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Topic Review
β-hydroxybutyrate as an Anti-Aging Metabolite
The ketone bodies, especially β-hydroxybutyrate (β-HB), derive from fatty acid oxidation and alternatively serve as a fuel source for peripheral tissues including the brain, heart, and skeletal muscle. β-HB is currently considered not solely an energy substrate for maintaining metabolic homeostasis but also acts as a signaling molecule of modulating lipolysis, oxidative stress, and neuroprotection. Besides, it serves as an epigenetic regulator in terms of histone methylation, acetylation, β-hydroxybutyrylation to delay various age-related diseases. In addition, studies support endogenous β-HB administration or exogenous supplementation as effective strategies to induce a metabolic state of nutritional ketosis. The purpose of this review article is to provide an overview of β-HB metabolism and its relationship and application in age-related diseases. Future studies are needed to reveal whether β-HB has the potential to serve as adjunctive nutritional therapy for aging.
  • 1.7K
  • 19 Oct 2021
Topic Review
The Discovery of Infrared Radiation
This entry is mainly about the story of infrared radiation
  • 1.7K
  • 02 Dec 2021
Topic Review
The Concept of Genus
The genus concept and its implication in classifying pathogenic relevant microorganisms:  The Brucella and Ochrobactrum
  • 1.7K
  • 31 Mar 2022
Topic Review
Anti-Inflammatory and Antiviral Effects of Cannabinoids
The COVID-19 pandemic caused by the SARS-CoV-2 virus made it necessary to search for new options for both causal treatment and mitigation of its symptoms. Scientists and researchers around the world are constantly looking for the best therapeutic options. These difficult circumstances have also spurred the re-examination of the potential of natural substances contained in Cannabis sativa L. Cannabinoids, apart from CB1 and CB2 receptors, may act multifacetedly through a number of other receptors, such as the GPR55, TRPV1, PPARs, 5-HT1A, adenosine and glycine receptors. The complex anti-inflammatory and antiviral effects of cannabinoids have been confirmed by interactions with various signaling pathways. Considering the fact that the SARS-CoV-2 virus causes excessive immune response and triggers an inflammatory cascade, and that cannabinoids have the ability to regulate these processes, it can be assumed that they have potential to be used in the treatment of COVID-19.
  • 1.7K
  • 22 Apr 2022
Topic Review
Gene Therapy for Cholestasis
Cholestatic diseases can be caused by the dysfunction of transporters involved in hepatobiliary circulation. Although pharmacological treatments constitute the current standard of care for these diseases, none are curative, with liver transplantation being the only long-term solution for severe cholestasis, albeit with many disadvantages. Liver-directed gene therapy has shown promising results in clinical trials for genetic diseases, and it could constitute a potential new therapeutic approach for cholestatic diseases. Gene therapy has emerged as a promising approach to achieve safe, stable, and efficient long-term correction for a wide range of genetic diseases, including monogenic liver disorders, for which liver transplantation remains the only cure, as well as acquired liver diseases.
  • 1.7K
  • 14 Jun 2022
Topic Review
3D Biometrics
Biometrics have been used to identify humans since the 19th century. Over time, these biometrics became 3D. The main reason for this was the growing need for more features in the images to create more reliable identification models. Three main categories of 3D biometrics were identified. These were face, hand and gait. The corresponding percentages for these categories were 74.07%, 20.37% and 5.56%, respectively. The face is further categorized into facial, ear, iris and skull, while the hand is divided into fingerprint, finger vein and palm. In each category, facial and fingerprint were predominant, and their respective percentages were 80% and 54.55%. The use of the 3D reconstruction algorithms was also determined. These were stereo vision, structure-from-silhouette (SfS), structure-from-motion (SfM), structured light, time-of-flight (ToF), photometric stereo and tomography. Stereo vision and SfS were the most commonly used algorithms with a combined percentage of 51%. The state of the art for each category and the available datasets are also presented. Finally, multimodal biometrics, generalization of 3D reconstruction algorithms and anti-spoofing metrics are the three areas that should attract scientific interest for further research. 
