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Topic Review
Rating Site
A rating site (less commonly, a rate-me site) is a website designed for users to vote on or rate people, content, or other things. Rating sites are typically organized around attributes such as physical appearance, body parts, voice, personality, etc. They may also be devoted to the subjects' occupational ability, for example teachers, professors, lawyers, doctors, etc.
  • 1.5K
  • 19 Oct 2022
Topic Review
Strategic Urban Planning
The general objectives of strategic urban planning (SUP) include clarifying which city model is desired and working towards that goal, coordinating public and private efforts, channelling energy, adapting to new circumstances and improving the living conditions of the citizens affected. Strategic planning is a technique that has been applied to many facets of human activity; we have only to mention Sun Tzu, Arthur Thomson or Henry Mintzberg; however, the application of strategic planning to urban contexts, or cities, regions and other metropolitan areas is a relatively recent development whose beginnings were eminently practical and artistical: a mixture of thought, techniques and art or expertise. Fifteen years of practice proved to be enough time for the technique to spread and for the first “Meeting of American and European cities for the Exchange of Experiences in Strategic Planning” to be organized. Institutions sponsoring the meeting, held in Barcelona in 1993, included the Inter-American Development Bank, the European Community Commission and the Iberoamerican Cooperation Institute. The cities of Amsterdam, Lisbon, Lille, Barcelona, Toronto and Santiago de Chile participated, among others. At that meeting it was demonstrated, along with other relevant aspects, that if cooperative processes are used in large cities in order to carry out strategic planning processes, and if a reasonable degree of comprehension is reached between the administration, businesses and an ample representation of social agents, organizational synergies will develop that will eventually improve resource management and citizens’ quality of life.
  • 1.5K
  • 24 Oct 2022
Topic Review
Industrial Applications of Nanotechnology
Nanotechnology is impacting the field of consumer goods, several products that incorporate nanomaterials are already in a variety of items; many of which people do not even realize contain nanoparticles, products with novel functions ranging from easy-to-clean to scratch-resistant. Examples of that car bumpers are made lighter, clothing is more stain repellant, sunscreen is more radiation resistant, synthetic bones are stronger, cell phone screens are lighter weight, glass packaging for drinks leads to a longer shelf-life, and balls for various sports are made more durable. Using nanotech, in the mid-term modern textiles will become "smart", through embedded "wearable electronics", such novel products have also a promising potential especially in the field of cosmetics, and has numerous potential applications in heavy industry. Nanotechnology is predicted to be a main driver of technology and business in this century and holds the promise of higher performance materials, intelligent systems and new production methods with significant impact for all aspects of society.
  • 1.5K
  • 29 Nov 2022
Topic Review
Cognitive Closure
In philosophy of science and philosophy of mind, cognitive closure is the proposition that human minds are constitutionally incapable of solving certain perennial philosophical problems. Owen Flanagan calls this position anti-constructive naturalism or the "new mysterianism" and the primary advocate of the hypothesis, Colin McGinn, calls it transcendental naturalism acknowledging the possibility that solutions may be knowable to an intelligent non-human of some kind. According to McGinn, such philosophical questions include the mind-body problem, identity of the self, foundations of meaning, free will, and knowledge, both a priori and empirical.
  • 1.5K
  • 30 Nov 2022
Topic Review
Alternative Investment Fund Managers Directive 2011
The Alternative Investment Fund Managers Directive 2011/61/EU (or "AIFMD" for short) is an EU law on the financial regulation of hedge funds, private equity, real estate funds, and other "Alternative Investment Fund Managers" (AIFMs) in the European Union. The Directive requires all covered AIFMs to obtain authorisation, and make various disclosures as a condition of operation. It followed the global financial crisis. Before, the alternative investment industry had not been regulated at EU level. It was reported in May 2014 that only one-third of EU member states had successfully implemented the directive into law. As of 2014, the countries that had transposed AIFMD into law include Cyprus, the Czech Republic, the United Kingdom, Luxembourg, (Germany), France, Malta and Ireland. In December 2014, the European Commission issued a formal warning to countries including Spain, Latvia and Poland for not complying with AIFMD implementation.
