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Topic Review
Surface-Enhanced Raman Spectroscopy Substrates for Food Safety Detection
Food safety analysis currently relies on the enzyme-linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), high-performance liquid chromatography (HPLC), gas chromatography (GC), UV-visible spectrophotometry, and tandem mass spectrometry (MS), all of which require significant time to train qualified food safety testing laboratory operators. These factors have hindered the development of rapid food safety monitoring systems, especially in remote areas or areas with a relative lack of testing resources. Surface-enhanced Raman spectroscopy (SERS) has emerged as one of the tools of choice for food safety testing that can overcome these dilemmas. SERS offers advantages over chromatographic mass spectrometry analysis due to its portability, non-destructive nature, and lower cost implications. However, as it currently stands, Raman spectroscopy is a supplemental tool in chemical analysis, reinforcing and enhancing the completeness and coverage of the food safety analysis system. SERS combines portability with non-destructive and cheaper detection costs to gain an advantage over chromatographic mass spectrometry analysis. 
  • 1.5K
  • 10 Jul 2023
Topic Review
Digitalization and Supply Chain Performance
Supply chain digitization (SCD) is a driving force, integrating digital technologies like big data, cloud computing, blockchain, Internet of Things (IoT), and artificial intelligence into supply chain activities. SCD focuses on “data-driven decision-making”, creating operational processes enriched by digital technologies.
  • 1.5K
  • 17 Jan 2024
Topic Review
WNT Signaling Pathways in Skin Development
The WNT signaling pathway plays a critical role in a variety of biological processes, including development, adult tissue homeostasis maintenance, and stem cell regulation. Variations in skin conditions can influence the expression of the WNT signaling pathway.
  • 1.5K
  • 06 Dec 2023
Topic Review
Zinc Signaling in Prostate Cancer
Prostate cancer (PCa) is one of the most common cancers and the second leading cause of cancer-related death among men worldwide. Despite progresses in early diagnosis and therapeutic strategies, prognosis for patients with advanced PCa remains poor. Therefore, it is necessary to develop novel strategies to prevent, diagnose and effectively treat PCa patients in clinic. Noteworthily, a unique feature of healthy prostate is its highest level of zinc content among all soft tissues in the human body, which dramatically decreases during prostate tumorigenesis. Here, we discuss clinical applications of zinc-containing compounds and proteins involved in PCa signaling pathways. Based on currently available studies, we conclude that zinc can serve as a biomarker in PCa diagnosis and therapies.
  • 1.5K
  • 05 Nov 2021
Topic Review
Short-Term Firm-Level Energy Consumption Forecasting
To minimise environmental impact, avoid regulatory penalties, and improve competitiveness, energy-intensive manufacturing firms require accurate forecasts of their energy consumption so that precautionary and mitigation measures can be taken. Deep learning is widely touted as a superior analytical technique to traditional artificial neural networks, machine learning, and other classical time series models due to its high dimensionality and problem solving capabilities. Despite this, research on its application in demand-side energy forecasting is limited. We compare two benchmarks (Autoregressive Integrated Moving Average (ARIMA), and an existing manual technique used at the case site) against three deep learning models (simple Recurrent Neural Networks (RNN), Long Short-Term Memory (LSTM), and Gated Recurrent Unit (GRU)) and two machine learning models (Support Vector Regression (SVR), and Random Forest) for short term load forecasting (STLF) using data from a Brazilian thermoplastic resin manufacturing plant. We use the grid search method to identify the best configurations for each model, and then use Diebold-Mariano testing to confirm the results. Results suggests that the legacy approach used at the case site is the worst performing, and that the GRU model outperformed all other models tested.
  • 1.5K
  • 23 Dec 2020
Topic Review
Brassica Bioactives May Ameliorate Endometriosis
Endometriosis is a chronic, inflammatory, hormone-dependent disease characterized by histological lesions produced by the presence of endometrial tissue outside the uterine cavity. Despite the fact that an estimated 176 million women are affected worldwide by this gynecological disorder, risk factors that cause endometriosis have not been properly defined and current treatments are not efficient. Although the interaction between diet and human health has been the focus of many studies, little information about the correlation of foods and their bioactive derivates with endometriosis is available. In this framework, Brassica crops have emerged as potential candidates for ameliorating the chronic inflammatory condition of endometriosis, due to their abundant content of health-promoting compounds such as glucosinolates and their hydrolysis products, isothiocyanates.
  • 1.5K
  • 22 Dec 2020
Topic Review
HBSL
Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL) is a condition that affects the brain and spinal cord (central nervous system). In particular, the condition affects nerves in specific regions (called tracts) within the spinal cord and the brainstem, which is the part of the brain that connects to the spinal cord. HBSL is a form of leukodystrophy, which is a group of conditions that involve abnormalities of the nervous system's white matter. The white matter consists of nerve fibers covered by a fatty substance, called myelin, that insulates the fibers and promotes the rapid transmission of nerve impulses. In HBSL, the nervous system has a reduced ability to form myelin (hypomyelination).
