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Topic Review
The ROR Pathway
The WNT pathway is one of the major signaling cascades frequently deregulated in human cancer. Binding of WNT ligands to their respective receptors can trigger various downstream signaling cascades centered around cell proliferation, survival or migration. In particular, WNT signaling via the receptor tyrosine kinase-like orphan receptors (RORs) has gained increasing attention in cancer research due to their overexpression in a multitude of tumor entities.
  • 1.8K
  • 19 Feb 2021
Topic Review
Fyn
Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years after the original description of Fyn, this protein continues to attract extreme interest because of its multiplicity of actions in the molecular signaling pathways underlying neurodevelopmental as well as neuropathologic events. Fyn is a common factor in healthy and diseased brains that targets different proteins and shapes different transduction signals according to the neurological conditions. In particular, Fyn mediates signaling pathways involved in neuronal differentiation and plasticity that have been subjected to considerable attention lately, opening the fascinating scenario to target Fyn TK for the development of potential therapeutic interventions for the treatment of CNS injuries and certain neurodegenerative disorders like Alzheimer's disease.
  • 1.8K
  • 05 Nov 2020
Topic Review
Biowastes on Soil Remediation
Biowastes refer to the biodegradable food residues from private household and food industry, garden industry, municipal wastes, and sewage sludge.
  • 1.8K
  • 29 Jul 2021
Topic Review
Fire-Safe Polymer Composites
Currently, polymers are competing with metals and ceramics to realize various material characteristics, including mechanical and electrical properties. Flame retardants can also be introduced to further reinforce the fire performance of polymers.
  • 1.8K
  • 09 Apr 2021
Topic Review
Marine Gas Engine
The interest in natural gas engines as an alternative to diesel engines has intensified as crude oil prices have risen and global environmental regulations have become more stringent. Natural gas engines can improve thermal efficiency through lean combustion, owing to combustion of a wide range of fuels; meanwhile, the low carbon content of the fuel reduces CO2 emissions, which is crucial in reducing greenhouse gas emissions. Natural gas engines also exhibit excellent fuel economy and low fuel costs. Unlike crude oil, natural gas is widely distributed worldwide and offers an advantage in terms of supply and demand. As a result, the demand for gas engines is increasing rapidly. Therefore, many marine engine manufacturers have developed micropilot-type gas engines that inject diesel fuel only for ignition.
  • 1.8K
  • 25 May 2021
Topic Review
Women Sustainable Entrepreneurship
Sustainability is a concept that tries to represent the balance between three different factors: the environment, equity and the economy. This concept is based on the fact that resources are finite and that they should be conserved and utilized wisely with a definition that prioritizes a long-term approach.
  • 1.8K
  • 18 Nov 2021
Topic Review
Impacts of COVID-19 on Fisheries and Aquaculture Sector
Fish is a major source of food and nutritional security for subsistence communities in developing countries, it also has linkages with the economic and supply-chain dimensions of these countries. It is revealed that COVID-19 has posed numerous challenges to fish supply chain actors, including a shortage of inputs, a lack of technical assistance, an inability to sell the product, a lack of transportation for the fish supply, export restrictions on fish and fisheries products, and a low fish price. These challenges lead to inadequate production, unanticipated stock retention, and a loss in returns. COVID-19 has also resulted in food insecurity for many small-scale fish growers. Fish farmers are becoming less motivated to raise fish and related products as a result of these cumulative consequences. Because of COVID-19’s different restriction measures, the demand and supply sides of the fish food chain have been disrupted, resulting in reduced livelihoods and economic vulnerability.
