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Topic Review
Microalgae Encapsulation
Microalgae are microorganisms with a singular biochemical composition, including several biologically active compounds with proven pharmacological activities, such as anticancer, antioxidant and anti-inflammatory activities, among others. These properties make microalgae an interesting natural resource to be used as a functional ingredient, as well as in the prevention and treatment of diseases, or cosmetic formulations. Nevertheless, natural bioactives often possess inherent chemical instability and/or poor solubility, which are usually associated with low bioavailability. As such, their industrial potential as a health-promoting substance might be severely compromised. In this context, encapsulation systems are considered as a promising and emerging strategy to overcome these shortcomings due to the presence of a surrounding protective layer.
  • 1.6K
  • 23 Apr 2021
Topic Review
Desiccation Tolerance in Lichens
Lichens are symbiotic associations (holobionts) established between fungi (mycobionts) and certain groups of cyanobacteria or unicellular green algae (photobionts). This symbiotic association has been essential in the colonization of terrestrial dry habitats. Lichens possess key mechanisms involved in desiccation tolerance (DT) that are constitutively present such as high amounts of polyols, LEA proteins, HSPs, a powerful antioxidant system, thylakoidal oligogalactolipids, etc. This strategy allows them to be always ready to survive drastic changes in their water content. However, several studies indicate that at least some protective mechanisms require a minimal time to be induced, such as the induction of the antioxidant system, the activation of non-photochemical quenching including the de-epoxidation of violaxanthin to zeaxanthin, lipid membrane remodeling, changes in the proportions of polyols, ultrastructural changes, marked polysaccharide remodeling of the cell wall, etc. Although DT in lichens is achieved mainly through constitutive mechanisms, the induction of protection mechanisms might allow them to face desiccation stress in a better condition. The proportion and relevance of constitutive and inducible DT mechanisms seem to be related to the ecology at which lichens are adapted to. 
  • 1.6K
  • 05 May 2021
Topic Review
Nonalcoholic Steatohepatitis
Nonalcoholic Steatohepatitis (NASH) may further progress to cirrhosis and end-stage liver disease hepatocellular carcinoma (HCC). NASH-related  HCC is currently the most rapid-growing indication for liver transplant in HCC patients.
  • 1.6K
  • 31 May 2021
Topic Review
Core–Shell Pigments Nanostructure
Uses of novel technologies for improving the durability and lifespan of the construction materials have emerged as viable solutions toward the sustainable future wherein the coating industry plays a significant role in economy growth and better livelihoods. Thus, the continual innovation of various technologies to introduce diverse market products has become indispensable. Properties of materials like color stability under UV, elevated temperatures and aggressive environments, and skid and abrasion resistance are the main challenges faced by commercial coating materials, leading to more demand of natural materials as sustainable agents. Lately, nanostructured core–shell pigments with unique compositions have widely been utilized in composite materials to enhance their properties. Core–shell particles exhibit smart properties and have immense benefits when combined with building materials. 
  • 1.6K
  • 13 Jul 2021
Topic Review
Wastewater Treatment Using Constructed Wetland
Constructed wetlands (CW) is an environmentally friendly technique for removing pollutants from wastewater and has been applied to municipal wastewater, petroleum refinery wastewater, agriculture drainage, acid mine drainage, etc.
  • 1.6K
  • 17 Nov 2021
Topic Review
2D and 3D Echo in Mitral Stenosis
Mitral stenosis is an important cause of heart valve disease globally. Echocardiography is the main imaging modality used to diagnose and assess the severity and hemodynamic consequences of mitral stenosis as well as valve morphology. Transthoracic echocardiography (TTE) is sufficient for the management of most patients.
  • 1.6K
  • 15 Dec 2021
Topic Review
NLRC4 Inflammasome
The NLR family apoptosis inhibitory proteins (NAIP)-NLR family caspase-associated recruitment domain-containing protein 4 (NLRC4) inflammasome is important for mounting an immune response against Gram-negative bacteria. NLRC4 is activated through NAIPs sensing type 3 secretion system (T3SS) proteins from Gram-negative bacteria, such as Salmonella Typhimurium. Mutations in NAIPs and NLRC4 are linked to autoinflammatory disorders in humans.
