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Topic Review
Platelet in Atherosclerosis Plaque Formation
Besides their role in hemostasis and thrombosis, it has become increasingly clear that platelets are also involved in many other pathological processes of the vascular system, such as atherosclerotic plaque formation. Atherosclerosis is a chronic vascular inflammatory disease, which preferentially develops at sites under disturbed blood flow with low speeds and chaotic directions. Hyperglycemia, hyperlipidemia, and hypertension are all risk factors for atherosclerosis. When the vascular microenvironment changes, platelets can respond quickly to interact with endothelial cells and leukocytes, participating in atherosclerosis.
  • 1.6K
  • 10 Feb 2021
Topic Review
Bacteriophages in Cancer
Bacteriophages are a class of prokaryotic viruses with different sizes and shapes (icosahedral, such as T4, T7, or λ; filamentous, such as M13), which infect the host bacterial cell initiating either a lytic or a lysogenic cycle.
  • 1.6K
  • 03 Jun 2021
Topic Review
Climate Change and Homelessness
Although climate change is a global issue, it disproportionately affects homeless populations due to increased exposure and vulnerability associated with homelessness. Climate change is defined as "a change of climate which is attributed directly or indirectly to human activity that alters the composition of the global atmosphere and which is in addition to climate variability observed over comparable time periods". Homelessness can be defined as circumstances in which "an individual, family or community without stable, permanent, appropriate housing, or the immediate prospect, means and ability of acquiring it".
  • 1.6K
  • 08 Jun 2021
Topic Review
Small Molecule Natural Products Targeting Nrf2-HO-1 Signaling
The global burden of chronic kidney disease (CKD) intertwined with cardiovascular disease has become a major health problem. Oxidative stress (OS) plays an important role in the pathophysiology of CKD. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant responsive element (ARE) antioxidant system plays a critical role in kidney protection by regulating antioxidants during OS. Heme oxygenase-1 (HO-1), one of the targets of Nrf2-ARE, plays an important role in regulating OS and is protective in a variety of human and animal models of kidney disease. Thus, activation of Nrf2-HO-1 signaling may offer a potential approach to the design of novel therapeutic agents for kidney diseases.
  • 1.6K
  • 06 Jun 2022
Biography
Magdalena Gornik
Magdalena Gornik (also Gornikova Lenčka or Alenka; 19 July 1835 – 23 February 1896) was a Slovenian Roman-catholic mystic, theologian and stigmatic. Magdalena Gornik was born on July 19, 1835 at 4 Janeži 4 (today #11), to parents Jožef and Ana Gornik. That day, she was carried to the local church of Our Lady of the Snows for her baptism by her godparents Mihael Levstek and Marjeta Košir
  • 1.6K
  • 09 Dec 2022
Topic Review
The Role of ABC Transporters in the Skin
ABC transporters are expressed in skin cells to protect them against harmful xenobiotics. These transmembrane proteins have a number of additional functions that ensure skin homeostasis. 
  • 1.6K
  • 03 Jan 2023
Topic Review
Roles of ERFs in Pathogen Response and Ripening
Fleshy fruits are generally hard and unpalatable when unripe; however, as they mature, their quality is transformed by the complex and dynamic genetic and biochemical process of ripening, which affects all cell compartments. Ripening fruits are enriched with nutrients such as acids, sugars, vitamins, attractive volatiles and pigments and develop a pleasant taste and texture and become attractive to eat. Ripening also increases sensitivity to pathogens, and this presents a crucial problem for fruit postharvest transport and storage: how to enhance pathogen resistance while maintaining ripening quality. Fruit development and ripening involve many changes in gene expression regulated by transcription factors (TFs), some of which respond to hormones such as auxin, abscisic acid (ABA) and ethylene. Ethylene response factor (ERF) TFs regulate both fruit ripening and resistance to pathogen stresses. Different ERFs regulate fruit ripening and/or pathogen responses in both fleshy climacteric and non-climacteric fruits and function cooperatively or independently of other TFs. The research summarizes the current status of studies on ERFs that regulate fruit ripening and responses to infection by several fungal pathogens, including a systematic ERF transcriptome analysis of fungal grey mould infection of tomato caused by Botrytis cinerea. This deepening understanding of the function of ERFs in fruit ripening and pathogen responses may identify novel approaches for engineering transcriptional regulation to improve fruit quality and pathogen resistance.