  • 1.5K
  • 04 Jan 2021
Topic Review
Geographic Information System
Geographic information systems (GIS) are composed of software, hardware, data, administrators, and methods for processing and analyzing data.  Creating and sharing spatial data in digital form is not only good practice but is also regulated by specific legal acts. Currently created in map portals and the widely available General Geographic Object Databases offer a reliable, current, and continuous source of spatial information for the entire country, extremely helpful in the planning process at various levels of generalization. The database implemented into the Spatial Information System is its most important element and should constitute a complete and reliable representation of elements of the real world.  GIS systems allow us to formulate models in a structured and formal way to reflect both the current situation and forecast changes that will occur in space when certain conditions are met. The proposed methodology can be used in practical applications:• Preparing planning studies, both regarding spatial policy and local law, as well as in economic planning and shaping the structure of rural space (structure of ownership and structure of use).• The development of thematic spatial information systems related to planning studies and works shaping the rural space.• Reports submitted to EU authorities relating to the utilization of funds dedicated to rural development in the multiannual financial framework and modification of the implemented actions.• The use of renewable energy sources to improve Poland’s energy security.
  • 1.5K
  • 19 Jan 2021
Topic Review
Liver Diseases and Nutritional Status
Liver fibrosis is the consequence of different inflammatory processes occurring in any chronic liver disease. Its progression determines the development of cirrhosis and portal hypertension. The natural history of cirrhosis is characterized by a compensated phase, with or without portal hypertension, and a decompensated phase characterized by the appearance of major complications, such as ascites, portal hypertensive bleeding, encephalopathy, and jaundice. Malnutrition is frequent in patients with liver cirrhosis, which progresses in parallel with the worsening of the disease. Its etiology is multifactorial, given the great impact of liver disease on multiple processes related to nutrition.
  • 1.5K
  • 27 May 2021
Topic Review
Gastric Intestinal Metaplasia
Gastric cancer (GC) remains one of the most common causes of mortality worldwide. Intestinal metaplasia (IM) is one of the preneoplastic gastric lesions and is considered an essential predisposing factor in GC development. Here we present a review of recent most relevant papers to summarize major findings on the molecular alterations in gastric IM. The latest progress in novel diagnostic methods allows scientists to identify various types of molecular alterations in IM, such as polymorphisms in various genes, changes in the expression of micro-RNAs and long noncoding RNAs, and altered microbiome profiles. The results have shown that some of these alterations have strong associations with IM and a potential to be used for screening, treatment, and prognostic purposes; however, one of the most important limiting factors is the inhomogeneity of the studies. Therefore, further large-scale studies and clinical trials with standardized methods designed by multicenter consortiums are needed. As of today, various molecular alterations in IM could become a part of personalized medicine in the near future, which would help us deliver a personalized approach for each patient and identify those at risk of progression to GC.
  • 1.5K
  • 24 Jun 2021
Topic Review
Alpha-Linolenic and Linoleic Fatty Acids
Good sources of the long-chain n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) include cold-water fish and seafood; however, vegan diets (VGNs) do not include animal-origin foods. 
  • 1.5K
  • 02 Sep 2021
Topic Review
Smoothened-Dependent/-Independent Hedgehog Signaling Pathway
The Hedgehog (Hh)-glioma-associated oncogene homolog (GLI) signaling pathway is highly conserved among mammals, with crucial roles in regulating embryonic development as well as in cancer initiation and progression. The GLI transcription factors (GLI1, GLI2, and GLI3) are effectors of the Hh pathway and are regulated via Smoothened (SMO)-dependent and SMO-independent mechanisms. The SMO-dependent route involves the common Hh-PTCH-SMO axis, and mutations or transcriptional and epigenetic dysregulation at these levels lead to the constitutive activation of GLI transcription factors. Conversely, the SMO-independent route involves the SMO bypass regulation of GLI transcription factors by external signaling pathways and their interacting proteins or by epigenetic and transcriptional regulation of GLI transcription factors expression. Both routes of GLI activation, when dysregulated, have been heavily implicated in tumorigenesis of many known cancers, making them important targets for cancer treatment. 
  • 1.5K
  • 15 Sep 2021
Topic Review
Immunological Mechanisms of Vaccine-Induced Protection against SARS-CoV-2 Infections
SARS-CoV-2 is attached to host cells via binding to the viral spike (S) proteins and its cellular receptors angiotensin-converting enzyme 2 (ACE2). Consequently, the S protein is primed with serine proteases TMPRSS2 and TMPRSS4, which facilitate the fusion of viral and cellular membranes result in the entry of viral RNA into the host cell. The long-term protective immunity is provided by the vaccine antigen (or pathogen)-specific immune effectors and the activation of immune memory cells that can be efficiently and rapidly reactivated upon pathogen exposure.
