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Topic Review
Spotlight on MicroPulse Laser Trabeculoplasty in Open-Angle Glaucoma
Glaucoma is the most common cause of permanent blindness in the world, caused by a progressive optic neuropathy. Patients with glaucoma are often treated with topical medicines therapy in order to reduce intra-ocular pressure (IOP). On the other hand, laser therapies, with the introduction of Argon Laser Trabeculoplasty (ALT) and successively with Selective Laser Trabeculoplasty (SLT), were reported to be effective in IOP control, with low adverse effect rates. In recent years, the micropulse laser, a subthreshold laser technology, was introduced with the goal of reducing side effects while maintaining the effectiveness of the laser treatments. Several studies focused on Micropulse Diode Laser Trabeculoplasty (MDLT) in open-angle glaucoma, to evaluate its effectiveness and possible side effects. Promising results were reported, but irradiation circumstances have not been standardized yet and its role as a substitute for previous laser techniques has yet to be defined.
  • 929
  • 08 Feb 2022
Topic Review
Treatment of Fungal Endophthalmitis
 In recent, large case series of fungal endophthalmitis (FE), the most frequent etiologic agents for all types of FE are molds (usually Aspergillus species, while Fusarium is the prevalent etiology in keratitis-related FE). Candida was the organism found in most cases of endogenous FE. Lately, polymerase chain reaction (PCR) was increasingly used for the diagnosis of FE, allowing for very high diagnostic sensitivity, while the costs become more affordable with time. The most important shortcoming of PCR—the limited number of pathogens that can be simultaneously searched for—may be overcome by newer techniques, such as next-generation sequencing. There are even hopes of searching for genetic sequences that codify resistance to antifungals.
  • 929
  • 17 Mar 2022
Topic Review
Optical Coherence Tomography Angiography
Optical coherence tomography angiography (OCTA) is a non-invasive imaging modality used to visualize the retinal layers and vessels which shows encouraging results in the study of various neurological conditions, including dementia.
  • 929
  • 25 Mar 2022
Topic Review
Erythropoietin in Optic Neuropathies
Erythropoietin (EPO) is known as a hormone for erythropoiesis in response to anemia and hypoxia. EPO could interact with its heterodimer receptor (EPOR/βcR) to exert its anti-apoptosis, anti-inflammation and anti-oxidation effects in preventing retinal ganglion cells death through different intracellular signaling pathways.
  • 916
  • 12 Aug 2022
Topic Review
Surgical Temporary Ocular Discomfort Syndrome
The term STODS (Surgical Temporary Ocular Discomfort Syndrome) has been coined to describe the ocular surface perturbations induced by surgery. As one of the most important refractive elements of the eye, Guided Ocular Surface and Lid Disease (GOLD) optimization is fundamental to success in achieving refractive outcomes and mitigating STODS. Effective GOLD optimization and the prevention/treatment of STODS requires an understanding of the molecular, cellular, and anatomic factors that influence ocular surface microenvironment and the associated perturbations induced by surgical intervention. 
  • 915
  • 08 Mar 2023
Topic Review
Overcoming Antimicrobial Resistance in Endophthalmitis
Endophthalmitis is a rare but vision-threatening infection characterized by marked inflammation of intraocular fluids and tissues, uncommonly seen following surgery and intravitreal injection. Antimicrobials are used worldwide in the prophylaxis and treatment of bacterial and fungal infections of the eye and are standard treatment in the preoperative and postoperative care of surgical patients. However, antimicrobials are reported to be overprescribed in many parts of the world, which contributes to antimicrobial resistance (AMR). AMR complicates the prophylaxis and treatment of endophthalmitis. 
  • 905
  • 18 Mar 2024
Topic Review
Basic Principles of Adaptive Optics
The eye, the photoreceptive organ used to perceive the external environment, is of great importance to humans. It has been proven that some diseases in humans are accompanied by fundus changes; therefore, the health status of people may be interpreted from retinal images. However, the human eye is not a perfect refractive system for the existence of ocular aberrations. These aberrations not only affect the ability of human visual discrimination and recognition, but restrict the observation of the fine structures of human eye and reduce the possibility of exploring the mechanisms of eye disease. Adaptive optics (AO) is a technique that corrects optical wavefront aberrations. Once integrated into ophthalmoscopes, AO enables retinal imaging at the cellular level.
  • 905
  • 19 May 2022
Topic Review
Anatomy and Barriers of Ocular Drug Delivery
Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology and biomaterial science, primarily due to the intricate anatomical and physiological barriers unique to the eye.
  • 904
  • 13 Nov 2023
Topic Review
The Role of Atropine in Preventing Myopia Progression
Myopia, also known as ‘nearsightedness’, is the one of the most common refractive diseases worldwide, and its prevalence is likely to rapidly increase in the near future.
  • 903
  • 30 May 2022
Topic Review
Sjögren’s Syndrome Dry Eye
Sjögren’s syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye and other systemic manifestations. However, due to the high prevalence of dry eye disease and the lack of objective and clinically reliable diagnostic tools, discriminating Sjögren’s syndrome dry eye (SSDE) from non-Sjögren’s syndrome dry eye (NSSDE) remains a challenge for clinicians. Diagnosing Sjögren’s syndrome is important to improve the quality of life of patients through timely referral for systemic workups, as SS is associated with serious systemic complications such as lymphoma and other autoimmune diseases. 
