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Topic Review
Shenxian Zhuan
The Shenxian Zhuan, sometimes given in translation as the Biographies of the Deities and Immortals, is a hagiography of immortals and description of Chinese gods, partially attributed to the Daoist scholar Ge Hong (283-343). In the history of Chinese literature, the Shenxian Zhuan followed the Liexian Zhuan ("Collected Biographies the Immortals").
  • 1.6K
  • 11 Nov 2022
Topic Review
Leukocytosis Associated with Clozapine Treatment
Clozapine is the only antipsychotic approved for treatment-resistant schizophrenia. Despite its superior efficacy profile as compared with other antipsychotics, clozapine remains underutilized. Clozapine monitoring systems clearly describe the proposed management of clozapine-induced neutropenia; however, no specific mention is made of how to interpret neutrophilic leukocytosis, despite that being a relatively frequent finding. 
  • 1.6K
  • 28 Sep 2021
Topic Review
Formation and Partitioning Theories of the Mixed Micelle
When two or more surfactants are mixed, the critical micelle concentration and solubilization capability are changed, and a careful selection of the combination promotes the micelle formation and enhances the solubilizing capability. Thus, understanding the mechanism behind the phenomena is essential for controlling the physical properties of the mixed micelle. The interaction parameters β and B that describe the formation of mixed micelles and their partitioning of solutes, respectively, were proposed by Treiner four decades ago. 
  • 1.6K
  • 26 Feb 2024
Topic Review
Continuous Microfluidics-Based Technologies for HIV
HIV-1 is the causative agent of acquired immunodeficiency syndrome (AIDS). It affects millions of people worldwide and the pandemic persists despite the implementation of highly active antiretroviral therapy. A wide spectrum of techniques has been implemented in order to diagnose and monitor AIDS progression over the years. Besides the conventional approaches, microfluidics has provided useful methods for monitoring HIV-1 infection. In this review, we introduce continuous microfluidics as well as the fabrication and handling of microfluidic chips.
  • 1.6K
  • 14 Sep 2020
Topic Review
Pharmacological Activities of Galactomannan Derivatives
Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied. The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in galactomannans. The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial. 
  • 1.6K
  • 24 Feb 2021
Topic Review
Spermine in Prostate Cancer
Spermine, a member of polyamines, exists in all organisms and is essential for normal cell growth and function. It is highly expressed in the prostate compared with other organs and is detectable in urine, tissue, expressed prostatic secretions, and erythrocyte. A significant reduction of spermine level was observed in prostate cancer (PCa) tissue compared with benign prostate tissue, and the level of urinary spermine was also significantly lower in men with PCa. Decreased spermine level may be used as an indicator of malignant phenotype transformation from normal to malignant tissue in prostate.
  • 1.6K
  • 25 May 2021
Topic Review
Circularly Polarized Hybrid DR Antennas
It has been a feasible approach to build an antenna, in view of the potential advantages they offer. One of the recent trends in dielectric resonator antenna research is the use of compound and hybrid structures. Several considerable investigations have been already underway showing quite interesting and significant features in bandwidth, gain, and generation of circular polarization. 
  • 1.6K
  • 28 Jun 2021
Topic Review
The “Sustainable Development” Conundrum
Sustainability has become a buzz word in popular discourse, especially around environmental sustainability. Sustainability indicates that a system has the ability to be maintained and renewed within a normal balance of lifecycles, not becoming depleted or extinct. Defining sustainability as merely about the natural environment is incomplete as it ignores the social systems that intertwine with the environment. These social systems are the elements that determine whether the broad ecological system is sustainable. Social systems include worldviews, culture, economics, politics, family, and community subsystems, each contributing to overall sustainability. 
  • 1.6K
  • 27 Oct 2021
Topic Review
Green Technologies Applied in Fruit and Vegetable Beverages
Green technologies can enhance nutraceutical content and/or availability, even after their incorporation into foods and beverages.
