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Topic Review
The Concept of Child-Centred Care in Healthcare
The position of children in healthcare reflects their changing and evolving positioning in society more broadly. The concept of child-centred care orientates children to a more central position within children’s healthcare, where the child is at the centre of thinking and practice. However, a clear definition of child-centred care and clarity around the concept is yet to be achieved.
  • 1.7K
  • 12 Mar 2024
Topic Review
History of the Minimum Wage
The history of minimum wage is about the attempts and measures governments have made to introduce a standard amount of periodic pay below which employers could not compensate their workers.
  • 1.7K
  • 05 Dec 2022
Topic Review
Non-Standard Analysis
The history of calculus is fraught with philosophical debates about the meaning and logical validity of fluxions or infinitesimal numbers. The standard way to resolve these debates is to define the operations of calculus using epsilon–delta procedures rather than infinitesimals. Non-standard analysis instead reformulates the calculus using a logically rigorous notion of infinitesimal numbers. Non-standard analysis was originated in the early 1960s by the mathematician Abraham Robinson. He wrote: "... the idea of infinitely small or infinitesimal quantities seems to appeal naturally to our intuition. At any rate, the use of infinitesimals was widespread during the formative stages of the Differential and Integral Calculus. As for the objection ... that the distance between two distinct real numbers cannot be infinitely small, Gottfried Wilhelm Leibniz argued that the theory of infinitesimals implies the introduction of ideal numbers which might be infinitely small or infinitely large compared with the real numbers but which were to possess the same properties as the latter". Robinson argued that this law of continuity of Leibniz's is a precursor of the transfer principle. Robinson continued: "However, neither he nor his disciples and successors were able to give a rational development leading up to a system of this sort. As a result, the theory of infinitesimals gradually fell into disrepute and was replaced eventually by the classical theory of limits." "It is shown in this book that Leibniz's ideas can be fully vindicated and that they lead to a novel and fruitful approach to classical Analysis and to many other branches of mathematics. The key to our method is provided by the detailed analysis of the relation between mathematical languages and mathematical structures which lies at the bottom of contemporary model theory." In 1973, intuitionist Arend Heyting praised non-standard analysis as "a standard model of important mathematical research".
  • 1.7K
  • 17 Nov 2022
Topic Review
New Organizational Structures
The structure of an organization can be defined as a relatively fixed pattern of formal authority, responsibility relationships, and information flows and sources. Although the traditional forms of the organizational structure have been widely studied (Mintzberg, 1989), new organizational structures have yet to be clearly defined. 
  • 1.7K
  • 02 Feb 2021
Topic Review
VBS1
VBS1 (Virtual Battlefield Systems 1) is a military simulator which relies heavily on modern game technology and is therefore generally referred to as a serious game. The platform is derived from the first-person entertainment game Operation Flashpoint and is developed by Bohemia Interactive Australia. The system enables the practice of small unit military tactics in an interactive multiplayer 3D environment. The platform provides real-time scenario management facilities, customized vehicles and equipment, user-definable mission scenarios, and variable environmental conditions. This combination of military simulator functionality and modern gaming technology proved to be a success and resulted in a broad military customer base. VBS2 is the successor of this platform.
  • 1.7K
  • 29 Nov 2022
Topic Review
Gla-Rich Protein in CKD
Chronic kidney disease (CKD) is estimated to affect more than 10% of the global population and represents an increasing health and economic burden for the society. Cardiovascular disease (CVD) is the most important complication of CKD and the primary cause of death in these patients. Chronic kidney disease-mineral and bone disorder (CKD-MBD), which is a common complication of CKD patients, involves changes in mineral ion homeostasis, bone quality and turnover, cardiovascular and soft tissue calcifications, highly contributing for cardiovascular outcomes. Vascular calcification (VC) is one of the strongest predictors of cardiovascular risk in chronic kidney disease (CKD) patients which is associated with significant morbidity and mortality. New diagnostic/prognostic tools are required for early detection of VC allowing interventional strategies. Gla-rich protein (GRP) is a cardiovascular calcification inhibitor, whose clinical utility still remained unknown. The present clinical study including a cohort of 80 diabetic patients with mild to moderate CKD (stages 2–4) explored, for the first time, correlations between levels of GRP in serum with CKD developmental stage, mineral metabolism markers, VC and pulse pressure (PP). The results shown an association between GRP, renal dysfunction and CKD-MBD. The relationship between low levels of GRP and vascular calcifications suggests a potential clinical utility for GRP as an early marker of vascular damage in CKD.
