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Topic Review
Osteoclast Multinucleation
       Osteoclasts  are derived from hemopoietic progenitors of the monocyte-macrophage lineage. They differentiate upon exposure to macrophage colony stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL), which are presented by osteoblasts and osteocytesare. Multinucleation in a late phase of osteoclastogenesis is a hallmark of osteoclast maturation. The unique and dynamic multinucleation process not only increases cell size but causes functional alterations through reconstruction of the cytoskeleton, creating the actin ring and ruffled border that enable efficient bone resorption.  The process of osteoclast multinucleation is dynamic, complicated and finely controlled by multiple entangled factors. At the beginning of the 21st century, two master fusogens, DC-STAMP and OC-STAMP, had been identified that directly regulate osteoclast multinucleation.
  • 1.6K
  • 17 Aug 2020
Topic Review
Cardoon
Cardoon, Cynara cardunculus L., is a perennial plant belonging to the family Asteraceae, which is native to the Mediterranean area. Cardoon, also known as artichoke thistle, is a complex species comprising three botanical varieties: the globe artichoke (var. scolymus (L.) Fiori), the cultivated cardoon (var. altilis DC.), and the wild cardoon (var. sylvestris (Lamk) Fiori). Cardoon is commonly used in the preparation of salads and soup dishes, production of energy and its flowers are used as vegetal rennet in cheese making. Cardoon leaves and stems, main by-products, are rich in bioactive compounds with important health benefits.
  • 1.6K
  • 08 Dec 2020
Topic Review
Microglia
Microglia, the innate immune cells of the brain, are commonly perceived as resident macrophages of the central nervous system (CNS). This definition, however, requires further specification, as under healthy homeostatic conditions, neither morphological nor functional properties of microglia mirror those of classical macrophages.
  • 1.6K
  • 04 Feb 2021
Topic Review
Rabbit Sperm Cryopreservation
Sperm cryopreservation is one of the most efficient ways to preserve rabbit strains because it is easy to collect ejaculate repeatedly from a single male and inseminate artificially into multiple females. During the cooling, freezing and thawing process of sperms, the plasma membrane, cytoplasm and genome structures could be damaged by osmotic stress, cold shock, intracellular ice crystal formation, and excessive production of reactive oxygen species.
  • 1.6K
  • 07 May 2021
Topic Review
Order-Picking System
Companies have been trying continuously to reduce their logistics costs in the current competitive markets. Warehouses are important components of the logistics systems and they must be managed effectively and efficiently to reduce the production cost as well as maintain customer satisfaction. Order-picking is the core of warehouse operations and an order-picking system (OPS) is essential to meet customer needs and orders. Failure to perform the OPS process properly results in high costs and customer dissatisfaction. 
  • 1.6K
  • 13 Dec 2021
Topic Review
Electrospun Polymer Nanofibers in Photocatalytic Hybrid Materials
A wide variety of materials, strategies, and methods have been proposed to face the challenge of wastewater pollution. The most innovative and promising approaches include the hybrid materials made of polymeric nanofibers and photocatalytic nanoparticles. Electrospun nanofibers with unique properties, such as nanosized diameter, large specific surface area, and high aspect ratio, represent promising materials to support and stabilize photocatalytic nanosized semiconductors. Additionally, the role performed by polymer nanofibers can be extended even further since they can act as an active medium for the in situ synthesis of photocatalytic metal nanoparticles or contribute to pollutant adsorption, facilitating their approach to the photocatalytic sites and their subsequent photodegradation. 
  • 1.6K
  • 10 Mar 2022
Topic Review
Post-COVID Syndrome and Long-Term Consequences
Post-COVID syndrome or long COVID is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection, the pathogen responsible for coronavirus disease. The content herein presented reviews the reported long-term consequences and aftereffects of COVID-19 infection and the potential strategies to adopt for their management. Recent studies have shown that severe forms of COVID-19 can progress into acute respiratory distress syndrome (ARDS), a predisposing factor of pulmonary fibrosis that can irreversibly compromise respiratory function. Considering that the most serious complications are observed in the airways, the inhalation delivery of drugs directly to the lungs should be preferred, since it allows to lower the dose and systemic side effects. Although further studies are needed to optimize these techniques, recent studies have also shown the importance of in vitro models to recreate the SARS-CoV-2 infection and study its sequelae. The information reported suggests the necessity to develop new inhalation therapies in order to improve the quality of life of patients who suffer from this condition.
