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Topic Review
Entropy-Enthalpy Compensations Fold Proteins
 we reveal a protein-folding mechanism based on the entropy-enthalpy compensations that initially driven by laterally hydrophobic collapse among the side-chains of adjacent residues in the sequences of unfolded protein chains. This hydrophobic collapse promotes the formation of the H-bonds within the polypeptide backbone structures through the entropy-enthalpy compensation mechanism, enabling secondary structures and tertiary structures to fold reproducibly following explicit physical folding codes and forces. The temperature dependence of protein folding is thus attributed to the environment dependence of the conformational Gibbs free energy equation. The folding codes and forces in the amino acid sequence that dictate the formation of β-strands and α-helices can be deciphered with great accuracy through evaluation of the hydrophobic interactions among neighboring side-chains of an unfolded polypeptide from a β-strand-like thermodynamic metastable state. The folding of protein quaternary structures is found to be guided by the entropy-enthalpy compensations in between the docking sites of protein subunits according to the Gibbs free energy equation that is verified by bioinformatics analyses of a dozen structures of dimers. Protein folding is therefore guided by multistage entropy-enthalpy compensations of the system of polypeptide chains and water molecules under the solution conditions. 
  • 1.8K
  • 08 Oct 2021
Topic Review
Therapeutic Actions of Anthocyanins in Chronic Diseases
Anthocyanins are secondary metabolites and distributed in flowers, fruits and vegetables. They provide various colours such as red, pink, blue and purple. To date, more than 700 anthocyanins have been identified in nature. These anthocyanins have been associated with many health benefits through different mechanisms. Some of the therapeutic potentials of anthocyanins and their mechanisms of action are highlighted.
  • 1.8K
  • 18 Sep 2022
Topic Review
Immortalization of Human B Cells
Human B cell immortalization that maintains the constant growth characteristics and antibody expression of B cells in vitro is very critical for the development of antibody drugs and products for the diagnosis and bio-therapeutics of human diseases. Human B cell immortalization methods include Epstein-Barr virus (EBV) transformation, Simian virus 40 (SV40) virus infection, in vitro genetic modification, and activating CD40, etc. Immortalized human B cells produce monoclonal antibodies (mAbs) very efficiently, and the antibodies produced in this way can overcome the immune rejection caused by heterologous antibodies. It is an effective way to prepare mAbs and an important method for developing therapeutic monoclonal antibodies. 
  • 1.8K
  • 04 Jan 2024
Topic Review
NeWS
NeWS (Network extensible Window System) is a discontinued windowing system developed by Sun Microsystems in the mid-1980s. Originally known as "SunDew", its primary authors were James Gosling and David S. H. Rosenthal. The NeWS interpreter was based on PostScript (as was the later Display PostScript, although the two projects were otherwise unrelated) extending it to allow interaction and multiple "contexts" to support windows. Like PostScript, NeWS could be used as a complete programming language, but unlike PostScript, NeWS could be used to make complete interactive programs with mouse support and a GUI.
  • 1.8K
  • 14 Nov 2022
Topic Review
Breeding Approaches for Orchid Cultivation and Conservation
Orchid cultivation is gaining momentum attributed to the development of new orchid varieties with unique features of colors and appearance. To bridge this demand and supply gap, both traditional and molecular breeding approaches are employed with consistent efforts.
  • 1.8K
  • 27 Feb 2024
Topic Review
Financial Derivatives
This book, Financial Derivatives, a blessing or a curse? (DerivaQuote, 2006), introduces financial derivatives, their uses and the debates surrounding their use. It looks at whether one should fear them or embrace them by digging into literature, theory and case studies.  The world seems to be divided into two camps: those who embrace financial derivatives as the ‘Holy Grail’ of the new investment area, and those who denigrate derivatives as the financial Antichrist (Edington, 1994). As the quote above suggests, there are many conflicting views and opinions on derivatives and their use. Derivatives are seen either as useful instruments or as a complete waste of time and money. Experience has indicated that derivative products have transformed the way firms view financial risk and mitigate it. It is no longer relatively simple, and risks are changing continuously with innovation. Risks are no longer nationwide but global and the internet and other fast communication channels have further complicated the issue. In the article, ‘Are Derivatives Financial "Weapons of Mass Destruction"?’ Simon (2008) explains that although derivative instruments have been used to hedge risks that were previously left open, there are still those who are sceptical about using these instruments. As the Group of Thirty (G30) (1993) note, users from “both inside and outside of the financial industry, remain uncomfortable with derivatives activity.” Moreover, the latest survey by the Bank for International Settlements (2009) suggests that there is widespread employment of derivatives with adequate risk management systems. Nevertheless, not all firms are immune to derivatives misuse. This book uses literature and case studies to determine whether it is misuse of this financial instrument, and not the derivatives instrument itself, that causes firm failure and large losses. These case studies help to pinpoint the root causes of these incidents.
