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Topic Review
Obstetric Brachial Palsy
Obstetric Brachial Palsy (OBP) is defined as a partial or total flaccid paralysis that affects the upper limb of the newborn due to brachial plexus injury occurring in normal delivery, and, more rarely, in cesarean section, often associated with shoulder dystocia
  • 1.5K
  • 05 Nov 2020
Topic Review
Heat-stable Enterotoxin b
Enterotoxigenic Escherichia coli (ETEC) is known to cause travelers’ diarrhea and diarrhea in farm animals. The global burden of ETEC infection is extensive and remains a major public health issue. In 2006, the World Health Organization estimated annually 400–500 million diarrheal episodes in newborns and children and 400 million in individuals 15 years or older, all ETEC related. ETEC can be characterized by its capability to produce and secrete several virulence factors, including colonization factors (adhesins) and enterotoxins. Adhesins allow for the attachment of the bacteria to intestinal epithelial cells. These can be characterized as filamentous appendages on the surface of the bacteria called fimbriae, on which adhesins can be found. The loss of these colonization factors may render the bacteria unable to colonize and cause infection. Colonization of the intestinal tract allows for specific delivery of enterotoxins which disrupt normal intestinal fluid homeostasis. ETEC enterotoxins are differentiated by their heat stability. They are classified into heat-labile (LT-I and LT-II) and heat-stable (STa and STb) enterotoxins.
  • 1.5K
  • 16 Dec 2020
Topic Review
Benchmarking Data Sets
Developing realistic data sets for evaluating virtual screening methods is a task that has been tackled by the cheminformatics community for many years. Numerous artificially constructed data collections were developed, such as DUD, DUD-E, or DEKOIS. However, they all suffer from multiple drawbacks, one of which is the absence of experimental results confirming the impotence of presumably inactive molecules, leading to possible false negatives in the ligand sets. In light of this problem, the PubChem BioAssay database, an open-access repository providing the bioactivity information of compounds that were already tested on a biological target, is now a recommended source for data set construction. Nevertheless, there exist several issues with the use of such data that need to be properly addressed. In this article, an overview of benchmarking data collections built upon experimental PubChem BioAssay input is provided, along with a thorough discussion of noteworthy issues that one must consider during the design of new ligand sets from this database. The points raised in this review are expected to guide future developments in this regard, in hopes of offering better evaluation tools for novel in silico screening procedures.
  • 1.5K
  • 26 Oct 2020
Topic Review
Brain Stroke Monitoring
Stroke is a medical disease that affects millions of people worldwide per year, which leads to permanent disabilities or even death. It occurs when the regular flow of rich-oxygen blood through a brain vessel is interrupted due to a clot or a burst of it, triggering the death of brain cells and requiring prompt diagnosis and intervention after its onset to improve the prognosis significantly. The two main types of stroke are hemorrhagic and ischemic ones.
  • 1.5K
  • 27 Oct 2020
Topic Review
Advanced Driver-Assistance Systems
Advanced Driver-Assistance Systems (ADASs) are used for increasing safety in the automotive domain, yet current ADASs notably operate without taking into account drivers’ states, e.g., whether she/he is emotionally apt to drive.
  • 1.5K
  • 23 Dec 2020
Topic Review
Benign Prostate Hyperplasia
This entry presents B-mode and color Doppler imaging of the prostate and testes in dogs suffering from benign prostate hyperplasia (BPH), and receiving Deslorelin Acetate (SuprelorinTM) or Osaterone Acetate (YpozaneTM). The study was planned as a controlled clinical trial, dogs were divided into negative control (healthy dogs, n = 10), positive control (dogs with BPH, n = 10), and study groups, III (n = 15), receiving deslorelin acetate (DA), and IV (n = 10), receiving osaterone acetate (OA). The B-mode appearance of the prostate parenchyma improved in all investigated dogs from the DA group, and in 60% of OA dogs.