  • 1.6K
  • 09 Jun 2022
Topic Review
LaGaO3-Based Solid Oxide Fuel Cell Electrolytes
Solid oxide fuel cells (SOFCs) are efficient electrochemical devices that allow for the direct conversion of fuels (their chemical energy) into electricity. Although conventional SOFCs based on YSZ electrolytes are widely used from laboratory to commercial scales, the development of alternative ion-conducting electrolytes is of great importance for improving SOFC performance at reduced operation temperatures. The basic information has been studied on representative family of oxygen-conducting electrolytes, such as doped lanthanum gallates (LaGaO3). Complex oxides based on LaGaO3 offer a convenient basis for the design of oxygen-conducting electrolytes that can be employed in intermediate-temperature solid oxide fuel cells. A rational combination of appropriate dopants incorporated at various sublattices of LaGaO3 allows superior transport properties to be achieved for co-doped derivatives (La1−xSrxGa1−yMgyO3−δ, LSGM).
  • 1.6K
  • 20 Jun 2022
Topic Review
Structural and Regulation Aspects of IGF2
Insulin-like growth factor two (IGF-II) is a key protein regulating growth, particularly during normal fetal development, but it is also often dysregulated during tumorigenesis. IGF-II belongs to a larger system including several different regulatory factors and generally referred to as the “IGF system”. IGF-I and IGF-II are the main ligands of the type 1 IGF receptor (IGF-1R).
  • 1.6K
  • 28 Jun 2022
Topic Review
PXL-2000
The PXL-2000 (also known as Fisher-Price PXL2000, Fisher-Price PixelVision, Sanwa Sanpix1000, KiddieCorder, and Georgia) is a toy black-and-white camcorder produced in 1987 that uses a compact audio cassette as its recording medium. The PXL-2000 was created by a team of inventors led by James Wickstead, who sold the rights to Fisher-Price in 1987 at the American International Toy Fair in Manhattan. Surviving on the market for merely a year, only around 400,000 units were ever produced, resulting in the PXL-2000's eventual present status as a sought-after cult object among many artists and media historians.
  • 1.6K
  • 02 Nov 2022
Topic Review
Great Green Wall
The Great Green Wall or Great Green Wall of the Sahara and the Sahel (French: Grande Muraille Verte pour le Sahara et le Sahel) is Africa's flagship initiative to combat the increasing desertification. Led by the African Union, the initiative aims to transform the lives of millions of people by creating a mosaic of green and productive landscapes across North Africa. From the initial idea of a line of trees from east to west bordering the Saharan Desert, the vision of a Great Green Wall has evolved into that of a mosaic of interventions addressing the challenges facing the people in the Sahel and the Sahara. As a programming tool for rural development, the overall goal of this partnership is to strengthen regional resilience and natural systems with sound ecosystem management, protection of rural heritage, and improved living conditions. The project is a response to the combined effect of natural resources degradation and drought in rural areas. It is a partnership that supports communities working towards sustainable management and use of forests, rangelands and other natural resources. It seeks to help communities mitigate and adapt to climate change, as well as improve food security. It is expected that the population in the Sahel would double by 2039, adding urgency to the project.
  • 1.6K
  • 14 Nov 2022
Topic Review
Glucose Metabolism in Thyroid Cancer
Metabolism is a series of life-sustaining chemical reactions in organisms, providing energy required for cellular processes and building blocks for cellular constituents of proteins, lipids, carbohydrates and nucleic acids. Cancer cells frequently reprogram their metabolic behaviors to adapt their rapid proliferation and altered tumor microenvironments.
