Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Treatment of irAE Colitis
Immune checkpoint inhibitor treatment has shown revolutionary therapeutic effects in various carcinomas. However, immune-related adverse events (irAE) following the treatment can sometimes lead to treatment discontinuation. One such frequently encountered adverse event is immune-related colitis (irAE colitis). Corticosteroids (CS) are the first-line treatment for irAE colitis, but we often encounter CS-refractory or resistant cases. Application of multiple biologics has been proposed as a therapeutic drug to be administered after CS treatment; however, the efficacy and safety of biologics for patients with irAE colitis who do not respond to CS have not been established. The treatment regimens available for irAE colitis is summarized, focusing on the mechanism of action of corticosteroids, infliximab, vedolizumab, and other drugs.
  • 1.4K
  • 22 Jun 2022
Topic Review
Endodontic Microsurgery of Mandibular Molars
Endodontic microsurgery is a highly predictable treatment option in most cases when conventional endodontic treatment is not feasible. 
  • 1.4K
  • 22 Apr 2021
Topic Review
Microbiological Food Safety of Seaweeds
The use of seaweeds in the human diet has a long history in Asia and has now been increasing also in the western world. Concurrent with this trend, there is a corresponding increase in cultivation and harvesting for commercial production. Edible seaweed is a heterogenous product category including species within the green, red, and brown macroalgae. Moreover, the species are utilized on their own or in combinatorial food products, eaten fresh or processed by a variety of technologies. 
  • 1.4K
  • 11 Nov 2021
Topic Review
Endocytosis and Signaling Regulation
Cellular trafficking through the endosomal–lysosomal system is essential for the transport of cargo proteins, receptors and lipids from the plasma membrane inside the cells and across membranous organelles. By acting as sorting stations, vesicle compartments direct the fate of their content for degradation, recycling to the membrane or transport to the trans-Golgi network. To effectively communicate with their neighbors, cells need to regulate their compartmentation and guide their signaling machineries to cortical membranes underlying these contact sites. Endosomal trafficking is indispensable for the polarized distribution of fate determinants, adaptors and junctional proteins. Conversely, endocytic machineries cooperate with polarity and scaffolding components to internalize receptors and target them to discrete membrane domains. Depending on the cell and tissue context, receptor endocytosis can terminate signaling responses but can also activate them within endosomes that act as signaling platforms. Therefore, cell homeostasis and responses to environmental cues rely on the dynamic cooperation of endosomal–lysosomal machineries with polarity and signaling cues. 
  • 1.4K
  • 07 May 2022
Topic Review
Heat Stress on Wheat Grain Yield and Quality
Climate change threatens to impact wheat productivity, quality and global food security. Maintaining crop productivity under abiotic stresses such as high temperature is therefore imperative to managing the nutritional needs of a growing global population.
  • 1.4K
  • 22 Jul 2022
Topic Review
Current Challenges in Breast Implantation
Breast implantation (BI) is the most common plastic surgery worldwide performed among women. Generally, BI is performed both in aesthetic and oncoplastic procedures. 
  • 1.4K
  • 18 Aug 2022
Topic Review
Trending Methods for Rapid Cannabinoids Detection
Roadside testing of illicit drugs such as tetrahydrocannabinol (THC) requires simple, rapid, and cost-effective methods. The need for non-invasive detection tools has led to the development of selective and sensitive platforms, able to detect phyto- and synthetic cannabinoids by means of their main metabolites in breath, saliva, and urine samples. One may estimate the time passed from drug exposure and the frequency of use by corroborating the detection results with pharmacokinetic data. Modified surfaces can also act as filters that allow only the target analyte to participate in the electrode reaction. In the case of cannabinoids, as in the case of other drugs, the investigation of the mechanism of action within the organism is the basis of biosensor development.
  • 1.4K
  • 18 Nov 2022
Topic Review
PSR J0737-3039
PSR J0737−3039 is the only known double pulsar. It consists of two neutron stars emitting electromagnetic waves in the radio wavelength in a relativistic binary system. The two pulsars are known as PSR J0737−3039A and PSR J0737−3039B. It was discovered in 2003 at Australia's Parkes Observatory by an international team led by the radio astronomer Marta Burgay during a high-latitude pulsar survey.