  • 1.5K
  • 05 Dec 2022
Topic Review
Java Transaction API
The Java Transaction API (JTA), one of the Java Enterprise Edition (Java EE) APIs, enables distributed transactions to be done across multiple X/Open XA resources in a Java environment. JTA is a specification developed under the Java Community Process as JSR 907. JTA provides for:
  • 1.5K
  • 05 Dec 2022
Topic Review
E-Learning Readiness Assessment
Assessing e-learning readiness is crucial for educational institutions to identify areas in their e-learning systems needing improvement and to develop strategies to enhance students’ readiness.
  • 1.5K
  • 12 Jun 2023
Topic Review
Vitamins B1, B3 and B6 in Charcot–Marie–Tooth Disease
The molecular mechanisms of Charcot–Marie–Tooth (CMT) disease, involving impaired vitamin metabolism and/or actions, are considered in light of the potential therapeutic actions of vitamins B1, B3 and B6 in the disease.
  • 1.5K
  • 27 Jun 2023
Topic Review
Knowledge of Autism
Definitions of autism have been deficit-focused and grounded in a medical perspective. 
  • 1.5K
  • 24 Jul 2023
Topic Review
Watershed Processes and Streamflow Prediction
Accurate streamflow prediction (SFP) is crucial for water resource management, flood and drought forecasting, and reservoir operations. However, complex interactions between surface and subsurface processes in watersheds make predicting extreme events challenging. This work highlights the importance of incorporating physical understanding and process knowledge into data-driven SFP models for reliable and robust predictions, especially during extreme events.
  • 1.5K
  • 26 Feb 2024
Topic Review
Polyphenols and Stroke
Polyphenols are an important family of molecules of vegetal origin present in many medicinal and edible plants, which represent important alimentary sources in the human diet. Polyphenols are known for their beneficial health effects and have been investigated for their potential protective role against various pathologies, including cancer, brain dysfunctions, cardiovascular diseases and stroke.
  • 1.5K
  • 15 Jan 2021
Topic Review
Biologically inspired metaheuristics
A metaheuristic is a high level, problem-independent framework that provides a series of steps and guidelines used to develop heuristic optimizers. Nowadays, the tendency is to use the term for both the general framework and for the algorithms built based on its rules. In the latest years, the literature has shown an increase in the number of proposals of new optimization metaheuristics and their improvements through step alterations, local search procedures or hybridizations.
  • 1.5K
  • 09 Oct 2021
Topic Review
Small Public Urban Green Spaces for Mental Restoration
Small public urban green space (SPUGS) was defined as urban public spaces which did not exceeding 5,000 m2 in size with vegetation and their own entrance. Exposure to SPUGS has been demonstrated to have mental benefits for older adults. However, studies on identifying the objective environmental features of SPUGS and their effects on mental restoration for older adults remain limited. The research results showed that: (1) Both the green view index, and the boundary enclosure had a strong impact on the mental restoration of older adults; (2) The colorfulness index showed the strongest relationship with the vitalizing effect. (3) Sky view factor and, number of seats only influenced the ROS score, while the results of revitalization suggest that large areas of water should be avoided. (4) Physiological Equivalent Temperature (PET) was also confirmed to have negative effects on the psychological health of seniors in autumn. 
  • 1.5K
  • 20 May 2022
Topic Review
List of Sequence Alignment Software
This list of sequence alignment software is a compilation of software tools and web portals used in pairwise sequence alignment and multiple sequence alignment. See structural alignment software for structural alignment of proteins.