  • 1.8K
  • 28 Oct 2020
Topic Review
SIRT1-NF-κB Axis
Inflammation is an adaptive response triggered by harmful conditions or stimuli, such as an infection or tissue damage pursuing homeostasis reestablishment. Liver diseases cause approximately 2 million deaths per year worldwide and hepatic inflammation is a common factor to all of them, being the main driver of hepatic tissue damage and causing progression from NAFLD (non-alcoholic fatty liver disease) to NASH (non-alcoholic steatohepatitis), cirrhosis and, ultimately, HCC (hepatocellular carcinoma). The metabolic sensor SIRT1, a class III histone deacetylase with strong expression in metabolic tissues such as liver, and transcription factor NF-κB, a master regulator of inflammatory response, show an antagonistic relationship in controlling inflammation. For this reason, SIRT1 targeting is emerging as a potential strategy to improve different metabolic and/or inflammatory pathologies. In this review, we explore diverse upstream regulators and some natural/synthetic activators of SIRT1 as possible therapeutic treatment for liver diseases.
  • 1.8K
  • 27 Oct 2020
Topic Review
Alginate/Chitosan Microparticles for Agricultural Application
Encapsulation into biopolymer microparticles ensures the protection and targeted delivery of active agents while offering controlled release with higher efficiency and environmental safety for ecological and sustainable plant production. Encapsulation of biological agents provides protection and increases its survivability while providing an environment safe for growth. The application of microparticles loaded with chemical and biological agents presents an innovative way to stimulate plant metabolites synthesis. This enhances plants’ defense against pests and pathogens and results in the production of higher quality food (i.e., higher plant metabolites share). Ionic gelation was presented as a sustainable method in developing biopolymeric microparticles based on the next-generation biopolymers alginate and chitosan. 
  • 1.8K
  • 21 May 2021
Topic Review
Melittin
Melittin, a 26-amino acid peptide, is the main component of the venom of four honeybee species and exhibits neuroprotective actions. Melittin alleviates HT22 in vivo and in vitro oxidative stress injury induced by Aβ25–35; For the first time, melittin has been reported to enhance cognitive function in a learning memory-deficit model; Melittin ameliorating mechanisms were observed via the nuclear translocation of Nrf2, stimulating 1-HO production and the regulation of the TrkB/CREB/BDNF pathway.
  • 1.8K
  • 23 Nov 2021
Topic Review
Detrimental Effects of School Corporal Punishment on Children
School corporal punishment (SCP) is still a widely used and legal practice in many countries for disciplining children. The infliction of SCP upon children is associated with externalizing behavior problems, internalizing behavior problems, and reduced school performance. Awareness of its detrimental effects is needed to make the school environment a safe place for all children across the world.
  • 1.8K
  • 18 Mar 2022
Topic Review
Bell Ihua
Dr. Bell Ihua (born Ugwushi Bellema Ihua, December 20, 1979) is the Executive Director at Africa Polling Institute (API), an independent, non-profit and non-partisan public opinion think-tank, which conducts opinion polls, surveys, social research and evaluation studies at the intersection of democracy, governance, economic conditions and public life. He is a seasoned social researcher, public opinion pollster, survey expert, management consultant, and adjunct professor. Dr. Ihua is involved in the general management of the Institute's day-to-day operations. Prior to joining API, he was CEO of Nigeria's premier opinion polling company, NOI Polls Limited. He also served as Principal Consultant at DBI Analytics Consulting; and currently serves on the Boards of SMYLE Africa Group and Dumena Code Academy.
  • 1.8K
  • 02 Oct 2022
Topic Review
Anisakis
Anisakis is a genus of parasitic nematodes that have life cycles involving fish and marine mammals. They are infective to humans and cause anisakiasis. People who produce immunoglobulin E in response to this parasite may subsequently have an allergic reaction, including anaphylaxis, after eating fish infected with Anisakis species.
  • 1.8K
  • 14 Oct 2022
Topic Review
Acute Stress Disorder
Acute stress disorder (ASD, also known as acute stress reaction, psychological shock, mental shock, or simply shock) is a psychological response to a terrifying, traumatic, or surprising experience. Acute stress disorder is not fatal, but it may bring about delayed stress reactions (better known as posttraumatic stress disorder, or PTSD) if not correctly addressed.
