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Topic Review
Hydrodynamics on Microbial Adhesion and Biofilm Formation
Studying microbial adhesion and biofilm growth is crucial for understanding the physiology of sessile organisms and forming the basis for the development of novel antimicrobial materials. Fluid hydrodynamics is one of the most important factors affecting cell adhesion, as well as biofilm structure and behavior. Therefore, to simulate the relevant biofilms of different fields (environment, industry, and medicine) in the laboratory, it is of utmost importance to select an adequate biofilm platform and be able to operate it at hydrodynamic conditions that are as close as possible to those encountered in a real scenario.
  • 1.5K
  • 21 Oct 2021
Topic Review
Profiling the Cycling-Induced Oxide Trapped Charge
NAND Flash memories have gained tremendous attention owing to the increasing demand for storage capacity. This implies that NAND cells need to scale continuously to maintain the pace of technological evolution. Even though NAND Flash memory technology has evolved from a traditional 2D concept toward a 3D structure, the traditional reliability problems related to the tunnel oxide continue to persist.
  • 1.5K
  • 02 Nov 2021
Topic Review
3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry
3-Phenylcoumarins are a family of heterocyclic molecules that are widely used in both organic and medicinal chemistry. 3-Phenylcoumarins have been used by several research groups in the search for new chemical entities with potential in the discovery of new therapeutic solutions for several diseases. The versatility and chemical properties of this scaffold have been attracting the attention of researchers all over the world.
  • 1.5K
  • 25 Nov 2021
Topic Review
CD40 as Therapeutic Target
Targeting of CD40 with the aim to stimulate or inhibit this receptor attracts considerable translational interest. Inhibitory CD40 targeting appears particularly attractive in the field of organ transplantation and in the treatment of autoimmune diseases. CD40 blockade might also elicit antitumoral activity on CD40-expressing tumors. Agonistic CD40 targeting typically aims at the exploitation of the strong immunostimulatory activities of CD40 for tumor immunotherapy and vaccination against various infectious pathogens.
  • 1.5K
  • 03 Nov 2022
Topic Review
Foreman
Foreman (also known as The Foreman) is an open source complete life cycle systems management tool for provisioning, configuring and monitoring of physical and virtual servers. Foreman has deep integration to configuration management software, with Ansible, Puppet, Chef, Salt and other solutions through plugins, which allows users to automate repetitive tasks, deploy applications, and manage change to deployed servers. Foreman provides provisioning on bare-metal (through managed DHCP, DNS, TFTP, and PXE-based unattended installations), virtualization and cloud. Foreman provides comprehensive, auditable interaction facilities including a web frontend, a command line interface, and a robust REST API.
  • 1.5K
  • 16 Nov 2022
Topic Review
Intelligent Dispatcher Training Simulator
The concept of dispatcher training simulator (DTS) was first proposed by Latimer in 1977, and the first DTS device was developed in the same year. After a large discussion on DTS organized by Electric Power Research Institute (EPRI) in 1978, DTS was rapidly promoted in the power industry. In the 1990s, dynamic simulation and object-oriented techniques were introduced into DTS. Traditional DTS has been unable to meet the needs of the continuously developing smart grid. As artificial intelligence (AI) advances, more intelligent techniques are introduced into DTS, and the intelligent dispatcher training simulator (IDTS) is taking the historical stage. Nico Brose designed the first visualized IDTS in Germany, using software PRINS, which is coupled via a tele-control server with the Root-Mean-Square (RMS) real-time simulation core (with the software PowerFactory) for dynamic grid simulations.
  • 1.5K
  • 06 Feb 2023
Topic Review
Contaminant Cocktails of High Concern in Honey
Environmental pollution is a crucial problem in our society, having a better understanding of its consequences, which include the increase of contaminant cocktails present in the environment. The contamination of honeybees can occur through their interaction with the nearby environment. Therefore, if honeybees are previously contaminated, there is a possibility of contamination of their products, such as honey as natural, or minimally processed, product, resulting from the honeybees’ activity.