  • 1.6K
  • 08 Dec 2022
Topic Review
Seaweed Products
Seaweed, or, macroalgae, are a plant group of multicellular algae that have been exploited on a large-scale for the extraction of valuable functional food ingredients (primarily alginates, agar, and carrageenan). Seaweed is in the spotlight as a promising source of nutrition for humans as the search for sustainable food production systems continues. Seaweed has a well-documented rich nutritional profile containing compounds such as polyphenols, carotenoids and polysaccharides as well as proteins, fatty acids and minerals. Seaweed processing for the extraction of functional ingredients such as alginate, agar, and carrageenan is well-established. Novel pretreatments such as ultrasound assisted extraction or high-pressure processing can be incorporated to more efficiently extract these targeted ingredients. The scope of products that can be created using seaweed are wide ranging: from bread and noodles to yoghurt and milk and even as an ingredient to enhance the nutritional profile and stability of meat products. There are opportunities for food producers in this area to develop novel food products using seaweed.  
  • 1.6K
  • 09 Mar 2023
Topic Review
The Use of Steel Slags in Asphalt Pavements
Steel slag is a by-product obtained through the separation of molten steel from impurities in steel-making furnaces. It can be produced by different types of furnaces (blast, basic oxygen, electric arc, ladle furnaces). The reuse of metallurgical slags in road pavements can pursue aims of recycling and environmental sustainability.
  • 1.6K
  • 20 Jun 2023
Topic Review
Theoretical Concepts Underlying LSTM and BiLSTM Networks
Precise anticipation of electrical demand holds crucial importance for the optimal operation of power systems and the effective management of energy markets within the domain of energy planning. The primary aim of bidirectional Long Short-Term Memory (LSTM) network is to enhance predictive performance by capturing intricate temporal patterns and interdependencies within time series data.
  • 1.6K
  • 15 Dec 2023
Topic Review
Cougar
The Cougar (Puma concolor), also known as the mountain lion, puma, or panther, is a large felid native to the Americas. Renowned for its elusive nature and wide distribution across diverse habitats, including forests, mountains, and deserts, the Cougar is one of the most adaptable and widespread carnivores in the Western Hemisphere. As a formidable apex predator, it plays a crucial role in regulating prey populations and maintaining ecosystem balance throughout its range.
  • 1.6K
  • 28 Feb 2024
Topic Review
ESKAPE Bacteria in the Dog
ESKAPE bacteria (i.e., Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are a group of common opportunistic pathogens associated mainly with nosocomial infections.
  • 1.6K
  • 30 Oct 2020
Topic Review
Legacy Effect in Cardiovascular Disease
The "legacy effect" describes the long-term benefits that may persist for many years after the end of an intervention period, involving different biological processes. The legacy effect in cardiovascular disease (CVD) prevention has been evaluated by a limited number of studies, mostly based on pharmacological interventions, while few manuscripts on dietary interventions have been published. Most of these studies are focused on intensive treatment regimens, whose main goal is to achieve tight control of one or more cardiovascular risk factors. 
  • 1.6K
  • 16 Nov 2020
Topic Review
Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a highly effective procedure for advanced osteoarthritis of the knee. Thirty-day hospital readmission is an adverse outcome related to complications, which can be mitigated by identifying associated risk factors. 
  • 1.6K
  • 21 Jan 2021
Topic Review
Spoken ATC Instruction Understanding
Spoken ATC Instruction Understanding means in air traffic control, speech communication with radio transmission is the primary way to exchange information between the controller and aircrew. A wealth of contextual situational dynamics is embedded implicitly; thus, understanding the spoken instruction is particularly significant to the ATC research. ATC is a complicated and time-varying system, in which operational safety is always a hot research topic. All achievements of an ATC center can be vetoed without any hesitation if any safety incident occurs. Air traffic safety is affected by various aspects of air traffic operation, from mechanical maintenance, resource management, to air traffic control. The safety of air traffic control is particularly important since the aircraft is already in the air. There is no doubt that any effort deserves to be made to improve ATC safety.
  • 1.6K
  • 06 Apr 2021
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