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Waseem, M. Abscisic Acid-Mediated Drought Stress. Encyclopedia. Available online: https://encyclopedia.pub/entry/18742 (accessed on 19 May 2024).
Waseem M. Abscisic Acid-Mediated Drought Stress. Encyclopedia. Available at: https://encyclopedia.pub/entry/18742. Accessed May 19, 2024.
Waseem, Muhammad. "Abscisic Acid-Mediated Drought Stress" Encyclopedia, https://encyclopedia.pub/entry/18742 (accessed May 19, 2024).
Waseem, M. (2022, January 25). Abscisic Acid-Mediated Drought Stress. In Encyclopedia. https://encyclopedia.pub/entry/18742
Waseem, Muhammad. "Abscisic Acid-Mediated Drought Stress." Encyclopedia. Web. 25 January, 2022.
Abscisic Acid-Mediated Drought Stress
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This entry is adapted from the peer-reviewed paper 10.3390/ijms23031084

Drought is one of the major constraints to rain-fed agricultural production, especially under climate change conditions. Plants evolved an array of adaptive strategies that perceive stress stimuli and respond to these stress signals through specific mechanisms. Abscisic acid (ABA) is a premier signal for plants to respond to drought and plays a critical role in plant growth and development. 

ABA drought metabolites signaling

1. Introduction

Drought stress reduces soil water content which restricts water uptake by the plant root thereby limiting plant growth and productivity [1]. Plants have evolved a wide range of morpho-physiological, metabolic, and molecular mechanisms to resist long- or short-term responses to drought stress [2]. Phytohormones are important plant growth regulators and mediators of environmental stresses such as drought which adversely influence crop yield and pose threats to global food security [2]. To cope with drought stress, potent and novel approaches should be introduced, and phytohormone engineering could be a method of choice for sustainable crop production and breeding programs. In the last decade, the interest to understand the spatiotemporal changes of ABA to modulate plant responses is growing [3]. Abscisic acid (ABA) is critical for plant development and can redesign various physiological and biochemical signal transduction cascades in plants to cope with environmental stresses particularly drought [4][5]. Additionally, ABA plays a critical role in biomolecules biosynthesis, senescence, seed germination, stomatal closure, and root architecture modification [6][7].
ABA is classified as an isoprenoid molecule, synthesized from carotenoids (C40) derivative of isopentenyl diphosphate (IPP) through the methylerythritol phosphate (MEP) pathway in plastids [8]. The synthesis of ABA undergoes a series of steps, and each step is catalyzed by a specific enzyme. The conversion of zeaxanthin to all trans-violaxanthin is the first step in ABA biosynthesis occurring in the plastid. This cyclic hydroxylation of epoxycarotenoids to all-xanthin is catalyzed by zeaxanthin epoxidase (ZEP) through an intermediate antheraxanthin. In the next step, cis-isomerization of all trans-violaxanthin to violaxanthin or cisneoxanthin through an unknown enzymatic reaction. After that, 9-cis-epoxycarotenoid dioxygenase (NCED) enzymes split the cis-isomers of violaxanthin and neoxanthin to generate a C15 intermediate product called xanthoxin, finally exported to cytosol. In the cytosol, xanthoxin is converted into ABA through two enzymatic reactions. Next, xanthoxin is first converted to an abscisic aldehyde catalyzed by short-chain alcohol dehydrogenase/reductase (SDR). Finally, the oxidation of abscisic aldehyde to ABA by aldehyde oxidase (AAO) (Figure 1a) [9].
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Figure 1. ABA biosynthesis and ABA-mediated drought-responsive pathways in plants. (a) Scheme of ABA biosynthesis. The precursors of ABA, β-carotene undergoes a series of oxidative reactions in the plastids and each step is catalyzed by specific enzyme such as ZEP (zeaxanthin epoxidase) or NCED (9-cis-epoxycarotenoid dioxygenase). The derived xanthoxin is exported to the cytosol and converted into ABA through an oxidation reaction mediated by AAO (aldehyde oxidase) and SDR (alcohol dehydrogenase/reductase), (b) ABA-dependent and -independent signaling pathways in the plant, which consists of several core components including ABA receptors and regulators. The ABA-dependent and -independent pathways are indicated by black and red arrows, respectively. Transcription factors (TFs) include bZIPs, MYB/MYC2, NAC (RD26), and WRKY bind to their corresponding cis-acting elements W-box, ABRE, MYB, MYC, DREB2, AREB/ABF, and NACRs.
Plants show a significant increase in ABA levels under drought stress, changes in expression of genes, and induction of ABA biosynthesis enzymes corresponding to mRNA level lead to enhanced ABA accumulation [10]. The transcript abundances of several ABA biosynthesis genes, such as ZEP/ABA1, AAO3, 9-cis-epoxycarotenoid dioxygenase (NCED3), and molybdenum cofactor sulfurase (MCSU/LOS5/ABA3), has been upregulated through an ABA-dependent or ABA-independent pathway [11] assisted by binding factors such as ABF, MYC MYB, NAC, ERF, bZIP, and DREB/CBF transcription factors (TFs) (Figure 1b) [12].
ABA is a prime mediator of drought [13] and plays an important role in regulating plant growth, development, and responses to several environmental stresses [14]. Under drought conditions, ABA-mediated stomatal conductance prevents transpiration water loss [10]. Zhang et al. [15] found that multidrug and toxic compound extrusion (MATE) transporter family, detoxification efflux carrier (AtDTX50), participate in ABA transport. ABA receptors such as PYRABACTIN RESISTANCE (PYR), or regulatory component of ABA receptor (RCAR) enhanced ABA responses and confer drought tolerance in Arabidopsis [16]. Similarly, ABA responsive-element binding protein (ABP9) a member of the bZIP family (Figure 1) improves photosynthetic capacity under drought [17]. Histone acetylation has been reported to be critical in ABA-mediated gene regulation to acclimatize plants to drought [18]. It has been shown that mitogen-activated protein kinase (MAPK) signaling cascade plays a critical role in ABA-mediated drought regulation at transcription and proteome level in various plant species including rice, maize, and Arabidopsis [19][20]. Altogether, ABA is a pivotal hormone governing plant responses to drought through complex molecular signaling mechanisms. Therefore, exploration of ABA regulators could assist in developing drought-tolerant crops through breeding programs.