  • 1.7K
  • 02 Sep 2022
Topic Review
Loopholes in Bell Test Experiments
In Bell test experiments, there may be problems of experimental design or set-up that affect the validity of the experimental findings. These problems are often referred to as "loopholes". See the article on Bell's theorem for the theoretical background to these experimental efforts (see also John Stewart Bell). The purpose of the experiment is to test whether nature is best described using a local hidden variable theory or by the quantum entanglement theory of quantum mechanics. The "detection efficiency", or "fair sampling" problem is the most prevalent loophole in optical experiments. Another loophole that has more often been addressed is that of communication, i.e. locality. There is also the "disjoint measurement" loophole which entails multiple samples used to obtain correlations as compared to "joint measurement" where a single sample is used to obtain all correlations used in an inequality. To date, no test has simultaneously closed all loopholes. Ronald Hanson of the Delft University of Technology claims the first Bell experiment that closes both the detection and the communication loopholes. (This was not an optical experiment in the sense discussed below; the entangled degrees of freedom were electron spins rather than photon polarization.) Nevertheless, correlations of classical optical fields also violate Bell's inequality. In some experiments there may be additional defects that make "local realist" explanations of Bell test violations possible; these are briefly described below. Many modern experiments are directed at detecting quantum entanglement rather than ruling out local hidden variable theories, and these tasks are different since the former accepts quantum mechanics at the outset (no entanglement without quantum mechanics). This is regularly done using Bell's theorem, but in this situation the theorem is used as an entanglement witness, a dividing line between entangled quantum states and separable quantum states, and is as such not as sensitive to the problems described here. In October 2015, scientists from the Kavli Institute of Nanoscience reported that the Quantum nonlocality phenomenon is supported at the 96% confidence level based on a "loophole-free Bell test" study. These results were confirmed by two studies with statistical significance over 5 standard deviations which were published in December 2015. However, Alain Aspect writes that No experiment can be said to be totally loophole-free.
  • 1.7K
  • 10 Oct 2022
Topic Review
Speech-Language Pathology
Speech-language pathology is a field of expertise practiced by a clinician known as a speech-language pathologist (SLP) or a speech and language therapist, both of whom may be known by the shortened description, speech therapist. SLP is considered a "related health profession" or "allied health profession" along with audiology, optometry, occupational therapy, rehabilitation psychology, physical therapy, behavior analysis and others. SLPs specialize in the evaluation, diagnosis, and treatment of communication disorders (speech disorders and language disorders), cognitive-communication disorders, voice disorders, and swallowing disorders. SLPs also play an important role in the diagnosis and treatment of autism spectrum disorder (often in a team with pediatricians and psychologists).
  • 1.7K
  • 28 Nov 2022
Topic Review
Economics in Marine Spatial Planning
There has been a rapid increase in the use of Marine Spatial Planning (MSP) worldwide, partly due to the continued loss of marine biodiversity and habitat. The sustainability of marine resources is threatened in all regions of the world by major events such as climate change, marine pollution, and overfishing, as well as illegal, unreported and unregulated fishing both on the high seas and in country waters.
  • 1.7K
  • 20 Feb 2024
Topic Review
Equine Endometrium Morphology
Mares are seasonal polyestric. The morphology of the healthy equine endometrium is influenced by the season of the year, the stage of the endometrial cycle, as well as the presence of endometrial diseases. The latter have an impact on the wellbeing of individual mares and can also inflict major financial losses for the horse breeding industry. The microscopic examination of an endometrial biopsy is an important diagnostic tool, since it can also detect subclinical diseases. This review provides an overview about morphological and molecular features of the healthy and diseased equine endometrium. It reviews the diagnostic findings of inflammatory and degenerative endometrial disease of mares, as well as the current state of knowledge regarding their cellular and molecular pathogenesis. It further shows that the comparative evaluation of morphological features and molecular characteristics of the healthy and diseased equine endometrium is an important prerequisite for the identification of disease-associated molecular markers, which in turn will facilitate the development of diagnostic and predictive biomarkers, as well as novel prophylactic and therapeutic options. Although currently numerous molecular data are already available, future studies are required to establish their translation into clinical practice.
  • 1.7K
  • 01 Nov 2020
Topic Review
Cell Migration
Directional migration of cells is essential for multicellular organisms development and survival. In this review we outline the importance of calcium signaling, and in particular store-operated calcium entry, in regulating cell migration in nomral and metastatic cells. Interestingly, calcium signaling is polarized and differentially regulates focal adhesion and the cytoskeleton at the front and rear ends of the cell. 