  • 1.5K
  • 08 Nov 2022
Topic Review
Role of p300 and Tumours
p300 acts as a transcription coactivator and an acetyltransferase that plays an important role in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is an important regulator in regulating the evolution of malignant tumours and it also has extensive functions. From the perspective of non-posttranslational modification, it has been proven that p300 can participate in regulating many pathophysiological processes, such as activating oncogene transcription, promoting tumour cell growth, inducing apoptosis, regulating immune function and affecting embryo development. p300 has been found to act as an acetyltransferase that catalyses a variety of protein modification types, such as acetylation, propanylation, butyylation, 2-hydroxyisobutyration, and lactylation. Under the catalysis of this acetyltransferase, it plays its crucial tumourigenic driving role in many malignant tumours. Therefore, the function of p300 acetyltransferase has gradually become a research hotspot. From a posttranslational modification perspective, p300 is involved in the activation of multiple transcription factors and additional processes that promote malignant biological behaviours, such as tumour cell proliferation, migration, and invasion, as well as tumour cell apoptosis, drug resistance, and metabolism.
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  • 13 Mar 2023
Topic Review
Effects of Capsaicin on Cerebrovascular Function and Cognition
Impaired cognition is the primary symptom of dementia, which can lead to functional disability and reduced quality of life among an increasingly ageing population. Ageing is associated with increased oxidative stress, chronic low-grade systemic inflammation, and endothelial dysfunction, which reduces cerebrovascular function leading to cognitive decline. Chronic low-grade systemic inflammatory conditions, such as obesity, exacerbate this decline beyond normal ageing and predispose individuals to neurodegenerative diseases, such as dementia. Capsaicin, the major pungent molecule of chilli, has recently demonstrated improvements in cognition in animal models via activation of the transient receptor potential vanilloid channel 1 (TRPV1). Capsaicin-induced TRPV1 activation reduces adiposity, chronic low-grade systemic inflammation, and oxidative stress, as well as improves endothelial function, all of which are associated with cerebrovascular function and cognition. 
  • 1.5K
  • 30 Mar 2023
Topic Review
Cybersecurity in Microgrids
The demand for clean and sustainable energy sources is increasing at a rapid pace, and microgrids (MGs) have emerged as a promising solution for achieving energy resilience, efficiency, and security. As a general definition, a microgrid is a localized power system that integrates renewable energy resources, energy storage systems, and loads to operate autonomously or in parallel with the main grid. As MGs continue to grow in popularity as a means of providing reliable and sustainable energy to communities and businesses, the issue of cybersecurity becomes increasingly important. With the use of digital technology and communication systems, MGs are vulnerable to cyberattacks that can compromise their operation and even cause physical damage. 
  • 1.5K
  • 25 Jun 2023
Topic Review Video Peer Reviewed
The Domestication of Humans
The domestication of humans is not an issue of domesticity but of the effects of the domestication syndrome on a hominin species and its genome. These effects are well expressed in the ‘anatomically modern humans’, in their physiology, behavior, genetic defects, neuropathology, and distinctive neoteny. The physiological differences between modern (gracile) humans and their ancestors, robust Homo sapiens types, are all accounted for by the domestication syndrome. From deductions we can draw about early human behavior, it appears that modifications are attributable to the same cause. The domestication hypothesis ascribes the initiation of the changes to selective breeding introduced by the consistent selection of neotenous features. That would trigger genetic pleiotropy, causing the changes that are observed.
  • 1.5K
  • 31 Jul 2023
Topic Review
Methods to Eliminate Viruses from Lily
Lilies are important crops that are commonly used as cut flowers (Lilium spp.) and edible bulb crops (Lilium davidii var. unicolor). However, virus infections can significantly impact the quantity and quality of lily production. Various methods have been developed to eliminate viruses in lilies, including in vitro culture and virus detection techniques. Meristem culture is the most effective method, which can be combined with other techniques such as thermotherapy and chemotherapy. Nonetheless, virus elimination is affected by several factors, including cultivar, explants used, virus type, and duration of treatments. Efficient diagnostic methods, such as serological and molecular techniques, have been developed to detect viral infections in lilies, including enzyme-linked immunosorbent assay (ELISA) and real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR).
  • 1.5K
  • 07 Aug 2023
Topic Review
Lightning Strike Damage Assessments of Composites
Lightning strike events pose significant challenges to the structural integrity and performance of composite materials, particularly in aerospace, wind turbine blade, and infrastructure applications. 
  • 1.5K
  • 07 Feb 2024
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