  • 1.4K
  • 12 Oct 2022
Topic Review
List of Delta IV Medium Launches
Since November 2002, rockets from the Delta 4 Medium family have been launched 29 times, all of which were successful. Its last flight was with a 3rd generation GPS satellite in August 2019.
  • 1.4K
  • 18 Oct 2022
Topic Review
Protease Inhibitor
In biology and biochemistry, protease inhibitors, or antiproteases, are molecules that inhibit the function of proteases (enzymes that aid the breakdown of proteins). Many naturally occurring protease inhibitors are proteins. In medicine, protease inhibitor is often used interchangeably with alpha 1-antitrypsin (A1AT, which is abbreviated PI for this reason). A1AT is indeed the protease inhibitor most often involved in disease, namely in alpha-1 antitrypsin deficiency.
  • 1.4K
  • 26 Oct 2022
Topic Review
Computer Vision-Based Wood Identification
The impact of wood identification extends beyond illegal trading and ecological issues. Wood identification is paramount for the timber industry, civil and structural engineering, criminology, archaeology, art history, ethnography, and conservation and restoration, and many other disciplines.
  • 1.4K
  • 15 Dec 2022
Topic Review
Oxygen Reduction Reaction Catalysts Derived from Biopolymers
Due to the limited reaction rate of the oxygen reduction reaction (ORR), it is considered as a limiting factor in the performance of fuel cells and metal-air batteries. Platinum is considered the benchmark catalyst for ORR; however, the scarcity of platinum, its high price, the drift phenomenon, its insufficient durability, and its susceptibility to gas poisoning are the reasons for the constant search for new ORR catalysts. Carbon-based catalysts show exceptional promise in this respect considering economic profitability and activity, and, in addition, they have favorable conductivity and often a large specific surface area.
  • 1.4K
  • 13 Feb 2023
Topic Review
Wildfire Spread Risk Challenge
Wildfires are sudden and destructive natural hazards that pose significant challenges in response and relief efforts. Wildfires occur annually across the globe, influenced by factors such as climate, combustible materials, and ignition sources. In recent years, researchers have shown increasing interest in studying wildfires, resulting in a large number of related studies. These studies cover a variety of topics including wildfire forecasting and forecasting, spatial and temporal pattern analysis, ecological impact assessment, simulation of wildfire behavior, identification of contributing factors, development of risk assessment models, management techniques for combustible materials, firefighting decision-making techniques, and fire protection. burning method. Understanding the factors that influence wildfire spread behavior, employing modeling methods, and conducting risk assessments are critical for effective wildfire prevention, mitigation, and emergency response.
  • 1.4K
  • 16 Jun 2023
Topic Review
Peripheral Mitochondrial Dysfunction and Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive disease, where dementia symptoms gradually worsen. The causes of AD are complex and are characterized by changes in the brain that lead to the accumulation of two proteins, amyloid beta and tau, forming structures called plaques and tangles, respectively. It is challenging to identify the mechanisms for the initiation and progression of AD. Oxidative stress and inflammation derived from peripheral mitochondrial dysfunction have also been suggested as alternative contributors of AD pathogenesis.
  • 1.4K
  • 04 Aug 2023
Topic Review
Long Non-Coding RNAs in Heart Failure
Heart failure (HF) is a widespread cardiovascular condition that poses significant risks to a wide spectrum of age groups and leads to terminal illness. Although our understanding of the underlying mechanisms of HF has improved, the available treatments still remain inadequate. Recently, long non-coding RNAs (lncRNAs) have emerged as crucial players in cardiac function, showing possibilities as potential targets for HF therapy. These versatile molecules interact with chromatin, proteins, RNA, and DNA, influencing gene regulation.
  • 1.4K
  • 27 Feb 2024
Topic Review
Physical Activity for the Elderly Cardiovascular Diseases Prevention
Cardiovascular disease prevention in the general population, and especially in older adults, starts from lifestyle modification. To prevent cardiovascular disease not just in elderly patients, but in all age groups, it is recommended to avoid a sedentary lifestyle and to exercise within the limits of individual tolerance. It is common knowledge that physical exercise has a positive impact on improving health and quality of life. In the elderly, regular exercise can exert an important contribution in reducing falls, maintaining good physical function and maintaining a good quality of life.