  • 1.5K
  • 30 Dec 2020
Topic Review
Inteins in Science
Inteins are mobile genetic elements that apply standard enzymatic strategies to excise themselves post-translationally from the precursor protein via protein splicing. Since their discovery in the 1990s, recent advances in intein technology allow for them to be implemented as a modern biotechnological contrivance. Radical improvement in the structure and catalytic framework of cis- and trans-splicing inteins devised the development of engineered inteins that contribute to various efficient downstream techniques. 
  • 1.5K
  • 26 Jan 2021
Topic Review
Sideroflexins/SLC56 Family
Sideroflexins (SLC56 family) are highly conserved multi-spanning transmembrane proteins inserted in the inner mitochondrial membrane in eukaryotes.
  • 1.5K
  • 26 Feb 2021
Topic Review
Antioxidants and Atherosclerosis
Atherosclerosis is a chronic inflammatory disease which is a major cause of coronary heart disease and stroke in humans. It is characterized by intimal plaques and cholesterol accumulation in arterial walls. The side effects of currently prescribed synthetic drugs and their high cost in the treatment of atherosclerosis has prompted the use of alternative herbal medicines, dietary supplements, and antioxidants associated with fewer adverse effects for the treatment of atherosclerosis. Natural and synthetic antioxidants have a crucial role in the prevention and treatment of atherosclerosis through different mechanisms. These include: The inhibition of low density lipoprotein (LDL) oxidation, the reduction of reactive oxygen species (ROS) generation, the inhibition of cytokine secretion, the prevention of atherosclerotic plaque formation and platelet aggregation, the preclusion of mononuclear cell infiltration, the improvement of endothelial dysfunction and vasodilation, the augmentation of nitric oxide (NO) bioavailability, the modulation of the expression of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) on endothelial cells, and the suppression of foam cell formation.
  • 1.5K
  • 23 Jul 2021
Topic Review
NLRP3 Inflammasome Inhibitors
Nucleotide-binding oligomerization domain NOD-like receptors (NLRs) are conserved cytosolic pattern recognition receptors (PRRs) that track the intracellular milieu for the existence of infection, disease-causing microbes, as well as metabolic distresses. The NLRP3 inflammasome agglomerates are consequent to sensing a wide spectrum of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). Certain members of the NLR family have been documented to lump into multimolecular conglomerates called inflammasomes, which are inherently linked to stimulation of the cysteine protease caspase-1.
  • 1.5K
  • 28 Sep 2021
Topic Review
Assessing Rainwater Harvesting Potential in Urban Areas
Water scarcity has become a major problem for many countries, resulting in declining water supply and creating a need to find alternative solutions. One potential solution is rainwater harvesting (RwH), which allows rainwater to be stored for human needs. 
  • 1.5K
  • 23 Nov 2021
Topic Review
Growth Hormone and IGF1 Actions in Kidney
Growth hormone (GH) exerts multiple effects on different organs including the kidneys, either directly or via its main mediator, insulin-like-growth factor-1 (IGF-1).
  • 1.5K
  • 17 Dec 2021
Topic Review
Development of Organ Specificity among Endothelial Cells
Endothelial cells have a mesodermal origin; during vasculogenesis, a “first draft” of the vascular system is laid down to support the growing embryo. Vascular endothelial cells line the entire circulatory system and show remarkable heterogeneity. Even though endothelial cells originate from the same progenitor cells during development, they eventually contribute to different subtypes of endothelia. Based on morphology, the microvasculature consists of three main phenotypes: discontinuous, fenestrated, and non-fenestrated endothelium.
  • 1.5K
  • 21 Feb 2022
Topic Review
Glioblastoma Cells
Glioblastoma multiforme (GBM) is the most common brain cancer in adults. GBM starts from a small fraction of poorly differentiated and aggressive cancer stem cells (CSCs) responsible for aberrant proliferation and invasion. Due to extreme tumor heterogeneity, actual therapies provide poor positive outcomes, and cancers usually recur. Therefore, alternative approaches, possibly targeting CSCs, are necessary against GBM.
