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Topic Review
Romney Family
The Romney family, prominent in U.S. politics and other professions, is most known for its connection with George W. Romney (1907 in Colonia Dublán, Galeana, Chihuahua, Mexico – 1995 at Bloomfield Hills, Michigan), 43rd governor of Michigan (1963–1969) and his son, Mitt Romney (born 1947 in Detroit, Michigan), 70th governor of Massachusetts (2003–2007), and Republican nominee for the presidency of the United States in 2012. George Romney's father was Gaskell Romney (1871 in St. George, Utah – 1955 in Salt Lake City, Utah), and his mother was Anna Amelia Pratt. Anna's grandfather was renowned early Mormon leader Parley Parker Pratt. Based upon the family's heritage going back to the first Mormon generation and to their modern-day prominence in business, politics, and as part of The Church of Jesus Christ of Latter-day Saints, authors Richard and Joan Ostling have written variously that the Romneys are "an LDS political dynasty" and that "The Romneys are LDS royalty." The family is linked by marriage to the Smith family, and has a lateral relationship with the Matheson family, the Huntsman family, and the Eyring family. A branch of the Romneys reside in the Mormon colonies in Mexico. The Romney family emigrated to the United States from Dalton-in-Furness, England in the 1840s.
  • 1.7K
  • 26 Nov 2022
Topic Review
Metabolic Reprogramming in Cancer Cells
Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth and proliferation. Altered metabolic flux in cancer is controlled by tumor-host cell interactions, key oncogenes, tumor suppressors, and other regulatory molecules, including non-coding RNAs. Changes to metabolic pathways in cancer are dynamic, exhibit plasticity, and are often dependent on the type of tumor and the tumor microenvironment, leading in a shift of thought from the Warburg Effect and the “reverse Warburg Effect” to metabolic plasticity. 
  • 1.7K
  • 27 Jul 2021
Topic Review
Deception, Speaking and Writing
When addressing lying and deception in language production, it is imperative to acknowledge that behavioral indicators may play a role. This include evaluation of multiple distinct verbal and nonverbal behavioral indicators, such as gaze cues, pulse rate, hand movements, and manifestations of nervousness. Here, the role of cognitive load during speaking and writing, and how cognitive load due to the parallel tasks of deciding what to say/write, and how to say it while actually expressing the thought may be visible during language production is discussed. The assumption is that lying and deception would increase the cognitive load and that this will, to some extent, be observable through the behavioral indicators. 
  • 1.7K
  • 11 Mar 2024
Topic Review
Aesthetic and Educational Aspects in Religious Architecture
The major importance in the process of human development involves personal, individual and group experiences of meetings in various areas of religious architecture that operate with the language of signs and symbols, modern artistic forms, single-space harmony, and atmosphere—an invisible order of things. In recent years, a number of studies have been carried out that attempted to define what makes the place of sacrum sufficiently meaningful, mysterious, and still necessary in order to establish a spiritual relationship with the community of believers and with God, which is relevant in one’s transition to adulthood.
  • 1.7K
  • 20 May 2022
Topic Review
Large-Scale CFB Boiler Engineering Tests and Measurement Methods
Circulating fluidized bed (CFB) boilers offer a technically viable and environmentally friendly means for the clean and efficient utilization of solid fuels. However, the complex gas–solid two-phase flow processes within them have hindered a thorough resolution of prediction issues related to coupled combustion, heat transfer, and pollutant generation characteristics. To address the deficiencies in scientific research, meet the practical operational needs of CFB boilers, and comply with new carbon emission policies, conducting full-scale field tests on large-scale CFB boilers is needed, so that the complex gas–solid flow, combustion, and heat transfer mechanisms in the furnace can be comprehended.
  • 1.7K
  • 28 Feb 2024
Topic Review
Nanostructured Materials for Uranium Removal
Groundwater is commonly used as a drinking water resource all over the world. Therefore, groundwater contamination by toxic metals is an important issue of utmost concern for public health, and several technologies are applied for their effective removal, such as coagulation, ion exchange, adsorption, and membrane applications like reverse osmosis. Adsorption is acknowledged as a simple, effective and economic technology, which has received increased interest recently, despite certain limitations regarding operational applications. The respective scientific efforts have been specifically focused on the development and implementation of novel nano-structured adsorbent materials, which may offer extensive specific surface areas, much higher than the conventional adsorbents, and hence, are expected to present higher removal efficiencies of pollutants. In this paper, the recent developments of nanomaterial applications for uranium removal from groundwaters are critically reviewed. Particularly, the use of novel composite materials, based mainly on hybrid metallic oxide nanoparticles and on composites based on graphene oxide (GO) (i.e., graphene-based hybrids), showed promising evidences to achieve efficient removal of toxic metals from water sources, even in full scale applications.