2. ABA: A Key Player under Drought

Abscisic acid is of prime importance due to its stress-related responses and its involvement in various plant growth processes, making it possible to adapt to drought conditions. Upon drought stress, ABA-mediated stomatal closure reduces water loss by decreasing transpiration rate. Moreover, ABA progressively increases hydraulic conductivity and stimulates root cell elongation, enabling plants recovery from water-limited conditions [21]. Recent advancements in plant genomics accelerated the identification and functional characterization of ABA-dependent candidate genes responsive to drought. For instance, Zhang et al. [15] found that the MATE transporter gene, AtDTX50, is involved in ABA efflux, while mutants of dtx50 show enhanced tolerance to drought with reduced stomatal conductance relative to WT plants. It is widely acknowledged that ABA binds to pyrabactin-resistance 1/pyrabactin resistance like/regulatory component of aba receptor (PYR/PYL/RCAR) receptors, the initial step of the core ABA signaling pathway, concerning previously characterized protein phosphatases 2C (PP2Cs) and sucrose nonfermenting related kinases 2 (SnRK2s) (Figure 1b) [22][23][24]. The PYR/PYL/RCAR) proteins are reported to be involved in improving drought tolerance in many species such as Arabidopsis, tomato, and rice [25][26][27][28].
ABA has also been reported to regulate calcium-dependent protein kinases (CPK) signaling by inducing CPK6 expression under drought stress. CPKs interact and phosphorylates some core ABA-related TFs, ABFs/AREBs (ABA-responsive element-binding factors) enhancing their transcriptional activities [29]. Similarly, transgenic plants overexpressing ZEP confers tolerance to stresses such as drought [30]. Overexpression of OsbZIP72 showed increased expression of ABA-responsive gene LEAs (late embryogenesis abundant genes) and improved drought resistance in rice, which may be useful for the engineering of drought-resilient crops [31]. Arabidopsis plants overexpressing ABCG25 showed reduced water loss under drought by limiting evapotranspiration. Likewise, mutants of AtABCG40 exhibited more sensitivity to drought [32], indicating the prime importance of ABA-related genes in regulating ABA responses to drought conditions.
The ABA hormone has mainly been associated with the regulation of water deficiency in plants. A plethora of studies have shown the critical roles of ABA in regulating genes expression, proteins, and enzymatic activities involved in plant cell dehydration tolerance [33][34]. For instance, the ABA levels were exponentially elevated in Arabidopsis, wheat, rice, tomato, soybean, maize, and sesame under drought [35][36]. Similarly, Wang et al. [37] and Baek et al. [38] demonstrated how multiple genes regulate ABA-mediated drought responses in Arabidopsis, Vigna. radiata, and V. angularis. These findings suggest that ABA-mediated drought tolerance is required for plants to fully respond to drought stress.

3. ABA-Mediated Drought Responses through Physio-Biochemical Alteration

Plants have evolved distinct adaptive mechanisms to survive and minimize the adverse effect of drought stress [39]. Reactive oxygen species (ROS) serve as a signal molecule that regulates plant responses to stresses. Upon drought, plants synthesize an array of secondary metabolites (SMs) assisting plant survival [40]. ABA is able to synchronize a wide range of functions in plants, facilitating to overcome drought stress [4]. Therefore, to tackle water limitations, dynamic and novel strategies should be formulated and engineered including ROS and SMs as an adaptive strategy to maintain plant growth and productivity.