  • 1.6K
  • 16 May 2022
Topic Review
Quantum Stream Cipher
Quantum cryptography includes quantum key distribution (QKD) and quantum stream cipher, but the researchers point out that the latter is expected as the core technology of next-generation communication systems. Various ideas have been proposed for QKD quantum cryptography, but most of them use a single-photon or similar signal. Then, although such technologies are applicable to special situations, these methods still have several difficulties to provide functions that surpass conventional technologies for social systems in the real environment. Thus, the quantum stream cipher has come to be expected as one promising countermeasure, which artificially creates quantum properties using special modulation techniques based on the macroscopic coherent state. In addition, it has the possibility to provide superior security performance than one-time pad cipher.
  • 1.6K
  • 25 May 2022
Topic Review
Dynamical System (Definition)
The dynamical system concept is a mathematical formalization for any fixed "rule" that describes the time dependence of a point's position in its ambient space. The concept unifies very different types of such "rules" in mathematics: the different choices made for how time is measured and the special properties of the ambient space may give an idea of the vastness of the class of objects described by this concept. Time can be measured by integers, by real or complex numbers or can be a more general algebraic object, losing the memory of its physical origin, and the ambient space may be simply a set, without the need of a smooth space-time structure defined on it.
  • 1.6K
  • 10 Oct 2022
Topic Review
Neural Circuit
A neural circuit, is a population of neurons interconnected by synapses to carry out a specific function when activated. Neural circuits interconnect to one another to form large scale brain networks. Biological neural networks have inspired the design of artificial neural networks.
  • 1.6K
  • 19 Oct 2022
Topic Review
Harsh Physical Discipline and Externalizing Behaviors in Children
There is growing debate in the parenting literature as to whether using physical punishment to discipline children is an effective strategy or leads to the development of aggressive behaviors and other antisocial attributes. Research suggests that the use of harsh physical punishment in children is associated with increases in externalizing behaviors over time. This classification of behaviors can be characterized by outward expressions that reflect negatively on a child’s external environment and can be a major risk factor for aggression, delinquency, antisocial behavior and conduct problems.
  • 1.6K
  • 15 Nov 2022
Topic Review
Shavit
Shavit (Hebrew: "comet" – שביט) is a small lift launch vehicle produced by Israel from 1982 onwards, to launch satellites into orbit. It was first launched on September 19, 1988 (carrying an Ofeq satellite payload), making Israel the eighth nation to have an orbital launch capability after the USSR, United States , France , Japan , People’s Republic of China, United Kingdom , and India . The Shavit project is believed to have been an offshoot development, resulting from Israel's Jericho nuclear armed intercontinental ballistic missile program. Shavit rockets are launched from Palmachim Airbase by the Israel Space Agency into highly retrograde orbits over the Mediterranean Sea to prevent debris coming down in populated areas and also to avoid flying over nations hostile to Israel to the east; this results in a lower payload-to-orbit than east-directed launches would allow. The launcher consists of three stages powered by solid-fuel rocket motors, with an optional liquid-fuel fourth stage, and is manufactured by IAI. The Republic of South Africa produced and tested a licensed version in cooperation with Israel called the RSA-3 in an ultimately unsuccessful bid to produce a domestic satellite launch vehicle and ballistic missile; the South African program was closed in 1994. An earlier unrelated project called Shavit 2 was the first Israeli sounding rocket, launched on 5 July 1961 for meteorological research. Shavit Three, with an altitude reported as 100 miles, was launched on 11 August 1961.
  • 1.6K
  • 28 Nov 2022
Topic Review
mTORC1-Autophagy Axis for Skeletal Muscle Diseases
The mechanistic target of rapamycin (mTOR) complex 1, mTORC1, integrates nutrient and growth factor signals with cellular responses and plays critical roles in regulating cell growth, proliferation, and lifespan. mTORC1 signaling has been reported as a central regulator of autophagy by modulating almost all aspects of the autophagic process, including initiation, expansion, and termination. An increasing number of studies suggest that mTORC1 and autophagy are critical for the physiological function of skeletal muscle and are involved in diverse muscle diseases.
