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Topic Review
Prostate Cancer
Metastasis of prostate cancer often results in death of the patient. A cluster of fatty acid-binding protein (FABP) genes involved in transportation, accumulation and utilization of fatty acids are co-amplified and preferentially expressed in metastatic prostate cancer compared to localized disease. These genes, namely FABP12, FABP4, FABP9, FABP8 and FABP5, individually and collectively, promote properties associated with prostate cancer metastasis. Levels of these FABP genes may serve as an indicator of prostate cancer aggressiveness, and that inhibiting the action of FABP genes may provide a new approach to prevent and/or treat metastatic prostate cancer. 
  • 1.8K
  • 31 Dec 2020
Topic Review
Curcumin in Chronic Hepatitis
Curcumin, as a natural product, is inexpensive, without side effects, and can stimulate very well certain areas of the human immune system. The cytotoxicity of curcumin as photosensitizer could be expanded by the intravenous blue laser blood irradiation (IVBLBI) or photobiomodulation in patients with chronic hepatitis B infection, Hepatitis B e-antigen (HBeAg)-positive, noncirrhotic, but nonresponsive to classical therapy. 
  • 1.8K
  • 26 May 2021
Topic Review
Homogeneous charge compression ignition (HCCI)
Homogeneous charge compression ignition (HCCI) is considered an advanced combustion method for internal combustion engines that offers simultaneous reductions in oxides of nitrogen (NOx) emissions and increased fuel efficiency. The present study examines the influence of intake air temperature (IAT) and premixed diesel fuel on fuel self-ignition characteristics in a light-duty compression ignition engine. Partial HCCI was achieved by port injection of the diesel fuel through air-assisted injection while sustaining direct diesel fuel injection into the cylinder for initiating combustion. The self-ignition of diesel fuel under such a set-up was studied with variations in premixed ratios (0–0.60) and inlet temperatures (40–100 °C) under a constant 1600 rpm engine speed with 20 Nm load. 
  • 1.8K
  • 23 Aug 2021
Topic Review
Nanostructured Lipid Carriers-Hydrogels System for Drug Delivery
Nanostructured lipid carriers (NLC) are lipid nanoparticles of the second generation made up of solid lipid matrices mixed with liquid lipids (oils). The hybrid system between NLC and hydrogel may results in the enhancement of each component's synergistic properties in the mechanical strength of the hydrogel and concomitantly decrease aggregation of the NLC. Therefore, the advanced hybrid component development in nanotechnology provides superior functionality in the application of scientific knowledge for the drug delivery industry. 
  • 1.8K
  • 25 Jan 2022
Topic Review
Solar Reactors for Hydrogen Production
Green hydrogen production is at the core of the transition away from conventional fuels. Along with popularly investigated pathways for hydrogen production, thermochemical water splitting using redox materials is an interesting option for utilizing thermal energy, as this approach makes use of temperature looping over the material to produce hydrogen from water. Solar reactors have conventionally been used for such reactions, as temperatures up to 2000 °C can be reached, which are beneficial for the reduction of the redox material. 
  • 1.8K
  • 27 Apr 2022
Topic Review
Material Reactions, Degradation and Applications of Polyvinylidene Fluoride
Polyvinylidene fluoride (PVDF), the chemical formula is (C2H2F2)n. Its basic building blocks are therefore carbon, hydrogen, and fluorine. These three elements can form several crystalline chain conformations. Conformations are defined by polar and nonpolar phases. Four phases are most commonly found in the literature: α-, β-, γ-, and δ-. 
  • 1.8K
  • 17 Oct 2022
Topic Review
Youth Road Safety Behavior in Serbia
Road traffic crashes are a leading cause of death for young people. Aberrant driver behaviors, such as drink driving, speeding, not wearing seatbelts, non-compliance with traffic rules and aggressive driving, are key contributors to these crashes. Gender and urban/rural differences are also risk factors. Younger people have the highest road crash and fatality risk.
  • 1.8K
  • 07 Nov 2022
Topic Review
Immortalization of Human B Cells
Human B cell immortalization that maintains the constant growth characteristics and antibody expression of B cells in vitro is very critical for the development of antibody drugs and products for the diagnosis and bio-therapeutics of human diseases. Human B cell immortalization methods include Epstein-Barr virus (EBV) transformation, Simian virus 40 (SV40) virus infection, in vitro genetic modification, and activating CD40, etc. Immortalized human B cells produce monoclonal antibodies (mAbs) very efficiently, and the antibodies produced in this way can overcome the immune rejection caused by heterologous antibodies. It is an effective way to prepare mAbs and an important method for developing therapeutic monoclonal antibodies. 
  • 1.8K
  • 04 Jan 2024
Topic Review
Breeding Approaches for Orchid Cultivation and Conservation
Orchid cultivation is gaining momentum attributed to the development of new orchid varieties with unique features of colors and appearance. To bridge this demand and supply gap, both traditional and molecular breeding approaches are employed with consistent efforts.