  • 1.7K
  • 02 Nov 2020
Topic Review
Mycobacterium avium Complex
Slow-growing mycobacteria, Mycobacterium avium, and rapid-growing mycobacteria, Mycobacterium abscessus, are important emerging human pathogens causing disease in vulnerable populations such as severelyimmunocompromised patients, patients with chronic lung diseases, and others with underlying health conditions. Their incidence is increasing worldwide in industrialized countries and they cause substantial yet underacknowledged burden of disease. An overview of the general characteristics, vulnerable populations most at risk, pathogenesis, treatment, and prevention for infections caused by Mycobacterium avium, in the context of MAC, and M. abscessus are presented in this review.
  • 1.7K
  • 14 Aug 2020
Topic Review
Microbial Communities
Although ice-free areas cover only about 0.1% of Antarctica and are characterized by harsh environmental conditions, these regions provide quite diverse conditions for the soil-forming process, having various physical and geochemical properties, and also assuring different conditions for living organisms. This study is aimed to determine existing soil microbial communities, their relationship with soil parameters and the influence of anthropogenic activity in Larsemann Hills, Eastern Antarctica. The soil microbiome was investigated at different locations using 16S rRNA gene pyrosequencing. The taxonomic analysis of the soil microbiomes revealed 12 predominant bacterial and archaeal phyla—Proteobacteria, Actinobacteria, Acidobacteria, Chloroflexi, Gemmatimonadetes, Verrucomicrobia, Planctomycetes, Bacteroidetes, Armatimonadetes, Firmicutes, Cyanobacteria, Thaumarchaeota. Some specific phyla have been also found in sub-surface horizons of soils investigated, thus providing additional evidence of the crucial role of gravel pavement in saving the favorable conditions for both soil and microbiome development. Moreover, our study also revealed that some bacterial species might be introduced into Antarctic soils by human activities. We also assessed the effect of different soil parameters on microbial community in the harsh environmental conditions of Eastern Antarctica. pH, carbon and nitrogen, as well as fine earth content, were revealed as the most accurate predictors of soil bacterial community composition.
  • 1.7K
  • 19 Aug 2020
Topic Review
Hypoxia-Inducible Factor
The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby maintaining cellular homeostasis.
  • 1.7K
  • 18 Jan 2021
Topic Review
Analytical Methods for Codeine Determination
Codeine is derived from morphine, an opioid analgesic, and has weaker analgesic and sedative effects than the parent molecule. This weak opioid is commonly used in combination with other drugs for over-the-counter cough relief medication. Due to the psychoactive properties of opioid drugs, the easily obtained codeine often becomes subject to misuse. Codeine misuse has emerged as a concerning public health issue due to its associated adverse effects such as headache, nausea, vomiting, and hemorrhage. Thus, it is very important to develop reliable analytical techniques to detect codeine for both quality control of pharmaceutical formulations and identifying drug misuse in the community. This review aims to provide critical outlooks on analytical methods napplicable to the determination of codeine.
  • 1.7K
  • 11 Mar 2021
Topic Review
Autosomal Recessive Polycystic Kidney Disease
Autosomal recessive polycystic kidney disease (ARPKD) is a rare disorder and one of the most severe forms of polycystic kidney disease, leading to end-stage renal disease (ESRD) in childhood. PKHD1 is the gene that is responsible for the vast majority of ARPKD. However, some cases have been related to a new gene that was recently identified (DZIP1L gene), as well as several ciliary genes that can mimic a ARPKD-like phenotypic spectrum. In addition, a number of molecular pathways involved in the ARPKD pathogenesis and progression were elucidated using cellular and animal models. However, the function of the ARPKD proteins and the molecular mechanism of the disease currently remain incompletely understood. 
  • 1.7K
  • 25 Jun 2021
Topic Review
Artificial Intelligence in Pathology
Tissue Biomarkers are information written in the tissue and used in Pathology to recognize specific subsets of patients with diagnostic, prognostic or predictive purposes, thus representing the key elements of Personalized Medicine. The advent of Artificial Intelligence (AI) promises to further reinforce the role of Pathology in the scenario of Personalized Medicine: AI-based devices are expected to standardize the evaluation of tissue biomarkers and also to discover novel information, which would otherwise be ignored by human review, and use them to make specific predictions. 