  • 1.6K
  • 26 Nov 2021
Topic Review
MERTK and AXL in NSCLC
MERTK and AXL are members of the TAM family of receptor tyrosine kinases and are abnormally expressed in 69% and 93% of non-small cell lung cancers (NSCLCs), respectively. Expression of MERTK and/or AXL provides a survival advantage for NSCLC cells and correlates with lymph node metastasis, drug resistance, and disease progression in patients with NSCLC. The TAM receptors on host tumor infiltrating cells also play important roles in the immunosuppressive tumor microenvironment. Thus, MERTK and AXL are attractive biologic targets for NSCLC treatment. 
  • 1.6K
  • 29 Mar 2022
Topic Review
Plant Secondary Metabolites as Defense Tools against Herbivores
Plants have evolved several adaptive strategies through physiological changes in response to herbivore attacks. Plant secondary metabolites (PSMs) are synthesized to provide defensive functions and regulate defense signaling pathways to safeguard plants against herbivores. Herbivore injury initiates complex reactions which ultimately lead to synthesis and accumulation of PSMs. The biosynthesis of these metabolites is regulated by the interplay of signaling molecules comprising phytohormones. Plant volatile metabolites are released upon herbivore attack and are capable of directly inducing or priming hormonal defense signaling pathways. Secondary metabolites enable plants to quickly detect herbivore attacks and respond in a timely way in a rapidly changing scenario of pest and environment.Several studies have suggested that the potential for adaptation and/or resistance by insect herbivores to secondary metabolites is limited. These metabolites cause direct toxicity to insect pests, stimulate antixenosis mechanisms in plants to insect herbivores, and, by recruiting herbivore natural enemies, indirectly protect the plants. Herbivores adapt to secondary metabolites by the up/down regulation of sensory genes, and sequestration or detoxification of toxic metabolites. PSMs modulate multi-trophic interactions involving host plants, herbivores, natural enemies and pollinators. Although the role of secondary metabolites in plant-pollinator interplay has been little explored, several reports suggest that both plants and pollinators are mutually benefited. Molecular insights into the regulatory proteins and genes involved in the biosynthesis of secondary metabolites will pave the way for the metabolic engineering of biosynthetic pathway intermediates for improving plant tolerance to herbivores. 
  • 1.6K
  • 14 Mar 2022
Topic Review
Solid Oxide Fuel Cells
The result indicated that SOFCs (Solid Oxide Fuel Cells) have better implications for environmental performance, as well as being the least cost-effective option for commercially competitive purposes.
  • 1.6K
  • 01 Dec 2022
Topic Review
Equity
In finance, equity is ownership of assets that may have debts or other liabilities attached to them. Equity is measured for accounting purposes by subtracting liabilities from the value of the assets. For example, if someone owns a car worth $24,000 and owes $10,000 on the loan used to buy the car, the difference of $14,000 is equity. Equity can apply to a single asset, such as a car or house, or to an entire business. A business that needs to start up or expand its operations can sell its equity in order to raise cash that does not have to be repaid on a set schedule. When liabilities attached to an asset exceed its value, the difference is called a deficit and the asset is informally said to be "underwater" or "upside-down". In government finance or other non-profit settings, equity is known as "net position" or "net assets".
  • 1.6K
  • 25 Oct 2022
Topic Review
Network Threat Detection with ML/DL in SDN-Based Platforms
A revolution in network technology has been ushered in by software defined networking (SDN), which makes it possible to control the network from a central location and provides an overview of the network’s security. Despite this, SDN has a single point of failure that increases the risk of potential threats. Network intrusion detection systems (NIDS) prevent intrusions into a network and preserve the network’s integrity, availability, and confidentiality. Much work has been done on NIDS but there are still improvements needed in reducing false alarms and increasing threat detection accuracy. Advanced approaches such as deep learning (DL) and machine learning (ML) have been implemented in SDN-based NIDS to overcome the security issues within a network.