  • 1.5K
  • 14 Apr 2023
Topic Review
Surface-Enhanced Raman Spectroscopy Substrates for Food Safety Detection
Food safety analysis currently relies on the enzyme-linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), high-performance liquid chromatography (HPLC), gas chromatography (GC), UV-visible spectrophotometry, and tandem mass spectrometry (MS), all of which require significant time to train qualified food safety testing laboratory operators. These factors have hindered the development of rapid food safety monitoring systems, especially in remote areas or areas with a relative lack of testing resources. Surface-enhanced Raman spectroscopy (SERS) has emerged as one of the tools of choice for food safety testing that can overcome these dilemmas. SERS offers advantages over chromatographic mass spectrometry analysis due to its portability, non-destructive nature, and lower cost implications. However, as it currently stands, Raman spectroscopy is a supplemental tool in chemical analysis, reinforcing and enhancing the completeness and coverage of the food safety analysis system. SERS combines portability with non-destructive and cheaper detection costs to gain an advantage over chromatographic mass spectrometry analysis. 
  • 1.5K
  • 10 Jul 2023
Topic Review
Lipid-Based Delivery Systems for Flavonoids and Flavonolignans
Herbal chemicals with a long history in medicine have attracted a lot of attention. Flavonolignans and flavonoids are considered as two classes of the above-mentioned compounds with different functional groups which exhibit several therapeutic capabilities such as antimicrobial, anti-inflammatory, antioxidant, antidiabetic, and anticancer activities. Based on the studies, high hydrophobic properties of the aforementioned compounds limit their bioavailability inside the human body and restrict their wide application. Nanoscale formulations such as solid lipid nanoparticles, liposomes, and other types of lipid-based delivery systems have been introduced to overcome the above-mentioned challenges. This approach allows the aforementioned hydrophobic therapeutic compounds to be encapsulated between hydrophobic structures, resulting in improving their bioavailability. The above-mentioned enhanced delivery system improves delivery to the targeted sites and reduces the daily required dosage.
  • 1.5K
  • 31 Jul 2023
Topic Review
Conceptual Overview of Energy Security
In a dynamically changing socio-economic environment with significant technical and technological progress, the notion of energy security takes on a new, broader meaning. Modern literature presents a variety of operational definitions of energy security. Most authors dealing with the issue of energy security expose its different aspects while standing in opposition to competing concepts. As a result, literature that addresses the problems of energy policy is becoming a platform for debates on the essence of energy security and the applicability of its various approaches to individual situations. There is no unanimity among authors with regard to the theoretical framework or the components of this notion. However, the issue of diversity of views is quite typical in social sciences and should not be taken negatively. Despite this, and perhaps contrary to the definitional wealth, experts in the field of energy policy constantly stress the necessity and urgency of undertaking work on the conceptualization of energy security.
  • 1.5K
  • 19 Sep 2023
Topic Review
Franklinothrips vespiformis
Species of Franklinothrips (Thysanoptera: Aeolothripidae) are predatory on various other insects. These fast moving, ant-mimicking predatory thrips are widely distributed in the tropics. F. vespiformis has gained attention for its potential as a biocontrol agent for a diverse range of greenhouse pests, and it has already been commercially cultured in Europe for certain use.
  • 1.5K
  • 29 Jan 2022
Topic Review
Pathophysiology of NAFLD
Nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), is a growing cause of liver cirrhosis and liver cancer worldwide because of the global increases in obesity, dyslipidemia, hypertension, and type 2 diabetes mellitus.
  • 1.5K
  • 27 Apr 2022
Topic Review
The Emergence of Hydrochar as a Sustainable Adsorbent
Hydrochar, a carbonaceous material, is derived through the process of hydrothermal carbonization (HTC) applied to biomass feedstocks.
  • 1.5K
  • 22 Jan 2024
Topic Review
Zinc Signaling in Prostate Cancer
Prostate cancer (PCa) is one of the most common cancers and the second leading cause of cancer-related death among men worldwide. Despite progresses in early diagnosis and therapeutic strategies, prognosis for patients with advanced PCa remains poor. Therefore, it is necessary to develop novel strategies to prevent, diagnose and effectively treat PCa patients in clinic. Noteworthily, a unique feature of healthy prostate is its highest level of zinc content among all soft tissues in the human body, which dramatically decreases during prostate tumorigenesis. Here, we discuss clinical applications of zinc-containing compounds and proteins involved in PCa signaling pathways. Based on currently available studies, we conclude that zinc can serve as a biomarker in PCa diagnosis and therapies.