  • 1.6K
  • 24 Oct 2023
Topic Review
Production of Ultra-High-Performance Concrete
Ultra-high-performance concrete (UHPC) is defined as a type of concrete that exhibits compressive strength greater than 120 MPa, a nominal maximum aggregate size of less than 5 mm, and flowability between 200 mm and 250 mm. UHPC exhibits a tensile strength greater than 5 MPa. According to the Federal Highway Administration (FHWA), USA, UHPC is characterized by the use of a combination of Portland cement and supplementary cementitious materials, an optimised gradation of granular materials, a high volume of discontinuous internal fibres, and a low water-to-cementitious materials ratio of less than 0.25. The microstructure of UHPC is characterized irregular pores, which control liquid evaporation and enhance durability in comparison to conventional and high-performance concretes.
  • 1.6K
  • 08 Feb 2024
Topic Review
Cognitive Interventions
With older adults, cognitive intervention programs are most often used for preventing or reversing a decline in cognitive functions. Under the heading of cognitive intervention, a multitude of diverse programs are found. In order to classify this field, we will distinguish between: (1) cognitive training programs (programs that train basic cognitive strategies), (2) cognitive rehabilitation (mono or multidimensional programs on specific skills like memory, attention, arithmetic, etc.), and (3) cognitive stimulation (continuous practice programs or use of external resources).
  • 1.6K
  • 27 Oct 2020
Topic Review
Lipid-Based Nanocarriers
Nanoparticle-based drug delivery has demonstrated promising results for topical ophthalmic nanotherapies in the treatment of intraocular diseases. Studies have revealed that nanocarriers enhance the intraocular half-life and bioavailability of several therapies including proteins, peptides and genetic material. Amongst the array of nanoparticles available nowadays, lipid-based nanosystems have shown an increased efficiency and feasibility in topical formulations, making them an important target for constant and thorough research in both preclinical and clinical practice.
  • 1.6K
  • 19 Jun 2021
Topic Review
Smart Technologies for Sustainable Water Management
As projections highlight that half of the global population will be living in regions facing severe water scarcity by 2050, sustainable water management policies and practices are more imperative than ever. Following the Sustainable Development Goals for equitable water access and prudent use of natural resources, emerging digital technologies may foster efficient monitoring, control, optimization, and forecasting of freshwater consumption and pollution. Indicatively, the use of sensors, Internet of Things, machine learning, and big data analytics has been catalyzing smart water management.
  • 1.6K
  • 20 Dec 2021
Topic Review
Gestational Diabetes and Its Prevention
Gestational diabetes mellitus (GDM) complicates between 5 and 12% of pregnancies, withassociated maternal, fetal, and neonatal complications. The ideal screening and diagnostic criteriato diagnose and treat GDM have not been established, and in recent years, significant research has been undertaken to identify a first-trimester biomarker that can predict GDM later in pregnancy, enable early intervention, and reduce GDM-related adverse outcomes. This review summarizes current data on first-trimester biomarkers, the advantages, and thelimitations.
  • 1.6K
  • 30 Dec 2021
Topic Review
Quietism
Quietism in philosophy sees the role of philosophy as broadly therapeutic or remedial. Quietist philosophers believe that philosophy has no positive thesis to contribute, but rather that its value is in defusing confusions in the linguistic and conceptual frameworks of other subjects, including non-quietist philosophy. For quietists, advancing knowledge or settling debates (particularly those between realists and non-realists) is not the job of philosophy, rather philosophy should liberate the mind by diagnosing confusing concepts.