  • 1.8K
  • 27 Feb 2024
Topic Review
Routing in the Data Center
To have adequate routing and forwarding, it is imperative to fully exploit the topological characteristics of fat trees. Some basic requirements should be satisfied: forwarding loops avoidance, rapid failure detection, efficient network utilization (e.g., spanning-tree solutions are not acceptable), routing scalability (in addition to physical scalability). In principle, being the data center a single administrative domain, the candidates to fulfill the routing role are popular link-state IGPs. However, as they have been designed for arbitrary topologies, the flood of link-state advertisements may suffer from scalability issues. Therefore, the possible solutions should entail reducing the message flooding, exploiting the topology knowledge, or using other routing algorithms. In this regard, the following routing protocols will be considered in this work: BGP with a specific configuration for the data center, link-state algorithms with flooding reduction, and ongoing Internet Engineering Task Force (IETF) efforts, namely Routing in Fat Trees (RIFT) and Link State Vector Routing (LSVR), which are leveraging link-state and distance-vector advantages to design specific routing algorithms for data centers.This entry only consider distributed control plane solutions, i.e., routing protocols. Consequently, logically centralized Software-Defined Networking (SDN) solutions are not analyzed.
  • 1.8K
  • 27 Jan 2022
Topic Review
Radar Depth and Velocity Estimation
Radar can measure range and Doppler velocity, but both of them cannot be directly used for downstream tasks. The range measurements are sparse and therefore difficult to associate with their visual correspondences. The Doppler velocity is measured in the radial axis and, therefore, cannot be directly used for tracking.
  • 1.8K
  • 08 Jun 2022
Topic Review
Morphological Variations of the Liver
Radiologists and oncogynecologists should be familiar with different liver shape variations to avoid diagnostic errors and unwanted intraoperative surgical complications. Surgeons should be aware of variations in liver shape as in such cases, the vasculature or gallbladder may have a variant anatomical location.
  • 1.8K
  • 16 Jan 2024
Topic Review
Lipid Phosphate Phosphatases
Lipid phosphate phosphatases (LPPs) consist of three enzymes (LPP1–3), which have been classified as phospholipid phosphatases (PLPP). The LPPs dephosphorylate a wide spectrum of bioactive lipid phosphates, among which lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) are two important extracellular signaling molecules. The LPPs are integral membrane proteins, which are partly localized on plasma membranes. These activities participate in regulating the concentrations of extracellular LPA and S1P and thus signaling through their families of G protein coupled receptors. The expression of the LPPs on intracellular membranes, including endoplasmic reticulum and Golgi net work, are thought to attenuate signaling downstream of the activation of LPA and protease activates receptors. The LPPs differentially regulate signal transduction in cancer cells. LPP1 and LPP3 have decreased expressions in several caners and this is associated with increased tumor growth and metastasis.  Conversely, LPP2 activity is increased in these cancers and this accelerates progression through the cell cycle. Increasing the relative activities of LPP1 and LPP3 and decreasing LPP2 activity, therefore, provides a novel approach to treating some cancers.
  • 1.8K
  • 11 Sep 2020
Topic Review
Dental Pulp Regeneration
Dental pulp regeneration requires an integrated use of three key elements, including cells, biomaterial scaffolds, and signaling molecules, which enables the recapitulation of biological processes for normal tissue development.
  • 1.8K
  • 03 Jun 2021
Topic Review
Lacunar Stroke
Lacunar strokes are small subcortical infacts that occur in the territory of one perforatng artery. Lacunar infarcts represent one of the most frequent subtypes of ischemic strokes and may represent the first recognizable manifestation of a progressive disease of the small perforating arteries, capillaries, and venules of the brain, defined as cerebral small vessel disease.
  • 1.8K
  • 15 Feb 2022
Topic Review
Role of Resilience in Education for Sustainable Development
Resilience is defined as an individual’s capability to sustain a normal state of balance when exposed to exceptionally adverse situations.
  • 1.8K
  • 05 May 2022
Topic Review
CimTrak
CimTrak is computer software for file integrity monitoring and regulatory compliance auditing. It assists in ensuring the availability and integrity of critical IT assets by detecting the root-cause and responding immediately to any unexpected changes to the host operating system, applications, and network devices located on the IT infrastructure. CimTrak works cross-platform and is supported on multiple Windows, Linux, Unix, and Macintosh operating systems. It is licensed as commercial software.
  • 1.8K
  • 22 Nov 2022
Topic Review
Delivery of Nucleic Acid Using Dendrimers
Dendrimers are a class of three-dimensional nanosized synthetic macromolecules with a well-defined globular architecture. Due to their unique properties of monodispersity, biocompatibility, and excellent biodegradability, dendrimers themselves represent an intriguing class of nanovectors for the delivery of nucleic acid-based vaccines. In this entry, researchers have demonstrated the growing interest in dendrimers as carriers of DNA and mRNA vaccines, which can become an alternative to other delivery methods.
  • 1.8K
  • 28 Apr 2023
Topic Review
Apical Periodontitis
Apical periodontitis is the inflammation and destruction of periradicular tissues, mediated by microbial factors originating from the infected pulp space. This bacteria-mediated inflammatory disease is known to interfere with root development in immature permanent teeth.
  • 1.8K
  • 20 Jun 2023
Topic Review
AI-Based Cyber-Attack Detection and Mitigation in Microgrids
With the inclusion of communication networks and smart metering devices, the attack surface has increased in microgrids, making them vulnerable to various cyber-attacks. The negative impact of such attacks may render the microgrids out-of-service, and the attacks may propagate throughout the network due to the absence of efficient mitigation approaches. AI-based techniques are being employed to tackle such data-driven cyber-attacks due to their exceptional pattern recognition and learning capabilities. AI-based methods for cyber-attack detection and mitigation that address the cyber-attacks in microgrids are summarized. 
  • 1.8K
  • 22 Nov 2023
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