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Topic Review
Artificial Intelligence in Cardiovascular Genetics
Polygenic diseases, which are genetic disorders caused by the combined action of multiple genes, pose unique and significant challenges for the diagnosis and management of affected patients. A major goal of cardiovascular medicine has been to understand how genetic variation leads to the clinical heterogeneity seen in polygenic cardiovascular diseases (CVDs). Recent advances and emerging technologies in artificial intelligence (AI), coupled with the ever-increasing availability of next generation sequencing (NGS) technologies, now provide researchers with unprecedented possibilities for dynamic and complex biological genomic analyses. Combining these technologies may lead to a deeper understanding of heterogeneous polygenic CVDs, better prognostic guidance, and, ultimately, greater personalized medicine. Advances will likely be achieved through increasingly frequent and robust genomic characterization of patients, as well the integration of genomic data with other clinical data, such as cardiac imaging, coronary angiography, and clinical biomarkers. 
  • 1.5K
  • 28 Mar 2022
Topic Review
Multiplex Tissue Imaging
Multiplex spatial analysis methods have recently been developed; these have offered insight into how cellular crosstalk dynamics and heterogeneity affect cancer prognoses and responses to treatment. Multiplex (imaging) technologies and computational analysis methods allow for the spatial visualization and quantification of cell–cell interactions and properties. These technological advances allow for the discovery of cellular interactions within the tumor microenvironment and provide detailed single-cell information on properties that define cellular behavior.
  • 1.5K
  • 08 Jul 2022
Topic Review
Intramedullary Spinal Cord Abscess among Children
Intramedullary spinal cord abscesses (ISCA) are rare. Typical symptoms include signs of infection and neurological deficits. Symptoms among (younger) children can be highly uncharacteristic. Therefore, prompt and proper diagnoses may be difficult. Typical therapeutic options include antibiotics and neurosurgical exploration and drainage.
  • 1.5K
  • 09 Aug 2022
Topic Review
Furstenberg–Sárközy Theorem
The Furstenberg–Sárközy theorem is a result in additive number theory on sets of numbers no two of which differ by a square. It states that, if [math]\displaystyle{ S }[/math] is a set of natural numbers with the property that no two numbers in [math]\displaystyle{ S }[/math] differ by a square number, then the natural density of [math]\displaystyle{ S }[/math] is zero. That is, for every [math]\displaystyle{ \varepsilon \gt 0 }[/math], and for all sufficiently large [math]\displaystyle{ n }[/math], the fraction of the numbers up to [math]\displaystyle{ n }[/math] that are in [math]\displaystyle{ S }[/math] is less than [math]\displaystyle{ \varepsilon }[/math]. Equivalently, every set of natural numbers with positive upper density contains two numbers whose difference is a square (and more strongly infinitely many such pairs). The theorem is named after Hillel Furstenberg and András Sárközy, who proved it in the late 1970s.
  • 1.5K
  • 10 Nov 2022
Topic Review
Heat and Moisture Transfer in Clothing Materials
Clothing as a tool connecting the human body and environment provides thermal and moisture comfort, and protective performance in cold, moderate, and extremely hot environments. The heat and moisture transfer properties of clothing materials are commonly evaluated using experimental study, mathematical modeling, and computer simulation.
  • 1.5K
  • 08 Feb 2023
Topic Review
Protective Mechanisms of Pomegranate Polyphenols in Neurodegenerative Diseases
Pomegranate (Punica granatum L.) is a polyphenol-rich food and medicinal plant containing flavonols, anthocyanins, and tannins. Ellagitannins (ETs) are the most abundant polyphenols in pomegranate. A growing body of research shows that polyphenol-rich pomegranate extracts and their metabolites target multiple types of brain cell and support their redox balance, proliferation and survival, as well as cell signaling. Independent studies have demonstrated that the significant neuroprotective effects of ETs are mediated by their antioxidant and anti-inflammatory effects, their chelating properties, by their ability to activate various signaling pathways, as well as the ability to influence mitochondrial damage, thus regulating autophagy, apoptosis and neurotransmitter signaling. 
  • 1.5K
  • 13 Feb 2023
Topic Review
Machine Failure Prediction Using Survival Analysis
With the rapid growth of cloud computing and the creation of large-scale systems such as IoT environments, the failure of machines/devices and, by extension, the systems that rely on them is a major risk to their performance, usability, and the security systems that support them. The need to predict such anomalies in combination with the creation of fault-tolerant systems to manage them is a key factor for the development of safer and more stable systems. 
  • 1.5K
  • 19 Oct 2023
Topic Review
Transformer-Based Model for Predicting Customers’ NPD in e-Commerce
Transformers offer advantages in capturing long-term dependencies within time series data through self-attention mechanisms. This adaptability to various time series patterns, including trends, seasonality, and irregularities, makes them a promising choice for next purchase day (NPD) prediction. The transformer model demonstrates improvements in prediction accuracy compared to the baselines. 
  • 1.5K
  • 02 Nov 2023
Topic Review
Wearable Technology for Monitoring Electrocardiograms in Adults
In the rapidly evolving landscape of continuous electrocardiogram (ECG) monitoring systems, there is a heightened demand for non-invasive sensors capable of measuring ECGs and detecting heart rate variability (HRV) in diverse populations, ranging from cardiovascular patients to sports enthusiasts. Challenges like device accuracy, patient privacy, signal noise, and long-term safety impede the use of wearable devices in clinical practice.
