is capable of improving service and working conditions and may even reduce costs. Teleorthodontics will have a role to play in the near future.
  • 1.4K
  • 31 Jul 2020
Topic Review
Anticancer Potential of Furanocoumarins
       Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication.        This review highlights the potential for furanocoumarins to be clinically beneficial in cancer, particularly given their specificity to tumor cells (while sparing normal cells). In vitro investigations have shown that furanocoumarins affect a range of cellular mechanisms, such as apoptosis, autophagy, and cell cycle arrest. ER stress induction mainly caused by NF-κB inactivation, PI3K/Akt inhibition, and p53 modulation. Furanocoumarins are also effective in different MDR cancers that are the main cause of anticancer therapeutics failure.       Compounds in this class have also have been shown to positively synergize with commonly used anticancer drugs. The fast absorption of furanocoumarins from food into the human bloodstream is also noteworthy.  Furanocoumarins, by inhibiting CYP P450 3A4, not only have anticancer properties but also when co-administered with a low bioavailability anticancer compound can increase oral bioavailability. To date, most focus has been on in vitro studies, making it hard to reach solid conclusions on the efficacy of furanocoumarins in vivo.       Nonetheless, studies aimed at characterizing furanocoumarin’s efficacy in vivo as well as clinical studies are encouraging, supporting the need for future studies to better characterize furanocoumarin’s potential as efficacious anticancer treatment modalities.
  • 1.4K
  • 27 Aug 2020
Topic Review
Ionic Liquids and Lignin
This entry gives overview of the lignin separation methods from lignocellulosic biomass using various methods but the main attention has been paid on lignin separation using ionic liquids. Lignin is a natural polymer, one that has an abundant and renewable resource in biomass. Due to a tendency towards the use of biochemicals, the efficient utilization of lignin has gained wide attention. The delignification of lignocellulosic biomass makes its fractions (cellulose, hemicellulose, and lignin) susceptible to easier transformation to many different commodities like energy, chemicals, and materials that could be produced using the biorefinery concept. 
  • 1.4K
  • 10 Oct 2020
Topic Review
Cardiac Tissue Engineering Systems
Cardiac tissue engineering is very much in a current focus of regenerative medicine research as it represents a promising strategy for cardiac disease modelling, cardiotoxicity testing and cardiovascular repair. Advances in this field over the last two decades have enabled the generation of human engineered cardiac tissue constructs with progressively increased functional capabilities. Numerous studies have demonstrated that the therapeutic benefits exerted by cells are mainly attributable to the release of complementary paracrine factors and the efficacy is limited as only a small percentage of transplanted cells engrafted in the infarcted tissue. Studies on animal models showed that combining cell therapy with tissue engineering techniques for the creation of cell sheets and patches, can increase stem cell survival and boost therapeutic action. Therefore, tissue engineering has been considered as a potential approach for cardiac regeneration after MI. 
  • 1.4K
  • 30 Mar 2021
Topic Review
Photovoltaic Arrays, Solar Power Generation
The recent environmental awareness triggered governments and private companies around the world to encourage further research and capital investment into the development and deployment of efficient and cost-effective solar technologies. This entry reports on advances in the technological approaches that can be employed to convert sunlight to electricity. This entry presents a short survey of the state-of-the-art architectures of photovoltaic arrays and a review of the concepts and strategies of their associated electronic power processors for solar energy generation.
  • 1.4K
  • 23 Aug 2021
Topic Review
Konstanz Method of Dilemma Discussion
The Konstanz Method of Dilemma Discussion (KMDD®) as an educational and psycho-didactic tool that is aimed at fostering moral competence development in a course of moral and spiritual education and supporting overall personal and psychological development. The authors consider moral education to be of pedagogical importance, the task of which is to support and stimulate the individual development of the moral autonomy of an individual. Spiritual education is understood similarly, but it relates to the sphere of spiritual autonomy. Within the concept of spiritual education, a more specific area of religious education can be distinguished from the perspective of a specific religion. Given that a contemporary spiritual and moral crisis translates into an increase in ideological, moral, and religious conflicts (Agrimson and Taft 2009), the spiritual and moral education of the next generation, the development of respect for other cultures, religious tolerance, and the development of readiness for cooperation are the most urgent challenges facing today’s education. Moral and religious education in eastern Europe is underestimated in schools and is treated as indoctrination entities in which moral educators tell people what to do and religious educators what to believe. The aim of both should be to help sensitize students to ethical issues and help them to form their own judgments and beliefs within the context of a broader social perspective. Therefore, fostering personal development is one of the most important, as well as one of the most demanding, tasks of education at all levels.