  • 1.6K
  • 29 Dec 2022
Topic Review
Health, Hope, and Harmony
Myriad determinants of happiness were found that were placed into three broad categories labeled Health, Hope, and Harmony. The predominant happiness determinants were mental, emotional, and physical well-being, a purposeful holistic work–life balance, nurturing social relationships, caring for self and others, and being in harmony with one’s culture, traditions, community, religion, and environment.
  • 1.6K
  • 15 Mar 2023
Topic Review
Implementation of Soil and Water Conservation in Indonesia
Soil and water are natural resources that support the life of various creatures on Earth, including humans. The main problem, so far, is that both resources can be easily damaged or degraded by human-induced drivers. The threat of damage or degradation is increasing due to rapid human population growth and humans’ insatiable daily necessities.
  • 1.6K
  • 13 Jul 2023
Topic Review
Toll-like Receptor 2 in Pro- and Anti-Inflammatory Processes
While a certain level of inflammation is critical for humans to survive infection and injury, a prolonged inflammatory response can have fatal consequences. Pattern recognition Toll-like receptors (TLRs) are key players in the initiation of an inflammatory process. TLR2 is one of the most studied pattern recognition receptors (PRRs) and is known to form heterodimers with either TLR1, TLR4, TLR6, and TLR10, allowing it to recognize a wide range of pathogens.
  • 1.6K
  • 17 Aug 2023
Topic Review
ALS-Specific GWAS Challenges
Amyotrophic Lateral Sclerosis (ALS) is the most common late-onset motor neuron disorder, but our current knowledge of the molecular mechanisms and pathways underlying this disease remains elusive. Genome-Wide Association Studies (GWAS) aim to identify Single Nucleotide Polymorphisms (SNPs) and other types of genetic variation that are more frequent in patients than in people without the disease, using a variety of statistical tests. Despite the rapid recent technological advances and great efforts in the GWAS field that have led to the genomic profiling of large ALS cohorts, the identified associations have been able to explain only a very small fraction of the ALS heritability and aetiology. Here, we outline ALS-Specific GWAS Challenges, explaining the limitations of traditional GWAS analyses, considering known features of the ALS genetic architecture and hypotheses about ALS pathology (e.g., multilocus interactions, rare variations with low effect size). Future advances in the genomic and machine learning fields may bring about a better understanding of ALS genetic architecture and enable improved personalized approaches to this and other devastating and complex diseases.
  • 1.6K
  • 01 Dec 2021
Topic Review
Airborne Wind Energy Systems
Because of the near-term risk of extreme weather events and other adverse consequences from climate change and, at least in the longer term, global fossil fuel depletion, there is worldwide interest in shifting to noncarbon energy sources, especially renewable energy (RE). Because of possible limitations on conventional renewable energy sources, researchers have looked for ways of overcoming these shortcomings by introducing radically new energy technologies. For wind energy, a possible alternative is airborne wind turbines.
  • 1.6K
  • 14 Jan 2021
Topic Review
Aptamer Sensors
Recently, aptamers have attracted attention in the biosensing field as signal recognition elements because of their high binding affinity toward specific targets such as proteins, cells, small molecules, and even metal ions. Aptamers have intrinsic advantages, such as their availability for both chemical modifications and conjugation with different labels, facilitating their ability to be used to construct a sensitive and highly selective platform sensor. Aptamers can be easily functionalized and engineered, providing several signaling modes such as colorimetric, fluorometric, and electrochemical, in what is known as aptasensors.
  • 1.6K
  • 17 Jun 2021
Topic Review
Abscisic Acid-Mediated Drought Stress
Drought is one of the major constraints to rain-fed agricultural production, especially under climate change conditions. Plants evolved an array of adaptive strategies that perceive stress stimuli and respond to these stress signals through specific mechanisms. Abscisic acid (ABA) is a premier signal for plants to respond to drought and plays a critical role in plant growth and development. 
  • 1.6K
  • 25 Jan 2022
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