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Topic Review
ALS-Specific GWAS Challenges
Amyotrophic Lateral Sclerosis (ALS) is the most common late-onset motor neuron disorder, but our current knowledge of the molecular mechanisms and pathways underlying this disease remains elusive. Genome-Wide Association Studies (GWAS) aim to identify Single Nucleotide Polymorphisms (SNPs) and other types of genetic variation that are more frequent in patients than in people without the disease, using a variety of statistical tests. Despite the rapid recent technological advances and great efforts in the GWAS field that have led to the genomic profiling of large ALS cohorts, the identified associations have been able to explain only a very small fraction of the ALS heritability and aetiology. Here, we outline ALS-Specific GWAS Challenges, explaining the limitations of traditional GWAS analyses, considering known features of the ALS genetic architecture and hypotheses about ALS pathology (e.g., multilocus interactions, rare variations with low effect size). Future advances in the genomic and machine learning fields may bring about a better understanding of ALS genetic architecture and enable improved personalized approaches to this and other devastating and complex diseases.
  • 1.6K
  • 01 Dec 2021
Topic Review
Ursolic and Oleanolic Acids
Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in the plant defence system against water loss and pathogens. Nowadays these triterpenoids are also regarded as potential pharmaceutical compounds, compounds or triterpenoid-enriched plant extracts exert various beneficial effects, including anti-oxidative, anti-inflammatory and anticancer, on model systems of both human or animal origin. Some of those effects have been linked to the ability of ursolic and oleanolic acids to modulate intracellular antioxidant systems and also inflammation and cell death-related pathways.
  • 1.6K
  • 07 May 2021
Topic Review
Heat Stress on Rabbit Production
Heat stress is a major environmental stress that causes substantial economic loss in the rabbit industry. Compared to other agricultural animals, rabbits are more sensitive to heat stress as they have fewer sweat glands and a thicker coat of fur, increasing the heat dissipation complexity.
  • 1.6K
  • 20 Jul 2023
Topic Review
Pharmacology of Cynomorium songaricum
Cynomorium songaricum Rupr. (CSR) belongs to the family Cynomoriaceae. It is a perennial succulent parasitic herb with a reddish-brown coloration, predominantly submerged in sand and lacking chlorophyll. 
  • 1.6K
  • 06 Mar 2024
Topic Review
Health, Hope, and Harmony
Myriad determinants of happiness were found that were placed into three broad categories labeled Health, Hope, and Harmony. The predominant happiness determinants were mental, emotional, and physical well-being, a purposeful holistic work–life balance, nurturing social relationships, caring for self and others, and being in harmony with one’s culture, traditions, community, religion, and environment.
  • 1.6K
  • 15 Mar 2023
Topic Review
Probiotics and Synbiotics on Hirsutism
Probiotics and synbiotics are known to have beneficial effects on human health and disease. Hirsutism, a disorder that is characterised by the presence of coarse terminal hairs in a male-like pattern, is usually caused by elevated androgen levels in blood plasma. This disorder is usually ob-served in PCOS women and it is linked to insulin resistance (IR). Although idiopathic hirsutism (IH) is not shown to have excess androgen production from the ovarian and adrenal glands, in-creased 5α-reductase in peripheral tissues and insulin resistance are common observations.
  • 1.6K
  • 27 Jan 2021
Topic Review
Genus Mentha
Mint (Mentha species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-obesity, antimicrobial, anti-inflammatory, anti-diabetic, and cardioprotective effects, as a result of its antioxidant potential, combined with low toxicity and high efficacy. Mentha species are widely used in savory dishes, food, beverages, and confectionary products. Phytochemicals derived from mint also showed anticancer activity against different types of human cancers such as cervix, lung, breast and many others. Mint essential oils show a great cytotoxicity potential, by modulating MAPK and PI3k/Akt pathways; they also induce apoptosis, suppress invasion and migration potential of cancer cells lines along with cell cycle arrest, upregulation of Bax and p53 genes, modulation of TNF, IL-6, IFN-γ, IL-8, and induction of senescence phenotype. Essential oils from mint have also been found to exert antibacterial activities against Bacillus subtilis, Streptococcus aureus, Pseudomonas aeruginosa, and many others.