  • 1.7K
  • 05 Jul 2021
Topic Review
Evolution of Innovation Ecosystems
Despite the rising interest in smart city initiatives worldwide, governmental theories along with the managerial perspectives of city planning are greatly lacking in the literature. It is definitely understandable that the adoption of configurational pathways toward the ‘smart’ ‘governance’ models is required as a key factor and smartness’ facilitator in modern cities.
  • 1.7K
  • 20 Jul 2021
Topic Review
Claudins and Gastric Cancer
Despite recent improvements in diagnostic ability and treatment strategies, advanced gastric cancer (GC) has a high frequency of recurrence and metastasis, with poor prognosis. To improve the treatment results of GC, the search for new treatment targets from proteins related to epithelial–mesenchymal transition (EMT) and cell–cell adhesion is currently being conducted. EMT plays an important role in cancer metastasis and is initiated by the loss of cell–cell adhesion, such as tight junctions (TJs), adherens junctions, desmosomes, and gap junctions. Among these, claudins (CLDNs) are highly expressed in some cancers, including GC. Abnormal expression of CLDN1, CLDN2, CLDN3, CLDN4, CLDN6, CLDN7, CLDN10, CLDN11, CLDN14, CLDN17, CLDN18, and CLDN23 have been reported. Among these, CLDN18 is of particular interest. In The Cancer Genome Atlas, GC was classified into four new molecular subtypes, and CLDN18–ARHGAP fusion was observed in the genomically stable type. An anti-CLDN18.2 antibody drug was recently developed as a therapeutic drug for GC, and the results of clinical trials are highly predictable. Thus, CLDNs are highly expressed in GC as TJs and are expected targets for new antibody drugs. 
  • 1.7K
  • 10 Jan 2022
Topic Review
Distributed Edge Computing in IoT-Based Smart Cities
Smart cities using the Internet of Things (IoT) can operate various IoT systems with better services that provide intelligent and efficient solutions for various aspects of urban life. With the rapidly growing number of IoT systems, the many smart city services, and their various quality of service (QoS) constraints, servers face the challenge of allocating limited resources across all Internet-based applications to achieve an efficient per-formance. The presence of a cloud in the IoT system of a smart city results in high energy con-sumption and delays in the network. Edge computing is based on a cloud computing framework where computation, storage, and network resources are moved close to the data source. The IoT framework is identical to cloud computing. The critical issue in edge computing when executing tasks generated by IoT systems is the efficient use of energy while maintaining delay limitations.
  • 1.7K
  • 21 Jul 2022
Topic Review
Specialized Pro-Resolving Mediators in Neuroinflammation
Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to play an important role in the inflammation environment, preventing an overreaction of the organism and promoting the resolution of inflammation.
  • 1.7K
  • 10 Aug 2022
Topic Review
PledgeMusic
PledgeMusic is an online direct-to-fan music platform, launched in August 2009, that facilitates musicians reaching out to their fanbase (termed Pledgers) to pre-sell, market, and distribute music projects including recordings, music videos, and concerts. Broadly speaking it bears some similarities to such platforms as ArtistShare, Kickstarter, Indiegogo, Patreon, RocketHub and Sellaband.
  • 1.7K
  • 08 Nov 2022
Topic Review
Mobile Robot Path Planning
One of the most significant processes in the autonomous navigation is path planning. Path planning involves the determination of a possible path for a mobile robot to move from a start to a target location in a particular environment while considering optimization parameters like path distance, time and path smoothness. Mobile robot path planning is a subcategory of trajectory planning.
  • 1.7K
  • 21 Nov 2022
Topic Review
Java Servlet
A Java servlet is a Java software component that extends the capabilities of a server. Although servlets can respond to many types of requests, they most commonly implement web containers for hosting web applications on web servers and thus qualify as a server-side servlet web API. Such web servlets are the Java counterpart to other dynamic web content technologies such as PHP and ASP.NET.
  • 1.7K
  • 25 Nov 2022
Topic Review
Malnutrition in Children
Malnutrition in children is common globally and may result in both short and long term irreversible negative health outcomes. The World Health Organization (WHO) estimates that malnutrition accounts for 54 percent of child mortality worldwide, about 1 million children. Another estimate also by WHO states that childhood underweight is the cause for about 35% of all deaths of children under the age of five years worldwide. The main causes are unsafe water, inadequate sanitation or insufficient hygiene, factors related to society and poverty, diseases, maternal factors, gender issues and – overall – poverty. Malnutrition in this article specifically refers to undernutrition where an individual is not getting enough calories, protein, or micronutrients. (It could also refer to a condition where too much food is consumed such that the diet causes health problems).
  • 1.7K
  • 25 Nov 2022
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