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Topic Review
Cellulosic-Based Conductive Hydrogels for Electro-Active Tissues
The use of hydrogel in tissue engineering is not entirely new. In the last six decades, researchers have used hydrogel to develop artificial organs and tissue for the diagnosis of real-life problems and research purposes. Trial and error dominated the first forty years of tissue generation. Nowadays, biomaterials research is constantly progressing in the direction of new materials with expanded capabilities to better meet the current needs.
  • 1.2K
  • 14 Mar 2022
Topic Review
Raman Spectroscopy in Biosensing
The effect of Raman scattering is a result of inelastic light scattering processes, which lead to the emission of scattered light with a different frequency associated with molecular vibrations of the identified molecule. Spontaneous Raman scattering is usually weak, resulting in complexities with the separation of weak inelastically scattered light and intense Rayleigh scattering. These limitations have led to the development of various techniques for enhancing Raman scattering, including resonance Raman spectroscopy (RRS) and nonlinear Raman spectroscopy (coherent anti-Stokes Raman spectroscopy and stimulated Raman spectroscopy). Furthermore, the discovery of the phenomenon of enhanced Raman scattering near metallic nanostructures gave impetus to the development of the surface-enhanced Raman spectroscopy (SERS) as well as its combination with resonance Raman spectroscopy and nonlinear Raman spectroscopic techniques. The combination of nonlinear and resonant optical effects with metal substrates or nanoparticles can be used to increase speed, spatial resolution, and signal amplification in Raman spectroscopy, making these techniques promising for the analysis and characterization of biological samples.
  • 1.2K
  • 07 Jan 2022
Topic Review
Synthesis of Functional Geopolymeric Hybrid Materials
New synthetic hybrid materials, with an inorganic and organic nature, have been developed to promote their application as protective coatings and/or structural consolidants for several substrates in the construction industry and cultural heritage field. In this background, the scientific community paid attention to geopolymers and their new hybrid functional derivatives to design and develop innovative and sustainable composites with better chemical resistance, durability and mechanical characteristics. 
  • 1.2K
  • 14 Mar 2022
Topic Review
Medical Applications of Metallic Bismuth Nanoparticles
In the diagnostic field, preclinical proofs of concept have been demonstrated for X-ray, photoacoustic and fluorescence imaging. In the therapeutic field, several preclinical studies have shown the potential of bismuth nanoparticles as X-ray radiosensitizers for use in radiotherapy and as photothermal agents for applications in near infrared phototherapy.
  • 1.2K
  • 10 Nov 2021
Topic Review
Antimicrobial Resistance and Inorganic Nanoparticles
A bacterium becomes resistant due to the transfer of genes encoding antibiotic resistance. Bacteria constantly mutate; therefore, their defense mechanisms change constantly.  Nanotechnology plays a key role in antimicrobial resistance due to materials modified at the nanometer scale, allowing large numbers of molecules to assemble to have a dynamic interface. These nanomaterials act as carriers, and their design is mainly focused on introducing the temporal and spatial release of the payload of antibiotics. In addition, they generate new antimicrobial modalities for the bacteria, which are not capable of protecting themselves.
  • 1.2K
  • 18 Dec 2021
Topic Review
Nanomaterials to Enhance Polymerase Chain Reaction
Polymerase Chain Reaction (PCR) is one of the most common technologies used to produce millions of copies of targeted nucleic acid in vitro and has become an indispensable technique in molecular biology. However, it suffers from low efficiency and specificity problems, false positive results, and so on. Although many conditions can be optimized to increase PCR yield, such as the magnesium ion concentration, the DNA polymerases, the number of cycles, and so on, they are not all-purpose and the optimization can be case dependent. Nano-sized materials offer a possible solution to improve both the quality and productivity of PCR. Nanoparticles (NPs) have attracted significant attention and gradually penetrated the field of life sciences because of their unique chemical and physical properties, such as their large surface area and small size effect, which have greatly promoted developments in life science and technology. Additionally, PCR technology assisted by NPs (NanoPCR) such as gold NPs (Au NPs), quantum dots (QDs), and carbon nanotubes (CNTs), etc., have been developed to significantly improve the specificity, efficiency, and sensitivity of PCR and to accelerate the PCR reaction process. 