  • 1.6K
  • 14 Nov 2022
Topic Review
RSA BSAFE
RSA BSAFE is a FIPS 140-2 validated cryptography library, available in both C and Java, offered by RSA Security. It was one of the most common ones before the RSA patent expired in September 2000. It also contained implementations of the RCx ciphers, with the most common one being RC4. From 2004 to 2013 the default random number generator in the library was a NIST-approved RNG standard, widely known to be insecure from at least 2006, withdrawn in 2014, suspected to contain an alleged kleptographic backdoor from the American National Security Agency (NSA), as part of its secret Bullrun program.
  • 1.6K
  • 25 Nov 2022
Topic Review
Cardiothoracic Surgical Critical Care Medicine
Cardiothoracic surgical critical care medicine (CT-CCM) is a medical discipline centered on the perioperative care of diverse groups of patients. With an aging demographic and an increase in burden of chronic diseases the utilization of cardiothoracic surgical critical care units is likely to escalate. Given these projections, it is important to assess the state of cardiothoracic surgical intensive care, to develop goals and objectives for the future, and to identify knowledge gaps in need of scientific inquiry.
  • 1.6K
  • 09 Jan 2023
Topic Review
ALK Inhibitor
ALK inhibitors are anti-cancer drugs that act on tumours with variations of anaplastic lymphoma kinase (ALK) such as an EML4-ALK translocation. They fall under the category of tyrosine kinase inhibitors, which work by inhibiting proteins involved in the abnormal growth of tumour cells. All the current approved ALK inhibitors function by binding to the ATP pocket of the abnormal ALK protein, blocking its access to energy and deactivating it. A majority of ALK-rearranged NSCLC harbour the EML4-ALK fusion, although as of 2020, over 92 fusion partners have been discovered in ALK+ NSCLC. For each fusion partner, there can be several fusion variants depending on the position the two genes were fused at, and this may have implications on the response of the tumour and prognosis of the patient.
  • 1.6K
  • 31 Oct 2022
Topic Review
Aspartame Safety as a Food Sweetener
Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. Over time, it has become a very popular artificial sweetener. However, since its approval by the main food safety agencies, several concerns have been raised related to neuropsychiatric effects and neurotoxicity due to its ability to activate glutamate receptors, as well as carcinogenic risks due to the increased production of reactive oxygen species. 
  • 1.6K
  • 13 Sep 2023
Topic Review
Enzymatic Metabolism of Flavonoids
Gastrointestinal (GI) cancer is a prevalent global health disease with a massive burden on health care providers. Internal and external factors such as obesity, smoking, diet (red meat), low socioeconomic status and infection with Helicobacter pylori are the critical risk factors of GI cancers. Flavonoids are natural phenolic compounds found abundantly in fruits and vegetables. Upon ingestion, 90% of flavonoids consumed require further enzymatic metabolism by the gut microbiome to enhance their bioavailability and absorption. Several epidemiological studies reported that consumption of flavonoids and their enzymatic conversion by gut microbes is strongly associated with the reduced risk of GI cancer development. This review summarizes the current knowledge on the enzymatic conversion of flavonoids by the human gut microbiome. It also addresses the underlying anti-GI cancer effects on metabolic pathways such as apoptosis and cellular proliferation. Overall, metabolites produced from flavonoid’s enzymatic conversion illustrate anti-GI cancer effects, but the mechanisms of action need further clarification.
  • 1.6K
  • 09 Aug 2021
Topic Review
SIRT7
Sirtuins are key players for maintaining cellular homeostasis and are often deregulated in different human diseases. SIRT7 is the only member of mammalian sirtuins that principally resides in the nucleolus, a nuclear compartment involved in ribosomal biogenesis, senescence, and cellular stress responses. The ablation of SIRT7 induces global genomic instability, premature ageing, metabolic dysfunctions, and reduced stress tolerance, highlighting its critical role in counteracting ageing-associated processes.
  • 1.6K
  • 15 Oct 2021
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