  • 1.8K
  • 09 Feb 2022
Topic Review
Models for Evaluation Intrusion Detection Systems in IoT
Using the Internet of Things (IoT) for various applications, such as home and wearables devices, network applications, and even self-driven vehicles, detecting abnormal traffic is one of the problematic areas for researchers to protect network infrastructure from adversary activities. Several network systems suffer from drawbacks that allow intruders to use malicious traffic to obtain unauthorized access. Attacks such as Distributed Denial of Service attacks (DDoS), Denial of Service attacks (DoS), and Service Scans demand a unique automatic system capable of identifying traffic abnormality at the earliest stage to avoid system damage. Numerous automatic approaches can detect abnormal traffic. However, accuracy is not only the issue with current Intrusion Detection Systems (IDS), but the efficiency, flexibility, and scalability need to be enhanced to detect attack traffic from various IoT networks. 
  • 1.8K
  • 27 May 2022
Topic Review
Carbon Mineralization Technologies
Carbon dioxide is a byproduct of the industrial society. It is released into the atmosphere, which has an adverse effect on the environment. Carbon dioxide management is necessary to limit the global average temperature increase to 1.5 degrees Celsius and mitigate the effects of climate change, as outlined in the Paris Agreement. 
  • 1.8K
  • 29 Jun 2022
Topic Review
Campylobacter Jejuni
Campylobacter jejuni (/ˈkæmpɪloʊˌbæktər dʒəˈdʒuːni/) is one of the most common causes of food poisoning in Europe and in the United States. The vast majority of cases occur as isolated events, not as part of recognized outbreaks. Active surveillance through the Foodborne Diseases Active Surveillance Network (FoodNet) indicates that about 20 cases are diagnosed each year for each 100,000 people in the US, while many more cases are undiagnosed or unreported; the CDC estimates a total of 1.5 million infections every year. The European Food Safety Authority reported 246,571 cases in 2018, and estimated approximately nine million cases of human campylobacteriosis per year in the European Union. Campylobacter jejuni is in a genus of bacteria that is among the most common causes of bacterial infections in humans worldwide. Campylobacter means "curved rod", deriving from the Greek kampylos (curved) and baktron (rod). Of its many species, C. jejuni is considered one of the most important from both a microbiological and public health perspective. C. jejuni is commonly associated with poultry, and is also commonly found in animal feces. Campylobacter is a helical-shaped, non-spore-forming, Gram-negative, microaerophilic, nonfermenting motile bacterium with a single flagellum at one or both poles, which are also oxidase-positive and grow optimally at 37 to 42 °C. When exposed to atmospheric oxygen, C. jejuni is able to change into a coccal form. This species of pathogenic bacteria is one of the most common causes of human gastroenteritis in the world. Food poisoning caused by Campylobacter species can be severely debilitating, but is rarely life-threatening. It has been linked with subsequent development of Guillain–Barré syndrome, which usually develops two to three weeks after the initial illness. Individuals with recent C. jejuni infections develop Guillain-Barré syndrome at a rate of 0.3 per 1000 infections, about 100 times more often than the general population. Another chronic condition that may be associated with Campylobacter infection is reactive arthritis. Reactive arthritis is a complication strongly associated with a particular genetic make-up. That is, persons who have the human leukocyte antigen B27 (HLA-B27) are most susceptible. Most often, the symptoms of reactive arthritis will occur up to several weeks after infection.
  • 1.8K
  • 10 Nov 2022
Topic Review
Gold Nanoparticles
Nanomaterials are popularly used in drug delivery, disease diagnosis and therapy. Among a number of functionalized nanomaterials such as carbon nanotubes, peptide nanostructures, liposomes and polymers, gold nanoparticles (Au NPs) make excellent drug and anticancer agent carriers in biomedical and cancer therapy application. Recent advances of synthetic technique improved the surface coating of Au NPs with accurate control of particle size, shape and surface chemistry. These make the gold nanomaterials a much easier and safer cancer agent and drug to be applied to the patient’s tumor. Although many studies on Au NPs have been published, more results are in the pipeline due to the rapid development of nanotechnology. The purpose of this review is to assess how the novel nanomaterials fabricated by Au NPs can impact biomedical applications such as drug delivery and cancer therapy. Moreover, this review explores the viability, property and cytotoxicity of various Au NPs.