  • 1.8K
  • 14 Oct 2022
Topic Review
Facet (Psychology)
In psychology, a facet is a specific and unique aspect of a broader personality trait. Both the concept and the term "facet" were introduced by Paul Costa and Robert McCrae in the first edition of the NEO-Personality Inventory (NEO-PI) Manual. Facets were originally elaborated only for the neuroticism, openness to experience, and extraversion traits; Costa and McCrae introduced facet scales for the agreeableness and conscientiousness traits in the Revised NEO-PI (NEO PI-R). Each of the Big Five personality traits in the five factor model contains six facets, each of which is measured with a separate scale. The use of facets and facet scales has since expanded beyond the NEO PI-R, with alternative facet and domain structures derived from other models of personality. Examples include the HEXACO model of personality structure, psycholexical studies, circumplex models (e.g., Goldberg's Abridged Big-Five Dimensional Circumplex), the Multidimensional Personality Questionnaire (MPQ), and the California Psychological Inventory.
  • 1.8K
  • 28 Nov 2022
Biography
Chu Ching-wu
Paul Chu, JP (traditional Chinese: 朱經武; simplified Chinese: 朱经武; pinyin: Zhū Jīngwǔ; Wade–Giles: Chu Ching-Wu; born February 12, 1941) is a Chinese-American physicist specializing in superconductivity, magnetism, and dielectrics. He is a Professor of physics and T.L.L. Temple Chair of Science in the Physics Department at the University of Houston College of Natural Sciences and
  • 1.8K
  • 29 Nov 2022
Topic Review
Curcumin–Cyclodextrin Supramolecular System
Supramolecular systems are based on molecular recognition, in which two or more molecules are bound by intermolecular non-covalent bonding forces to form complex and ordered entities or aggregates with specific functions and properties.
  • 1.8K
  • 22 Dec 2022
Topic Review
Dietary Macronutrients That Prompt MetS via Mitochondria
Metabolic syndrome (MetS) is a cluster of metabolic risk factors for diabetes, coronary heart disease, non-alcoholic fatty liver disease, and some tumors. It includes insulin resistance, visceral adiposity, hypertension, and dyslipidemia. MetS is primarily linked to lipotoxicity, with ectopic fat deposition from fat storage exhaustion, more than obesity per se. Excessive intake of long-chain saturated fatty acid and sugar closely relates to lipotoxicity and MetS through several pathways, including toll-like receptor 4 activation, peroxisome proliferator-activated receptor-gamma regulation (PPARγ), sphingolipids remodeling, and protein kinase C activation. These mechanisms prompt mitochondrial dysfunction, which plays a key role in disrupting the metabolism of fatty acids and proteins and in developing insulin resistance. 
  • 1.8K
  • 21 Mar 2023
Topic Review
Korg Wavestation
The Korg Wavestation is a vector synthesis synthesizer first produced in the early 1990s and later re-released as a software synthesizer in 2004. Its primary innovation was Wave Sequencing, a method of multi-timbral sound generation in which different PCM waveform data are played successively, resulting in continuously evolving sounds. The Wavestation's "Advanced Vector Synthesis" sound architecture resembled early vector synths such as the Sequential Circuits Prophet VS. Designed as a "pure" synthesizer rather than a music workstation, it lacked an on-board song sequencer, yet the Wavestation, unlike any synthesizer prior to its release, was capable of generating complex, lush timbres and rhythmic sequences that sounded like a complete soundtrack by pressing only one key. Keyboard Magazine readers gave the Wavestation its "Hardware Innovation of the Year" award, and in 1995 Keyboard listed it as one of the "20 Instruments that Shook the World." The Wavestation lineup consisted of four models: the Wavestation and Wavestation EX keyboards, and the Wavestation A/D and Wavestation SR rackmount sound modules.
  • 1.8K
  • 09 Nov 2022
Topic Review
Veterinary Drug Residues
Veterinary drugs are substances or mixtures used for the prevention, treatment, or diagnosis of animal diseases or for purposeful regulation of animal physiological functions
  • 1.8K
  • 10 Jun 2021
Topic Review
Soil Biology in the Ecuadorian Amazon
For many decades the Ecuadorian Amazon has been used as source of resources for cities both at national and international level. These facts had important consequences and environmental impacts, affecting from the smallest living organisms of the soil to the indigenous communities and peoples that inhabit the Amazon rainforest, as well as the flora and fauna biodiversity. With the change in land use, the Amazonian territory has been progressively affected and it is gradually decreasing, leaving behind poor soils.  Production conditions result modified by the implementation of large monocultures and livestock systems, a situation that directly affects soil and soil fauna. For this reason, we considered interesting to study, understand and compare the behavior of building organisms in natural and intervened areas, through sampling, inventories and laboratory analysis with the aim of developing and implementing production systems (chakras, agroforestry or silvopastoral systems), which benefit both the small producer and the ecosystem and life that inhabits it. Since there are no easily available compiled papers regarding the "Soil Biology in the Ecuadorian Amazon" in this work we collect information that allows us to offer a framework on the topics of changes in land use, typology of Amazonian soils and its main inhabitats organisms. All these date let to be considered as evidences of the degree of the health/disturbance of the corresponding soils.
  • 1.8K
  • 28 Oct 2020
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