  • 1.6K
  • 18 Mar 2021
Topic Review
Microalgae Encapsulation
Microalgae are microorganisms with a singular biochemical composition, including several biologically active compounds with proven pharmacological activities, such as anticancer, antioxidant and anti-inflammatory activities, among others. These properties make microalgae an interesting natural resource to be used as a functional ingredient, as well as in the prevention and treatment of diseases, or cosmetic formulations. Nevertheless, natural bioactives often possess inherent chemical instability and/or poor solubility, which are usually associated with low bioavailability. As such, their industrial potential as a health-promoting substance might be severely compromised. In this context, encapsulation systems are considered as a promising and emerging strategy to overcome these shortcomings due to the presence of a surrounding protective layer.
  • 1.6K
  • 23 Apr 2021
Topic Review
Machine Learning and Vegetable Science
Along with essential nutrients and trace elements, vegetables provide raw materials for the food processing industry. Despite this, plant diseases and unfavorable weather patterns continue to threaten the delicate balance between vegetable production and consumption. It is critical to utilize machine learning (ML) in this setting because it provides context for decision-making related to breeding goals. 
  • 1.6K
  • 29 Jan 2022
Topic Review
Wastewater Treatment Using Constructed Wetland
Constructed wetlands (CW) is an environmentally friendly technique for removing pollutants from wastewater and has been applied to municipal wastewater, petroleum refinery wastewater, agriculture drainage, acid mine drainage, etc.
  • 1.6K
  • 17 Nov 2021
Topic Review
Deno
Deno is a runtime for JavaScript, TypeScript, and WebAssembly that is based on the V8 JavaScript engine and the Rust programming language. Deno was co-created by Ryan Dahl, who also created Node.js. Deno explicitly takes on the role of both runtime and package manager within a single executable, rather than requiring a separate package-management program.
  • 1.6K
  • 19 Oct 2022
Topic Review
Apache Wave
Apache Wave was a software framework for real-time collaborative editing online. Google originally developed it as Google Wave. It was announced at the Google I/O conference on May 27, 2009. Wave is a web-based computing platform and communications protocol designed to merge key features of communications media such as email, instant messaging, wikis, and social networking. Communications using the system can be synchronous or asynchronous. Software extensions provide contextual spelling and grammar checking, automated language translation and other features. Initially released only to developers, a preview release of Google Wave was extended to 100,000 users in September 2009, each allowed to invite additional users. Google accepted most requests submitted starting November 29, 2009, soon after the September extended release of the technical preview. On May 19, 2010, it was released to the general public. On August 4, 2010, Google announced the suspension of stand-alone Wave development and the intent of maintaining the web site at least for the remainder of the year, and on November 22, 2011, announced that existing Waves would become read-only in January 2012 and all Waves would be deleted in April 2012. Development was handed over to the Apache Software Foundation which started to develop a server-based product called Wave in a Box. It was retired in January 2018.
  • 1.6K
  • 24 Oct 2022
Topic Review
Domestic Refrigerators in Smart Grids
Domestic refrigeration and freezing appliances can be used for electrical load shifting from peak to off-peak demand periods, thus allowing greater penetration of renewable energy sources (RES) and significantly contributing to the reduction of CO2 emissions. The full realization of this potential can be achieved with the synergistic combination of smart grid (SG) technologies and the application of phase-change materials (PCMs). Being permanently online, these ubiquitous appliances are available for the most advanced strategies of demand-side load management (DSLM), including real-time demand response (DR) and direct load control (DLC).
  • 1.6K
  • 27 Oct 2022
Topic Review
Enchroma
EnChroma lenses are glasses designed to improve and modify some aspects of color vision deficiency for color blind people. The glasses were invented by Dr. Donald McPherson in 2002. Wearing the glasses results in subtle differences when color blind people look longer and more carefully.