  • 1.6K
  • 17 Nov 2022
Topic Review
Acid-Resistant Thin-Film Composite Nanofiltration Membrane
Membrane filtration technology has attracted extensive attention in academia and industry due to its advantages of eco-friendliness related to environmental protection and high efficiency. Polyamide thin-film composite nanofiltration (PA TFC NF) membranes have been widely used due to their high separation performance. Non-acid-resistant PA TFC NF membranes face tremendous challenges in an acidic environment. Novel and relatively acid-resistant polysulfonamide-based and triazine-based TFC NF membranes have been developed, but these have a serious trade-off in terms of permeability and selectivity. Hence, how to improve acid resistance of TFC NF membranes and their separation performance in acidic environments is a pivotal issue for the design and preparation of these membranes.
  • 1.6K
  • 12 Jan 2023
Topic Review
Data Storage and Retrieval Using IPFS and Blockchain
Blockchain technology has been successfully applied in recent years to promote the immutability, traceability, and authenticity of previously collected and stored data. However, the amount of data stored in the blockchain is usually limited for economic and technological issues. Namely, the blockchain usually stores only a fingerprint of data, such as the hash of data, while full, raw information is stored off-chain. This is generally enough to guarantee immutability and traceability, but misses to support another important property, that is, data availability. This is particularly true when a traditional, centralized database is chosen for off-chain storage. For this reason, many proposals try to properly combine blockchain with decentralized IPFS storage. However, the storage of data on IPFS could pose some privacy problems. This entry proposes a solution that properly combines blockchain, IPFS, and encryption techniques to guarantee immutability, traceability, availability, and data privacy.
  • 1.6K
  • 26 Mar 2024
Topic Review
Walking and Cycling
Walking and cycling are not only frequently-utilized modes of transport but also a popular component of people’s daily physical activity. As two alternatives to motorized travel modes such as private driving, walking and cycling can effectively reduce transport costs and, at the same time, mitigate traffic congestion induced by the explosion of motorized transport [1]. 
  • 1.6K
  • 26 Oct 2020
Topic Review
Enteric Nervous System
The gastrointestinal tract has the function of digesting food, absorbing the nutrients, and forming a barrier against harmful agents, but it is also an immune-hormonal system. Functional aspects of this system, such as peristaltic movements, substance transport, and local blood flow, are regulated by an intrinsic network of neuronal ganglia known as the enteric nervous system (ENS). The ENS provides motor excitatory neurons, innervate muscle layers, secretory glands, and the lymphatic vascular system. It is the largest and most complex part of the peripheral nervous system, being organized into distinct neuron networks within the gut wall, where individual small ganglia are interconnected by dense fiber bundles. These nerve plexuses are organized into two layers of neuronal ganglia and enteroglial cells that are interconnected: The myenteric plexus (Auerbach plexus) and the submucosa plexus (Meissner plexus). The ENS forms a complete sensory-motor reflex composed of intrinsic primary afferent neurons (IPANs), interneurons, and motor neurons.
  • 1.6K
  • 14 Jan 2021
Topic Review
PhaLP
Phage lytic proteins are a clinically advanced class of novel enzyme-based antibiotics, so-called enzybiotics. PhaLP is a database of phage lytic proteins, which serves as an open portal to facilitate the development of phage lytic proteins. PhaLP is a comprehensive, easily accessible and automatically updated database.
  • 1.6K
  • 26 Jul 2021
Topic Review
Sleep Apnea Detection Systems
Sleep apnea detection can be performed with externally mounted devices or ambient sensors, other than biomedical sensors. One such technique for sleep apnea detection is based on smartphones.
  • 1.6K
  • 06 Sep 2021
Topic Review
Organosolv Lignin-Based Polyurethane
Polyurethanes (PUs) present an important class of polymers due to outstanding mechanical, chemical and physical properties. Thus, they find application in many industrial sectors in the form of flexible or rigid foams, coatings, adhesives, elastomers, thermoplasts or thermosets. Modern PU coating applications include self-healing coating films that can also be applied to rather rough surfaces, such as wood.
  • 1.6K
  • 22 Mar 2022
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