3.1. ROS Scavenging System

Drought and ABA have an intricate relationship [41] that triggers various downstream responses to plant assisting adaption to drought in an ABA-dependent manner [14]. Drought may alter the metabolic and cellular redox status of plants that influence the cellular susceptibility to ABA accumulation [42] suggested the link between metabolic status and ABA signaling [43]. ABA is an indicator of soil water deficit and endogenous ABA concentration rapidly increases to initiate stomatal closure in the plant [44]. Previous studies have also been demonstrated that drought escape induced by water stress depends on ABA. For instance, ABA could improve the plant ability to scavenge ROS by activating antioxidant enzymes [45] such as SOD (superoxide dismutase), POD (peroxidase), CAT (catalase), APX (ascorbate peroxidase), and GR (glutathione reductase) in wheat seedlings under drought, thus regulating the osmotic adjustment, reducing oxidative damage, and improving the conductivity of roots by inducing aquaporin gene expression [45][46][47]. Kwak et al. [48] showed that ABA activates H2O2 biosynthesis in stomata guard cells via a membrane-bound NADPH oxidase causing stomata closure by activating plasma membrane Ca2+ channels [49].

3.2. Primary Metabolism

Land plants synthesize diverse primary metabolites (PMs) having higher medicinal and nutritional value which are essential for survival [50]. In general, PMs function in protein–disulfide linkage, redox regulation, methylation reactions, including DNA methylation, mRNA capping, synthesis of phosphatidylcholine, and synthesis of polyamines [51]. Primary metabolites and their associated metabolic genes are considered pivotal factors that contribute to drought tolerance via the involvement of different metabolic pathways [52]. To date, in planta, an estimate of 200,000 metabolites are reported [53]. Among those carbohydrates, nucleosides/nucleotides, and sulfur-containing metabolites were mainly induced by ABA [54]. The major pathways responsible for PMs are glycolysis, the TCA cycle, pentose phosphate pathway, shikimate pathway, aliphatic, and aromatic amino acids which produce secondary metabolites (SMs). Abscisic acid is tightly associated with changes in water availability to fine-tune plant growth [55][56][57][58][59][60] acting as a signaling molecule for plants to adjust their metabolism and growth in response to drought stress [55].
A. thaliana and Camelina sativa ABA-inducible WSD1 (Wax synthase/acyl-CoA:diacylglycerol acyltransferase) enhanced drought tolerance through leaf and stem wax loading and epicuticular wax accumulation [61]. Canola crop is sensitive to drought, which leads to severe yield losses. However, understanding the genetic basis of ABA-mediated drought tolerance will pave the way to engineering crops with improved drought resistance. Recently, the application of Omics approaches identified various ABA-induced and suppressed proteins involved in metabolism, photosynthesis, protein synthesis, membrane transport processes, protein folding/transport and degradation, and stress/defense responsiveness [62]. This finding suggests that various ABA-induced and suppressed metabolites were used as indicators in improving our knowledge of ABA signaling to drought tolerance.

3.3. Secondary Metabolites

Plants are surrounded by a complex set of environmental stresses and respond equally to them. Plant metabolites are sensitive to changing environments such as drought [63]. The metabolic profiles of plants have been analyzed to predict their role under drought [64][65]. Plants have adapted two distinct strategies including osmotic adjustment [66] and accumulation of specialized secondary metabolites [67] to mitigate drought responses [68]. It has been shown that metabolites such as phenolic compounds, proline, glycine-betaine, soluble sugars, and other compatible solutes accumulated by plants during stress responses. These metabolites maintain water potential, cell turgor maintenance, osmotic adjustment, survival, stabilize proteins and membrane lipid bilayer structures under drought assisting to retain normal physiological processes (Figure 2) [66]. On the other hand, secondary metabolites act as scavengers of free radicals to mitigate oxidative stress in plants under drought stress.
Ijms 23 01084 g002 550
Figure 2. Metabolites and their functions in drought stress tolerance. Drought-induced accumulation of compatible solutes such as sugars, flavonoids, and amino acids for osmotic adjustment, free radical (ROS) scavenging to mitigate drought stress in plants. Genes involved in this metabolite biosynthesis against drought stress are useful in the metabolic engineering of drought resistance.
Metabolic profiling revealed ABA-inducible metabolic networks in response to drought which encourages the accumulation of dehydration-inducible branched-chain amino acids, and key dehydration-inducible genes such as lysine ketoglutarate reductase/saccharopine dehydrogenase (AtLKR/SDH), branch-chain aminotransferase (AtBCAT2), arginine decarboxylase, and delta 1-pyrroline-5-carboxylase (P5CS) [69]. For instance, the accumulation of most amino acids such as tryptophan, glutamine, alanine, proline, aspartate, leucine, isoleucine, ornithine, valine, citric acid cycle precursors including cis-aconitate, succinate, and 2-oxoglutarate; flavonoids such as cyanidin and quercetin; and lipids such as acylated sterylglycosides and glycosyl inositol phosphoceramides were increased under drought in Arabidopsis [70][71][72] and a few crop plants, such as maize, barley, and rice [73][74][75]. In maize, ZmPIS, a phosphatidylinositol synthase, efficiently improved drought tolerance by altering membrane lipid composition and ABA biosynthesis [76]. Overexpression of ABF3 in Glycine max significantly altered various primary and secondary metabolites such as glycerophospholipids, glycolipids, fatty acyls, prenol-lipids, and their derivatives [77].

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Subjects: Agriculture, Dairy & Animal Science
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MUHAMMAD WASEEM
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