  • 1.8K
  • 27 Oct 2020
Topic Review
Dietary Iron
Iron (Fe) is a biochemical microelement important for the health of the population and Fe is necessary for the fetus and all stages of growth individuals. Fe is an essential mineral necessary for delivering oxygen to tissue throughout the body as well as serving important roles in metabolism, respiration, and immune function.  Due to the importance of maintaining Fe stores, even Fe intake meets the recommended daily allowance (RDA), Fe supplementation may be justified, in states of Fe deficiency, with or without anemia, female in particular. The recommended oral Fe supplements are the first line of treatment, however, the bioavailability oral galenic forms is very low and have side effects that reduce tolerance and adherence to treatment.  Thus, a pharmaceutics strategy is to improve the bioavailability of Fe with a bioavailability enhancer.  Some studies indicate that the concomitant use of vitamin C (ascorbic acid), vitamin A, vitamin E, vitamin B9 (folic acid), vitamin B12 (cobalamin) and vitamin D3 (cholecalciferol) increases the bioavailability and absorption of Fe in the intestinal tract.
  • 1.8K
  • 10 Nov 2020
Topic Review
Cerebrovascular and Neurological Dysfunction
The recently discovered novel coronavirus, SARS-CoV-2 (COVID-19 virus), has brought the whole world to a standstill with critical challenges, affecting both health and economic sectors worldwide. Although initially, this pandemic was associated with causing severe pulmonary and respiratory disorders, recent case studies reported the association of cerebrovascular-neurological dysfunction in COVID-19 patients, which is also life-threatening. Several SARS-CoV-2 positive case studies have been reported where there are mild or no symptoms of this virus. However, a selection of patients is suffering from large artery ischemic strokes. Although the pathophysiology of the SARS-CoV-2 virus affecting the cerebrovascular system has not been elucidated yet, researchers have identified several pathogenic mechanisms, including a role for the ACE2 receptor. Therefore, it is extremely crucial to identify the risk factors related to the progression and adverse outcome of cerebrovascular-neurological dysfunction in COVID-19 patients. Since many articles have reported the effect of smoking (tobacco and cannabis) and vaping in cerebrovascular and neurological systems, and considering that smokers are more prone to viral and bacterial infection compared to non-smokers, it is high time to explore the probable correlation of smoking in COVID-19 patients. Herein, we have reviewed the possible role of smoking and vaping on cerebrovascular and neurological dysfunction in COVID-19 patients, along with potential pathogenic mechanisms associated with it.
  • 1.8K
  • 01 Apr 2021
Topic Review
Food Losses and Waste
Food losses and waste (FLW) refers to "a decrease, at all stages of the food chain, from harvest to consumption in mass, of food that was originally intended for human consumption, regardless of the cause". Food waste (FW) is a critical challenge in the Gulf Cooperation Council (GCC). This paper analyzes research dealing with food waste in the GCC countries (viz. Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, United Arab Emirates). It draws upon a systematic review performed on Scopus in January 2020. The paper covers both bibliometrics (e.g., authors, affliations, journals) and research topics (e.g., causes, food supply chain stages, extent and quantity, food security, economic impacts, environmental implications, management strategies). A main finding of the review is the scarcity of data onFWin the GCC in general and in Kuwait, Oman, and Bahrain in particular. Most of the selected articles address FW reuse and recycling (e.g., waste-to-energy conversion, compost production). Indeed, other FW management strategies, such as reduction/prevention and redistribution, are overlooked. The systematic review highlights that further research on FW in the GCC is highly needed with a focus on the identified research gaps such as causes and drivers, trends, magnitude and extent, environmental and economic impacts, along with implications of food wastage in terms of food security. Since food wastage is a common issue for all GCC countries, these research gaps should be addressed in a shared regional research agenda.
  • 1.8K
  • 27 Oct 2020
Topic Review
The Effect of Atmospheric Corrosion on Steel Structures
Atmospheric corrosion can seriously affect the performance of steel structures over long periods of time; thus, it is essential to evaluate the rate of corrosion and subsequent modification of dynamic properties of a structure over different time periods. Standards and codes represent the general guidelines and suggest general protection techniques to prevent structures from corrosion damage. 