  • 1.7K
  • 12 May 2020
Topic Review
Tissue Engineering
Tissue engineering has been an inveterate area in the field of regenerative medicine for several decades. However, there remains limitations to engineer and regenerate tissues. Targeted therapies using cell-encapsulated hydrogels, such as mesenchymal stem cells (MSCs), are capable of reducing inflammation and increasing the regenerative potential in several tissues. In addition, the use of MSC-derived nano-scale secretions (i.e., exosomes) has been promising. Exosomes originate from the multivesicular division of cells and have high therapeutic potential, yet neither self-replicate nor cause auto-immune reactions to the host. To maintain their biological activity and allow a controlled release, these paracrine factors can be encapsulated in biomaterials. Among the different types of biomaterials in which exosome infusion is exploited, hydrogels have proven to be the most user-friendly, economical, and accessible material.
  • 1.7K
  • 25 Jan 2022
Topic Review
Riboswitches
Riboswitches reside in the 5'- untranslated region of RNA and regulate genes involved in the homeostasis of molecules or Ions they bind to. Since their discovery at the beginning of this century, some of the riboswitches have been regarded as potential antibacterial targets due to their role in the regulation of the homeostasis of the essential metabolites. The pharmacological potential of such riboswitches is being explored u various approaches which include fragment screening, high-throughput screening and rational ligand design guided by X-ray crystallography.
  • 1.7K
  • 24 Feb 2021
Topic Review
Hydrogels in Hand Sanitizers
Hand hygiene can be considered a strategic key useful in the containment of infections such as COVID-19 both at home and in communities because it can dramatically reduce the widespread outbreak of infections. 
  • 1.7K
  • 08 May 2021
Topic Review
Blood-Plasma Self-Separation in Self-Driven Microfluidics
Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical analysis due to it contains various biomarkers. The majority of the blood plasma separation is still handled with centrifugation, which is off-chip and time-consuming. Therefore, in the Lab-on-a-chip (LOC) field, an effective microfluidic blood plasma separation platform attracts researchers’ attention globally. Blood plasma self-separation technologies are usually divided into two categories: active self-separation and passive self-separation. Passive self-separation technologies, in contrast with active self-separation, only rely on microchannel geometry, microfluidic phenomena and hydrodynamic forces. Passive self-separation devices are driven by the capillary flow, which is generated due to the characteristics of the surface of the channel and its interaction with the fluid. Comparing to the active plasma separation techniques, passive plasma separation methods are more considered in the microfluidic platform, owing to their ease of fabrication, portable, user-friendly features.
  • 1.7K
  • 12 Jul 2021
Topic Review
Chitosan/Graphene Oxide Composite Films
The healing of wounds is still one of the challenging clinical problems for which an efficient and fast treatment is needed. Therefore, recent studies have created a new generation of wound dressings which can accelerate the wound healing process with minimum side effects. Chitosan, a natural biopolymer, is an attractive candidate for preparing biocompatible dressings. The biodegradability, non-toxicity and antibacterial activity of chitosan have made it a promising biopolymer for treating wounds. Graphene oxide has also been considered by researchers as a non-toxic, inexpensive, and biocompatible material for wound healing applications. This review discusses the potential use of chitosan/graphene oxide composite films and their application in wound dressing and drug delivery systems. 
  • 1.7K
  • 02 Sep 2021
Topic Review
Friction Challenge in Hydraulic Fracturing
Hydraulic fracturing has become one of the most popular techniques for exploring sustainable energy sources. However, friction is associated with the entire fracturing process, presenting significant challenges for development. 
  • 1.7K
  • 27 Jan 2022
Topic Review
Cobalamin-Dependent Metabolism and Its Implication in Solid Cancers
Cobalamin or vitamin B12 (B12) is a cofactor for methionine synthase and methylmalonyl-CoA mutase, two enzymes implicated in key pathways for cell proliferation: methylation, purine synthesis, succinylation and ATP production. Ensuring these functions in cancer cells therefore requires important cobalamin needs and its uptake through the transcobalamin II receptor (TCII-R). 