  • 1.2K
  • 28 Dec 2022
Topic Review
Defining Blood Plasma and Serum Metabolome by GC-MS
Metabolomics uses advanced analytical chemistry methods to analyze metabolites in biological samples. The most intensively studied samples are blood and its liquid components: plasma and serum. Armed with advanced equipment and progressive software solutions, the scientific community has shown that small molecules’ roles in living systems are not limited to traditional “building blocks” or “just fuel” for cellular energy. 
  • 1.2K
  • 06 Jan 2022
Topic Review
General Aspects of Carbon Dot and Polymer Composites
Carbon dot-based composite materials have been extensively developed for versatile biomedical applications, such as drug delivery, tissue engineering, bioimaging, biosensors, and photothermal cancer therapy, owing to their excellent mechanical properties, electrical and thermal conductivity, large surface-to-volume ratio, and biocompatibility. For instance, the hydrophobicity and delocalized π-electrons of carbon dots enable insoluble drug loading in carbon composite-based drug delivery carriers. In addition, carbon dot-based materials are suitable for optical and electrochemical biosensor applications owing to their intrinsic properties.
  • 1.2K
  • 01 Nov 2022
Topic Review
Properties of Multi-Dimensional Biological Models with Cross-Scale Features
The rise in structural performance requirements in engineering is driving the research and development of stronger, stiffer, and lighter materials. However, most traditional artificial materials are unable to meet the needs of modern industrial and technological development. In fact, multifarious creatures in nature are further ahead in their use of structural materials. There is a fairly limited selection of natural structural materials at ambient temperatures. They usually consist of hard and soft phases arranged in a complex hierarchy with characteristic dimensions ranging from nanoscale to macroscale. The resulting materials usually show a nearly perfect combination of strength and toughness integrated with lightweight characteristics. This is exactly what is required of engineering materials.
  • 1.2K
  • 12 Nov 2021
Topic Review
Macrocyclic Receptors
An important direction in the design of tetrapyrrole macrocyclic receptors for a certain substrate type is modification of the macrocycle periphery with bulky substituents or molecular fragments of different natures. Bulky highly-branched lateral substituents are capable of forming additional complexing cavities that can be used for identification and selective binding of substrates of a certain type.
  • 1.2K
  • 14 Sep 2021
Topic Review
Characterization of Berry Pomace Powders
The processing of berry juice, wine, or other beverages results in a considerable amount of pomace, including skins, seeds, and, occasionally, stalks. Pomace has been estimated at 30% of the total grape use in winemaking or 60% of the total cranberry use in juice production. However, berry pomace is no longer seen as a by-product and is further processed as a value-added food ingredient.
  • 1.2K
  • 09 Mar 2022
Topic Review
Chrysoeriol7 against Brown Planthopper in Rice
Brown planthopper (BPH, Nilaparvata lugens Stal.) is the most damaging rice pest affecting stable rice yields worldwide. Currently, methods for controlling BPH include breeding a BPH‐resistant cultivar and using synthetic pesticides. Nevertheless, the continuous cultivation of resistant cultivars allows for the emergence of various resistant races, and the use of synthetic pesticides can induce environmental pollution as well as the emergence of unpredictable new pest species. As plants cannot migrate to other locations on their own to combat various stresses, the production of secondary metabolites allows plants to protect themselves from stress and tolerate their reproduction. Pesticides using natural products are currently being developed to prevent environmental pollution and ecosystem disturbance caused by synthetic pesticides. In this study, after BPH infection in rice, chrysoeriol7 (C7), a secondary metabolite that induces resistance against BPH, was assessed. After C7 treatment and BPH infection, relative expression levels of the flavonoid‐related genes were elevated, suggesting that in plants subjected to BPH, compounds related to flavonoids, among the secondary metabolites, play an important role in inducing resistance. The plant‐derived natural compound chrysoeriol7 can potentially thus be used to develop environmentally friendly pesticides. The suggested control of BPH can be effectively used to alleviate concerns regarding environmental pollution and to construct a relatively safe rice breeding environment.