  • 1.6K
  • 17 Nov 2022
Topic Review
Shavit
Shavit (Hebrew: "comet" – שביט) is a small lift launch vehicle produced by Israel from 1982 onwards, to launch satellites into orbit. It was first launched on September 19, 1988 (carrying an Ofeq satellite payload), making Israel the eighth nation to have an orbital launch capability after the USSR, United States , France , Japan , People’s Republic of China, United Kingdom , and India . The Shavit project is believed to have been an offshoot development, resulting from Israel's Jericho nuclear armed intercontinental ballistic missile program. Shavit rockets are launched from Palmachim Airbase by the Israel Space Agency into highly retrograde orbits over the Mediterranean Sea to prevent debris coming down in populated areas and also to avoid flying over nations hostile to Israel to the east; this results in a lower payload-to-orbit than east-directed launches would allow. The launcher consists of three stages powered by solid-fuel rocket motors, with an optional liquid-fuel fourth stage, and is manufactured by IAI. The Republic of South Africa produced and tested a licensed version in cooperation with Israel called the RSA-3 in an ultimately unsuccessful bid to produce a domestic satellite launch vehicle and ballistic missile; the South African program was closed in 1994. An earlier unrelated project called Shavit 2 was the first Israeli sounding rocket, launched on 5 July 1961 for meteorological research. Shavit Three, with an altitude reported as 100 miles, was launched on 11 August 1961.
  • 1.6K
  • 28 Nov 2022
Topic Review
Effects of Whole-Cell and Acellular Pertussis Vaccines
After the pertussis vaccine had been introduced in the 1940s and was shown to be very successful in reducing the morbidity and mortality associated with the disease, the possibility of improving both vaccine composition and vaccination schedules has become the subject of continuous interest.
  • 1.6K
  • 13 Jan 2023
Topic Review
Hybrid Nanostructured Materials as Energy Storage Devices
Hybrid nanostructured materials composed of transition metal oxides/hydroxides, metal chalcogenides, metal carbides, metal–organic frameworks, carbonaceous compounds and polymer-based porous materials have been used as electrodes for designing energy storage systems such as batteries, supercapacitors (SCs), and so on.  Available energy storage devices can be classified into various types; for example, based on storage duration, there are three types: short-, mid-, and long-term. Depending on their reaction time, they are considered to be either rapid or slow. According to their storage capacity, they can be classified as small-, medium-, or large-scale. There are many techniques for the storage of various types of energies, including electrical, mechanical, chemical, and thermal. Moreover, based on the precise needs and applications, storage technologies have different technical and economic criteria.
  • 1.6K
  • 15 May 2023
Topic Review
Implementation of Soil and Water Conservation in Indonesia
Soil and water are natural resources that support the life of various creatures on Earth, including humans. The main problem, so far, is that both resources can be easily damaged or degraded by human-induced drivers. The threat of damage or degradation is increasing due to rapid human population growth and humans’ insatiable daily necessities.
  • 1.6K
  • 13 Jul 2023
Topic Review
Hypertension, Anxiety and Obstructive Sleep Apnea
Increased anxiety in these conditions may be linked to a high-salt diet through stimulation of the sympathetic nervous system, which increases blood pressure while releasing catecholamines, causing a “fight or flight” response. A rostral shift of fluid overload from the lower to the upper body occurs in obstructive sleep apnea associated with COVID-19 and cardiovascular disease, and may be related to sodium and fluid retention triggered by hypertonic dehydration. Chronic activation of the renin-angiotensin-aldosterone system responds to salt-induced dehydration by increasing reabsorption of sodium and fluid, potentially exacerbating fluid overload. Anxiety may also be related to angiotensin II that stimulates the sympathetic nervous system to release catecholamines. 
  • 1.6K
  • 14 Mar 2024
Topic Review
Clonal Hematopoiesis in Liquid Biopsy
       Clonal hematopoiesis (CH), a process that involves the accumulation of somatic mutations in hematopoietic stem cells which leads to clonal expansion of mutations in blood cells, may account for the non-tumor derived mutations detected from plasma. These CH mutations may act as a biological noise to cfDNA analysis and complicate the interpretation of mutations detected from liquid biopsy.
  • 1.6K
  • 26 Aug 2020
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