  • 1.7K
  • 13 Jun 2022
Topic Review
Biomimetic Implant Surfaces
The increased use of dental implants in oral rehabilitation has been followed by the development of new biomaterials as well as improvements in the performance of biomaterials already in use inspired by the properties of the tissues to be replaced. An implant is considered osseointegrated when there is no relative movement between the implant and the bone and no symptoms under a loading force. It is now known that surface topography is one of the key biomimetic factors that can directly affect the proliferation, structure, and alignment of human cells and their function and is also considered to be a critical determinant of cell adhesion.
  • 1.7K
  • 24 Jun 2022
Topic Review
Fragment-Based Drug Discovery against Mycobacteria
The emergence of drug-resistant mycobacteria, including Mycobacterium tuberculosis (Mtb) and non-tuberculous mycobacteria (NTM), poses an increasing global threat that urgently demands the development of new potent anti-mycobacterial drugs. One of the approaches toward the identification of new drugs is fragment-based drug discovery (FBDD), which is the most ingenious among other drug discovery models, such as structure-based drug design (SBDD) and high-throughput screening. Specialized techniques, such as X-ray crystallography, nuclear magnetic resonance spectroscopy, and many others, are part of the drug discovery approach to combat the Mtb and NTM global menaces.
  • 1.7K
  • 23 Sep 2022
Topic Review
Digital Economy and Sustainability
The digital economy is defined as the global network of economic activities, professional interactions, and commercial exchanges facilitated by information and communication technologies (ICT). It indicates the world’s transition to the fourth industrial revolution. Technologies such as big data and analytics, artificial intelligence, machine learning, cloud computing, and virtual reality are changing the business landscape. The technologies that characterize the digital economy contribute to sustainable development, providing innovations that help improve people’s standard of living and providing advanced techniques to protect the planet, ensuring organizational profitability.
  • 1.7K
  • 31 Jul 2023
Topic Review
Norma
Norma, Latin for "the square," is a small southern constellation located in the Milky Way. Despite its diminutive size and lack of bright stars, it remains one of the 88 modern constellations recognized by the International Astronomical Union (IAU).
  • 1.7K
  • 15 Mar 2024
Topic Review
Liquid Air Energy Storage Technologies
Liquid air energy storage (LAES) has gained prominence as an alternative to existing large-scale electrical energy storage solutions such as compressed air (CAES) and pumped hydro energy storage (PHES), especially in the context of medium-to-long-term storage. LAES offers a high volumetric energy density, surpassing the geographical constraints that hinder current mature energy storage technologies. The basic principle of LAES involves liquefying and storing air to be utilized later for electricity generation.
  • 1.7K
  • 08 Sep 2023
Topic Review
Aggregation-Induced Emission Properties in Polymers
Aggregation-Induced Emission (AIE) is a phenomenon that consists of the appearance of fluorescence in solid state or aggregation greater than that of molecules in solution and has recently attracted the attention of the scientific community because of their potential applications in different fields. Compared to small molecules, little attention has been paid to polymers and oligomers that exhibit AIE, despite having excellent properties such as high emission efficiency in aggregate and solid states, signal amplification effect, good processability and the availability of multiple functionalization sites. In addition to these features, if the molecular structure is fully conjugated, intramolecular electronic interactions between the composing chromophores may appear, thus giving rise to a wealth of new photophysical properties. In this review, we focus on selected fully conjugated oligomers, dendrimers and polymers, and briefly summarize their synthetic routes, fluorescence properties and potential applications. An exhaustive comparison between spectroscopic results in solution and aggregates or in solid state has been collected in almost all examples, and an opinion on the future direction of the field is briefly stated.
  • 1.7K
  • 02 Feb 2021
Topic Review
Leptin Receptors
It is widely accepted that the endocrine hormone leptin controls food intake and energy homeostasis via activation of leptin receptors expressed on hypothalamic arcuate neurons. The hippocampal formation also displays raised levels of leptin receptor expression and accumulating evidence indicates that leptin has a significant impact on hippocampal synaptic function.
  • 1.7K
  • 09 Mar 2021
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