  • 1.2K
  • 21 Mar 2022
Topic Review
Thiazolidinedione Derivatives
Thiazolidinediones (TZDs) are a kind of DMII drug. The data revealed that compounds (4–6) have higher potency than the reference drugs. Compounds (4–7) were able to regulate hyperlipidemia levels (cholesterol, triglyceride, high-density lipoproteins and low- and very-low-density lipoproteins) to nearly normal value at the 30th day.
  • 1.2K
  • 29 Jan 2022
Topic Review
ATT Triplex and DNA
Due to the involvement of DNA:RNA hybrids and triplex helices in many essential functions in cells, this entry’s main aim is to detect benzothiazole based moieties with selective binding or spectroscopic response to these nucleic structures compared to regular (non-hybrid) DNA and RNA duplexes and single-stranded forms.
  • 1.2K
  • 29 Mar 2022
Topic Review
Chitosan and Fibroin
For the creation of tissue-engineered structures based on natural biopolymers with the necessary chemical, physical, adhesive, morphological, and regenerative properties, biocompatible materials based on polysaccharides and proteins are used.  This entry is devoted to a problem of the technology of polymeric materials for biomedical purposes: the creation of biopolymer tissue engineering matrix and the development of a methodology for studying morphology and functional properties of their surface to establish the prospects for using the material for contact with living objects.
  • 1.2K
  • 12 Apr 2021
Topic Review
Dehydrogenases involved in Reduction of CO2 to CH3OH
The three dehydrogenase enzymes involved in the CO2 to methanol conversion are: Formate dehydrogenase, Formaldehyde dehydrogenase and Alcohol dehydrogenase.
  • 1.2K
  • 26 Aug 2022
Topic Review
Magnetic Nanoparticles for Diagnosis and Treatment of Cancer
Cancer is a disease that has resulted in millions of deaths worldwide. The current conventional therapies utilized for the treatment of cancer have detrimental side effects. This led scientific researchers to explore new therapeutic avenues with an improved benefit to risk profile. 
  • 1.2K
  • 10 Dec 2021
Topic Review
Pressure-Induced Polymerization
Under pressure of 1–100 GPa, unsaturated organic molecules tend to form covalent bond to each other for a negative enthalpy change, which often produces polymeric materials with extended carbon skeleton. The polymerization reactions typically happen in crystal, which promotes the topochemical process. 
  • 1.1K
  • 10 Feb 2022
Topic Review
Recent Advances in the Development of Fire-Resistant Biocomposites
Biocomposites reinforced with natural fibers represent an eco-friendly and inexpensive alternative to conventional petroleum-based materials and have been increasingly utilized in a wide variety of industrial applications due to their numerous advantages, such as their good mechanical properties, low production costs, renewability, and biodegradability. However, these engineered composite materials have inherent downsides, such as their increased flammability when subjected to heat flux or flame initiators, which can limit their range of applications. As a result, certain attempts are still being made to reduce the flammability of biocomposites. The combustion of biobased composites can potentially create life-threatening conditions in buildings, resulting in substantial human and material losses. Additives known as flame-retardants (FRs) have been commonly used to improve the fire protection of wood and biocomposite materials, textiles, and other fields for the purpose of widening their application areas. At present, this practice is very common in the construction sector due to stringent fire safety regulations on residential and public buildings. 
  • 1.1K
  • 28 Jan 2022
Topic Review
Polymeric Nanostructures Containing Proteins
Over the last three decades, proteins and peptides have attracted great interest as drugs of choice for combating a broad spectrum of diseases, including diabetes mellitus, cancer, and infectious and neurological diseases. However, the delivery of therapeutic proteins to target sites should take into account the obstacles and limitations related to their intrinsic sensitivity to different environmental conditions, fragile tertiary structures, and short half-life. Polymeric nanostructures have emerged as competent vehicles for protein delivery, as they are multifunctional and can be tailored according to their peculiarities.
  • 1.1K
  • 24 Feb 2022
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