  • 903
  • 13 Feb 2023
Topic Review
Amino Acids Metabolism in Retinopathy
The characterization of amino acids in diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinopathy of prematurity (ROP) by metabolomics from clinical and basic research perspectives has been discussed. This entry delineates the significance of amino acid metabolism in retinopathy and provides possible direction to discover therapeutic targets for retinopathy.
  • 901
  • 15 Dec 2022
Topic Review
Ophthalmology Clinics in Alzheimer’s Disease
Alzheimer’s disease (AD) is the leading cause of dementia, which is a growing public health concern. Although there is no curative treatment for established AD, early recognition and modification of the known risk factors can reduce both severity and the rate of progression.  Currently, an early diagnosis of AD is rarely achieved, as there is no screening for AD. The cognitive decline in AD is gradual and often goes unnoticed by patients and caregivers, resulting in patients presenting at later stages of the disease.  Primary care physicians (general practitioners in the UK) can administer a battery of tests for patients presenting with memory problems and cognitive impairment, however final diagnosis of AD is usually made by specialised tertiary level clinics.  Recent studies suggest that in AD, visuospatial difficulties develop prior to the development of memory problems and screening for visuospatial difficulties may offer a tool to screen for early stage AD. AD and cataracts share common risk and predisposing factors, and the stage of cataract presentation for intervention has shifted dramatically with early cataract referral and surgical intervention becoming the norm. This presentation offers an ideal opportunity to administer a screening test for AD, and visuospatial tools can be administered at post-operative visits by eye clinics.  Abnormal findings can be communicated to primary care physicians for further follow up and assessment, or possible interventions which modify risk factors such as diabetes, hypertension and obesity can be undertaken.
  • 900
  • 05 Nov 2020
Topic Review
Diagnosis of Fungal Endophthalmitis
In large case series of fungal endophthalmitis (FE), the most frequent etiologic agents for all types of FE are molds (usually Aspergillus species, while Fusarium is the prevalent etiology in keratitis-related FE). Candida was the organism found in most cases of endogenous FE. Lately, polymerase chain reaction (PCR) was increasingly used for the diagnosis of FE, allowing for very high diagnostic sensitivity, while the costs become more affordable with time. The most important shortcoming of PCR—the limited number of pathogens that can be simultaneously searched for—may be overcome by newer techniques, such as next-generation sequencing. There are even hopes of searching for genetic sequences that codify resistance to antifungals. 
  • 896
  • 10 May 2022
Topic Review
Oxidative Stress in Retinal Dystrophies
Retinal cell survival requires an equilibrium between oxygen, reactive oxygen species, and antioxidant molecules that counteract oxidative stress damage. Oxidative stress alters cell homeostasis and elicits a protective cell response, which is most relevant in photoreceptors and retinal ganglion cells, neurons with a high metabolic rate that are continuously subject to light/oxidative stress insults. Any alteration on the retinal cell mechanisms to respond to oxidative stress injuries results in cell damage and apoptosis. Therefore, antioxidants agents, modulators of gene expression and inducers of cytoprotective signaling pathways may be used as potential therapies to ameliorate phenotypic symptoms in multifactorial and rare retinal dystrophies associated to oxidative stress injuries.
  • 892
  • 22 Sep 2021
Topic Review
Nutritional Factors in Glaucoma and Ophthalmologic Pathologies
Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma and limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, and micronutrients have been gaining increasing interest as integrative IOP-independent strategies to delay or halt glaucomatous retinal ganglion cell degeneration. 
  • 890
  • 09 May 2023
Topic Review Video
Airborne Chemical Exposure and Ocular Surface Irritation
In our recent paper "An Assessment of the Ocular Toxicity of Two Major Sources of Environmental Exposure" we discuss the impact on the eye of specific chemicals released from burn pits and from the East Palestine, Ohio train derailment. This entry discusses the importance of investigating the nature and consequences of these exposures in hopes of raising awareness of an underrecognized health issue.
  • 890
  • 29 Sep 2025
Topic Review
Stem Cell Therapies in AMD
Age-related macular degeneration (AMD) is a highly prevalent irreversible impairment in the elderly population worldwide. Stem cell therapies have been considered potentially viable for treating AMD through the direct replacement of degenerated cells or secretion of trophic factors that facilitate the survival of existing cells. 
  • 887
  • 31 May 2021
Topic Review
Uveal Melanoma Tumors
Uveal melanoma (UM), a rare form of melanoma, is the most common intraocular cancer in adults.
  • 886
  • 26 Oct 2021
Topic Review
Uveal Melanomas
Traditionally, it has been thought that metastatic spread in uveal melanoma (UM) and dissemination occurs prior to presentation and that treatment of the primary tumor does not change outcome. However, it seems as though small UM tumours can not only be lethal with high risk monosomy 3 mutations, treated at an earlier time point at a smaller stage seems to improve mortality outcomes. 
  • 882
  • 22 Sep 2021
Topic Review
Nano-Based DDS for Anterior Segment Diseases
The eye is a delicate and complex organ protected by anatomical barriers that limit the bioavailability and residence time of topically administered drugs. Polymeric nano-based drug delivery systems (DDS) have been developed to address this challenge and improve therapeutic outcomes. Biodegradable polymers are often used in these DDS to minimize adverse effects and control the release of different loaded drugs.
  • 880
  • 12 May 2023
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