  • 1.5K
  • 27 Feb 2024
Topic Review
Glioblastoma Therapy
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer. Despite multimodality treatments, recurrence is almost universal with survival rates under 2 years after diagnosis. 
  • 1.5K
  • 15 Mar 2024
Topic Review
High-resolution melt method
HRM (High-resolution melt) analysis is a powerful molecular biology detection method used for the identification of genetic mutations, DNA methylation analysis or species identification. 
  • 1.5K
  • 27 Oct 2020
Topic Review
Coastal Dune
This work analyzes the evolution of the large shifting dune included in the Corrubedo Natural Park from 1956 until the present day. The analysis was carried out using aerial images, orthophotographs, topographic surveys and LiDAR (Light Detection and Ranging) data. Variations were analyzed in terms of four different aspects: evolution of pathways in each period, changes in the position of the mobile dune front and the degree of vegetation cover, all between 1956 and 2017; and variations in elevation and volume of the dune system between 2001 and 2015. To analyze these aspects, geospatial and geostatistical techniques were employed, which revealed that the dune front had undergone two different phases: one until the 1980s, with a mean seaward advance of 32 m and another one between the 1980 s and 2017, when the front prograded to the continent, with an approximate mean advance of 82 m. Loss of volume, related to the expansion of the mobile dune towards the north, was confirmed in this sector. It is evident that these changes are closely linked to anthropic influence, due to sand extraction until the early 1990s and, more recently, due to an increase in the number of visitors to the Natural Park. The results obtained highlight the need to carry out detailed studies to understand the evolution of this system and to prevent further damage in the future. Moreover, based on these analyses, a strategy to improve coastal and environmental management in the Corrubedo Natural Park could be designed.
  • 1.5K
  • 06 Jan 2021
Topic Review
Hashtag Recommendation
Hashtag recommendation suggests hashtags to users while they write microblogs in social media platforms. Although researchers have investigated various methods and factors that affect the performance of hashtag recommendations in Twitter and Sina Weibo, a systematic review of these methods is lacking.
  • 1.5K
  • 25 May 2021
Topic Review
RNA–Protein
RNA–protein interactions are the nodes in a complex regulatory network that controls the fate of each RNA expressed in a cell.
  • 1.5K
  • 15 Jun 2021
Topic Review
Selenium Nanoparticles in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a common chronic inflammation-mediated disorder having systematic complications. RA triggers a self-directed inflammatory and immunological cascade that culminates in joint destruction. Though a range of treatment options are available, none of them are without adverse effects, leading researchers to search for alternative solutions. Nanomedicine has emerged as a powerful therapeutic alternative, and selenium (Se) is an essential micronutrient trace element that has a crucial role in human health and disease.  The potential of SeNPs can be attributed to the effect of functional groups bound to them, concentration, and most importantly to their nano range size. The antirheumatic effect of SeNPs is considerable due to its potential in amelioration of oxidative stress-mediated inflammation via downregulation of radical and nonradical species, markers of inflammation, and upregulation of inherent antioxidant defenses.
  • 1.5K
  • 16 Aug 2021
Topic Review
Calmodulin Interactions with Voltage-Gated Sodium-Channels
Calmodulin (CaM) is a small protein that acts as a ubiquitous signal transducer and regulates neuronal plasticity, muscle contraction, and immune response. It interacts with ion channels and plays regulatory roles in cellular electrophysiology. CaM modulates the voltage-gated sodium channel gating process, alters sodium current density, and regulates sodium channel protein trafficking and expression.
  • 1.5K
  • 24 Sep 2021
Topic Review
Direct-Seeded Rice Root System Architecture
Direct-seeded rice (DSR) is such a system of rice cultivation that has the potential to decrease water consumption, in addition to lessening labor requirements and at the same time enhance resource-use efficiency and system productivity, and check greenhouse gas emissions. Identifying ideal traits and breeding new rice varieties with efficient root system architecture (RSA) has great potential to increase resource-use efficiency and grain yield, especially under direct-seeded rice, by adapting to aerobic soil conditions. 
  • 1.5K
  • 09 Feb 2022
Topic Review
Architecture of Computing System
Computing systems are widely used in medical diagnosis, climate prediction, self-driving cars, and more. This entry mainly introduces the Chiplet-based computing system architecture design technology, which can solve the conflict between performance, efficiency and cost in computing system design, and provide instructions for the design of a high-performance computing system.
  • 1.5K
  • 28 Mar 2022
Topic Review
Creatine Supplementation for Muscle Growth
Muscle growth involves increasing muscular size, typically through strength training and protein supplementation.
  • 1.5K
  • 29 Mar 2022
Topic Review
Breakthrough Infections in Measles Elimination
Measles is one of the most contagious diseases known to man. Despite the existence of a safe and effective live attenuated vaccine, measles can appear in vaccinated individuals. Paradoxically, breakthrough cases increase as vaccination coverage in the general population rises. In measles endemic areas, breakthrough cases represent less than 10% of total infections, while in areas with high vaccination coverage these are over 10% of the total. Two different vaccination failures have been described: primary vaccination failure, which consists in the complete absence of humoral response and occurs in around 5% of vaccinated individuals; and secondary vaccination failure is due to waning immunity or incomplete immunity and occurs in 2–10% of vaccinees. Vaccination failures are generally associated with lower viral loads and milder disease (modified measles) since vaccination limits the risk of complicated disease. Vaccination failure seems to occur between six and twenty-six years after the last vaccine dose administration. 
  • 1.5K
  • 15 Aug 2022
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