  • 1.5K
  • 31 Mar 2022
Topic Review
Arboviruses as a Cause of Undifferentiated Febrile Illnesses
Arthropod-borne viruses (arboviruses) are, by definition, transmitted between vertebrate hosts by biting arthropods (mosquitoes, ticks, sandflies, midges and gnats). Some arboviral infections — notably, dengue, chikungunya, Zika, Japanese encephalitis, yellow fever and West Nile viruses — pose a major public health threat worldwide. Many others are known or thought to lead to acute undifferentiated febrile illness (UFI), of which a significant proportion of cases are not diagnosed. In low-income countries, a diagnosis of UFI is extremely common due to the lack of pathology laboratory resources. Yet, even in high-income nations, which have adequate access to and quality of diagnostic tools, up to one third of pyrexias may be of unknown origin. It has been estimated that between 12-35% of hospitalized patients with UFI die from UFI-associated complications. In this context, identifying the contribution of hitherto less studied arboviruses as potential etiological agents of UFI and prioritizing the development and availability of diagnostic tests may greatly assist in reducing the global burden of UFI-related disease.
  • 1.5K
  • 22 Apr 2022
Topic Review
Effects of Palmitoylethanolamide on Neurodegenerative Diseases
Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its neuroprotective, anti-inflammatory, and analgesic functions. PEA belonging to the N-acetylanolamine class of phospholipids was first isolated from soy lecithin, egg yolk, and peanut flour. It is currently used for the treatment of different types of neuropathic pain, such as fibromyalgia, osteoarthritis, carpal tunnel syndrome, and many other conditions. 
  • 1.5K
  • 19 May 2022
Topic Review
The Role of BUB3 in Human Cancers
The BUB3 protein plays a key role in the activation of the spindle assembly checkpoint (SAC), a ubiquitous surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis and, consequently, prevents chromosome mis-segregation and aneuploidy. Besides its role in SAC signaling, BUB3 regulates chromosome attachment to the spindle microtubules. It is also involved in telomere replication and maintenance. Deficiency of the BUB3 gene has been closely linked to premature aging. Upregulation of the BUB3 gene has been found in a variety of human cancers and is associated with poor prognoses.
  • 1.5K
  • 25 May 2022
Topic Review
JPEG XT
JPEG XT (ISO/IEC 18477) is an image compression standard which specifies backward-compatible extensions of the base JPEG standard (ISO/IEC 10918-1 and ITU Rec. T.81). JPEG XT extends JPEG with support for higher integer bit depths, high dynamic range imaging and floating-point coding, lossless coding, alpha channel coding, and an extensible file format based on JFIF. It also includes reference software implementation and conformance testing specification. JPEG XT extensions are backward compatible with base JPEG/JFIF file format - existing software is forward compatible and can read the JPEG XT binary stream, though it would only decode the base 8-bit lossy image.
  • 1.5K
  • 28 Sep 2022
Topic Review
Perfectionism
In ethics and value theory, perfectionism is the persistence of will in obtaining the optimal quality of spiritual, mental, physical, and material being. The neo-Aristotelean Thomas Hurka describes perfectionism as follows: The perfectionist does not necessarily believe that one can attain a perfect life or state of living. Rather, a perfectionist practices steadfast perseverance in obtaining the best possible life or state of living.
  • 1.5K
  • 13 Oct 2022
Topic Review
Identification of Soccer Scoring Techniques
The immense charm of soccer to millions of players and spectators can be traced back to the most prime idea of the game: to score goals—an idea that will always be captivating. This basic idea shapes the soccer scoring technique (SST) to be the crucial and final determinant of every offensive-maneuver fate of any team. Therefore, the identification of SSTs is particularly important.
  • 1.5K
  • 01 Nov 2022
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