  • 1.4K
  • 30 Dec 2021
Topic Review
Electrospinning in GBR
Nanofibre-based membranes or scaffolds exhibit high surface-to-volume ratio, which allows an improved cell adhesion, representing an attractive subgroup of biomaterials due to their unique properties. Guided bone regeneration is a surgical procedure in which bone regeneration, due to bone atrophy following tooth loss, is “guided” by an occlusive barrier. New approaches such as multifunctional multilayering and coupling with bone promoting factors or antimicrobial agents, makes this technology very attractive also for bone regeneration procedures. The technical limitations of traditional electrospinning strategies for bone-tissue engineering applications might be critical for the preparation of three-dimensional scaffolds.  
  • 1.4K
  • 30 Oct 2020
Topic Review
Delpazolid for Tuberculosis Treatment
A novel oxazolidinone with cyclic amidrazone, delpazolid (LCB01-0371), was synthesized by LegoChem BioSciences, Inc. (Daejeon, Korea). Delpazolid can improve the minimum bactericidal concentration of Mycobacterium tuberculosis H37Rv and significantly reduce resistance rates,especially of multi-drug-resistant tuberculosis (MDR-TB) isolates, compared with linezolid. Therefore, delpazolid can be used to treat MDR-TB. The safety, tolerability, and pharmacokinetics of delpazolid have been evaluated in a phase 1 clinical trial, which revealed that it does not cause adverse events such as myelosuppression even after three weeks of repeated dosing. 
  • 1.4K
  • 29 Oct 2020
Topic Review
Lightweight Proof of Game (LPoG)
Interoperability is widely adopted in the case of cross-departmental or specialization cases. As the human body demands multiple specialized and cross-disciplined medical experiments, interoperability of business entities like different departments, different specializations, the involvement of legal and government monitoring issues etc. are not sufficient to reduce the active medical cases. A patient-centric system with high capability to collect, retrieve, store or exchange data is the demand for present and future times. Such data-centric health processes would bring automated patient medication, or patient self-driven trusted and high satisfaction capabilities. However, data-centric processes are having a huge set of challenges such as security, technology, governance, adoption, deployment, integration etc. This work has explored the feasibility to integrate resource-constrained devices-based wearable kidney systems in the Industry 4.0 network and facilitates data collection, liquidity, storage, retrieval and exchange systems. Thereafter, a Healthcare 4.0 processes-based wearable kidney system is proposed that is having the blockchain technology advantages. Further, game theory-based consensus algorithms are proposed for resource-constrained devices in the kidney system. The overall system design would bring an example for the transition from the specialization or departmental-centric approach to data and patient-centric approach that would bring more transparency, trust and healthy practices in the healthcare sector. Results show a variation of 0.10 million GH/s to 0.18 million GH/s hash rate for the proposed approach. The chances of a majority attack in the proposed scheme are statistically proved to be minimum. Further Average Packet Delivery Rate (ADPR) lies between 95% to 97%, approximately, without the presence of outliers. In the presence of outliers, network performance decreases below 80% APDR (to a minimum of 41.3%) and this indicates that there are outliers present in the network. Simulation results show that the Average Throughput (AT) value lies between 120 Kbps to 250 Kbps.
  • 1.4K
  • 29 Oct 2020
Topic Review
SARS-CoV-2 Infection
The SARS-CoV-2 pandemic represents the focus of the biomedical research worldwide. The identification of the molecular events related to the SARS-CoV-2 infection, as well as the characterization of its clinical features, could put an end to this dramatic health emergency. In this scenario, the interpretation of histopathological data in light of the clinical imaging characteristics of SARS-CoV-2 infection can provide the scientific rationale to develop diagnostic and therapeutic protocols that are capable of improving the management of infected patients. Specifically, morphological and molecular analysis of SARS-CoV-2 infected tissues could highlight new useful prognostic and predictive biomarkers for in vivo investigations.
  • 1.4K
  • 06 Nov 2020
  • Page
  • of
  • 2728
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback