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Topic Review
Immune-Mediated Drug-Induced Liver Injury
Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries.
  • 1.5K
  • 12 Oct 2021
Topic Review
Plug-In Electric Vehicles in Canada
The stock of plug-in electric passenger cars in Canada in use totaled 141,060 units at the end of 2019, consisting of 78,680 all-electric cars and 62,380 plug-in hybrids. Sales totaled 50,960 units in 2019. The Chevrolet Volt was the top selling plug-in hybrid, with cumulative sales of 13,619 units through December 2017, and the Tesla Model S was the top selling all-electric car with 6,731 units as of December 2017. Quebec is the regional market leader in Canada, with about 11,000 plug-in electric cars registered (As of September 2016), of which, 55% are plug-in hybrids. Registrations in the province totaled 3,100 units in 2015, representing a market share of 0.7% of new car sales, and 45% of total Canadian plug-in electric car sales that year.
  • 1.5K
  • 09 Nov 2022
Topic Review
Autism and Working Memory
Autism is a variation of neural development diagnosed as impaired social interaction and communication, and by restricted and repetitive behavior. In this article, the word autism is used for referring to the whole range of variations on the autism spectrum, which is not uncommon. Working memory is the system that actively holds multiple pieces of transitory information in the mind, where they can be manipulated. This system has a limited capacity. Working memory is a part of the executive functions (EF), an umbrella term for cognitive processes that regulate, control, and manage other cognitive processes, for instance planning and attention.
  • 1.5K
  • 17 Nov 2022
Topic Review
Galactosemia
Galactosemia is a disorder that affects how the body processes a simple sugar called galactose.
  • 1.5K
  • 23 Dec 2020
Topic Review
Biofilms and Bacterial Recalcitrance
Biofilms are associations of microorganisms embedded in a self-produced extracellular matrix. They create particular environments that confer bacterial tolerance and resistance to antibiotics by different mechanisms that depend upon factors such as biofilm composition, architecture, the stage of biofilm development, and growth conditions. The biofilm structure hinders the penetration of antibiotics and may prevent the accumulation of bactericidal concentrations throughout the entire biofilm. In addition, biofilm can induce a variety of physiological states involving different metabolism (aerobic, microaerobic, and fermentative) and growth rates (fast and slow growth, dormant cells, and persister cells). Thus, some bacteria are less vulnerable to antibiotics as a consequence of the inactivity of antibiotic targets, a phenomenon called “drug indifference”. Also, cells in biofilms enhance efflux-pump production that excretes antibiotics. Moreover, the biofilm environment enhance interbacterial communication, horizontal gene transfer and spontaneous mutations that ultimately increase resistance to antibiotics. Thus, the tolerance and resistance to antibiotics conferred by biofilms is multifactorial.
  • 1.5K
  • 12 Jan 2021
Topic Review
Water-Soluble Organic Aerosols
Water-soluble organic aerosols (OA) are an important component of atmospheric particulate matter and one of the key drivers that impact both climate and human health. Understanding these processes involving water-soluble OA depends on how well the chemical composition of this aerosol component is decoded. Yet, obtaining such a detailed chemical information faces several challenges, of which the complexity of the sample matrix is one of the most demanding issues. A number of different advanced multidimensional analytical techniques are available today with the potential to tackel the complex chemical nature of water-soluble OA, allowing the untargeted profilling of new chemical structures without the need for use of databases or libraries. This critical review is aimed at nonspecialists who are interested in learning more about the potential and impact of such multidimensional non-targeted analytical strategies in water-soluble OA research.
  • 1.5K
  • 19 Mar 2021
Topic Review
Gender Equality in Tanzanite Mine-to-Market
In the mining industry, the contemporary concept of mapping artisanal and small-scale mining to the UN Sustainable Development Goals is a newer aspect of sustainability. SDG 5 aims to achieve gender equality and empower all women and girls. However, while there have been initiatives to support gemstone mining in Tanzania and East Africa, to date, the role of women in the lucrative tanzanite mine-to-market (M2M) supply chain has been less visible and a missed opportunity. This is a concern, as in 2019, pre-COVID-19 pandemic, gemstone and precious metals accounted for an incredible 33.2% of Tanzania’s total exports. In contrast, in leading mining countries such as Australia and Canada, the participation of women continues to steadily advance, economically empowering the women involved.
  • 1.5K
  • 02 Apr 2022
Topic Review
Source and Structure of Exopolysaccharides
Marine microorganisms, as important members of marine organisms, can produce numerous specific active substances in an extreme environment in low temperature, high salt, high pressure, and oligotrophic conditions. They have gained scientific interest due to their potential applications in the pharmaceutical, cosmetic and food industries, for environmental remediation, and astrobiology. The monosaccharide composition, high molecular weight, hydrophobicity and polycharged characteristics of marine Exopolysaccharides (EPS) are involved in their cryoprotective effect, water-holding capacity, and good thermostability. The source and structure  of exopolysaccharides are summarized. 
  • 1.5K
  • 23 Aug 2022
Topic Review
Drikung Kagyu
Drikung Kagyu or Drigung Kagyu (Wylie: 'bri-gung bka'-brgyud) is one of the eight "minor" lineages of the Kagyu school of Tibetan Buddhism. "Major" here refers to those Kagyu lineages founded by the immediate disciples of Gampopa (1079-1153) while "minor" refers to all the lineages founded by disciples of Phagmo Drupa (1110-1170), the main disciple of Gampopa.
  • 1.5K
  • 18 Nov 2022
Topic Review
Development of Schwann Cells
Schwann cells are glial cells of the peripheral nervous system. They exist in several subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are interesting for applications ranging from disease modeling to tissue engineering. Since primary human Schwann cells are challenging to obtain in large quantities, in vitro differentiation from other cell types presents an alternative. To achieve differentiation of Schwann cells from stem cell sources in vitro, cultures are manipulated using molecular factors to emulate developmental signaling events which lead to development of Schwann cells in vivo. Therefore, knowledge of molecular determinants in embryonal development of the Schwann cell fate is key to develop and refine in vitro differentiation protocols.
  • 1.5K
  • 05 Dec 2022
Topic Review
Presentation of Film Deposition Method
The functional layer is an important part of the storage mechanism in lithium-ion batteries, as it helps to improve the performance and stability of the interface and allows for the efficient transfer of ions and electrons. The film deposition techniques are vital for the development of lithium-ion batteries by providing a functional layer at the interface between electrode and electrolyte, which fabricates a solid-state battery with a different approach from the traditional methods.
  • 1.5K
  • 07 Mar 2023
Topic Review
Adsorption Techniques for Lead Removal
The long-term sustainability of the global water supply, with a paramount emphasis on cleanliness and safety, stands as a formidable challenge in modern era. In response to this pressing issue, adsorption techniques have emerged as pivotal and widely recognized solutions for the removal of hazardous pollutants, with a particular emphasis on lead adsorption from wastewater.
  • 1.5K
  • 08 Dec 2023
Topic Review
Television Infrared Observation Satellite
TIROS, or Television InfraRed Observation Satellite, is a series of early weather satellites launched by the United States , beginning with TIROS-1 in 1960. TIROS was the first satellite that was capable of remote sensing of the Earth, enabling scientists to view the Earth from a new perspective: space. The program, promoted by Harry Wexler, proved the usefulness of satellite weather observation, at a time when military reconnaissance satellites were secretly in development or use. TIROS demonstrated at that time that "the key to genius is often simplicity". TIROS is an acronym of "Television InfraRed Observation Satellite" and is also the plural of "tiro" which means "a young soldier, a beginner". Participants in the TIROS project included the National Aeronautics and Space Administration (NASA), United States Army Signal Research and Development Laboratory, Radio Corporation of America (RCA), the United States Weather Bureau Service, the United States Naval Photographic Interpretation Center (NPIC), the Environmental Science Services Administration (ESSA), and the National Oceanic and Atmospheric Administration (NOAA).
  • 1.5K
  • 04 Nov 2022
Topic Review
Notch Signaling
Roles of Notch signaling in human development and cancer are reviewed herein. The four Notch paralogs along with the five Notch ligands are described. Their structures, mode of activation, and functions are briefly summarized based on published works.
  • 1.5K
  • 21 Oct 2020
Topic Review
Cryptococcosis
Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in patients with HIV infection. The current antifungal pharmacological treatment is limited; in addition, the high toxicity, increased resistance rate, and difficulty of the currently available antifungal molecules to cross the blood-brain barrier hamper the treatment. Thus, the search for new alternatives for the treatment of cryptococcosis is extremely necessary. Here we describe the therapeutic strategies currently available and discuss new molecules with antifungal potential in different phases of clinical trials and in the advanced pre-clinical phase.
  • 1.5K
  • 29 Oct 2020
Topic Review
FTO Intronic SNP
Browning of white adipose tissue shifts adipocytes from energy storage white to energy expenditure beige types. The balance between the two adipocyte populations in white adipose tissue is highly determined by noncoding variants of the Fat mass and obesity-associated (FTO) locus which has the strongest association with obesity. The rs1421085 FTO risk allele results in a loss of ARID5B repression of IRX3 and IRX5 which promotes excess white adipocyte formation. Recent studies have revealed the presence of brown adipose tissues at several anatomical sites in humans including the deep-neck (DN).  We found that the characteristic gene expression profile and associated pathways of DN brown adipocytes were determined by partially overlapping effects of tissue site specific commitments of the stem cells, PPARγ stimulation and the FTO status of donors. The presence of FTO rs1421085 risk alleles had a strong influence, manifested during differentiation, on browning resulting in compromised expression of metabolic and mitochondrial genes as well as pathways which are decisive in thermogenesis.
  • 1.5K
  • 30 Oct 2020
Topic Review
Grapevine Cane Extracts
Grapevine canes are viticulture waste that is usually discarded without any further use. However, recent studies have shown that they contain significant concentrations of healthpromoting compounds, such as stilbenes, secondary metabolites of plants produced as a response to biotic and abiotic stress from fungal disease or dryness. Stilbenes have been associated with antioxidant, anti‐inflammatory, and anti‐microbial properties and they have been tested as potential treatments of cardiovascular and neurological diseases, and even cancer, with promising results. Stilbenes have been described in the different genus of the Vitaceae family, the Vitis genera being one of the most widely studied due to its important applications and economic impact around the world. This entry presents an in‐depth study of the composition and concentration of stilbenes in grapevine canes. The results show that the concentration of stilbenes in grapevine canes is highly influenced by the Vitis genus and cultivar aspects (growing conditions, ultraviolet radiation, fungal attack, etc.). Different methods for extracting stilbenes from grapevine canes have been reviewed, and the extraction conditions have also been studied, underlining the advantages and disadvantages of each technique. After the stilbenes were extracted, they were analyzed to determine the stilbene composition and concentration. Analytical techniques have been employed with this aim, in most cases using liquid chromatography, coupled with others such as mass spectrometry and/or nuclear magnetic resonance to achieve the individual quantification. Finally, stilbene extracts may be applied in multiple fields based on their properties. The five most relevant are preservative, antifungal, insecticide, and biostimulant applications. The current state‐of‐the‐art of the above applications and their prospects are discussed.
  • 1.5K
  • 11 Sep 2020
Topic Review
Soil Health
Soil health is the capacity of the soil to provide an environment for optimum growth and development of plants, while also ensuring the health of animals and humans. Animal manure has been used for centuries as a source of nutrients in agriculture. However, many other soil properties that contribute to soil health are affected when manure is applied. Bulk density, aggregate stability, infiltration, water holding capacity, soil fertility, and biological properties are impacted to various degrees with manure application. The goal of this paper was to compile the research findings on the effects of various livestock manure types on soil fertility, soil physical properties, soil biology and the yield of various cereal crops. Specifically, this paper summarizes results for poultry, cattle, and swine manure used in various cropping systems. Although there are conflicting results in the literature with regards to the effect of manure on various soil properties, the literature offers convincing evidence of beneficial impacts of manure on soil and the growth of crops. The degree to which manure affects soil depends on the physical and chemical properties of the manure itself and various management and environmental factors including rate and timing of application, soil type, and climate.
  • 1.5K
  • 16 Nov 2020
Topic Review
Adhesins of Brucella
A central aspect of Brucella pathogenicity is its ability to invade, survive, and replicate in diverse phagocytic and non-phagocytic cell types, leading to chronic infections and chronic inflammatory phenomena. Adhesion to the target cell is a critical first step in the invasion process. Several Brucella adhesins have been shown to mediate adhesion to cells, extracellular matrix components (ECM), or both. These include the sialic acid-binding proteins SP29 and SP41, the BigA and BigB proteins that contain an Ig-like domain, the monomeric autotransporters BmaA, BmaB, and BmaC, the trimeric autotransporters BtaE and BtaF, and Bp26.
  • 1.5K
  • 05 Jan 2021
Topic Review
Bimetallic Ni-Based Catalysts CO2 Methanation
CO2 methanation has recently emerged as a process that targets the reduction in anthropogenic CO2 emissions, via the conversion of CO2 captured from point and mobile sources, as well as H2 produced from renewables into CH4. Ni, among the early transition metals, as well as Ru and Rh, among the noble metals, have been known to be among the most active methanation catalysts, with Ni being favoured due to its low cost and high natural abundance. However, insufficient low-temperature activity, low dispersion and reducibility, as well as nanoparticle sintering are some of the main drawbacks when using Ni-based catalysts. Such problems can be partly overcome via the introduction of a second transition metal (e.g., Fe, Co) or a noble metal (e.g., Ru, Rh, Pt, Pd and Re) in Ni-based catalysts. Through Ni-M alloy formation, or the intricate synergy between two adjacent metallic phases, new high-performing and low-cost methanation catalysts can be obtained.
  • 1.5K
  • 12 May 2021
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