  • 1.8K
  • 28 Mar 2022
Topic Review
The Simple Function Point (SFP) Method
The Simple Function Point (SFP) method is a lightweight Functional Measurement Method. The Simple Function Point method was designed to be compliant with the ISO14143-1 standard and compatible with the International Function Points User Group (IFPUG) Function Point Analysis (FPA) method. The original method is described in a manual produced by the Simple Function Point Association: the Simple Function Point Functional Size Measurement Method Reference Manual is available under the Creatives Commons Attribution-NoDerivatives 4.0 International Public License.
  • 1.8K
  • 27 Sep 2022
Topic Review
Reduction (Complexity)
In computability theory and computational complexity theory, a reduction is an algorithm for transforming one problem into another problem. A reduction from one problem to another may be used to show that the second problem is at least as difficult as the first. Intuitively, problem A is reducible to problem B if an algorithm for solving problem B efficiently (if it existed) could also be used as a subroutine to solve problem A efficiently. When this is true, solving A cannot be harder than solving B. "Harder" means having a higher estimate of the required computational resources in a given context (e.g., higher time complexity, greater memory requirement, expensive need for extra hardware processor cores for a parallel solution compared to a single-threaded solution, etc.). We write A ≤m B, usually with a subscript on the ≤ to indicate the type of reduction being used (m : mapping reduction, p : polynomial reduction). The mathematical structure generated on a set of problems by the reductions of a particular type generally forms a preorder, whose equivalence classes may be used to define degrees of unsolvability and complexity classes.
  • 1.8K
  • 30 Sep 2022
Topic Review
Token Ring
Token Ring is a computer networking technology used to build local area networks. It uses a special three-byte frame called a token that travels around a logical ring of workstations or servers. This token passing is a channel access method providing fair access for all stations, and eliminating the collisions of contention-based access methods. There were several other earlier implementations of token-passing networks. Token Ring was introduced by IBM in 1984, and standardized in 1989 as IEEE 802.5. It was a successful technology, particularly in corporate environments, but was gradually eclipsed by the later versions of Ethernet.
  • 1.8K
  • 10 Oct 2022
Topic Review
Visual Question Answering
Visual question answering (VQA) is a task that generates or predicts an answer to a question in human language about visual images. VQA is an active field combining two AI branches: Natural language processing (NLP) and computer vision. VQA usually has four components: vision featurization, text featurization, fusion model, and classifier. Vision featurization is a part of the multi-model responsible for extracting the vision features. Text featurization is another part of the VQA multi-model responsible for extracting text features. The combination of both features and their processes is the fusion component. The last component is the classifier that classifies the queries about the images and generates the answer.
  • 1.8K
  • 22 Sep 2023
Topic Review Peer Reviewed
What Options Are Available for Delivering Public Services, and How Do Local Governments Choose Between Them?
Local governments provide numerous services to their citizens. In doing so, they utilize two primary methods to deliver them: (1) producing them in-house with their own employees and equipment or (2) outsourcing them to external actors, which may take the form of other public agencies, for-profit firms, or non-profit organizations. In this entry, the authors review the logic of why local governments might choose one mechanism over another. The goal is to give readers a feel for the state of the academic literature in this regard. After reviewing basic concepts, such as the difference between the “provision” and “production” of services, the authors frame the discussion in terms of a variety of lenses used by scholars attempting to better understand the determinants of such decision-making. These include agency theory, transaction cost economics, and New Public Management. The authors also consider the role that management capacity plays in allowing cities to successfully deliver services to their constituents. Additionally, the authors offer a discussion regarding how local governments partner with non-profits in less formal ways than contracting to ensure their citizens have access to needed services. Finally, there is a review of the tradeoffs between efficiency and other values that should be accounted for when arranging service production.
  • 1.8K
  • 30 Jun 2025
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