  • 1.4K
  • 09 Sep 2021
Topic Review
Isothiocyanate Synthesis Using Elemental Sulfur
Isothiocyanates (ITCs) are biologically active molecules found in several natural products and pharmaceutical ingredients. Moreover, due to their high and versatile reactivity, they are widely used as intermediates in organic synthesis.This review considers the best practices for the synthesis of ITCs using elemental sulfur, highlighting recent developments. Additionally, we also reveal that in the catalyst‑free reaction of isocyanides and sulfur, two—until this time overlooked and not investigated—different mechanistic pathways exist.
  • 1.4K
  • 28 Sep 2021
Topic Review
Serotonin-Norepinephrine Reuptake Inhibitors
Serotonin-norepinephrine reuptake inhibitors (SNRIs) are among the most commonly prescribed medications in the United States annually. As their name suggests, the principle mechanism of action is the inhibition of presynaptic neuronal uptake of 5-HT (serotonin) and norepinephrine following release from the synaptic cleft.
  • 1.4K
  • 28 Oct 2021
Topic Review
Bromelain Exerts Antiarthritic Effects
Bromelain, a mixture of proteases in pineapple rhizome, has beneficial biological properties. Following absorption, the compound remains biologically active in mammalian blood and tissues. Bromelain has multiple clinical and therapeutic applications because of its anti-arthritic activities.
  • 1.4K
  • 29 Mar 2022
Topic Review
Monitoring of Six-Minute Walk Test
In the pandemic time, the monitoring of the progression of some diseases is affected and rehabilitation is more complicated. Remote monitoring may help solve this problem using mobile devices that embed low-cost sensors, which can help measure different physical parameters. Many tests can be applied remotely, one of which is the six-minute walk test (6MWT). The 6MWT is a sub-maximal exercise test that assesses aerobic capacity and endurance, allowing early detection of emerging medical conditions with changes. 
  • 1.4K
  • 02 Feb 2022
Topic Review
Ecological Footprint for the Algerian Fisheries Management
According to the estimated ecological footprint (EF) of fishery production (EFf), Algiers fishing is in the status of ecological surplus, as the demand for fisheries production averages 15,338.49 gha compared to more than 108 thousand gha of biologically productive fishing area. In addition to this overall output, this metric indicates each species’ primary production requirement (PPR), which could help to restructure the fishing effort based on the stock’s condition. For the energy component, the fuel consumption and greenhouse gas (GHG) emissions expressed in metric tons of CO2 were used to estimate the required area for carbon sequestration, valued roughly at 500 gha. The latter is a reference state and remains approximate because it was derived from unofficial data provided by the fishers.
  • 1.4K
  • 31 Jan 2022
Topic Review
The STEC–MFG Association
Shiga toxin-producing Escherichia coli (STEC) are zoonotic Gram-negative bacteria. While raw milk cheese consumption is healthful, contamination with pathogens such as STEC can occur due to poor hygiene practices at the farm level. STEC infections cause mild to serious symptoms in humans. The raw milk cheese-making process concentrates certain milk macromolecules such as proteins and milk fat globules (MFGs), allowing the intrinsic beneficial and pathogenic microflora to continue to thrive. MFGs are surrounded by a biological membrane, the milk fat globule membrane (MFGM), which has a globally positive health effect, including inhibition of pathogen adhesion.
  • 1.4K
  • 22 Apr 2022
Topic Review
Quinazoline Based HDAC Dual Inhibitors
Quinazolines are the most versatile, ubiquitous and privileged nitrogen bearing heterocyclic compounds with a wide array of biological and pharmacological applications. Most of the anti-cancer agents featuring quinazoline pharmacophore have shown promising therapeutic activity. Histone deacetylases (HDACs) have emerged as an important anti-cancer target in the recent years given its role in cellular growth, gene regulation, and metabolism.
  • 1.4K
  • 20 Jun 2022
Topic Review
Personal RF Safety Monitors
Electromagnetic field densitometers measure the exposure to electromagnetic radiation in certain ranges of the electromagnetic spectrum. This article concentrates on densitometers used in the telecommunication industry, which measure exposure to radio spectrum radiation. Other densitometers, like extremely low frequency densitometers which measure exposure to radiation from electric power lines, also exist. The major difference between a "Densitometer" and a "Dosimeter" is that a Dosimeter can measure the absorbed dose, which does not exist for RF Monitors. Monitors are also separated by "RF Monitors" that simply measure fields and "RF Personal Monitors" that are designed to function while mounted on the human body.
  • 1.4K
  • 14 Oct 2022
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