  • 1.7K
  • 25 May 2021
Topic Review
Transdermal Drug Delivery System
Transdermal drug delivery system (TDDS) is an attractive method for drug delivery with convenient application, less first-pass effect, and fewer systemic side effects. Among all generations of TDDS, transdermal nanocarriers show the greatest clinical potential because of their non-invasive properties and high drug delivery efficiency. However, it is still difficult to design optimal transdermal nanocarriers to overcome the skin barrier, control drug release, and achieve targeting. Hence, surface modification becomes a promising strategy to optimize and functionalize the transdermal nanocarriers with enhanced penetration efficiency, controlled drug release profile, and targeting drug delivery.
  • 1.7K
  • 14 Dec 2022
Topic Review
Single-Molecule Localization Microscopy
Super-resolution microscopy (SRM) achieves sub-diffraction limited resolution by either deterministic or stochastic time-controlled emission of fluorescence from only a subset of fluorophores from the total fluorophore population in the specimen. Single-molecule localization microscopy (SMLM) allows for the visualization of individual fluorophores at the level of individual molecules based on the temporal separation of individual fluorescent molecules. This relatively simple principle allows for the detection at subsequent time intervals of a sparse subset of well-separated fluorophores and reconstruction of a final super-resolved image from the localization of the centers of the fluorophores.
  • 1.7K
  • 11 Jul 2021
Topic Review
Socially Assistive Robots
Socially assistive robots (SARs) have been used to help to mitigate the effects of the pandemic on older adults, including loneliness and isolation, and to alleviate the workload of both formal and informal caregivers. We identify the specific applications of SARs during the pandemic to help the older population and their caregivers. The robots all have multimodal communication abilities, and were able to perform multiple functions, including: (1) health monitoring (routinely checking vital signs and alerting healthcare professionals of any abnormalities), (2) screening of visitors (checking for masks and measuring temperature upon entering facilities), (3) social facilitation (enabling video communication between residents and families or healthcare staff), (4) activity facilitation (singing, dancing), (5) providing information and reminders for tasks (weather and food menu, scheduled activities), and (6) cognitive and physical training activities (memory games, exercises). Physical characteristics of the robots are outlined, including: height, presence of touchscreen tablet, facial recognition, natural language processing.
  • 1.7K
  • 28 Sep 2021
Topic Review
Security Challenges and Malware Attacks in the IoT
Malware is a major security threat to the IoT, and detecting unknown malware is one of the key challenges for two reasons. First, the limitations of IoT devices, such as their low power retention capability and low computational processing capability, represent a significant challenge when aiming to apply security solutions. Second, introducing new ways to connect networks, such as cloud services, opens the door to many security attacks, such as malware attacks. Furthermore, connecting new devices that were not part of traditional networks via these new connection methods, such as smart sensors, makes applying security measures more complex. For these reasons, traditional malware detection mechanisms are not suitable for the IoT environment.
  • 1.7K
  • 10 Nov 2021
Topic Review
Neuropilin Related Pathological Conditions
Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane glycoprotein distributed in many human body tissues as a (co)receptor for a variety of different ligands.
  • 1.7K
  • 08 Oct 2022
Topic Review
Probation Officer
Probation and Parole Officers are officials appointed to investigate, report on, and supervise the conduct of convicted offenders on probation and/or those released from incarceration to community supervision such as parole. Most probation and parole officers are employed by the government of the jurisdiction in which they operate, although some are employed by private companies that provide contracted services to the government.
  • 1.7K
  • 14 Oct 2022
Biography
George Seldes
Henry George Seldes[1] (/ˈsɛldəs/ SEL-dəs;[aa][2] November 16, 1890 – July 2, 1995) was an American investigative journalist, foreign correspondent, editor, author, and media critic best known for the publication of the newsletter In Fact from 1940 to 1950. He was an investigative reporter of the kind known in early 20th century as a muckraker, using his journalism to fight injustice and j
  • 1.7K
  • 18 Nov 2022
Topic Review
Epigenetics in Crop Breeding
Epigenetic regulation has the potential to revolutionize plant breeding and improve crop yields by regulating gene expression in plants. DNA methylation and histone modifications are key epigenetic modifications that can impact plant development, stress responses, productivity, and yields. 
  • 1.7K
  • 11 Aug 2023
Topic Review Peer Reviewed
Co-Creation
Co-creation has gained traction in recent years and various fields, including marketing, product development, and innovation studies, as it leverages the collective expertise and insights of multiple parties to enhance outcomes. Broadly, co-creation refers to the collaborative process of involving stakeholders, such as customers, suppliers, employees, or the public, in creating or improving products, services, or experiences.
  • 1.7K
  • 15 Jan 2024
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