  • 1.5K
  • 29 Nov 2021
Topic Review
Self-Healing Elastomers
It is impossible to describe the recent progress of our society without considering the role of polymers; however, for a broad audience, “polymer” is usually related to environmental pollution. The poor disposal and management of polymeric waste has led to an important environmental crisis, and, within polymers, plastics have attracted bad press despite being easily reprocessable. Nonetheless, there is a group of polymeric materials that is particularly more complex to reprocess, rubbers. These macromolecules are formed by irreversible crosslinked networks that give them their characteristic elastic behavior, but at the same time avoid their reprocessing. Conferring them a self-healing capacity stands out as a decisive approach for overcoming this limitation. By this mean, rubbers would be able to repair or restore their damage automatically, autonomously, or by applying an external stimulus, increasing their lifetime, and making them compatible with the circular economy model.
  • 1.5K
  • 26 May 2022
Topic Review
Artificial Neural Networks in Water Supply Systems Development
A water supply system is considered an essential service to the population as it is about providing an essential good for life. This system typically consists of several sensors, transducers, pumps, etc., and some of these elements have high costs and/or complex installation. The indirect measurement of a quantity can be used to obtain a desired variable, dispensing with the use of a specific sensor in the plant. Among the contributions of this technique is the design of the pressure controller using the adaptive control, as well as the use of an artificial neural network for the construction of nonlinear models using inherent system parameters such as pressure, engine rotation frequency and control valve angle, with the purpose of estimating the flow. 
  • 1.5K
  • 27 May 2022
Topic Review
Green Port Implementation in Indonesia and Circular Economy
Several public seaports and fishing terminals are located in the same port complex but have different fragmented operations such as waste management. It is possible to provide a new initiative to ensure sustainability for all entities in the surrounding port ecosystem through the application of Green Port using the circular economy approach and mixed linear programming model. It was discovered that the integration model has the potential to generate new energy by recycling waste from all related entities in the production of a few main fishing products such as tuna, sardine, and squid, as well as vessel traffic, facilities, and cargo flow interactions in addition to other port operations.
  • 1.5K
  • 06 Jun 2022
Topic Review
Spatially Bounded Airspace Axiom
Axiom is a fundamental truth in mathematics and philosophy. A claim that we do not have to prove, but we accept it as a true statement. The term axiom, in addition to theorems and postulates, can already be found in Euclid’s Elements (BC. 300). We can find the basic truths in all walks of life, including air transport. Air transport takes place in the airspace. Our entry describes an axiom of an airspace based on the latest airspace concept.
  • 1.5K
  • 17 Jun 2022
Topic Review
Heat Therapy
Heat therapy, also called thermotherapy, is the use of heat in therapy, such as for pain relief and health. It can take the form of a hot cloth, hot water bottle, ultrasound, heating pad, hydrocollator packs, whirlpool baths, cordless FIR heat therapy wraps, and others. It can be beneficial to those with arthritis and stiff muscles and injuries to the deep tissue of the skin. Heat may be an effective self-care treatment for conditions like rheumatoid arthritis. Heat therapy is most commonly used for rehabilitation purposes. The therapeutic effects of heat include increasing the extensibility of collagen tissues; decreasing joint stiffness; reducing pain; relieving muscle spasms; reducing inflammation, edema, and aids in the post acute phase of healing; and increasing blood flow. The increased blood flow to the affected area provides proteins, nutrients, and oxygen for better healing.
  • 1.5K
  • 31 Oct 2022
Biography
John Texter
John Texter (born August 9, 1949, in Lancaster, Pennsylvania) is an American engineer, chemist, and educator, and is professor of polymer and coating technology at Eastern Michigan University (EMU) in Ypsilanti, Michigan.[1] He is best known for his work in applied dispersion technology and small particle science, for his international conference organization activities, including Particles 2001
  • 1.5K
  • 29 Dec 2022
Topic Review
Therapeutic Wound Healing Bioactivities of Medicinal Plants
Wound healing is a dynamic process underpinned by numerous cellular activities, including homeostasis, inflammation, proliferation, and remodeling, that require proper harmonious integration to effectively repair the damaged tissue. Natural phytomedicines that possess considerable pharmacological properties have been widely and effectively employed forwound treatment and infection prevention. Since ancient times, phytotherapy has been able to efficiently treat cutaneous wounds, reduce the onset of infections, and minimize the usage of antibiotics that cause critical antibiotic resistance. There are a remarkable number of wound-healing botanicals that have been widely used in the Northern Hemisphere, including Achiella millefolium, Aloe vera, Althaea officinalis, Calendula officinalis, Matricaria chamomilla, Curcuma longa, Eucalyptus, Jojoba, plantain, pine, green tea, pomegranate, and Inula.
  • 1.5K
  • 15 Feb 2023
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