  • 1.5K
  • 05 Nov 2021
Topic Review
Tuberculosis IRIS
Antiretroviral therapy (ART), while essential in combatting tuberculosis (TB) and HIV coinfection, is often complicated by TB-associated immune reconstitution inflammatory syndrome (TB-IRIS). Depending on the TB diagnosis and treatment status at ART initiation, this immune-mediated worsening of TB pathology can take the form of paradoxical TB-IRIS, unmasking TB-IRIS. Each form of TB-IRIS has unique implications for diagnosis and treatment. This entry is a discussion of TB-IRIS with an expanded focus on CNS TB-IRIS given its severe outcomes and anatomic and immunologic peculiarities.
  • 1.5K
  • 06 Nov 2020
Topic Review
Locomotion Assistive Devices
Locomotion assistive devices equipped with a microprocessor can potentially automatically adapt their behavior when the user is transitioning from one locomotion mode to another. Many developments in the field have come from machine learning driven controllers on locomotion assistive devices that recognize/predict the current locomotion mode or the upcoming one.
  • 1.5K
  • 24 Nov 2020
Topic Review
Virus and Cellular Senescence
Cellular senescence is considered a stress response that protects cells against malignant transformation, facilitates tissue repair and development, and prevents virus replication. However, excessive accumulation of senescent cells is associated with chronic diseases such as age-related disorders, cancer, inflammatory diseases and virus replication. The relationship between virus and cellular senescence is proving to be very complex. Cellular senescence can be induced in response to virus infection restricting virus propagation. Some viruses are able to exploit the senescence program to improve their replication, while others have developed strategies to subvert senescence. Therapeutic approaches to eliminate senescent cells may be used as a mechanism to ameliorate age-related diseases, but they may have an impact on virus replication.
  • 1.5K
  • 29 Dec 2020
Topic Review
Antioxidant-Based Therapies in Male Infertility
Under physiological conditions, reactive oxygen species (ROS) play pivotal roles in various processes of human spermatozoa. Indeed, semen requires the intervention of ROS to accomplish different stages of its maturation. However, ROS overproduction is a well-documented phenomenon occurring in the semen of infertile males, potentially causing permanent oxidative damages to a vast number of biological molecules (proteins, nucleic acids, polyunsaturated fatty acids of biological membrane lipids), negatively affecting the functionality and vitality of spermatozoa. ROS overproduction may concomitantly occur to the excess generation of reactive nitrogen species (RNS), leading to oxidative/nitrosative stress and frequently encountered in various human pathologies. Under different conditions of male infertility, very frequently accompanied by morpho-functional anomalies in the sperm analysis, several studies have provided evidence for clear biochemical signs of damages to biomolecules caused by oxidative/nitrosative stress. In the last decades, various studies aimed to verify whether antioxidant-based therapies may be beneficial to treat male infertility have been carried out.
  • 1.5K
  • 04 Mar 2021
Topic Review
Macrophage
Macrophages within solid tumors and metastatic sites are heterogenous populations with different developmental origins and substantially contribute to tumor progression. A number of tumor-promoting phenotypes associated with both tumor- and metastasis-associated macrophages are similar to innate programs of embryonic-derived tissue-resident macrophages. In contrast to recruited macrophages originating from marrow precursors, tissue-resident macrophages are seeded before birth and function to coordinate tissue remodeling and maintain tissue integrity and homeostasis. Both recruited and tissue-resident macrophage populations contribute to tumor growth and metastasis and are important mediators of resistance to chemotherapy, radiation therapy, and immune checkpoint blockade. Thus, targeting various macrophage populations and their tumor-promoting phenotypes holds therapeutic promise.
  • 1.5K
  • 25 May 2021
Topic Review
Vietnam SciMath Database Project
The Vietnam SciMath Database Project is a product of the mathematical research history initiative led by Professor Ngô Bảo Châu, a Vietnamese-French mathematician who won the Fields Medal in 2010.
  • 1.5K
  • 19 Jul 2021
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